LOCUS       NM_001401497           10017 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory subunit 9A
            (Ppp1r9a), transcript variant 1, mRNA.
ACCESSION   NM_001401497 XM_006236057
VERSION     NM_001401497.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10017)
  AUTHORS   Gao,J., Hu,X.D., Yang,H. and Xia,H.
  TITLE     Distinct Roles of Protein Phosphatase 1 Bound on Neurabin and
            Spinophilin and Its Regulation in AMPA Receptor Trafficking and LTD
            Induction
  JOURNAL   Mol Neurobiol 55 (9), 7179-7186 (2018)
   PUBMED   29383693
  REMARK    GeneRIF: PP1 bound on spinophilin, a close homolog of neurabin and
            another major synaptic PP1 anchoring protein, does not play a role
            in long term depression [LTD] induction, which suggests that
            neurabin plays a privileged role in nanodomain targeting of PP1 in
            LTD induction.
REFERENCE   2  (bases 1 to 10017)
  AUTHORS   Chen,Y., Liu,Y., Cottingham,C., McMahon,L., Jiao,K., Greengard,P.
            and Wang,Q.
  TITLE     Neurabin scaffolding of adenosine receptor and RGS4 regulates
            anti-seizure effect of endogenous adenosine
  JOURNAL   J Neurosci 32 (8), 2683-2695 (2012)
   PUBMED   22357852
REFERENCE   3  (bases 1 to 10017)
  AUTHORS   Ruscher,K., Shamloo,M., Rickhag,M., Ladunga,I., Soriano,L.,
            Gisselsson,L., Toresson,H., Ruslim-Litrus,L., Oksenberg,D.,
            Urfer,R., Johansson,B.B., Nikolich,K. and Wieloch,T.
  TITLE     The sigma-1 receptor enhances brain plasticity and functional
            recovery after experimental stroke
  JOURNAL   Brain 134 (Pt 3), 732-746 (2011)
   PUBMED   21278085
REFERENCE   4  (bases 1 to 10017)
  AUTHORS   Ragusa,M.J., Allaire,M., Nairn,A.C., Page,R. and Peti,W.
  TITLE     Flexibility in the PP1:spinophilin holoenzyme
  JOURNAL   FEBS Lett 585 (1), 36-40 (2011)
   PUBMED   21094159
  REMARK    GeneRIF: Data show that the PP1:spinophilin holoenzyme is dynamic
            in solution, which allows for an increased capture radius of
            spinophilin and is likely important for its biological role.
REFERENCE   5  (bases 1 to 10017)
  AUTHORS   Kakehashi,A., Ishii,N., Shibata,T., Wei,M., Okazaki,E.,
            Tachibana,T., Fukushima,S. and Wanibuchi,H.
  TITLE     Mitochondrial prohibitins and septin 9 are implicated in the onset
            of rat hepatocarcinogenesis
  JOURNAL   Toxicol Sci 119 (1), 61-72 (2011)
   PUBMED   20935162
REFERENCE   6  (bases 1 to 10017)
  AUTHORS   McAvoy,T., Allen,P.B., Obaishi,H., Nakanishi,H., Takai,Y.,
            Greengard,P., Nairn,A.C. and Hemmings,H.C. Jr.
  TITLE     Regulation of neurabin I interaction with protein phosphatase 1 by
            phosphorylation
  JOURNAL   Biochemistry 38 (39), 12943-12949 (1999)
   PUBMED   10504266
REFERENCE   7  (bases 1 to 10017)
  AUTHORS   Burnett,P.E., Blackshaw,S., Lai,M.M., Qureshi,I.A., Burnett,A.F.,
            Sabatini,D.M. and Snyder,S.H.
  TITLE     Neurabin is a synaptic protein linking p70 S6 kinase and the
            neuronal cytoskeleton
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8351-8356 (1998)
   PUBMED   9653190
REFERENCE   8  (bases 1 to 10017)
  AUTHORS   Satoh,A., Nakanishi,H., Obaishi,H., Wada,M., Takahashi,K.,
            Satoh,K., Hirao,K., Nishioka,H., Hata,Y., Mizoguchi,A. and Takai,Y.
