LOCUS       NM_057140               2234 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus protein phosphatase 2 scaffold subunit A alpha
            (Ppp2r1a), mRNA.
ACCESSION   NM_057140 XM_341764
VERSION     NM_057140.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Sonntag T, Ostojic J, Vaughan JM, Moresco JJ, Yoon YS, Yates JR 3rd
            and Montminy M.
  TITLE     Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A
            Recruitment
  JOURNAL   iScience 11, 134-145 (2019)
   PUBMED   30611118
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Hu MW, Wang ZB, Jiang ZZ, Qi ST, Huang L, Liang QX, Schatten H and
            Sun QY.
  TITLE     Scaffold subunit Aalpha of PP2A is essential for female meiosis and
            fertility in mice
  JOURNAL   Biol Reprod 91 (1), 19 (2014)
   PUBMED   24899574
REFERENCE   3  (bases 1 to 2234)
  AUTHORS   Kotlo K, Xing Y, Lather S, Grillon JM, Johnson K, Skidgel RA,
            Solaro RJ and Danziger RS.
  TITLE     PR65A phosphorylation regulates PP2A complex signaling
  JOURNAL   PLoS One 9 (1), e85000 (2014)
   PUBMED   24465463
  REMARK    GeneRIF: PR65A phosphorylation regulates PP2A complex signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2234)
  AUTHORS   Biesemann C, Gronborg M, Luquet E, Wichert SP, Bernard V, Bungers
            SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, Jahn O, Brose
            N and Herzog E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   5  (bases 1 to 2234)
  AUTHORS   Seshacharyulu P, Pandey P, Datta K and Batra SK.
  TITLE     Phosphatase: PP2A structural importance, regulation and its
            aberrant expression in cancer
  JOURNAL   Cancer Lett 335 (1), 9-18 (2013)
   PUBMED   23454242
  REMARK    Review article
REFERENCE   6  (bases 1 to 2234)
  AUTHORS   Trinidad JC, Specht CG, Thalhammer A, Schoepfer R and Burlingame
            AL.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   7  (bases 1 to 2234)
  AUTHORS   Chiang CW, Kanies C, Kim KW, Fang WB, Parkhurst C, Xie M, Henry T
            and Yang E.
  TITLE     Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays
            the gatekeeper role for BAD-mediated apoptosis
  JOURNAL   Mol Cell Biol 23 (18), 6350-6362 (2003)
   PUBMED   12944463
REFERENCE   8  (bases 1 to 2234)
  AUTHORS   Yoshinari K, Kobayashi K, Moore R, Kawamoto T and Negishi M.
  TITLE     Identification of the nuclear receptor CAR:HSP90 complex in mouse
            liver and recruitment of protein phosphatase 2A in response to
            phenobarbital
  JOURNAL   FEBS Lett 548 (1-3), 17-20 (2003)
   PUBMED   12885400
REFERENCE   9  (bases 1 to 2234)
  AUTHORS   Ruediger R, Fields K and Walter G.
  TITLE     Binding specificity of protein phosphatase 2A core enzyme for
            regulatory B subunits and T antigens
  JOURNAL   J Virol 73 (1), 839-842 (1999)
   PUBMED   9847399
REFERENCE   10 (bases 1 to 2234)
  AUTHORS   Hatano Y, Shima H, Haneji T, Miura AB, Sugimura T and Nagao M.
  TITLE     Expression of PP2A B regulatory subunit beta isotype in rat testis
  JOURNAL   FEBS Lett 324 (1), 71-75 (1993)
   PUBMED   8389301
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083859.1.
