LOCUS       NM_001107175            5383 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory subunit 15B
            (Ppp1r15b), mRNA.
ACCESSION   NM_001107175 XM_001060603 XM_222633
VERSION     NM_001107175.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5383)
  AUTHORS   Kernohan,K.D., Tetreault,M., Liwak-Muir,U., Geraghty,M.T., Qin,W.,
            Venkateswaran,S., Davila,J., Holcik,M., Majewski,J., Richer,J. and
            Boycott,K.M.
  CONSRTM   Care4Rare Canada Consortium
  TITLE     Homozygous mutation in the eukaryotic translation initiation factor
            2alpha phosphatase gene, PPP1R15B, is associated with severe
            microcephaly, short stature and intellectual disability
  JOURNAL   Hum Mol Genet 24 (22), 6293-6300 (2015)
   PUBMED   26307080
REFERENCE   2  (bases 1 to 5383)
  AUTHORS   Latreille,M. and Larose,L.
  TITLE     Nck in a complex containing the catalytic subunit of protein
            phosphatase 1 regulates eukaryotic initiation factor 2alpha
            signaling and cell survival to endoplasmic reticulum stress
  JOURNAL   J Biol Chem 281 (36), 26633-26644 (2006)
   PUBMED   16835242
REFERENCE   3  (bases 1 to 5383)
  AUTHORS   Jousse,C., Oyadomari,S., Novoa,I., Lu,P., Zhang,Y., Harding,H.P.
            and Ron,D.
  TITLE     Inhibition of a constitutive translation initiation factor 2alpha
            phosphatase, CReP, promotes survival of stressed cells
  JOURNAL   J Cell Biol 163 (4), 767-775 (2003)
   PUBMED   14638860
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_222633.4, XM_001060603.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB749751.1, CB759696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5383
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..5383
                     /gene="Ppp1r15b"
                     /note="protein phosphatase 1, regulatory subunit 15B"
                     /db_xref="GeneID:304799"
                     /db_xref="RGD:1307944"
     exon            1..2285
                     /gene="Ppp1r15b"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..2567
                     /gene="Ppp1r15b"
                     /note="protein phosphatase 1, regulatory (inhibitor)
                     subunit 15b"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 15B"
                     /protein_id="NP_001100645.1"
                     /db_xref="GeneID:304799"
                     /db_xref="RGD:1307944"
                     /translation="METGTHRARKRPTSRMGSWFRLPFLRRSHACTSEFPKPSSRPNL
                     EVSARPEPRTRYWTKLLSQLLALLPSLLQKLLIWSQLFGGMIPTRWLDFSASYSALRA
                     LRGREESAAPTVQKSLNSLRLDSSSEDLVVSSLDWLEEGLQGQCSSSDLELKFKAQER
                     ALDSTAHTFLLEQQLWGVELLPGSLQTGLVSHRELGSSSSGPLSTQSLGNFKVVSYLL
                     NPSYLDCLPQLELRCQNSVGGGQLVDFRTLSPESCYLSEDACHPQPLCAEMSATAWRR
                     CPPLSTEGLPEIHHLRMKRLEFLQANKGQELPTPDQDNGYHSLEEEHCLLRMDPQHCT
                     DKAAQAVSPAGASPQPTEKKVELVVEEVLQSPQGSSLSCELSVQKECEDYSDIGGNLP
                     VSTRPACTNKLIDYILGGASSDLDTSSDSESEDWDEEPEDDGFDSDGSLSESDREQDS
                     EGLHLWNSFYSVDPYNPQNFTATIQTAARIAPRDPSDSEKSWSGNSDVGSSQATLLPQ
                     TPDQSSGEEDDWESSADEAENLRLWNSFCNSEDPYNLLNFKAPFQTSGKSWKGSQASS
                     EATVVFSGHQTLLSCEAQLLESQEDNCPGCGLGEALSGERYTHIKRKKVTFLEEVTEY
                     YISGDEDRKGPWEEFARDGCRFQKRIQETEVAIGYCLTFEHRERVFSRLQDHVSKDLL
                     LYSSAKQREQPAALTHSISYLRGFS"