  TITLE     Neurabin-II/spinophilin. An actin filament-binding protein with one
            pdz domain localized at cadherin-based cell-cell adhesion sites
  JOURNAL   J Biol Chem 273 (6), 3470-3475 (1998)
   PUBMED   9452470
REFERENCE   9  (bases 1 to 10017)
  AUTHORS   Nakanishi,H., Obaishi,H., Satoh,A., Wada,M., Mandai,K., Satoh,K.,
            Nishioka,H., Matsuura,Y., Mizoguchi,A. and Takai,Y.
  TITLE     Neurabin: a novel neural tissue-specific actin filament-binding
            protein involved in neurite formation
  JOURNAL   J Cell Biol 139 (4), 951-961 (1997)
   PUBMED   9362513
REFERENCE   10 (bases 1 to 10017)
  AUTHORS   Colbran,R.J., Bass,M.A., McNeill,R.B., Bollen,M., Zhao,S.,
            Wadzinski,B.E. and Strack,S.
  TITLE     Association of brain protein phosphatase 1 with cytoskeletal
            targeting/regulatory subunits
  JOURNAL   J Neurochem 69 (3), 920-929 (1997)
   PUBMED   9282913
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 14, 2022 this sequence version replaced XM_006236057.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000004.1  33988827-33988883
            58-1665             JAXUCZ010000004.1  33991025-33992632
            1666-1798           JAXUCZ010000004.1  34144812-34144944
            1799-1919           JAXUCZ010000004.1  34154608-34154728
            1920-2024           JAXUCZ010000004.1  34161988-34162092
            2025-2160           JAXUCZ010000004.1  34171252-34171387
            2161-2226           JAXUCZ010000004.1  34176812-34176877
            2227-2382           JAXUCZ010000004.1  34193945-34194100
            2383-2436           JAXUCZ010000004.1  34205949-34206002
            2437-2666           JAXUCZ010000004.1  34208538-34208767
            2667-2763           JAXUCZ010000004.1  34210064-34210160
            2764-2935           JAXUCZ010000004.1  34210254-34210425
            2936-3093           JAXUCZ010000004.1  34227433-34227590
            3094-3337           JAXUCZ010000004.1  34228095-34228338
            3338-3425           JAXUCZ010000004.1  34236438-34236525
            3426-3503           JAXUCZ010000004.1  34236617-34236694
            3504-3702           JAXUCZ010000004.1  34247411-34247609
            3703-3822           JAXUCZ010000004.1  34249541-34249660
            3823-3846           JAXUCZ010000004.1  34250435-34250458
            3847-4029           JAXUCZ010000004.1  34251493-34251675
            4030-10017          JAXUCZ010000004.1  34252940-34258927
FEATURES             Location/Qualifiers
     source          1..10017
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..10017
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /note="protein phosphatase 1, regulatory subunit 9A"
                     /db_xref="GeneID:84685"
                     /db_xref="RGD:632280"
     exon            1..57
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            58..1665
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..4230
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neurabin-1; neurabin-I; neural tissue-specific
                     F-actin-binding protein I; actin-binding protein neurabin;
                     protein phosphatase 1, regulatory (inhibitor) subunit 9A"
