LOCUS       NM_153467               1734 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory subunit 17
            (Ppp1r17), mRNA.
ACCESSION   NM_153467
VERSION     NM_153467.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Nakazawa,T., Endo,S., Shimura,M., Kondo,M., Ueno,S. and Tamai,M.
  TITLE     Retinal G-substrate, potential downstream component of NO/cGMP/PKG
            pathway, is located in subtype of retinal ganglion cells and
            amacrine cells with protein phosphatases
  JOURNAL   Brain Res Mol Brain Res 135 (1-2), 58-68 (2005)
   PUBMED   15857669
  REMARK    GeneRIF: retinal G-substrate plays a role as a downstream component
            of the NO-cGMP-PKG pathway. The co-localization of retinal
            G-substrate with protein Ser/Thr phosphatases suggests that it acts
            as an endogenous protein phosphatase inhibitor.
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   Endo,S., Nairn,A.C., Greengard,P. and Ito,M.
  TITLE     Thr123 of rat G-substrate contributes to its action as a protein
            phosphatase inhibitor
  JOURNAL   Neurosci Res 45 (1), 79-89 (2003)
   PUBMED   12507727
  REMARK    GeneRIF: G-substrate works as protein phosphatase 1 and 2A
            inhibitor upon phosphorylation by PKG.
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Hall,K.U., Collins,S.P., Gamm,D.M., Massa,E., DePaoli-Roach,A.A.
            and Uhler,M.D.
  TITLE     Phosphorylation-dependent inhibition of protein phosphatase-1 by
            G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent
            protein kinase
  JOURNAL   J Biol Chem 274 (6), 3485-3495 (1999)
   PUBMED   9920894
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF294688.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF294688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1734
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs"
                     /note="protein phosphatase 1, regulatory subunit 17"
                     /db_xref="GeneID:266705"
                     /db_xref="RGD:628647"
     exon            1..51
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs"
                     /inference="alignment:Splign:2.1.0"
     exon            52..219
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..605
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs"
                     /function="inhibits protein phosphatase-1 and -2A when
                     phosphorylated by cGMP-dependent protein kinase"
                     /note="G-substrate"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 17"
                     /protein_id="NP_703197.1"
                     /db_xref="GeneID:266705"
                     /db_xref="RGD:628647"
                     /translation="MSTEMMTTEPVQSLELSEDILDKLDPHGSHSDDLSDQFIKDCDL
                     KKKPRKGKNVQATLNVESDQKKPRRKDTPALHIPPFIPGVISEHLIKRYDVQERIPKG
                     KTGPALHNTDVEQKRPRRKDTPAFHVPPFVAGLTLLEDEGTGVIMEDEEMDGDKLAI"
     exon            220..372
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs"
                     /inference="alignment:Splign:2.1.0"
     exon            373..525
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs"
                     /inference="alignment:Splign:2.1.0"
     exon            526..1734
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaactgc ttctagcctt cttctcctct gctcagcacc tgcattgact gtgctagaaa
       61 agactctctc tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc
      121 tgaggatgtc cactgagatg atgaccactg agccagtgca gtctctggag ctttcagaag
      181 acatactaga caagctcgat cctcatggca gccactcaga tgacctttca gaccagttca
      241 ttaaggactg tgacctgaaa aagaagccaa gaaaggggaa gaatgtacag gccactctga
      301 acgttgagtc cgatcaaaag aaacccagaa ggaaagatac gccagcattg cacatcccac
      361 ctttcatacc aggtgtgatt tcagaacact taattaaaag atatgacgtt caagagagaa
      421 ttccaaaggg caaaacaggt ccagctcttc ataacactga tgtggaacag aaaaggccaa
      481 ggagaaaaga cacacctgcc ttccatgtgc ctccctttgt tgcaggtttg actctcctcg
      541 aggatgaggg caccggagtg attatggagg atgaagaaat ggatggtgac aagctagcta
      601 tttaaagaca tctcccctga gactgcgtgt aaatagatta cattggttcc ctatggtgat
      661 ctagaggaaa aaatagattt gtctctgctc tcattttgtc ctagtcgact ctcagatcta
      721 gacacctcct ccccaggaga cctactactc agattgctgg tcacctcttt gtctttcctc
      781 tttagttgct ttgtagcccc accttccaaa ctttcatttc tctatacact gcaaaggaaa
      841 gtgatttttt tccaaagtaa gagagatgag acctcggtgc ttcatatcta caagcaaaaa
      901 acatggatga aagatggggt tgggaggagg tggtcctttc ttcctagctt atggtcaggc
      961 aatctgattc aacatcaagc actcaggagt tcagtagggc cacagctacc agttagactg
     1021 ggtgaacatg tggactctaa ttcacagaac gctctgacaa aatggttatt cctattttcc
     1081 tttctacctt gagagtccag ttctggccac actctaaaga ccctcattac agatgtcaca
     1141 agagtttaag aagaggaagc cggcccacca tgcaataaca aaagacataa gaggcagagg
     1201 atgctgatct atgtgtgtgg gggggtgtct tataattaat ttaattgtta aaaatgagag
     1261 ttcttaacta tattggttgt cttgacattt gtgaattatg tcataagcaa gccatcccta
     1321 atgggaggtg aataaatacc aatcgtaagg aatttatttt tttaactcta agtcccgtcg
     1381 aaggttcttc tgatagttct accatttcac ttactcaggc tctgacacat tttcttgtat
     1441 aagaggtggt gctgtctagt gaacacagat gtgcatgtga ctcctgtgca gctggcaatc
     1501 tctgagtgcc cgtgggaacg ttgcatctgc acttcatcca ccagacagca gacagggaga
     1561 aggtgaggac tgaaagggag aaaagcagag gatctagtgc tcagaccaag gtggggagca
     1621 tggggcagtt ctatacatac ttgcagtcca gctgtttgtt agcctttctg tctttctgtt
     1681 tcccttacaa agatgtggaa gatgcagtac atttcagaaa taaagacact tcag
//