     exon            2286..5383
                     /gene="Ppp1r15b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcgttcgt ttcgtcttgc agcttccggg tttgcggctg cggccatttt gagcttcgct
       61 tcctttcgct ctcgcccgcc acccagccct aacgtctgtg tatttcgcgc ctccgtgtgg
      121 gccgcggtct ccggaaacgt tgccgccgcc gccgtgtgag gggtcttctc tatggtggag
      181 cggtctcaca cggactaggg cgcctccatt ctcgccgaga tggacgtagt cgcggtcgcc
      241 accgcttgcg cgagccgccc ggccgtacgg tacatcgctc gctacggaag ccgccgctct
      301 ctgggcctct gctggcgcgg gaatcggaat gcagtaccca ctccgtgtct gggcaaggct
      361 aagactgtgt aggcctcgga tcctgcccgc tctgacgccg ctgagctccg tactcgtgcc
      421 cgagaagttg ccaaggaaag gagatggaga cgggaacaca cagggctcgg aagcggccta
      481 cctctcggat gggctcctgg ttccggctgc ccttccttcg gcgttcgcac gcctgcactt
      541 ccgagttccc gaagccttct tctcgaccaa atctcgaggt ctccgcccgg cccgagcctc
      601 ggaccaggta ctggaccaaa ttgctttccc agctccttgc cctgctccct agcttgctcc
      661 agaagctgct tatttggagt cagcttttcg gtggcatgat tccgaccaga tggttagatt
      721 tttcagcaag ttacagcgct ctaagagctt tgagaggacg ggaggaatca gccgctccca
      781 cagtgcagaa atctttgaat tctctgcggc tggactcttc ttcggaagac ttggttgtca
      841 gttctcttga ttggctagag gagggactcc aggggcagtg ctcgtcctca gacctggaat
      901 tgaaattcaa ggcccaggaa agagctttag actctacagc gcacactttc ctcttggagc
      961 agcagctgtg gggagtggag ttgctgcccg gtagtcttca aaccggtcta gtctcccacc
     1021 gagaacttgg ctcttcatcc tctgggcctc tgagtactca gagcttgggc aatttcaagg
     1081 tagtttccta tctcctgaac ccttcctacc tggactgcct tccccagtta gagctgcgct
     1141 gtcagaacag cgtcggaggt ggccaacttg tggatttccg aacactatcc ccagagagct
     1201 gctacctttc tgaagatgct tgtcaccctc agccgctgtg tgctgagatg tcggcaactg
     1261 cctggcggag gtgtccgccc ctctctacag aaggcctgcc agaaatccac caccttcgga
     1321 tgaaacgact agaattcctt caggcaaaca aggggcaaga gttacccacc cctgaccaag
     1381 acaatggcta tcatagcctg gaggaggagc actgccttct ccggatggat ccgcaacatt
     1441 gcacagataa ggcagcacag gcagtctccc ctgctggagc cagcccgcag cccactgaga
     1501 aaaaagtaga attggtggtt gaggaagttt tacagagccc ccagggaagc agtctgtctt
     1561 gtgagttaag tgtgcaaaaa gaatgtgaag actactcaga catagggggt aaccttccag
     1621 tctctaccag accagcttgt accaacaaac tgatagatta tattttggga ggagcctcca
     1681 gtgacttgga caccagctcc gattctgaaa gtgaggattg ggatgaggaa cctgaggatg
     1741 atggttttga tagtgatggc tccctatctg aatcagacag ggaacaagac tccgaagggc
     1801 ttcacctttg gaactctttc tacagtgtag atccttacaa cccccagaac tttacagcca
     1861 caattcagac tgctgccaga attgccccca gagacccatc tgattcagag aagtcctggt
     1921 ctggcaactc tgatgtaggg agttctcagg ccacactcct tccccagacc cctgaccaga
     1981 gttccgggga ggaggatgac tgggaatcca gtgcagatga agcagaaaat cttagattgt
     2041 ggaactcttt ctgtaattct gaggacccct acaacctttt aaattttaag gctcctttcc
     2101 aaacgtcagg gaagagctgg aaaggcagtc aggcatcctc tgaggccaca gtggtctttt
     2161 ctgggcatca gaccttactt tcttgtgagg cacaactgtt agagagccaa gaagacaatt
     2221 gtccaggctg tgggctgggt gaggcacttt ctggagaaag atacacccat atcaagagaa
     2281 aaaaggtaac cttccttgaa gaagttactg agtattatat aagtggtgat gaggatcgca
     2341 aaggaccatg ggaagaattt gcaagggatg gatgcaggtt ccagaaacga attcaggaaa
     2401 cagaagtcgc cattggctac tgcttgacat ttgagcatag agaaagagtg tttagtagac
     2461 tgcaagacca cgtttcaaag gacttactgt tgtacagcag tgctaagcag agggagcagc
     2521 ctgcagccct cacccactcc atctcttact tgagaggttt ctcttaaaaa caaacactgg
     2581 cagctgtcct tggacatgtt tttaaagaaa caacttgttt ctagtgatgt agtttttttt