                     /codon_start=1
                     /product="neurabin-1 isoform 1"
                     /protein_id="NP_001388426.1"
                     /db_xref="GeneID:84685"
                     /db_xref="RGD:632280"
                     /translation="MLKAESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKPDGEQK
                     TKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPNENAAIIAKTRGKGRPSSPQKRMKP
                     KEFVEKTDGSVVKLESSVSERISRFDTMHDGPSYAKFTETRKMFERSGHESGQNNRHS
                     PKKEKAGEAEPQDEWGGSKSNRGSSDSLDSLSPRTEAVSPTVSQLSAVFENSESPGAI
                     TPGKAENSNYSVTGHYPLNLPSVTVTNLDTFGRLKDSNSRPSSNKQATDTEEPEKSEA
                     VPVPEVAQKGTSLASLPSEERQLSTEAEDVTAQPDTPDSTDKDSPGEPSAESQAMPKS
                     NTLSRPKEPLEDAEANVVGSEAEQPQRRDLTGGGDLTSPDASASSCGKEVPEDSNSFE
                     GSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEGDDSDENNYYQPDMEYSEIVGLPQEE
                     EIPANRKIKFSCAPIKVFNTYSNEDYDRRNDDVDPVAASAEYELEKRVEKLELFPVEL
                     EKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISL
                     VGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLERHYAQ
                     YDADDDETTVAELQGVSGNCNNNNNRFLKTGEYATDEEEDEVGPILPGGDMAIEVFEL
                     PENEDMFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKNQ
                     LQQNIEENKERMVKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQ
                     QKELDFIRRQEVERKKLEEVEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNN
                     IFERRPSPGEVSKGDTMENVEVKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSV
                     KNRRQRPTRTRLYDSVSSTDGEDSLERKGWRVSSPEPECGVAPLTPVTSPRAFSSHHV
                     TESPEGSQQPERDPFSSVSGDTSPSLPSTSDHDTEDSPCRHQAIKKTLQEKDDANCPK
                     SLRTSSSFVVQRGKIKQKFADLGAPLRRNPSKGKKWKEKEVSRFSAGSRIFRSKLENW
                     KAKPASTVQASAPSPCMPFSWFNESRKGSYSFRNLPSAPNPLPPSPETQISDKTGSKN
                     FTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHT
                     QSQSRAVHEWSVQQVSHWLVGLSLDQYVSEFSAQNISGEQLLQLDGNKLKALGMTSSQ
                     DRALVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKSEKMTSTTEQP
                     "
     exon            1666..1798
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1919
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2024
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2160
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2226
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2382
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2436
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2666
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2763
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2935
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3093
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3337
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3425
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3503
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3702
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3822
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3846
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            3847..4029
