LOCUS       NM_001271305            3116 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory subunit 21
            (Ppp1r21), mRNA.
ACCESSION   NM_001271305 XM_001057346
VERSION     NM_001271305.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3116)
  AUTHORS   Rehman,A.U., Najafi,M., Kambouris,M., Al-Gazali,L.,
            Makrythanasis,P., Rad,A., Maroofian,R., Rajab,A., Stark,Z.,
            Hunter,J.V., Bakey,Z., Tokita,M.J., He,W., Vetrini,F., Petersen,A.,
            Santoni,F.A., Hamamy,H., Wu,K., Al-Jasmi,F., Helmstadter,M.,
            Arnold,S.J., Xia,F., Richmond,C., Liu,P., Karimiani,E.G., Karami
            Madani,G., Lunke,S., El-Shanti,H., Eng,C.M., Antonarakis,S.E.,
            Hertecant,J., Walkiewicz,M., Yang,Y. and Schmidts,M.
  TITLE     Biallelic loss of function variants in PPP1R21 cause a
            neurodevelopmental syndrome with impaired endocytic function
  JOURNAL   Hum Mutat 40 (3), 267-280 (2019)
   PUBMED   30520571
REFERENCE   2  (bases 1 to 3116)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3116)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   4  (bases 1 to 3116)
  AUTHORS   Bithell,A., Alberta,J., Hornby,F., Stiles,C.D. and Williams,B.P.
  TITLE     Expression of the guanine nucleotide exchange factor, mr-gef, is
            regulated during the differentiation of specific subsets of
            telencephalic neurons
  JOURNAL   Brain Res Dev Brain Res 146 (1-2), 107-118 (2003)
   PUBMED   14643017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 13, 2012 this sequence version replaced XM_001057346.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1852996.1,
                                           SRR26360190.485829.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000006.1  11724040-11724219   c
            181-249             JAXUCZ010000006.1  11711222-11711290   c
            250-396             JAXUCZ010000006.1  11708496-11708642   c
            397-498             JAXUCZ010000006.1  11706282-11706383   c
            499-663             JAXUCZ010000006.1  11704104-11704268   c
            664-722             JAXUCZ010000006.1  11703920-11703978   c
            723-817             JAXUCZ010000006.1  11703048-11703142   c
            818-870             JAXUCZ010000006.1  11698536-11698588   c
            871-1020            JAXUCZ010000006.1  11697703-11697852   c
            1021-1122           JAXUCZ010000006.1  11694655-11694756   c
            1123-1211           JAXUCZ010000006.1  11694476-11694564   c
            1212-1348           JAXUCZ010000006.1  11690639-11690775   c
            1349-1441           JAXUCZ010000006.1  11687484-11687576   c
            1442-1569           JAXUCZ010000006.1  11684285-11684412   c
            1570-1722           JAXUCZ010000006.1  11681125-11681277   c
            1723-1815           JAXUCZ010000006.1  11678870-11678962   c
            1816-2058           JAXUCZ010000006.1  11670814-11671056   c
            2059-2091           JAXUCZ010000006.1  11665976-11666008   c
            2092-2208           JAXUCZ010000006.1  11663541-11663657   c
            2209-2307           JAXUCZ010000006.1  11661494-11661592   c
            2308-2436           JAXUCZ010000006.1  11660069-11660197   c
            2437-3116           JAXUCZ010000006.1  11655059-11655738   c
FEATURES             Location/Qualifiers
     source          1..3116
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..3116
