LOCUS       NM_138912               4360 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory subunit 3B
            (Ppp1r3b), mRNA.
ACCESSION   NM_138912
VERSION     NM_138912.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4360)
  AUTHORS   Zhang,T., Wang,S., Lin,Y., Xu,W., Ye,D., Xiong,Y., Zhao,S. and
            Guan,K.L.
  TITLE     Acetylation negatively regulates glycogen phosphorylase by
            recruiting protein phosphatase 1
  JOURNAL   Cell Metab 15 (1), 75-87 (2012)
   PUBMED   22225877
REFERENCE   2  (bases 1 to 4360)
  AUTHORS   Zibrova,D., Grempler,R., Streicher,R. and Kauschke,S.G.
  TITLE     Inhibition of the interaction between protein phosphatase 1
            glycogen-targeting subunit and glycogen phosphorylase increases
            glycogen synthesis in primary rat hepatocytes
  JOURNAL   Biochem J 412 (2), 359-366 (2008)
   PUBMED   18298402
  REMARK    GeneRIF: Data show that inhibition of the interaction between
            protein phosphatase 1 glycogen-targeting subunit and glycogen
            phosphorylase increases glycogen synthesis in primary rat
            hepatocytes.
REFERENCE   3  (bases 1 to 4360)
  AUTHORS   Munro,S., Ceulemans,H., Bollen,M., Diplexcito,J. and Cohen,P.T.
  TITLE     A novel glycogen-targeting subunit of protein phosphatase 1 that is
            regulated by insulin and shows differential tissue distribution in
            humans and rodents
  JOURNAL   FEBS J 272 (6), 1478-1489 (2005)
   PUBMED   15752363
  REMARK    Erratum:[FEBS J. 2024 Feb;291(3):609. doi: 10.1111/febs.16963.
            PMID: 37766503]
REFERENCE   4  (bases 1 to 4360)
  AUTHORS   Ceulemans,H. and Bollen,M.
  TITLE     Functional diversity of protein phosphatase-1, a cellular
            economizer and reset button
  JOURNAL   Physiol Rev 84 (1), 1-39 (2004)
   PUBMED   14715909
  REMARK    Review article
REFERENCE   5  (bases 1 to 4360)
  AUTHORS   Browne,G.J., Delibegovic,M., Keppens,S., Stalmans,W. and Cohen,P.T.
  TITLE     The level of the glycogen targetting regulatory subunit R5 of
            protein phosphatase 1 is decreased in the livers of
            insulin-dependent diabetic rats and starved rats
  JOURNAL   Biochem J 360 (Pt 2), 449-459 (2001)
   PUBMED   11716774
REFERENCE   6  (bases 1 to 4360)
  AUTHORS   Doherty,M.J., Moorhead,G., Morrice,N., Cohen,P. and Cohen,P.T.
  TITLE     Amino acid sequence and expression of the hepatic glycogen-binding
            (GL)-subunit of protein phosphatase-1
  JOURNAL   FEBS Lett 375 (3), 294-298 (1995)
   PUBMED   7498521
REFERENCE   7  (bases 1 to 4360)
  AUTHORS   Moorhead,G., MacKintosh,C., Morrice,N. and Cohen,P.
  TITLE     Purification of the hepatic glycogen-associated form of protein
            phosphatase-1 by microcystin-Sepharose affinity chromatography
  JOURNAL   FEBS Lett 362 (2), 101-105 (1995)
   PUBMED   7720853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072514.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_138912.3.
