LOCUS       NM_001191072            1886 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory subunit 16B
            (Ppp1r16b), mRNA.
ACCESSION   NM_001191072 XM_001058014
VERSION     NM_001191072.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1886)
  AUTHORS   Boratko,A., Peter,M., Thalwieser,Z., Kovacs,E. and Csortos,C.
  TITLE     Elongation factor-1A1 is a novel substrate of the protein
            phosphatase 1-TIMAP complex
  JOURNAL   Int J Biochem Cell Biol 69, 105-113 (2015)
   PUBMED   26497934
REFERENCE   2  (bases 1 to 1886)
  AUTHORS   Obeidat,M., Li,L. and Ballermann,B.J.
  TITLE     TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt
            inhibition in human glomerular endothelial cells
  JOURNAL   Am J Physiol Renal Physiol 307 (5), F623-F633 (2014)
   PUBMED   25007873
REFERENCE   3  (bases 1 to 1886)
  AUTHORS   Poirier,C., Gorshkov,B.A., Zemskova,M.A., Bogatcheva,N.V. and
            Verin,A.D.
  TITLE     TIMAP protects endothelial barrier from LPS-induced vascular
            leakage and is down-regulated by LPS
  JOURNAL   Respir Physiol Neurobiol 179 (2-3), 334-337 (2011)
   PUBMED   21907835
REFERENCE   4  (bases 1 to 1886)
  AUTHORS   Czikora,I., Kim,K.M., Kasa,A., Becsi,B., Verin,A.D., Gergely,P.,
            Erdodi,F. and Csortos,C.
  TITLE     Characterization of the effect of TIMAP phosphorylation on its
            interaction with protein phosphatase 1
  JOURNAL   Biochimie 93 (7), 1139-1145 (2011)
   PUBMED   21466834
REFERENCE   5  (bases 1 to 1886)
  AUTHORS   Csortos,C., Czikora,I., Bogatcheva,N.V., Adyshev,D.M., Poirier,C.,
            Olah,G. and Verin,A.D.
  TITLE     TIMAP is a positive regulator of pulmonary endothelial barrier
            function
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 295 (3), L440-L450 (2008)
   PUBMED   18586956
REFERENCE   6  (bases 1 to 1886)
  AUTHORS   Kim,K., Li,L., Kozlowski,K., Suh,H.S., Cao,W. and Ballermann,B.J.
  TITLE     The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1
            phosphorylation
  JOURNAL   Biochem Biophys Res Commun 338 (3), 1327-1334 (2005)
   PUBMED   16263087
REFERENCE   7  (bases 1 to 1886)
  AUTHORS   Cao,W., Mattagajasingh,S.N., Xu,H., Kim,K., Fierlbeck,W., Deng,J.,
            Lowenstein,C.J. and Ballermann,B.J.
  TITLE     TIMAP, a novel CAAX box protein regulated by TGF-beta1 and
            expressed in endothelial cells
  JOURNAL   Am J Physiol Cell Physiol 283 (1), C327-C337 (2002)
   PUBMED   12055102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jul 17, 2010 this sequence version replaced XM_001058014.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.15404.1,
                                           SRR26643284.5111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000003.1  167743991-167744070
            81-429              JAXUCZ010000003.1  167771689-167772037
            430-500             JAXUCZ010000003.1  167815666-167815736
            501-646             JAXUCZ010000003.1  167822013-167822158
            647-750             JAXUCZ010000003.1  167824350-167824453
            751-875             JAXUCZ010000003.1  167826229-167826353
            876-1001            JAXUCZ010000003.1  167828233-167828358
            1002-1077           JAXUCZ010000003.1  167828902-167828977
            1078-1207           JAXUCZ010000003.1  167830038-167830167
            1208-1376           JAXUCZ010000003.1  167830257-167830425
            1377-1886           JAXUCZ010000003.1  167834743-167835252
FEATURES             Location/Qualifiers
     source          1..1886
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1886
                     /gene="Ppp1r16b"
                     /note="protein phosphatase 1, regulatory subunit 16B"
                     /db_xref="GeneID:680616"
                     /db_xref="RGD:1589460"
     exon            1..80
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            81..429
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1886
                     /gene="Ppp1r16b"
                     /note="protein phosphatase 1, regulatory (inhibitor)