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /note="protein phosphatase 1, regulatory subunit 21"
                     /db_xref="GeneID:362697"
                     /db_xref="RGD:1565310"
     exon            1..180
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2466
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 21"
                     /protein_id="NP_001258234.1"
                     /db_xref="GeneID:362697"
                     /db_xref="RGD:1565310"
                     /translation="MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQASSAALKEQ
                     LKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQ
                     EQKSVFDEDLQKKIEENERLHIQFFEADEHHKLVEAELRSRLATLETEAAQHQAVIDG
                     LTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKNLHEDLSGRLEES
                     LSIINEKVPFNDTKCNQYNALNVPLHNRRHQLKMRDLAGQALAFVQDLVPALLNFHTY
                     TEQRIQIFPVDSAIDTISPLNQKFSQHLHENAAYVRPLEEGMLHLFESITEDTVTVLE
                     TTVKLKVFSDHLTSYVRFLRKILPYQLKSLEEECESSLCTPALRARNLELSQDMKRMT
                     AVFEKLQTYITLLALPSTEPDGLLRTNYTSVLTNVGAALHGFHDVMKDISKHYSQKAS
                     IEHELPTATQKLVTTNDCILSSAVALTNGAGKIASFFSNNMDYFIASLSYGPKTASGF
                     ISPLSAECMLQYKKKAAAYMKSLRKPLAESVPYEEALANRRVLLSSTESREGLAQQVQ
                     QSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADRLRSTSSAQLLGLAQENATVSI
                     ASGQEEAAAKALTEPVQSTSLIGILTRTPESEAPDIESREDLIKSHYMARIAELTSQL
                     QLADSKSVHFYAECRALSKRLALAEKSKETLTEEMRLASQNVSRLQDELTTTKRSYED
                     QLSMMSDHLCSMNETLSKQRDEIDTLKMSSKGNAKKNRSR"
     exon            181..249
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            250..396
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            397..498
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            499..663
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            664..722
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            723..817
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            818..870
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1020
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1122
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1211
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1348
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1441
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1569
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1722
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1815
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2058
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2091
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2208
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2307
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2436
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..3116
                     /gene="Ppp1r21"
                     /gene_synonym="RGD1565310"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggcgcgg cggcggagct gcagaagctg gctgagccct gcccaggagc aagtgtgggg
       61 ttgggggcgg ggggcggggc tcagcagccc gggcggccag gcctggacgg ggcgggggag
      121 gccatggcct ccgcagagtt gcaggggaag taccagaagc tggctcagga gtactcgaag
      181 cttcgagctc agaatcaggt cctgaagaaa ggtgttgtgg atgagcaggc cagctctgct
      241 gctctaaagg agcaactgaa aatgaaggac cagtccttga ggaaactaca acaggaaatg
      301 gacagtttga catttcgaaa tctgcagctt gccaagaggg tggaactcct tcaagacgag
