LOCUS       NM_022676               1566 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory (inhibitor)
            subunit 1A (Ppp1r1a), mRNA.
ACCESSION   NM_022676
VERSION     NM_022676.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1566)
  AUTHORS   Jiang,L., Brackeva,B., Ling,Z., Kramer,G., Aerts,J.M., Schuit,F.,
            Keymeulen,B., Pipeleers,D., Gorus,F. and Martens,G.A.
  TITLE     Potential of protein phosphatase inhibitor 1 as biomarker of
            pancreatic beta-cell injury in vitro and in vivo
  JOURNAL   Diabetes 62 (8), 2683-2688 (2013)
   PUBMED   23557701
REFERENCE   2  (bases 1 to 1566)
  AUTHORS   Kawashima,H., Satoh,H., Saotome,M., Urushida,T., Katoh,H. and
            Hayashi,H.
  TITLE     Protein phosphatase inhibitor-1 augments a protein kinase
            A-dependent increase in the Ca2+ loading of the sarcoplasmic
            reticulum without changing its Ca2+ release
  JOURNAL   Circ J 73 (6), 1133-1140 (2009)
   PUBMED   19377265
  REMARK    GeneRIF: Protein phosphatase inhibitor-1 augments a protein kinase
            A-dependent increase in the Ca2+ loading of the sarcoplasmic
            reticulum without changing its Ca2+ release.
REFERENCE   3  (bases 1 to 1566)
  AUTHORS   El-Armouche,A., Bednorz,A., Pamminger,T., Ditz,D., Didie,M.,
            Dobrev,D. and Eschenhagen,T.
  TITLE     Role of calcineurin and protein phosphatase-2A in the regulation of
            phosphatase inhibitor-1 in cardiac myocytes
  JOURNAL   Biochem Biophys Res Commun 346 (3), 700-706 (2006)
   PUBMED   16774736
  REMARK    GeneRIF: calcineurin and protein phosphatase-2A act to maintain a
            low basal level of phosphorylated (active) phosphatase inhibitor-1
            in living cardiac myocytes
REFERENCE   4  (bases 1 to 1566)
  AUTHORS   Aleem,E.A., Flohr,T., Hunziker,A., Mayer,D., Bannasch,P. and
            Thielmann,H.W.
  TITLE     Detection and quantification of protein phosphatase inhibitor-1
            gene expression in total rat liver and isolated hepatocytes
  JOURNAL   Mol Cell Biochem 217 (1-2), 1-12 (2001)
   PUBMED   11269652
REFERENCE   5  (bases 1 to 1566)
  AUTHORS   Elbrecht,A., DiRenzo,J., Smith,R.G. and Shenolikar,S.
  TITLE     Molecular cloning of protein phosphatase inhibitor-1 and its
            expression in rat and rabbit tissues
  JOURNAL   J Biol Chem 265 (23), 13415-13418 (1990)
   PUBMED   1696252
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY648296.1.
            
            On Aug 15, 2004 this sequence version replaced NM_022676.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY648296.1, BC078820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1566
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1566
                     /gene="Ppp1r1a"
                     /note="protein phosphatase 1, regulatory (inhibitor)
                     subunit 1A"
                     /db_xref="GeneID:58977"
                     /db_xref="RGD:62018"
     exon            1..218
                     /gene="Ppp1r1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..650
                     /gene="Ppp1r1a"
                     /EC_number="3.1.3.16"
                     /note="PP1 inhibitor 1; I-1; IPP-1; protein phosphatase
                     inhibitor 1"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 1A"
                     /protein_id="NP_073167.1"
                     /db_xref="GeneID:58977"
                     /db_xref="RGD:62018"
                     /translation="MEPDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSD
                     QSSPEVDEDRIPNPLLKSTLSMSPRQRKKMTRTTPTMKELQTMVEHHLGQQKQGEEPE
                     GATESTGNQESCPPGIPDTGSASRPDTSGTAQKPAESKPKTQEQRGVEPSTEDLSAHM
                     LPLDSQGASLV"
     exon            219..279
                     /gene="Ppp1r1a"
                     /inference="alignment:Splign:2.1.0"
     exon            280..317
                     /gene="Ppp1r1a"
                     /inference="alignment:Splign:2.1.0"
     exon            318..381
                     /gene="Ppp1r1a"
                     /inference="alignment:Splign:2.1.0"
     exon            382..537
                     /gene="Ppp1r1a"
                     /inference="alignment:Splign:2.1.0"
     exon            538..644
                     /gene="Ppp1r1a"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1550
                     /gene="Ppp1r1a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      752
                     /gene="Ppp1r1a"
     polyA_site      1317
                     /gene="Ppp1r1a"
     polyA_site      1549
                     /gene="Ppp1r1a"
ORIGIN      
        1 agtccccaag cggagccggg cgcgccgagc caggagctgg gagccgagcg ccgggctggg
       61 gccggggccg gagcgcagcg aaaagggagc gcgcccgccc cagcccgagg tccgccgccg
      121 ccggaccggg cgccatggag cccgacaaca gtccacggaa gatccagttt acggttccgc
      181 tgctggagcc tcacctggac ccggaggcag ccgagcagat tcggaggcgc cgccccaccc
      241 ctgccacact tgtgctgacc agcgaccagt catccccaga agtagatgaa gaccggatcc
      301 ccaacccact tctcaagtcc acactgtcaa tgtctccacg gcaacggaag aagatgacaa
      361 ggactacacc caccatgaaa gagctccaga caatggttga acatcaccta gggcaacaga
      421 aacaagggga agaacctgag ggagccactg agagcacagg gaaccaggag tcctgcccac
      481 ctgggatccc agacacaggc tcagcgtcaa ggccagatac ctcggggaca gcacaaaagc
      541 ctgcagaatc caaacccaag actcaggagc agcgtggtgt ggagcccagc acagaggacc
      601 tttcagccca catgctacca ctggattccc aaggagccag cttggtctga cagaagttga
      661 catccgggga tcgccagtga gtgtggaagt tcatggacac tggatgtttc ttaatctctt
      721 gtttttaaac gtgataaatt tggtgttagg tccttggtgc ttttcttctt tccagcctgg
      781 ggattccttc ctccctcggc tcttgtctgc accccacagc ccccaccctc aggaccaact
      841 aagctaggaa ataggaaact gactgaagcc tagcctctac tagcataaag aaaaagagga
      901 gtgtggaagt aggagatcac ttcaaggctt tcctttctta ctgtggaaag ctccgcccac
      961 gtagcagggc cgcctacttg ggagactgcc actctaaagc agatacccag accagcgagg
     1021 gcttgctata gcaccatctg ctggacataa atgggaagtg catcttgtcc cgaaacccct
     1081 gacaaaggga gtatttggaa tctggttcca attgtgtggc actgttcctt attctaacct
     1141 gacaacaaag actgtcagaa aacccagtga ctagaaaccc ctcttccatt gtcctaccta
     1201 ctaaggtcag ggcaagacta acaccatgca caaatggaga agtggtctct gattctagcc
     1261 aggcttctgc tgctgattct gattttccca aagaattaaa gagatggagg gagaaggaag
     1321 actctttcgt ccccttttct tcagcagtac cacatagcta agaagagcat agcctgggca
     1381 gtgaaggact gtgtgccgta gcgccccacc cccaccccca gataggcttt acttgaatcc
     1441 ccgcttcaac actcatggag aataccatgg cagagttctg tctagcttag gaagataact
     1501 ataaatgaca cgtgagagag cttctaccta atgaacacca cacacatcca aaaaaaaaaa
     1561 aaaaaa
//