                     subunit 16B"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory inhibitor
                     subunit 16B"
                     /protein_id="NP_001178001.1"
                     /db_xref="GeneID:680616"
                     /db_xref="RGD:1589460"
                     /translation="MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDL
                     LHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGL
                     TALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADL
                     LAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRAAPEQKMISDIHCMIAA
                     GQDLDWIDGQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMP
                     MAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSR
                     RTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQQRSAAEEQRTSTYNGDIRETRT
                     DQENKDPNPRLEKPVLLSEFSTKISRGELDGPVENGLRAPVSTYQYALANGDIWKMHE
                     IPDYSMAYGNPGMADVPPPWSGFKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSVA
                     RSGEGSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPMEEMEEKVHGCCR
                     IS"
     exon            430..500
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            501..646
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            647..750
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            751..875
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1001
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1077
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1207
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1376
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1886
                     /gene="Ppp1r16b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcaccacc agctgcggct ctgggacctg cggattgagc cggggctggg agccgcccgg
       61 ggcagggctc gagagagcgg gccccaccat gaggctccag cccctcggga gcccctgtgc
      121 tcccctggcc ccgggctcac ggtgctagcc ccagacagag caagggcagg tgcggggcca
      181 tggccagcca cgtggacctg ctcacagagc tgcagctgct ggagaaggtg cctacactgg
      241 agcgcctgcg cgcagcccag aagcgccggg ctcagcagct gaagaagtgg gcacagtatg
      301 agcaggacct gcttcatcgc aagcgcaagc atgagcggaa gcgtagcacc ggtggacgtc
      361 gcaagaaggt gtccttcgag gccagtgtag cgttgctgga ggcctcactg aggaatgacg
      421 ctgaagaagt acgatacttc ctgaagaaca aggtcagccc tgatttgtgt aatgaggatg
      481 ggctcacagc cttgcaccag tgctgcattg acaacttcga agagattgtg aaactgttgc
      541 tctcccatgg tgcaaacgtg aacgccaagg acaacgagtt gtggacaccc ttgcacgctg
      601 cagccacctg cggccacatc aacctagtga agatcctcgt tcagtatggg gctgacttgc
      661 ttgctgtcaa ctctgatggg aacatgccct atgacctctg cgaggatgaa cccaccctgg
      721 atgtcatcga gacctgcatg gcgtaccaag gcatcaccca ggagaaaatc aatgagatgc
      781 gagcagctcc tgagcagaag atgatttcgg acatccactg catgatagca gccggccagg
      841 atctcgactg gatagatggc cagggtgcca cactgctaca catagctgga gccaatggat
      901 acctgcgggc agccgagctc ctcctggacc acggagtgcg tgtggacgtc aaggattggg
      961 atggctggga gcctctgcat gcagcagcct tctggggaca gatgccaatg gcagagctct
     1021 tggtgtccca tggagctagt ctcagtgcca ggacatccat ggatgagatg ccaatagact
     1081 tgtgtgagga ggaggaattc aaagtcctgc tgttggagct taaacacaag catgatgtaa
     1141 tcatgaagtc ccagctgaga cacaagtcat ccctgagccg gaggacatcc agtgcaggca
     1201 gccgtgggaa ggtggtgcgt cgagccagcc tgtcagacag aaccaaccta taccggaaag
     1261 aatatgaagg agaggccatc ttgtggcagc agcggagtgc agctgaggaa cagcgtactt
     1321 ccacctacaa cggagacatc agggagacca ggacagacca ggagaacaag gacccgaacc
     1381 ccaggctgga gaagcccgtg ctgctttcag aattctctac caagatctcc cggggagaac
     1441 tggatgggcc tgtggagaat ggcctccggg ctcctgtcag cacctaccag tatgcgctgg
     1501 ccaacgggga catatggaag atgcacgaga tacctgacta cagcatggcc tatggcaacc
     1561 ccggcatggc tgatgtcccc ccaccctgga gcggcttcaa agagcagagc ccccagacgc
     1621 tcctggagct gaagaggcag agggccgcag ccaagttgct cagccacccg ttcttaagca
     1681 cccacctggg cagcagtgtg gccaggtcgg gggagggcag cagcgaaggc aaggccccct
     1741 tgatcggagg cagaacttcc ccctacagca gcaacgggac ctcggtgtat tatacggtca
     1801 ccagcggaga tcccccgctc ttgaagttca aggcccccat ggaggagatg gaggagaaag
     1861 ttcacggctg ctgccggatc tcctaa
//
