LOCUS       NM_017040               1584 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus protein phosphatase 2 catalytic subunit beta
            (Ppp2cb), mRNA.
ACCESSION   NM_017040 XM_001067962
VERSION     NM_017040.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1584)
  AUTHORS   Seshacharyulu,P., Pandey,P., Datta,K. and Batra,S.K.
  TITLE     Phosphatase: PP2A structural importance, regulation and its
            aberrant expression in cancer
  JOURNAL   Cancer Lett 335 (1), 9-18 (2013)
   PUBMED   23454242
  REMARK    Review article
REFERENCE   2  (bases 1 to 1584)
  AUTHORS   Koh,P.O.
  TITLE     Ferulic acid attenuates the injury-induced decrease of protein
            phosphatase 2A subunit B in ischemic brain injury
  JOURNAL   PLoS One 8 (1), e54217 (2013)
   PUBMED   23349830
  REMARK    GeneRIF: Results suggest that the maintenance of PP2A subunit B by
            ferulic acid in ischemic brain injury plays an important role for
            the neuroprotective function of ferulic acid.
REFERENCE   3  (bases 1 to 1584)
  AUTHORS   Rahman,A., Khan,K.M., Al-Khaledi,G., Khan,I. and Al-Shemary,T.
  TITLE     Over activation of hippocampal serine/threonine protein
            phosphatases PP1 and PP2A is involved in lead-induced deficits in
            learning and memory in young rats
  JOURNAL   Neurotoxicology 33 (3), 370-383 (2012)
   PUBMED   22387731
REFERENCE   4  (bases 1 to 1584)
  AUTHORS   Yger,M. and Girault,J.A.
  TITLE     DARPP-32, Jack of All Trades em leader Master of Which?
  JOURNAL   Front Behav Neurosci 5, 56 (2011)
   PUBMED   21927600
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1584)
  AUTHORS   Chen,S., Li,B., Grundke-Iqbal,I. and Iqbal,K.
  TITLE     I1PP2A affects tau phosphorylation via association with the
            catalytic subunit of protein phosphatase 2A
  JOURNAL   J Biol Chem 283 (16), 10513-10521 (2008)
   PUBMED   18245083
  REMARK    GeneRIF: I1PP2A affects tau phosphorylation via association with
            the catalytic subunit of protein phosphatase 2A
REFERENCE   6  (bases 1 to 1584)
  AUTHORS   Nanahoshi,M., Nishiuma,T., Tsujishita,Y., Hara,K., Inui,S.,
            Sakaguchi,N. and Yonezawa,K.
  TITLE     Regulation of protein phosphatase 2A catalytic activity by alpha4
            protein and its yeast homolog Tap42
  JOURNAL   Biochem Biophys Res Commun 251 (2), 520-526 (1998)
   PUBMED   9792806
REFERENCE   7  (bases 1 to 1584)
  AUTHORS   Wadzinski,B.E., Heasley,L.E. and Johnson,G.L.
  TITLE     Multiplicity of protein serine-threonine phosphatases in PC12
            pheochromocytoma and FTO-2B hepatoma cells
  JOURNAL   J Biol Chem 265 (35), 21504-21508 (1990)
   PUBMED   2174876
REFERENCE   8  (bases 1 to 1584)
  AUTHORS   Sasaki,K., Kitagawa,Y., Shima,H., Irino,S., Sugimura,T. and
            Nagao,M.
  TITLE     Production of shorter mRNA for protein phosphatase 2A beta by
            alternative poly(A) addition
  JOURNAL   Biochem Biophys Res Commun 170 (1), 169-175 (1990)
   PUBMED   2164800
REFERENCE   9  (bases 1 to 1584)
  AUTHORS   Posas,F. and Arino,J.
  TITLE     Nucleotide sequence of a rat heart cDNA encoding the isotype beta
            of the catalytic subunit of protein phosphatase 2A
  JOURNAL   Nucleic Acids Res 17 (20), 8370 (1989)
   PUBMED   2554256
REFERENCE   10 (bases 1 to 1584)
  AUTHORS   Kitagawa,Y., Sakai,R., Tahira,T., Tsuda,H., Ito,N., Sugimura,T. and
            Nagao,M.
