LOCUS       NM_001012072            2783 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory subunit 3C
            (Ppp1r3c), mRNA.
ACCESSION   NM_001012072 XM_220048
VERSION     NM_001012072.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2783)
  AUTHORS   Luo,X., Zhang,Y., Ruan,X., Jiang,X., Zhu,L., Wang,X., Ding,Q.,
            Liu,W., Pan,Y., Wang,Z. and Chen,Y.
  TITLE     Fasting-induced protein phosphatase 1 regulatory subunit
            contributes to postprandial blood glucose homeostasis via
            regulation of hepatic glycogenesis
  JOURNAL   Diabetes 60 (5), 1435-1445 (2011)
   PUBMED   21471512
REFERENCE   2  (bases 1 to 2783)
  AUTHORS   Turnbull,J., DePaoli-Roach,A.A., Zhao,X., Cortez,M.A., Pencea,N.,
            Tiberia,E., Piliguian,M., Roach,P.J., Wang,P., Ackerley,C.A. and
            Minassian,B.A.
  TITLE     PTG depletion removes Lafora bodies and rescues the fatal epilepsy
            of Lafora disease
  JOURNAL   PLoS Genet 7 (4), e1002037 (2011)
   PUBMED   21552327
REFERENCE   3  (bases 1 to 2783)
  AUTHORS   Tagliabracci,V.S., Girard,J.M., Segvich,D., Meyer,C., Turnbull,J.,
            Zhao,X., Minassian,B.A., Depaoli-Roach,A.A. and Roach,P.J.
  TITLE     Abnormal metabolism of glycogen phosphate as a cause for Lafora
            disease
  JOURNAL   J Biol Chem 283 (49), 33816-33825 (2008)
   PUBMED   18852261
REFERENCE   4  (bases 1 to 2783)
  AUTHORS   Munro,S., Ceulemans,H., Bollen,M., Diplexcito,J. and Cohen,P.T.
  TITLE     A novel glycogen-targeting subunit of protein phosphatase 1 that is
            regulated by insulin and shows differential tissue distribution in
            humans and rodents
  JOURNAL   FEBS J 272 (6), 1478-1489 (2005)
   PUBMED   15752363
  REMARK    Erratum:[FEBS J. 2024 Feb;291(3):609. doi: 10.1111/febs.16963..
            PMID: 37766503]
REFERENCE   5  (bases 1 to 2783)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   6  (bases 1 to 2783)
  AUTHORS   Browne,G.J., Delibegovic,M., Keppens,S., Stalmans,W. and Cohen,P.T.
  TITLE     The level of the glycogen targetting regulatory subunit R5 of
            protein phosphatase 1 is decreased in the livers of
            insulin-dependent diabetic rats and starved rats
  JOURNAL   Biochem J 360 (Pt 2), 449-459 (2001)
   PUBMED   11716774
REFERENCE   7  (bases 1 to 2783)
  AUTHORS   O'Doherty,R.M., Jensen,P.B., Anderson,P., Jones,J.G., Berman,H.K.,
            Kearney,D. and Newgard,C.B.
  TITLE     Activation of direct and indirect pathways of glycogen synthesis by
            hepatic overexpression of protein targeting to glycogen
  JOURNAL   J Clin Invest 105 (4), 479-488 (2000)
   PUBMED   10683377
REFERENCE   8  (bases 1 to 2783)
  AUTHORS   Printen,J.A., Brady,M.J. and Saltiel,A.R.
  TITLE     PTG, a protein phosphatase 1-binding protein with a role in
            glycogen metabolism
  JOURNAL   Science 275 (5305), 1475-1478 (1997)
   PUBMED   9045612
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085894.1.
            
            On Feb 11, 2005 this sequence version replaced XM_220048.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ123707.1, FQ121796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..2783
                     /gene="Ppp1r3c"
                     /gene_synonym="PTG; R5"
                     /note="protein phosphatase 1, regulatory subunit 3C"
                     /db_xref="GeneID:309513"
                     /db_xref="RGD:1309132"
     exon            1..102
                     /gene="Ppp1r3c"
                     /gene_synonym="PTG; R5"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1042
                     /gene="Ppp1r3c"
                     /gene_synonym="PTG; R5"
                     /note="protein targeting to glycogen; protein phosphatase
                     1 regulatory subunit 5; PP1 subunit R5; protein
                     phosphatase 1, regulatory (inhibitor) subunit 3C; protein
                     phosphatase 1 regulatory subunit 3C-like"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 3C"
                     /protein_id="NP_001012072.1"
                     /db_xref="GeneID:309513"
                     /db_xref="RGD:1309132"