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
     exon            4030..10017
                     /gene="Ppp1r9a"
                     /gene_synonym="Neb1; p180; PP1bp175"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatttcgctg ctgggctccc tctctctgcg gccctagagt taatcccatc agccgagatg
       61 aacctctaga aaagagctat tttgtgtaac tcttgactgt gagtaaattt ctaatacacc
      121 cgttggaacc atcagtggac attagtgccc tttgagaggc cctttgcctg gtcaaatact
      181 ggggatcagg aagagaggtc tttttggttt gttgttgttt ttccccgtga tcattatgag
      241 cattggcttt tcacccttga agtaaaaatg ttgaaagctg aatcttcagg tgaacgaacc
      301 actctcagaa gtgcctctcc tcacaggaat gcatacagaa ctgagttcca ggcactgaaa
      361 agtacttttg acaaacccaa acctgatggg gaacagaaaa cgaaagaagg tgagggctcc
      421 cagcagagta ggggtaggaa gtatggctcc aatgtcaaca gaattaagaa cctgttcatg
      481 cagatgggta tggaacccaa cgagaatgct gctatcattg ccaaaacgag agggaaaggt
      541 aggccctcat cccctcagaa gaggatgaag cccaaagaat ttgtggagaa aaccgatggc
      601 tcagtggtta aactggagtc ctctgtctct gaacggatta gcagatttga cacaatgcac
      661 gatggccctt cgtatgctaa gttcacagag actcgaaaga tgtttgagag aagtgggcat
      721 gagtcagggc aaaataatcg ccattcccca aagaaagaga aagcgggaga ggctgagcca
      781 caggatgagt ggggtggctc caagtccaat agaggcagca gtgattcctt ggacagcctg
      841 agccctcgga cggaggctgt ctctccaact gtgagccaac tgagtgccgt gtttgagaac
      901 agtgagtctc caggtgccat cactcctggg aaggctgaga acagcaacta ctcggtgact
      961 gggcattacc ccctgaactt accatctgtt accgtaacca atctggatac ctttggccgt
     1021 ctcaaggatt ctaattcaag gccttcttca aacaaacaag ctaccgacac agaagagcct
     1081 gagaagagtg aggctgtgcc agtaccggaa gtggctcaga aaggtacctc tttagcttca
     1141 ttgcctagtg aagagagaca gctgagcacg gaagctgagg acgtcacagc tcaaccagac
     1201 actccggaca gcactgataa agacagtcct ggagaacctt ctgctgaaag ccaggcaatg
     1261 cccaagtcta acaccctctc ccgaccgaag gagccgttag aagatgctga agctaatgtg
     1321 gtcgggagtg aggcagagca gccacagagg agagacctga caggtggtgg tgacctcacc
     1381 tccccggacg cgtctgcttc cagctgtggg aaagaagtac ctgaagactc gaacagtttt
     1441 gagggctccc atgtatacat gcatagtgac tataacgtgt atcgggtgag atccaggtat
     1501 aactcggact ggggagagac gggcacagag caggatgagg gggacgacag cgatgagaac
     1561 aattactatc agcccgatat ggagtactcg gaaattgttg gcttgccgca agaggaagaa
     1621 atcccagcaa ataggaaaat taagtttagt tgtgctccga ttaaggtttt caacacgtac
     1681 tccaatgaag actatgacag gaggaatgat gacgttgacc ctgtggctgc atctgctgag
     1741 tacgaacttg aaaagcgagt agaaaagctg gaacttttcc cagtggaact ggagaaagat
     1801 gaggatgggc ttggcataag cattattgga atgggcgttg gtgctgatgc tggactggag
     1861 aagctgggga tattcgtcaa gacagtgact gaaggaggtg ctgctcagcg ggatggcagg
     1921 atccaagtca atgaccagat tgtggaagtg gatggaatca gcctggtggg ggtcacacag
     1981 aatttcgctg caactgttct gcggaacacc aagggcaacg tcaggtttgt tattggacga
     2041 gaaaaaccag gacaagtgag tgaggttgcc cagttgatca gccagaccct ggaacaagag
     2101 aggagacaga gggagctgct cgaacgccac tacgcccagt atgatgctga cgacgatgag
     2161 accactgtgg ctgaattgca aggagtgtct ggcaactgca ataacaataa caaccgtttc
     2221 cttaagaccg gagaatatgc cactgatgaa gaagaagatg aggttggacc cattcttcct
     2281 ggtggtgaca tggccattga agtcttcgag ctccctgaga atgaggacat gttttcccca