            
            On Jun 13, 2004 this sequence version replaced NM_138912.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072514.1, CK356711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..4360
                     /gene="Ppp1r3b"
                     /note="protein phosphatase 1, regulatory subunit 3B"
                     /db_xref="GeneID:192280"
                     /db_xref="RGD:621600"
     exon            1..203
                     /gene="Ppp1r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            204..4344
                     /gene="Ppp1r3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1083
                     /gene="Ppp1r3b"
                     /note="R4; 33 kDa glycogen-binding protein; protein
                     phosphatase 1 subunit GL; protein phosphatase 1 regulatory
                     subunit 4; hepatic glycogen-targeting protein phosphatase
                     1 regulatory subunit GL; PP1 subunit R4; protein
                     phosphatase 1 (GL-subunit); protein phosphatase 1,
                     regulatory (inhibitor) subunit 3B"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 3B"
                     /protein_id="NP_620267.2"
                     /db_xref="GeneID:192280"
                     /db_xref="RGD:621600"
                     /translation="MAVDIEYSYSSMAPSLRRERFTFKISPKLNKPLRPCIQLGSKDE
                     AGRMVAPTVQEKKVKKRVSFADNQGLALTMVKVFSEFDDPLDIPFNITELLDNIVSLT
                     TAESESFVLDFPQPSADYLDFRNRLQTNHVCLENCVLKEKAIAGTVKVQNLAFEKVVK
                     IRMTFDTWKSFTDFPCQYVKDTYAGSDRDTFSFDISLPEKIQSYERMEFAVCYECNGQ
                     SYWDSNKGKNYRITRAELRSTQGMTEPYNGPDFGISFDQFGSPRCSFGLFPEWPSYLG
                     YEKLGPYY"
ORIGIN      
        1 ctggaaagtt aaagggcgcc acgggctgct ggagccagaa tccagagtgc tgaaagccag
       61 agagcaggtg agagggctgc tgttgcaagg accaagccga gtgcctgccc cgcttttgcc
      121 gtcgtggttg ctgtcactgt catccagctc agatggtggg gcgggctgaa gggtctcccc
      181 tccatagtca agagctgtac cggacttcta gcctgcccct ctaacgtgat ggccgtggac
      241 atagaataca gctacagcag tatggcccct tctctgcgca gagagcgctt caccttcaag
      301 atctccccca aactgaacaa gccactgagg ccttgtattc agctgggcag caaggatgaa
      361 gccggcagaa tggtggcccc cacagtgcag gagaagaagg tgaagaagcg ggtgtccttc
      421 gccgacaacc aggggctggc cctaacaatg gtgaaagtgt tctcggaatt cgatgaccca
      481 ctagatattc cgtttaacat cactgagctc ctagacaaca tcgtgagtct gacgacagca
      541 gagagtgaga gctttgtttt ggattttccg cagccttctg cagattactt agactttaga
      601 aatcggcttc agaccaacca tgtctgcctc gaaaactgcg tgctgaagga gaaagccatc
      661 gcgggcaccg tcaaggtcca gaacctggca ttcgagaagg ttgtgaagat caggatgaca
      721 ttcgatacct ggaaaagctt cacagacttc ccttgtcagt atgtgaagga cacttacgct
      781 ggttcagaca gggacacatt ctcctttgat atcagcctac cggagaaaat ccagtcttat
      841 gaaagaatgg agttcgccgt gtgctacgag tgtaacggcc agtcgtactg ggacagcaac
      901 aaaggcaaaa actacaggat caccagggcc gaactcagat ccacccaggg aatgactgag
      961 ccgtacaatg ggccggattt tggaatctct tttgaccagt tcgggagccc tcggtgttcc
     1021 ttcggcctgt ttccagagtg gcctagttat ctggggtatg aaaagctggg gccctattac
     1081 tagtgagttg actgcagttg acagtctgtg tctctgatca aggtggaggt gagaacgcga
     1141 ggccagaggg aagttgatct gccattaggc gtggtttttg aaaagacagg atcctgttca
     1201 cctttttctc aaaccggcaa gtccagtgtg cttccatcac gcctggtttc ttgctcagag
     1261 gagaggaggc gtgctgaacc tctgtggtat ccgggttggc cacaagggaa tgcacaggat
     1321 ggtgccagaa gggtctggag aggagccaag ctggcaagga cagaaagctg gcctcccttc
     1381 cacacttggt cttcgaaagt cacccagaaa ccaggctcca gccttttcca gccttacagt
     1441 tgacctcgag gtcctgccct gcccatggct ttccaagtgt ctccttcatt ccacacggac