                     /translation="MSCTRMIHVLDPRPLTSSVMPVDMAMRICLAHSPPLKSFLGPYN
                     GLQRRHFVNKPKPLKPCLSVKQEAKSQKEWKSPHSQAKKRVVFADSKGLSLTAIHVFS
                     DLPEEPAWDLQFDLLDLNDISSSLKLHEEKNLVFDFPQPSSDYLSFRDRFQKNFVCLE
                     NCSLQDRTVTGTVKVKNVSFEKKVQVRITFDTWKTYTDVDCVYLKNVYGSSDSDTFSF
                     AIDLPRVIPTEEKIEFCISYHANGRVFWDNNEAQNYRIVHVQWKPDGVQTQVAPKDCA
                     FQQVPLKTELEPTVFGSPRLASGLFPEWQSWGRVENLASYR"
     exon            103..2751
                     /gene="Ppp1r3c"
                     /gene_synonym="PTG; R5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttgaccg cggcgctgca tccgctaagt gcgtggtgcg aagctgcgct gggtgcggtt
       61 gtcgcggtcg ccactgcctc tcggtccaat gagctgcacc aggatgatcc acgtgctgga
      121 tccacgacct ttgacaagtt cagtcatgcc cgtggacatg gccatgagga tttgcttggc
      181 acattcacca cccctgaaga gtttcctggg tccttacaat ggtcttcagc gaagacattt
      241 tgtgaataaa ccgaagccct tgaaaccgtg tctcagcgtc aagcaggaag ccaaatcaca
      301 gaaggaatgg aagagcccac acagccaagc caagaagcgg gtcgtgtttg ctgactccaa
      361 ggggctctcc ctcactgcca tccacgtctt ctcagacctt ccagaagaac ccgcgtggga
      421 cctgcagttt gacctcttgg accttaacga catctcctcc agcttaaaac ttcacgagga
      481 gaaaaatctg gttttcgatt tcccccagcc ttcaagcgac tacttaagtt tccgggaccg
      541 cttccagaag aactttgtct gcctcgagaa ctgctctttg caagatcgga cagtgactgg
      601 gacggtcaaa gtaaagaacg tgagcttcga gaagaaggtt caggtccgca tcacctttga
      661 cacctggaaa acctacaccg acgtggactg tgtatacttg aagaacgttt acggcagctc
      721 agacagtgac accttctcct ttgccatcga cttgccccgc gtcattccaa ctgaggagaa
      781 aatcgagttc tgcatttcct accatgctaa cgggagggtc ttctgggaca acaacgaggc
      841 tcagaactat agaattgtcc atgtacagtg gaaacccgac ggagtgcaga ctcaggtggc
      901 acccaaagac tgtgcattcc aacaggtgcc ccttaagact gagttagaac ccacggtctt
      961 tggcagtccg aggcttgcta gcggcctctt cccagagtgg cagagctggg ggagagtgga
     1021 gaacttggcc tcctatcgat gagttaggca atctatagac cggctttgtc tgatcagaat
     1081 cctcatgcaa ttctaggtct gtattgctca atattaggaa gtcgtattac tttctatcag
     1141 tagatttagg tacgagctgt tgggacctgg ctatggaagc tattgtcact tgagaattta
     1201 gtgttggggt ctatgagggt gacaccccca gctttgttct gaaggatcaa ggacagtctg
     1261 ggaactggtt ttctacagtc gacacctgtt tttttttttg ggggggagtg catttttcca
     1321 cttccctctc agttcactag ctctcacttt gaacaaagaa aggttggaag atggtgatgg
     1381 aaggctgtag taagggtgtg aggaacgtca aatgcttatg ctaaggctct gagactcaag
     1441 tcagaggagg agcaatggtt aaatgggtat taaaccattg gtgggaaaac ataatgttat
     1501 cttgtgtttc ggaatgggtt ctgctggctt ctcctgagga aatagctcaa agatgggaaa
     1561 ggaacccatt ctatgcattt ttgttttgca tagaaaaata aaagggtgtt ggatggtact
     1621 gcgggaagat gaactgtagt ttggaagaat caagatcttg agggctagag aagtagctca
     1681 gttggtcgtg tgcttgccta gcatgcatga agacctgggt tccaggcccg ctgggggtgg
     1741 cagcggcaca tgccttcaat cccagtatgt tatagcaaag gcagaggcag gaggattaga
     1801 aatccacagt catccttggc acacggaaag ttggaggcta gcttgggctc gttggaatcc
     1861 ctgtcgcagg aaacgatatt aaaagatctt aagtgaatcc ttctggttta aacagggtct
     1921 accagaaacc atgttatgga gagtgttgaa acaaatccga ctttgcattc ttaatcggat
     1981 aagtggcttt gtggtgaagc atcattcttc acagaatgct gtgtgctaca aaatgctgcc
     2041 caacatcggg catgctgtca ctaacggcta gcagcgtgta gggactccac ctcatgtcaa
     2101 agagagctct ttcagtgcct caattaaacc ggaacactgt acctgtttaa acgggttacc
     2161 tgaacgacca tctaataact catgattttt tggggcctta tttgaaggtc cattcgctgg
     2221 cgttctcccg aaatcatcag gagtgctgtc agtgtacaca aatcacgtcc ttcatattga
     2281 aggtgactca actttctgcc acactttttc gatgtgatgt ttgaagtggg gactgacacc
     2341 agagtcccag tgcaagaatc caggaccttg cacatgagag tatcggtcta tctcatgcct
     2401 actttttttt tgtcttgctg ttttaatttc tagtcaaaat gatttttgaa aatgcagata
     2461 tgaattattt cgaatgtgaa ctgtttttgt gtgtgcataa gtacactttg cgggatcttg
     2521 agacaggtgc cctgggatga atgccgttta cagtgtgcat gtcctttgag gtgtgttgga
     2581 aaagtgcagc gaattttaac gtatgtgatc cgccatgctg tgaaaacact attgggatac
     2641 ctcccctgtg acggtattgg aggtttggct agtatccgta agttctctgc tgtaaatacc
     2701 tacattgtcc gtatgagcct ctcactttaa gaataaatgt gcttggtaga aaaaaaaaaa
     2761 aaaaaaaaaa aaaaaaaaaa aaa
//