     2341 tctgacttgg atacaagcaa gctcagtcac aagttcaaag agttgcaaat caaacatgca
     2401 gttacagaag cagagattca aaaattgaag accaagctgc aagcagcaga gaatgagaaa
     2461 gtaaggtggg aactagaaaa gaaccaactg cagcagaata ttgaggagaa taaagaaagg
     2521 atggtaaagc tggagagcta ctggatcgag gcgcagacat tatgtcacac cgtgaacgag
     2581 catctcaaag agacccaaag ccagtatcag gccttggaaa agaagtacaa caaagccaag
     2641 aagttgatca aggattttca acaaaaagag ctcgatttca tcaggagaca agaagtagaa
     2701 agaaagaagc tggaggaggt ggaaaaagct caccttgttg aagtccaagg cctgcaagtt
     2761 cggattagag atttggaggc tgaggtgttc agactactaa agcaaaatgg gacccaagtt
     2821 aacaacaaca acaacatctt tgagagaaga ccatctcctg gggaagtctc aaaaggagac
     2881 actatggaga atgtggaagt caagcaaaca tcctgtcagg acggcttgag ccaagacttg
     2941 aatgaagcag tcccagagac agagcgcctg gattcgaaag cgctgaaaac tcgggcccag
     3001 ctctctgtga agaacaggcg ccagaggccc acaaggacaa ggctctatga cagcgtcagc
     3061 tccactgatg gggaggacag cctggagcgg aagggttgga gagtttcttc tccagaacca
     3121 gagtgtggtg tcgcacccct cacccctgtg acgagcccta gggccttctc atcccaccac
     3181 gtgactgagt ctccagaagg atcacagcag ccagaaaggg accctttctc ctctgtctct
     3241 ggagacactt caccctcctt gccttcaaca tctgatcacg atacagaaga ctctccttgc
     3301 cgccaccaag ccatcaagaa aacattacaa gagaaagacg atgccaattg tcctaaatca
     3361 ctaagaacat ccagttcatt cgtggtacaa agaggaaaaa ttaagcaaaa gtttgcagat
     3421 ctgggggcac ctttgcgaag gaatcccagc aaggggaaga aatggaaaga aaaagaagtc
     3481 agtaggtttt ctgcaggtag cagaatcttc agaagcaagt tggagaactg gaaagccaaa
     3541 ccagcctcta cagttcaggc ctccgccccc tctccttgca tgcctttctc atggtttaat
     3601 gaaagtcgga aaggatccta ttccttcagg aacctgcctt cagctccaaa tcccctcccg
     3661 ccttctcctg agactcaaat ttcagataaa acagggtcca agaatttcac cttcaatgat
     3721 gacttcagtc caagcagtac cagttcagca gacctgagcg gcttaggagc agaacccaaa
     3781 acgccagggc tctcccagtc cttggcactg tcctcagatg agagcctgga catgatagat
     3841 gatgagatcc ttgacgatgg acagtctccc aaacacactc agagtcagag ccgggccgtc
     3901 catgagtgga gtgtgcagca ggtttcacac tggttagtgg gcctcagtct ggaccagtat
     3961 gtgtctgaat tcagtgctca gaacatcagt ggtgagcagc tcctgcagct ggatggcaat
     4021 aaactgaagg ctcttggaat gacatcatcc caggatcggg cactggttaa aaaaaaactg
     4081 aaggaaatga agatgtctct cgagaaggct cgcaaggccc aggagaaaat ggaaaaacaa
     4141 agagaaaagc tgaggaggaa ggaacaagag caaatgcaga ggaagtctaa aaagtcggaa
     4201 aagatgactt ccacaaccga gcaaccgtga gcagtaaggt ctcgcctcct ccagtaggtg
     4261 ggaaagcttg agagaagtcc cgcccctttc tgcccccact ctcctgcaga ggatgaagaa
     4321 gaaactgatg gggatacacc actgtaggcg gttaaagaac tgtgtgttga atgcactctt
     4381 gattttaacc taaaatgacc cctcgccgcc gccttcggtt cattgactaa ccagaagtgt
     4441 catttttatc ttctacttac caacatccca tgttgtgtta agtgtgcggt gccacttaga
     4501 ggaccagcct gacccagcca atgagagcag gactctggtg ctgcgagtgg agtacccaga
     4561 attctcagtg agagcccctg aaactgaggt agtagcttgt gactgttggt gtgcagagga
     4621 tccctgcctt gagatgggga agcgcccctc aattctgaca gtagagcaag tgagttccat
     4681 ggtggggatg tgggtgccca gcacggaatt gccaactgag ggaaagagcg agcacgtgtg
     4741 ctatcccact cgctgagaat cagaacgagg ggggaaatag tagctattta ttaactgtag
     4801 aagaactgaa aagccttaag cacacagatg tgggtgtact tcggggtttg gaggataaca
     4861 ttttcctcca ggtattgttg aacaaagaag aaaaaaatgt cagagtgtag tgcaacggtg