     1501 tcggagggag tcgtctcagt tctgtgacac actggcctga taccctacag cctcagaaga
     1561 ggaatggggg acagccgttt tctgtgcaag ctctttcact acatttcctc cccttacaca
     1621 gcctatccag tgatctggat gtgatagtca aagcaaataa gtagtttgtg tctgggatag
     1681 gcagtccctc ccctctcttc ctgacccctc ctctgtatcc caacagagag caacatatta
     1741 gttactggaa agtcattggt tcccgtgtgg ggtcacatgg cacagcaccg ggacgaggtg
     1801 ggacagtctg aacttttagc ttttcctctt ggactttggg ggagctttcg aagcactcag
     1861 tttcaccccg agttttcaga agactcagtg acaagctgtg tgagctgctt ttgtttgaga
     1921 gagtcgtagc tctcacgtct cctggagtgt ccacttcagt gccttgtctg agactttcca
     1981 atagcaagac tagcatatcc tggaatcctc cagagcacgc ttaaatgtgt ttgcagtata
     2041 cagtcatatt caggatgctt tacggacccc caaggacact gagtaggttt tttttttttt
     2101 tatttatggt gtgtattata aaaggatagg ggagaaaaac cttaccaagt ttttctatgt
     2161 tattttaaat gtcaactctg aggtatcaga tgaatttttc ttaaccatat tggattgcag
     2221 ttatcattcg ctagtgtaag actcctggaa ctctgactgt tgggtaaacc tccaaaccct
     2281 gtgattttct ttagggcaaa ttaaaatttt ataggggagt ttggaaactt tttacatgca
     2341 tatttgtaga catttagggg tgttgttttg ttttggaagt ttggtaaaag acgtctgctt
     2401 ttcttactaa agtgatgttt ccctgagaca agagggagtc tcacagattc agaggcgggg
     2461 tcgctgagcg tagccctttg ccctctgact tcataagtta gcaacaggca gacatcaaat
     2521 gtttttgatc ctagcgtgtg tggtttattt tttatcttaa ctttttcact tttgaagtgt
     2581 aaagcatttt gactttttta aaatgttatt ttctatgata tcttattcct aaaactggta
     2641 ctagtctgta atctgtgaat tgtatattgt gcctctctca gaggggtagc gatctggggt
     2701 tgcatgctgg tatctgtgag gaaatcacct ttgtaaagtg aagctgaaat tgggcgatgg
     2761 ggagtttgtg ttttatctaa gcataccttt atgggcatac tttaaatgtt ccggatttgg
     2821 tggtcagagc agctagattt aaattggatg gaagcaaaac tgatctcttc tgggtcatgc
     2881 attttgtggt aagaaggaag gcagccaggg gcactgttac tgcagactac agatcatgaa
     2941 agggcctggg ggaactacag aatgaagtct atcgagtggt gtagaatgat gaccttcaga
     3001 cattccctgt cataatatga aatatggtaa ttccatgtta tgtatctctc ctaatacaga
     3061 cataccatca cccccttttg cccagatttg ccccagcttt cttgcttatg ggcgctagtt
     3121 gaacccccag ccagcacacc tggggtgcac acccactgct cagctcaaag ggcatgtctt
     3181 tgcctgcttg tcaggaccct tcccgatgaa gcagcctgta tgcttgactt ccttatcaag
     3241 gctgtcacgt agagactgaa gagtctgtct tctgttttct gcctccaaca cagcccttct
     3301 ccttttgacc cagtctgtcc catgactctg agatagccgc aggagctgca ttgagaaact
     3361 gtatgctgcg ttcagagttc accattgtag acaaatttac acacctcaga agatgacagg
     3421 ccctcttgct tgaagattcc actgcaggct tgacctggag atctgccttc gtgcaattct
     3481 tggttatggt gctggatgga ttccaatccc cacacactgt gatccaggaa gggaaggcaa
     3541 ctccattctc agttccacat ttatttcccc aaattcccta gggtgccttt ctttacaaaa
     3601 tgggtacaat aaataagcta gaccacaaga cacattctcc atgtttcttt caggaagcat
     3661 ttgggtattg taagaattct tcttaggaaa cctaggaaga caatggaagt ctatggttct
     3721 tcagaaactg aagcaacttg agtcaatggt gggagttatt ttatccctga gatggtagct
     3781 tggtggctcc ttgttctggt aaggtctgta ctcaattgtg tctcctggca taatcacaga
     3841 aactgcagat aagatgttct ggaaatcctg ggatcttacc tgtaacggga tcttccggag
     3901 tcactcaaag acgatgtggc agcgaggagg acaacaggca agagaggact ggtttctctg
     3961 gctgagggct gtgaggtacc cacagctcca tcagcaaagc tgtgtgtgtt tccacggtgt
     4021 cgctgctagt tcccagagac ccctggggcc caaggacttc tagaatgcac acgtgatgct
     4081 gttacacttc tgctttaatg tgaacattca actgaccggg cttgacgtca ctgtatgcct
     4141 aaatgtgcct tgtccagaaa cttctgcatg tttgtaagaa ctatttttgt atacattggt
     4201 agaggggaga tgcactttaa aaaaatcaca agaatggatg tgtgtgtgtg tgtgtgtgtg
     4261 tgtgtgtgtg tgtgtgtgtg tggtggaaga gaatggtttc tttgtatctc aaaagtgaaa
     4321 atgtaataaa tacagaaaaa aaaaaaaaaa aaaaaaaaaa
//