  TITLE     Molecular cloning of rat phosphoprotein phosphatase 2A beta cDNA
            and increased expressions of phosphatase 2A alpha and 2A beta in
            rat liver tumors
  JOURNAL   Biochem Biophys Res Commun 157 (2), 821-827 (1988)
   PUBMED   2849437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017040.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085926.1, M23591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676808, SAMN16676809
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000016.1  65282236-65282383   c
            149-358             JAXUCZ010000016.1  65270201-65270410   c
            359-532             JAXUCZ010000016.1  65269152-65269325   c
            533-622             JAXUCZ010000016.1  65265727-65265816   c
            623-784             JAXUCZ010000016.1  65265446-65265607   c
            785-903             JAXUCZ010000016.1  65263613-65263731   c
            904-1584            JAXUCZ010000016.1  65261178-65261858   c
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.3"
     gene            1..1584
                     /gene="Ppp2cb"
                     /gene_synonym="Pp2a2"
                     /note="protein phosphatase 2 catalytic subunit beta"
                     /db_xref="GeneID:24673"
                     /db_xref="RGD:3381"
     exon            1..148
                     /gene="Ppp2cb"
                     /gene_synonym="Pp2a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..976
                     /gene="Ppp2cb"
                     /gene_synonym="Pp2a2"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 2A catalytic alpha subunit;
                     PP2A-beta; protein phosphatase-2A-beta; protein
                     phosphatase 2, catalytic subunit, beta isozyme"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     catalytic subunit beta isoform"
                     /protein_id="NP_058736.1"
                     /db_xref="GeneID:24673"
                     /db_xref="RGD:3381"
                     /translation="MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESN
                     VQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
                     LKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVD
                     GQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGY
                     TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIM
                     ELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL"
     exon            149..358
                     /gene="Ppp2cb"
                     /gene_synonym="Pp2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            359..532
                     /gene="Ppp2cb"
                     /gene_synonym="Pp2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..622
                     /gene="Ppp2cb"
                     /gene_synonym="Pp2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..784
                     /gene="Ppp2cb"
                     /gene_synonym="Pp2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            785..903
                     /gene="Ppp2cb"
                     /gene_synonym="Pp2a2"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1584
                     /gene="Ppp2cb"
                     /gene_synonym="Pp2a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggccggc ggcgggggag gcggcgggga cgcgcggctc gccgccatgg acgacaaggc
       61 gttcaccaag gagctggacc agtgggtgga gcagctgaac gagtgtaagc agctgaacga
      121 gaaccaagtg cggacgctgt gcgagaaggc taaggaaatt ttaacaaaag aatcaaatgt
      181 acaagaggtt cgctgtcctg ttaccgtctg tggagatgtg catggccaat tccatgacct
      241 tatggaactc ttcagaattg gtggaaaatc accagacacc aactatctat tcatgggtga
      301 ctatgtagac agaggatatt attctgtgga gaccgtgact cttcttgtag cattaaaggt
      361 gcgctatcca gagcgtatca caatattgcg aggaaatcat gaaagccggc agatcacaca
      421 agtatatggc ttttatgatg aatgcctacg aaagtatggg aacgccaacg tgtggaaata
      481 ctttacagat ctctttgatt atcttccact tacagcttta gtagatggac agatattctg
      541 cctccacggt ggcctctctc catccataga tacactggat cacataagag ccctggatcg
      601 cttacaggaa gttccacatg agggcccaat gtgtgatctc ttatggtcag atccagatga
      661 ccgtggtggc tggggcattt ctccacgtgg tgctggctac acatttggac aagacatttc
      721 tgaaacattt aaccatgcca acggcctcac actggtgtcc cgtgctcacc agcttgtaat
      781 ggaaggatat aattggtgcc atgatcggaa tgtggtcacc atttttagtg cacccaatta
      841 ctgctaccgc tgtgggaacc aggctgctat catggaatta gacgacactt taaaatactc
      901 ttttcttcag tttgacccag cacctcgtcg tggagagcct catgtgaccc ggcgcacccc
      961 agactacttc ctataaattc ctccccagga cctgtctttg tatgttgaag tatacctggc
     1021 tttttaaaaa atatatatac atatatatat ttaaaaacaa cagttatctg tgtgtctctg
     1081 taacaaattg tgctatgtct tgacgttaaa acacatcatg gaccaaaacg tgccatacta
     1141 atggtgagcc atcagcacgg tgtgaacttg agtccactgt cctagccgag tcaaccaggc
     1201 agccgcctgc ccgcctgcct gctgtagtag ccgtccttcg tgactggtta agggaaaggg
     1261 tcactggtgg cttcatctcc tttgcgctta cttggaaatt tagttacaag tttaactggc
     1321 atggattata gagttggagt tttattttta agaattgaca agctgacttc cacttaaatt
     1381 cataaccctt tattttgttg aaatgtatga ctaactgaag aagagattct tgggagtatg
     1441 ttgtcataac actaagattt cctttcaagt ttcctgaact gaattactgt tggatgttga
     1501 cctgcacatt ctgtatattt gtcctgacag tgttgcatcc tccttgctgt actgaacaaa
     1561 taaacttccc aatttagaga gaca
//