     4921 gatgttggga tctgctactt tgtttgccag tgccgcgagc ccagtgtttg agccgcaccg
     4981 acaaacacag cacagctcct tccccgggaa caaattgaac aggaaattga tttttaagga
     5041 aaccaacatc ttcaggtttc ctctcctggg acattctggc tggccttcag cctgcctgtg
     5101 acaaaatcgt gaacttgtca catattttct actcagaatt tctcaagtgg gctcagtgtt
     5161 ttaacaaatg tcctttcaag gacttaaacc tagagatact ggttagagat taagatttga
     5221 gtaacagtca actagagaac tttttttctt ttttcttttt ttaatgtata cataattctt
     5281 tcctgtgaag gacagccatc atttacattt tacaggcatt tggaatgact ccctaagcca
     5341 ttctcttccg tattctagag agttcgagat ttgtttaaaa cagtacatgg gacagatttt
     5401 cacagtgtaa gagctggtat tacttgaata cttggtatta aggatttcag tgtttcacca
     5461 acctgagttg agtgcaggag actaggggag gaggagaaca gaaagtcttc ttgagacatt
     5521 tcacaccctc aggggttttt tgtttgtttg cttgtttgct tgcctttagt tttgcttttt
     5581 cttttcttct gaatctaact ctcattactg cattaactaa aacactggca tcatctactt
     5641 tatggtgagc agatttcaaa gtagagctgg aggccagatg aatccttgga cttcagggta
     5701 tttacttcct ttaccccaaa aggcccatgc gctgcccact ggcctgtgca catctcctct
     5761 gggtgcacag gtacgcaggg cctgcatcag gcgctggagt tatgacaaga atctgctagg
     5821 atagaggtca gctgcctgtg tggcctcact ttgtatttta acattgtgac ttttcatttt
     5881 tattgttatt actatttttg taacatgaat tttgagatta tctgaactag aaacttaatc
     5941 ctgttctttc tcccagagcc tgcttccttt tctggcccag cacacttctg ttaagttttg
     6001 gtccttctgg tacatacagc cccttcagtt tgaaacatga tatgagagtc gctctgtgct
     6061 ctgcgcaaac cagacctgct tcatggttct cttgtggagc agggtactga gtgcctgttt
     6121 atatcttcag atgcctgatg ctttgccact tataagagac atattactaa actacacatt
     6181 cagtaaatct ttcctaatgc cagaagacga agggaaaaat ctggcaatat taatacttgc
     6241 tattgtacat tttgccattt ttcttttctt tgggggaaaa aaaaagctgg attgcactgg
     6301 aagcttctct gtgttcattt tccagagtga aaacagaagg gtgatcattt taagttgtgt
     6361 ttacactttg atgatagttg aaaatgaatg tatatattga aaatgtctgt aagtctgcct
     6421 ctgcctgtaa cttatgacct cttatattgc atttcttaaa tacagtgttc ttactgtaac
     6481 tttattaaca ctccgtgctt ggatcagcgt tcacctaaca gctacaaatc aaattaatat
     6541 tccttacatc atttagttta tagttcagtc attttgattt ttaagttaaa ttattacaat
     6601 cttagaccaa aatgaattct tttaacattg ctatttaaaa ctattaggat tgtaaaaggc
     6661 tcttgattgc tttgttgggc aaaggataga aggttgatcc agtgtggaaa caaagtggag
     6721 gacctcagac cttgtgagca ttttgatttc ttgttcgctc ctttatttga ctgtggtgca
     6781 tgataataat tgagtttcca aagtcttgca caattctttc tttaatgctg tagttttcag
     6841 ggtttataca gtttaacaga gaattgttgt tgcttcgtag acgttaaggg ttttggacag
     6901 ttgttcaaca aatgaaccaa aggggttgtc tgcatattgt gaatgatact ctagtgaaag
     6961 ctagtgggtc cccaccagaa accaaaagtg tctggggtac aggttatgtt ccagagtggg
     7021 gtacatagtg aggccctgcc acagttggag agcattgtag tagtagtaac tgggtcaggg
     7081 ttccactaaa gaactttgaa cgggatttcc gtggttaaga tcatctccct taaagtaact
     7141 tatccttatg taatcatttc tttctcctcc ccagcatcag cagggtcctg ttagtgcaga
     7201 aaccatgccc tatccacttt actactccac cgaaggctgt cattgctgtc ataacagcca
     7261 agctcttctg aagccatctg ttgtcctttt gctggggttg agatggactt cccacgcccc
     7321 acctcacgta gacttttaaa gcaccgcagt agtttatatt acattatgaa aggagctaat
     7381 gccagacttg gcttgcaaga ggcccaccat ggtaccacct atcttgtgtt cctttatttt