            
            On Nov 26, 2004 this sequence version replaced XM_341764.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083859.1, SRR8487231.162368.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2234
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /note="protein phosphatase 2 scaffold subunit A alpha"
                     /db_xref="GeneID:117281"
                     /db_xref="RGD:620907"
     exon            1..79
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1771
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 2, regulatory subunit A, alpha"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A alpha isoform"
                     /protein_id="NP_476481.1"
                     /db_xref="GeneID:117281"
                     /db_xref="RGD:620907"
                     /translation="MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGV
                     ERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEET
                     VVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSS
                     AVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQD
                     SVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGP
                     EITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMTQILPCIKELV
                     SDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVN
                     EVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAW
                     LVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVL
                     SEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEK
                     LTQDQDVDVKYFAQEALTVLSLA"
     exon            80..170
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            171..271
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            272..504
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            505..652
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            653..808
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            809..923
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            924..994
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1129
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1303
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1364
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1519
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1662
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1754
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2208
                     /gene="Ppp2r1a"
                     /gene_synonym="PR65"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatggcagct gccgacggcg acgattcgct ctaccccatt gcggtgctca tagatgaact
       61 gcgcaatgag gacgttcagc ttcgtctcaa tagtatcaag aagctctcca ccattgcctt
      121 ggcccttggg gttgaacgga ccagaagtga gctcctgccc tttcttacag ataccatcta
      181 tgatgaagat gaggtcctct tggctttggc tgaacagctg ggaaccttca ccactttggt
      241 gggaggaccc gagtatgtgc actgtctgct gccacctctt gagtcactgg ccacagtgga
      301 agagacagta gtgcgagaca aggcggtaga atccttgcgg gccatctctc atgagcactc
      361 accttccgat ctagaggctc actttgtgcc tctggtgaag cggctggcgg gtggagactg
      421 gttcacctcc cgtacctcag cctgtggtct cttctcagtt tgctaccccc gagtatccag
      481 tgccgtgaag gcagaacttc gacagtactt ccggaacctg tgctcagatg atacccccat
      541 ggtgcggcgg gccgctgcct ccaagctggg ggagtttgcc aaggtactgg agctggacaa
      601 tgtcaagagt gagatcattc ccatgttctc taacctggcc tctgacgagc aggactcggt
      661 gcggctgctg gcagtagagg catgcgtgaa tatcgcccag cttctgcccc aggaggacct
      721 ggaggcctta gtgatgccca ccttgcgaca ggctgctgag gacaagtctt ggcgtgtccg
      781 ctacatggtg gcagacaaat tcacagagct ccagaaagca gttgggcctg agatcactaa
      841 gacagatctg gtgcctgcct tccagaacct gatgaaagac tgtgaggccg aggtgagggc
      901 cgcagcctcc cacaaggtca aagagttctg tgaaaatctc tcagctgact gccgggagaa
      961 tgtgatcatg acccagatct tgccctgcat caaggaactc gtgtccgatg ccaaccaaca
     1021 tgtcaagtca gcactggctt cagtcatcat gggcctctct cccattctgg gcaaagacaa
     1081 taccatcgaa cacctcttgc ccctgttctt ggctcagctg aaggatgagt gtcctgaggt
     1141 gcggctgaac atcatttcca acctggattg tgtgaatgaa gtgattggca tccggcagct
     1201 ctcgcagtcc ttgcttcctg ccatcgtgga actcgctgaa gatgccaagt ggcgagtgcg
     1261 gctggccatc attgaataca tgcctctgct ggctggacag ctcggtgtgg aattttttga
     1321 tgagaaactt aactctttgt gtatggcctg gctagtggat catgtctatg ctatccgtga
     1381 ggctgccacc agcaacctta agaagctagt ggagaagttc gggaaggagt gggcccatgc
     1441 cactatcatc cccaaggtct tagccatgtc tggagaccct aactacctgc accgaatgac
     1501 tacactcttc tgcatcaatg tgttgtctga ggtctgtggg caggatatta ccacgaagca
     1561 catgctgccc acagttcttc gtatggctgg ggacccagtc gccaatgtcc gcttcaatgt
     1621 ggccaagtca ctacagaaga taggacccat tcttgataac agcaccctgc aaagtgaagt
     1681 caagcctatc ctagagaagc tgacccagga ccaggatgtg gatgtcaagt actttgccca
     1741 ggaggctctg actgttctct ctcttgcctg atgctggaag aagaagcatt gccggcctct
     1801 ggtgtccacc ctccaacccc cacagttacc tcccttaggg aggtggtggg agcaaatgac
     1861 tgtcgctccc gtgcatggtc tgaccccagg cccctccctc agcacggttt ggtttctcct
     1921 ctctgtagcc tgggaagact tctctgtcca cctcctgcgg ggctggggca gtacaagttg
     1981 gggcaggaca gcagcctgaa aagaaggtct ggttgttcct gcccatattg ggagagatgg
     2041 gagcatccta ggtcactggc ttttgctgct gtaatgggga cccccctccc ccatctactt
     2101 acaagcaccc tttcctaacc ccaaccatgt ttttttgtgt gtgtcaattg tgccattttt
     2161 attttattcc tttccctact ctttacacag aataaaaatg tagaaataaa aaaaaaaaaa
     2221 aaaaaaaaaa aaaa
//