     2641 gggtaatgtg tctcattaga aacacacaac tccaataatg aaggatctct aatctttaat
     2701 cctttctttt cctatatagt tggatgtggg ttttgttttt ttttgagagg gtctcactgc
     2761 atagttggcc taggtatgta gaccaggttg gccttgaaat cgatatcttt ttgtctgttt
     2821 cctgtggcca ccatgcccag ctggaagtgt ttttaaatat cctctgctaa cctgagatga
     2881 gaggggccct ttgagtttaa ttctgcactt tcaaaatatt tttttctgga ggcagaggct
     2941 ggtcaggcca gctgggctat gtggtcctag agggcaagca gaacagaaca cagactactg
     3001 tagagacaga ggcaggagga gagacagtac caggtctgcc tggaactcag ctcaaagcca
     3061 gcgtggggcg tttagcaaga ccttttcact ttgaactcag ctggggaaat agctcagcag
     3121 cagagggccc tgcctacttg tgcaaggccc tggggtcagt ctccagtact gcaaggagag
     3181 aaaaaaagtc ttggataacc ataaggttta agcctcatat tcagtcctaa ctcaaattat
     3241 gcatacttat ctaaaaactg agttcttgta tgctttttct attctaaaat cagtgggttt
     3301 tatatgtttt ttttttcata tatttgtatg tctgttttat attttgaaac gggggattga
     3361 agcagggtct cactgtgacc ttgcgtatgg cagtcttcct gcttcaacct cctgagtgtt
     3421 gagatacttg tgttggtttt tggtttgttt gtgttttggt agtctaggct ggccttgaac
     3481 tcattactta gccaaggatg acttgaagag atcctcttgt cctctgtttg gattgcacat
     3541 ggcatgtgcc atacttccag atgtttttct atatctaggt ctatttaaga tatttccaag
     3601 gactgccaca aacccacaag tacagtactt tcttgactgg gaagccgtgt tggtatgctt
     3661 cttaaaggca tatgccgtgt tgcccagctg gtctgccaaa ctttaacatg taatgtattt
     3721 ggttcctgtg caaactccat ttagaaggct tctgtgtgtt gtagctccag ttgaatgcgg
     3781 cttttgtagc tctcaagaat gggcaaagat tgtaaagcac tctgggaagt gatcattgca
     3841 ttgtagactt ttagttttta aacttagaag cctagaattt ttctaggagg tatgtaggag
     3901 acgtctcaga aatttgttgt atgtatctta aaaccagtgt tacttatacc ctgcctcagc
     3961 actggcactt ttcaaacccg tcttagtgac cctctaaact tggattgtac agttctgagt
     4021 tttcaagtat gaaatgtcaa atacaaaggt caaatccagg ttggttgtgt tctaccttag
     4081 atagagagaa gcaaagcaga aatacagata gaacagccac aaagtctttt tttttttttt
     4141 tttttgggtc tttttttttg gagctgggga ccgaacccag ggccttgctc ttcctaggca
     4201 agcgctctac cactgagcta aatccccaac cccagccaca aaatcttagt gtcctccccg
     4261 aagcttgctt ttgaatagag tgtggtgatt gggcatgctt gttcaggtag cttcacctct
     4321 gtgcatgcgc agctctttgg tcccagtcct taccctggga ctgaatgtgc actaaagaga
     4381 ggcgctctgg attggtcgtg aggatgagct tttctcacaa gaactggcag ggtaactacc
     4441 tcagtttaca atctcctggt tattccgcct gatgtgctct aaggtctgcc tcagtggtgt
     4501 cagatgtcaa tccacacaca gtaggaagag tgcagtacta gaaaccttag gcttattttt
     4561 cgagaatcct catttctgtg gattttgtgc acctgccttt tgtgaactcc agagagggcg
     4621 ttgcagaatc tggtttagtg ctgtggaaat gggctagttt aaaagctgtg ttgtttggaa
     4681 agcaggcgtg ttgactttag gaagaaaaac tgtaacaatg tgtagacact tcttttaaaa
     4741 ccagactgca gcttaacact tgatttcaga tgattaggtt gtttttcttt ctgagaccct
     4801 agcacctgta tatttgcaag ggacgggata tctatacatt gacagtgtgt ttgagatgtt
     4861 tgaaaattgt tccagattat accctcacta tcaaatgaat aaatgactgg ttaaaataat
     4921 cacgcctgca gagatggtca aatggtggca aagacagaag ggtctaaact gaaggagaaa
     4981 aacaaaatta ctgtcattgt catcgaatcc caaggaaaga acacctccga ggcaaggcag
     5041 gcatggcggt tctagctgaa cacttacact cagtcttgca gtggtgcttt agagatctct
     5101 gtagcatgtg aggctctgta caggtgggga cccacacttc cgagtgctga aatgtggcaa
     5161 cccttatcta acttgaaatc aaaaccgtca gattttattt tttataattt aagaaaagta
     5221 gagacggaat gagaaatttt ttttttttgg aatgagatgt ttgagttggt ttcagatcat
     5281 tttacatgta actagtgtag attttatagc ggagattata tttgtatata attattaact
     5341 aatctgtaaa ttgtaataaa tatatttgca attattaaat gct
//