      361 ctggcgctga gtgagccgag aggcaagaaa aacaagaaaa gtggcgaatc ttcttctcag
      421 ttgagccaag agcaaaagag tgtctttgat gaagatttgc aaaagaaaat cgaggagaac
      481 gaacggctgc acatacagtt tttcgaagct gatgagcacc acaagcttgt ggaagcggag
      541 ctgcggagtc ggctggccac tctggaaaca gaagctgctc agcaccaggc tgtgattgac
      601 ggcctgaccc ggaagtacat ggagaccatt gagaaactcc agaatgacaa ggcaaagcta
      661 gaagtaaaat ctcagactct agaaaaggag gccaaggaat gccgacttcg aacagaggag
      721 tgtcaattac agctaaagaa tcttcatgaa gatttgtcag gtagattaga agaatcctta
      781 tcaatcatca atgaaaaagt cccttttaac gatacaaagt gtaatcagta caacgctctc
      841 aacgttccct tgcacaatag gcggcaccag ctgaagatgc gggatttagc tgggcaggcc
      901 ctggcctttg ttcaggatct tgtgccggct cttctgaact ttcacaccta taccgagcag
      961 aggattcaga tcttccctgt tgattcggcc atagacacta tatcaccatt gaatcagaag
     1021 ttctcccaac accttcatga aaacgcagcg tatgtccgcc ccctggagga aggaatgctg
     1081 catttatttg agagcattac agaagatact gtgactgtcc tggagacaac tgtgaaattg
     1141 aaagtgttct cagaccacct aacttcctat gtacgcttcc tgaggaagat ccttccttat
     1201 cagttaaaaa gtttagaaga agaatgtgaa tcttcccttt gcacacctgc attgagagcc
     1261 aggaacctgg agctgtccca ggacatgaag aggatgacag ccgtgtttga aaagctgcag
     1321 acgtacatca ctctcctcgc cttgccaagt acagagccag atggactcct tcggacaaac
     1381 tacacttctg tcttaacaaa tgttggtgct gctctgcatg gatttcatga cgtcatgaaa
     1441 gatatttcca agcactatag tcaaaaggct tccatagagc atgaacttcc aacagcaacg
     1501 cagaagctgg taacgactaa cgactgcatt ttgtcctcag cagtggcgtt aacaaacgga
     1561 gcggggaaga ttgcatcttt cttcagcaac aacatggact acttcattgc ttcactgagc
     1621 tatggaccca agacagccag tggattcatt agtcccctct cagctgaatg catgctacag
     1681 tacaagaaga aagctgctgc ctatatgaag tctttgagaa agcccctggc agagtctgta
     1741 ccttatgagg aagcattggc caaccgccgg gttcttctca gctctacgga gagtcgggaa
     1801 ggcctcgcac agcaggttca gcagagtttg gaaaagattt ctaaactgga gcaggaaaaa
     1861 gaacattgga tgttagaagc acagttagcc aaaatcaagc tggagaaaga aaaccagcgg
     1921 attgcggaca ggctgaggag cacgagcagt gcccagctgc ttgggctggc ccaggagaat
     1981 gccactgtgt ccattgcttc aggccaggag gaggctgcag ccaaggccct gacagagcct
     2041 gtgcagagca ccagtctgat cgggatttta accaggactc cagaaagtga ggctcccgac
     2101 attgagtccc gtgaagacct aattaagagt cactacatgg ccaggatagc agagctcacg
     2161 tctcagctgc agctggctga cagtaagtca gtacacttct acgccgagtg ccgagcgctc
     2221 tctaagagac tagccctggc ggagaagtcg aaggagacgc tgacagagga gatgaggctg
     2281 gccagtcaga acgtcagcag gctgcaggat gagctgacca ccaccaagag gagctacgag
     2341 gatcagctga gcatgatgag cgaccacctg tgcagcatga acgagacgct gtccaagcag
     2401 agggacgaga tcgacacgct caagatgtcc agtaagggaa atgctaagaa gaacaggagt
     2461 cggtagttga tgacctcggc tggccagtga ctgttccctc cagatcggct gcagctgctg
     2521 cctggagact cgagccagac tccacaacca gtgctggtgg ctgctgggaa gccatgtgct
     2581 gttggactta gactagccag tgtcgtctgt gaccctgaga catttgtaaa cagcgaggcg
     2641 aatgcagaat ttcatgttga cagtcaaatg gagaacaata gacataccca tggattgtag
     2701 gtttccttac gctgttttta ctgtgcactt tttaaaatta ggatttaatt tcagtatgta
     2761 agaacaacaa atattttgta tattttcaaa ctcaattata tggtaatgga tttggtatct
     2821 gtggaataga tatatgtttc tggataaaat gcttaaattg tcagatgtca ccacttcctg
     2881 tattgtcatt tcttcttata attgaaaaat tgaaagacat ctcagattcc ttttaaaaga
     2941 ctctctcctt gccctctctc cgtcctttgc cttccctttc ctctgtcccc tgggggtgac
     3001 aagccttaca gccctttaga gcctgtggct ttgctgtcat gtctgcagct gtacaaataa
     3061 ctgtgttcaa ataactgcta aaggaaatcc tgtcaataaa ttcatacgca catgaa
//
