LOCUS       NM_138823               2235 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory (inhibitor)
            subunit 2 (Ppp1r2), mRNA.
ACCESSION   NM_138823 XM_341000
VERSION     NM_138823.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Siddoway,B.A., Altimimi,H.F., Hou,H., Petralia,R.S., Xu,B.,
            Stellwagen,D. and Xia,H.
  TITLE     An essential role for inhibitor-2 regulation of protein
            phosphatase-1 in synaptic scaling
  JOURNAL   J Neurosci 33 (27), 11206-11211 (2013)
   PUBMED   23825423
  REMARK    GeneRIF: A novel calcium-induced IPP-2 activation pathway is found
            that is critical for homeostatic synaptic plasticity.
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Terry-Lorenzo,R.T., Elliot,E., Weiser,D.C., Prickett,T.D.,
            Brautigan,D.L. and Shenolikar,S.
  TITLE     Neurabins recruit protein phosphatase-1 and inhibitor-2 to the
            actin cytoskeleton
  JOURNAL   J Biol Chem 277 (48), 46535-46543 (2002)
   PUBMED   12270929
REFERENCE   3  (bases 1 to 2235)
  AUTHORS   Sakagami,H. and Kondo,H.
  TITLE     Molecular cloning of the cDNA for rat phosphatase inhibitor-2 and
            its wide gene expression in the central nervous system
  JOURNAL   J Chem Neuroanat 8 (4), 259-266 (1995)
   PUBMED   7669271
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138823.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092194.1, SRR26360176.537549.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               JAXUCZ010000011.1  82977634-82977889
            257-364             JAXUCZ010000011.1  82986808-82986915
            365-442             JAXUCZ010000011.1  82990357-82990434
            443-537             JAXUCZ010000011.1  82990975-82991069
            538-705             JAXUCZ010000011.1  82994825-82994992
            706-2235            JAXUCZ010000011.1  82997897-82999426
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..2235
                     /gene="Ppp1r2"
                     /gene_synonym="IPP-2"
                     /note="protein phosphatase 1, regulatory (inhibitor)
                     subunit 2"
                     /db_xref="GeneID:192361"
                     /db_xref="RGD:621099"
     exon            1..256
                     /gene="Ppp1r2"
                     /gene_synonym="IPP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..752
                     /gene="Ppp1r2"
                     /gene_synonym="IPP-2"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 1, regulatory subunit 2;
                     phosphatase inhibitor 2"
                     /codon_start=1
                     /product="protein phosphatase inhibitor 2"
                     /protein_id="NP_620178.1"
                     /db_xref="GeneID:192361"
                     /db_xref="RGD:621099"
                     /translation="MAASTASHRPIKGILKNKTSTTSSVVASAEQPRRTVEEELSKKS
                     QKWDEMNILATYHPADKDYGLMKIDEPDTPYHNMIGDDEDVCSDSEGNEVMTPEILAK
                     KLAAAEGSEPKFRTREQESSGEEDNDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQL
                     ISKDLHDDDEDEEMSETADADSMNIEESNQGSTAGDHLQHKSQSS"
     exon            257..364
                     /gene="Ppp1r2"
                     /gene_synonym="IPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..442
                     /gene="Ppp1r2"
                     /gene_synonym="IPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            443..537
                     /gene="Ppp1r2"
                     /gene_synonym="IPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..705
                     /gene="Ppp1r2"
                     /gene_synonym="IPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..2235
                     /gene="Ppp1r2"
                     /gene_synonym="IPP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgacagcag gtgcgactgc tttagcccgg cctgggctcc acggctgcct ggagggtctc
       61 tgcagtgccc accccttctc ctccgggacc ccacgccagc agcgaccctg agccagcagc
      121 cggagcgacc ggcaatggcg gcctcgacgg cctcgcaccg gcccatcaag ggaatcctga
      181 agaacaagac ctctacgact tcctcggtgg tggcctcggc cgaacagccc cgccggaccg
      241 tcgaagagga gctgagtaaa aagtctcaga agtgggatga aatgaacatc ctggcaacat
      301 atcatccagc tgacaaagac tacggcttga tgaagataga cgagccagac actccatacc
      361 acaatatgat aggtgatgat gaagatgtct gtagtgattc agaaggcaat gaagtcatga
      421 ctccagagat cttagcgaaa aagttagctg ctgctgaggg ctccgagcca aagtttcgga
      481 ctcgggaaca agaaagcagt ggagaggaag acaatgacct ctcccctgaa gagcgagaaa
      541 agaagcggca gtttgaaatg aaaaggaagc ttcattacaa cgaaggactg aatattaaat
      601 tagccagaca gttaatttca aaagacctac atgatgatga cgaagatgaa gaaatgtcag
      661 agactgcaga tgcagacagc atgaatattg aagagtcaaa tcaaggatct actgcaggcg
      721 accatctgca gcacaaatca caaagttcat aaacgtgttc atcagtgcag tcgttgtcaa
      781 atacaaacct tgttacttat accacactgc ttcttgttct ctacgactcg tgactatgta
      841 ccaaaataca caccagttat atattgccaa gaattaagac catagagact gagtagatgg
      901 aaaatgccta attaatgcat atattcttgt gcctcatatt tcaccacaaa tacagtgtaa
      961 tgttagtagt ccaaaactgc tttacttttg taagaacact ggttaatttg tataagatgt
     1021 tatatagctt tttatgcttt agagattaaa taatatgggg gaaactattt atttttgtca
     1081 cttctagatg gtggtacctc ttataaaatg tttgggggta gtttgatgtt ttttcttctt
     1141 ttaatctaaa gcctattcat aaagtgggat atgtagatgg ataaatattt aggctgaaag
     1201 atttttttaa gcatttatct ttagcttgtt ttggctaatt gaggtttcta agaggtattg
     1261 ttcattttct gatcaatgac ctttaaaatt cctgttgatt ttctttgtgc ttgaaaggaa
     1321 taaaatcttt tcatccaatc tggtttcccc cattcccatc cacactgaaa taaacgacca
     1381 ggttaaagtt gcactggtac ctgccctgct gttttggtgt tgtgcaggct tcagacgagg
     1441 attttaatac catggctatc ttagtgtccc tttgtcattt atattcctgg cttagcctgc
     1501 tctgatttcc tactttctct gcctatacac atagaggtgt gaaaattgta ttataggatg
     1561 gcaaaggcta ttggacgtga gggactcttc tcaagtagtc tgtcatctgc tgcagcactg
     1621 aattcttact ttgacagctg ctagttctaa cacacgaagg aaccagagct agtagtagcc
     1681 gtattgtggc aggaagggca tctcagcagc ttgatctctg gacttctctg actgacagcc
     1741 tgctcagtaa atggctgata ttggttcatt tgacgttaga ccttagaaaa caattgacta
     1801 aggctttttt tgcacgatga aagcattgta tgtaatcaga atatgattgt ttttgaatgt
     1861 acagaaagac ttatacctga acatttttaa atttaaaggt tctgaggagt ctgctttaaa
     1921 ggaatatgat tatgcacaca atgacaaatg aacgtgattc ctttaacatg atagaaatta
     1981 tttgggtttt tttccccctg aaatgcaacg ttgttcccgt gtgtcttagt ttagtgatgg
     2041 tttcctttgt agtcatttat ttgtatcgta agtttttggt agcaccaaat caatctgtta
     2101 tatgacagac ttttaaaata acttatgtat attatatata tgaaatggct tttattgaac
     2161 agctatcttc cactttaaat ttatggaact atcatgatgt caaaataaaa aaagtgggaa
     2221 gagtctttac tgtta
//
