LOCUS       NM_017039               1915 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 2 catalytic subunit alpha
            (Ppp2ca), mRNA.
ACCESSION   NM_017039
VERSION     NM_017039.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1915)
  AUTHORS   Zhu,P., Wu,X., Ni,L., Chen,K., Dong,Z., Du,J., Kong,F., Mao,Y.,
            Tao,H., Chu,M., Mao,H., Yang,H., Liu,Q., Gan,M. and Geng,D.
  TITLE     Inhibition of PP2A ameliorates intervertebral disc degeneration by
            reducing annulus fibrosus cells apoptosis via p38/MAPK signal
            pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166888 (2024)
   PUBMED   37722489
  REMARK    GeneRIF: Inhibition of PP2A ameliorates intervertebral disc
            degeneration by reducing annulus fibrosus cells apoptosis via
            p38/MAPK signal pathway.
REFERENCE   2  (bases 1 to 1915)
  AUTHORS   Lei,L., Feng,J., Wu,G., Wei,Z., Wang,J.Z., Zhang,B., Liu,R.,
            Liu,F., Wang,X. and Li,H.L.
  TITLE     HIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau
            Hyperphosphorylation and Cognitive Dysfunction during Chronic
            Hypoxia
  JOURNAL   Int J Mol Sci 23 (24), 16140 (2022)
   PUBMED   36555780
  REMARK    GeneRIF: HIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau
            Hyperphosphorylation and Cognitive Dysfunction during Chronic
            Hypoxia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1915)
  AUTHORS   Storman,E.M., Liu,N.J. and Gintzler,A.R.
  TITLE     Relevance of c-Src and protein phosphatase 2A to aromatase
            activity: Evidence of an acute self-regulating oestrogenic
            signalling complex in rat central nervous system
  JOURNAL   J Neuroendocrinol 34 (4), e13089 (2022)
   PUBMED   35043508
  REMARK    GeneRIF: Relevance of c-Src and protein phosphatase 2A to aromatase
            activity: Evidence of an acute self-regulating oestrogenic
            signalling complex in rat central nervous system.
REFERENCE   4  (bases 1 to 1915)
  AUTHORS   Lan,J., Zhong,Z., Wang,Y., Xiong,Y. and Ye,Q.
  TITLE     Endoplasmic reticulum stress induces liver cells apoptosis after
            brain death by suppressing the phosphorylation of protein
            phosphatase 2A
  JOURNAL   Mol Med Rep 21 (2), 567-574 (2020)
   PUBMED   31974600
  REMARK    GeneRIF: Endoplasmic reticulum stress induces liver cells apoptosis
            after brain death by suppressing the phosphorylation of protein
            phosphatase 2A.
REFERENCE   5  (bases 1 to 1915)
  AUTHORS   Sonntag,T., Ostojic,J., Vaughan,J.M., Moresco,J.J., Yoon,Y.S.,
            Yates,J.R. 3rd and Montminy,M.
  TITLE     Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A
            Recruitment
  JOURNAL   iScience 11, 134-145 (2019)
   PUBMED   30611118
REFERENCE   6  (bases 1 to 1915)
  AUTHORS   Wadzinski,B.E., Heasley,L.E. and Johnson,G.L.
  TITLE     Multiplicity of protein serine-threonine phosphatases in PC12
            pheochromocytoma and FTO-2B hepatoma cells
  JOURNAL   J Biol Chem 265 (35), 21504-21508 (1990)
   PUBMED   2174876
REFERENCE   7  (bases 1 to 1915)
  AUTHORS   Posas,F. and Arino,J.
  TITLE     Nucleotide sequence of a rat heart cDNA encoding the isotype beta
            of the catalytic subunit of protein phosphatase 2A
  JOURNAL   Nucleic Acids Res 17 (20), 8370 (1989)
   PUBMED   2554256
REFERENCE   8  (bases 1 to 1915)
  AUTHORS   Posas,F. and Arino,J.
  TITLE     Nucleotide sequence of a rat heart cDNA encoding the isotype alpha
            of the catalytic subunit of protein phosphatase 2A
  JOURNAL   Nucleic Acids Res 17 (20), 8369 (1989)
   PUBMED   2554255
REFERENCE   9  (bases 1 to 1915)
  AUTHORS   Nagao,M., Sakai,R., Kitagawa,Y., Ikeda,I., Sasaki,K., Shima,H. and
            Sugimura,T.
  TITLE     Role of protein phosphatases in malignant transformation
  JOURNAL   Princess Takamatsu Symp 20, 177-184 (1989)
   PUBMED   2562181
REFERENCE   10 (bases 1 to 1915)
  AUTHORS   Kitagawa,Y., Tahira,T., Ikeda,I., Kikuchi,K., Tsuiki,S.,
            Sugimura,T. and Nagao,M.
  TITLE     Molecular cloning of cDNA for the catalytic subunit of rat liver
            type 2A protein phosphatase, and detection of high levels of
            expression of the gene in normal and cancer cells
  JOURNAL   Biochim Biophys Acta 951 (1), 123-129 (1988)
   PUBMED   2461222
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072531.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_017039.3.