     7441 taggaagcaa agtagcagag gggcaagcac tcccactcag ctaccattcg tgctggacag
     7501 tgtttgccct gagatattaa ataccctgaa cctaagctgt aagagtgtcc gagtcagagt
     7561 tagcacctgg gcctctgcat tgtgctgacg aggaagaatt cccttttagg atctttgctc
     7621 gctaggatta acttgtacct gaaaattata taagaagaaa atgattgcat ttatacagct
     7681 attctaagtc atttataagc atgggagttt agataaattt gaggaggacc atcaacattt
     7741 aacaagggta ttgaagaaga ttccggagga tggagggcaa atgtttctaa aagaaacttg
     7801 tgtacactgg atgcaaattg ccctttcata aactgggata gcaaagaatt accaaattcc
     7861 atttgattag ctaaagcctc ttctcacaga gctggcgata agaaacatcc cactttgggg
     7921 gacaggaact aggagggttc atgtcacttg cttcagtgct atgaccctag tgatccctgg
     7981 ttggaaaggt aattaggaga ggatggggct acttctcatg ttttcttaat tgctttgagt
     8041 cagggctctg cctgtgtcta gttctgaagc agagcttata gaggtgaggt caaaacggtt
     8101 ctcatttcca aaggacaagg gggacttggg ggggtagtct caagacagca ttacaggaag
     8161 tccatttcac cattcagtcc tgagagctat actgaatgta ctgactgatt ttaatagtct
     8221 ttgcctcgaa tagttaaagt cctgtgaaat ttagccttga tcaaaatact ggggacggag
     8281 tggggaataa caccaaagaa aacacatatc aataccttga atagtaacat agaagaagct
     8341 ggagtaaccg gttagaggaa aaggaaaaaa aacctgcaca gtaaaccgcc cgctggagag
     8401 caacacaagc tccttacacc aaaacacggt gtcttctgga aggttggtca cttaaaactc
     8461 tcatctgtaa gcacctggat cctcagagta gggggcagaa gaacaaggtc tatgcttccc
     8521 tgaccctaca cacgccccac cccctacccc cacccccaga ccattaggga tccagcgata
     8581 tgcaagacaa tgtgcaagca gtaagagaag aagccacaaa ttctgttatg tgcatgccac
     8641 ttgtgtaggt gtcagagcct tgtgtgtgaa tatatccccc acctgacaca cacatgtata
     8701 ccttaagcac atggcacaaa tatatactct ccatggacta cagtggtgtt agttaggacc
     8761 ctgagctgta atcatagcat cgttactact ttttgtgttg tgtatacatt gaatggctca
     8821 tagattttaa gagttttttt ttaaatgtaa gcatcctact aaatgcactt atgcttctaa
     8881 atgtttgtat attttagtaa aattgattta ttagatcctt tggtattgta ttttagtaca
     8941 gtaaaatttc ctcagctgtt tgattaatgc tttgatgtca agattgcaca tttttagtta
     9001 ggacacagaa gatattatgc agcttcgggc attttcaact gcaggtcgcc tgcggttctc
     9061 ttgactaaat tgcactgtgt gttcttgtgt atcagctctc acctctaaaa cgaggtagat
     9121 catcagagta gccctgatgc ttctgtcgct gactcctggc tctctggtgg cagtatttct
     9181 gtcgtgtgac caccatttac ttcctaagcc atccgcttgc aatggcattt tggttgccac
     9241 caaaaataac acaatgggtt ctgagtctgt gttgttggaa gctgggtaca tcatttcctt
     9301 cagctgtttt atgcacgcac acacgttttt tgttaaagcg ttaagcattc agccatgaac
     9361 taacaattgg ccagaaacac cctaaattgc ctttaccaaa aaaaaggggg ggggcaggaa
     9421 gtgataccca gactttcaac ttttcaatca gtgagtaaca aacagcactc aacatgcata
     9481 tgtggcctct cctcagtatt atttaatgtc ataactactg cttttgtaat ttgtaatgat
     9541 gtttggatga aaccacttgg acacctgcta tagatcactg acaagaccga gcagctgaaa
     9601 acaaggagaa taaagttccg ttctactgta agatttgatt tatgttcatc tttccttata
     9661 gactattaaa gggaaagtgg tttgaaaagc atttgagtct ggtaagtata cataggccag
     9721 tacctgaacc ttttaatttg tacattttgc cgtctggtcc tttgcatggg agacacggta
     9781 gtgccacatc tgatttgttc tctggcgctt gattagtgtg tgctgttccc aatggcatcc
     9841 tttacttttc agttttcaga ggcattcgaa gcaaactata ccgtcagtgg cccattgttt
     9901 tctgaccatc taaaacttac ctgtgattaa acttaacttg ttagtgtaaa taaacctctt
     9961 gccaatgatt attattattg ttagagaatg aatgcaataa aaggaaattc agaggtc
//