            
            On Jun 13, 2004 this sequence version replaced NM_017039.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072531.1, M33114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1915
                     /gene="Ppp2ca"
                     /gene_synonym="Pp2a1"
                     /note="protein phosphatase 2 catalytic subunit alpha"
                     /db_xref="GeneID:24672"
                     /db_xref="RGD:3380"
     exon            1..299
                     /gene="Ppp2ca"
                     /gene_synonym="Pp2a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1127
                     /gene="Ppp2ca"
                     /gene_synonym="Pp2a1"
                     /EC_number="3.1.3.16"
                     /note="PP2A-alpha; protein phosphatase-2A-alpha; protein
                     phosphatase 2, catalytic subunit, alpha isozyme; protein
                     phosphatase 2A catalytic alpha subunit"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     catalytic subunit alpha isoform"
                     /protein_id="NP_058735.1"
                     /db_xref="GeneID:24672"
                     /db_xref="RGD:3380"
                     /translation="MDEKLFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESN
                     VQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
                     LKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVD
                     GQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGY
                     TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIM
                     ELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL"
     exon            300..509
                     /gene="Ppp2ca"
                     /gene_synonym="Pp2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..683
                     /gene="Ppp2ca"
                     /gene_synonym="Pp2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..773
                     /gene="Ppp2ca"
                     /gene_synonym="Pp2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..935
                     /gene="Ppp2ca"
                     /gene_synonym="Pp2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1054
                     /gene="Ppp2ca"
                     /gene_synonym="Pp2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1890
                     /gene="Ppp2ca"
                     /gene_synonym="Pp2a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgagcgga ggaggaggca cagcggccgg cggccgagca ctgcggagcg agccagcggg
       61 ccggcgccag cgcccagcag ccgcctgggg ccgcaggaag caccccgggg agcggcggcg
      121 gcgtgtgcgt gtggcccggg tgcgggcggc ggcgcgggag cagcgcagag cggcagccgg
      181 ttcgggcggg cggcatcatg gacgagaagt tgttcaccaa ggagctggac cagtggatcg
      241 agcagctgaa cgagtgcaag cagctctccg agtcccaggt caagagcctc tgcgagaagg
      301 ctaaagaaat cctgacaaaa gaatctaatg ttcaggaggt tcgatgtcca gtcactgtgt
      361 gtggagatgt gcatgggcaa tttcatgacc tcatggaact ctttagaatt ggtggtaaat
      421 caccagatac aaattacttg tttatgggag actatgtgga cagaggatat tactcagttg
      481 aaacagttac actgcttgta gctcttaagg ttcgttaccg agagcgtatc accatactcc
      541 gagggaatca cgagagcaga cagatcacac aagtttatgg tttctacgat gagtgtttaa
      601 ggaaatacgg aaatgcaaat gtttggaaat acttcacaga cctttttgac taccttcctc
      661 tcactgcctt ggtggatggg cagatcttct gtctacatgg tggtctttca ccatccatag
      721 acacactgga tcacatccga gcacttgatc gcctacaaga agttcctcat gagggtccaa
      781 tgtgtgactt gctgtggtca gatccagatg accgtggtgg ctgggggata tctcctcggg
      841 gagctggtta tacctttggc caagatattt ctgagacatt taatcatgcc aatggcctca
      901 cgttggtgtc cagagctcac cagctggtga tggagggata taactggtgc catgaccgga
      961 atgtagtaac aattttcagt gctccaaact attgctatcg ttgtggtaac caagctgcaa
     1021 tcatggaact tgatgacact cttaagtatt ctttcttgca gttcgatcca gcacctcgta
     1081 gaggcgagcc acatgtcact cgtcgtaccc cagactactt cctgtaatga aagtttaacc
     1141 ttgtacagta ttgccatgaa caccgtctgt tgacctaatg gaatcgggaa gagcagcagt
     1201 aactccaaag tgtcagaaat agttaacatt caaacttgtt tccacacgga ccaaaagatg
     1261 tgccatataa aatacaaagc ctcttgtcat caacagccgt gaccacttta gaatgaacca
     1321 gttcattgca tgctgacgcg acattgttgg tcaagaatcc agtttctggc atagcgctat
     1381 ttgtagttac ttttgctttc ttgagagact gcagatctag gatgtaacat taacacctgt
     1441 gagtccagtt gacttccact tagctgtagc ttactcagca tgactgtaga tgaggatagc
     1501 aaacaatcat tggagcttaa tgaacatttt taaatgagta ccaaggcctc ccctcttgtt
     1561 gtgttctttc agggatacta ttaatttaat tgtatgattt ctctgcactc agtttctccc
     1621 ttctcaaatc tcggccccgc gttgttcttt gttactgtca gaaaacctgg tgagttgttt
     1681 tgaacagaac tgtctccctc ctgtaagatg atgtactgca caagtcaccg cagtgttttc
     1741 ataataaact tgagaactga gaaagtcagg tttgaattgt atcagtgggc acgactggtg
     1801 ctgtttatta aacaagataa atctattgat caatttcaga atttgtagaa ttccaggtaa
     1861 agaaaaataa agatcaaggc cactgtgtaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
