LOCUS       NM_133546               2051 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory subunit 15A
            (Ppp1r15a), mRNA.
ACCESSION   NM_133546
VERSION     NM_133546.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Yang,T., He,R., Li,G., Liang,J., Zhao,L., Zhao,X., Li,L. and
            Wang,P.
  TITLE     Growth arrest and DNA damage-inducible protein 34 (GADD34)
            contributes to cerebral ischemic injury and can be detected in
            plasma exosomes
  JOURNAL   Neurosci Lett 758, 136004 (2021)
   PUBMED   34098025
  REMARK    GeneRIF: Growth arrest and DNA damage-inducible protein 34 (GADD34)
            contributes to cerebral ischemic injury and can be detected in
            plasma exosomes.
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Tan,Z., Zhang,W., Sun,J., Fu,Z., Ke,X., Zheng,C., Zhang,Y., Li,P.,
            Liu,Y., Hu,Q., Wang,H. and Zheng,Z.
  TITLE     ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of
            unfolded protein response in neural cells
  JOURNAL   J Neuroinflammation 15 (1), 275 (2018)
   PUBMED   30241539
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2051)
  AUTHORS   Ren,F., Shi,H., Zhang,L., Zhang,X., Wen,T., Xie,B., Zheng,S.,
            Chen,Y., Li,L., Chen,D. and Duan,Z.
  TITLE     The dysregulation of endoplasmic reticulum stress response in
            acute-on-chronic liver failure patients caused by acute
            exacerbation of chronic hepatitis B
  JOURNAL   J Viral Hepat 23 (1), 23-31 (2016)
   PUBMED   26234401
REFERENCE   4  (bases 1 to 2051)
  AUTHORS   Mohammad-Gharibani,P., Modi,J., Menzie,J., Genova,R., Ma,Z.,
            Tao,R., Prentice,H. and Wu,J.Y.
  TITLE     Mode of action of S-methyl-N, N-diethylthiocarbamate sulfoxide
            (DETC-MeSO) as a novel therapy for stroke in a rat model
  JOURNAL   Mol Neurobiol 50 (2), 655-672 (2014)
   PUBMED   24573692
REFERENCE   5  (bases 1 to 2051)
  AUTHORS   Lin,M.H., Yen,J.H., Weng,C.Y., Wang,L., Ha,C.L. and Wu,M.J.
  TITLE     Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers
            unfolded protein response and heme oxygenase-1 expression in PC12
            cells: Roles of ROS and MAPK pathways
  JOURNAL   Toxicology 315, 24-37 (2014)
   PUBMED   24291486
REFERENCE   6  (bases 1 to 2051)
  AUTHORS   Lee,Y.Y., Cevallos,R.C. and Jan,E.
  TITLE     An upstream open reading frame regulates translation of GADD34
            during cellular stresses that induce eIF2alpha phosphorylation
  JOURNAL   J Biol Chem 284 (11), 6661-6673 (2009)
   PUBMED   19131336
REFERENCE   7  (bases 1 to 2051)
  AUTHORS   Su,Z.Z., Goldstein,N.I., Jiang,H., Wang,M.N., Duigou,G.J.,
            Young,C.S. and Fisher,P.B.
  TITLE     PEG-3, a nontransforming cancer progression gene, is a positive
            regulator of cancer aggressiveness and angiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 96 (26), 15115-15120 (1999)
   PUBMED   10611347
REFERENCE   8  (bases 1 to 2051)
  AUTHORS   Doutheil,J., Althausen,S., Gissel,C. and Paschen,W.
  TITLE     Activation of MYD116 (gadd34) expression following transient
            forebrain ischemia of rat: implications for a role of disturbances
            of endoplasmic reticulum calcium homeostasis
  JOURNAL   Brain Res Mol Brain Res 63 (2), 225-232 (1999)
   PUBMED   9878749
REFERENCE   9  (bases 1 to 2051)
  AUTHORS   Amundson,S.A., Zhan,Q., Penn,L.Z. and Fornace,A.J. Jr.
  TITLE     Myc suppresses induction of the growth arrest genes gadd34, gadd45,
            and gadd153 by DNA-damaging agents
  JOURNAL   Oncogene 17 (17), 2149-2154 (1998)
   PUBMED   9811446
REFERENCE   10 (bases 1 to 2051)
  AUTHORS   Su,Z.Z., Shi,Y. and Fisher,P.B.
  TITLE     Subtraction hybridization identifies a transformation
            progression-associated gene PEG-3 with sequence homology to a
            growth arrest and DNA damage-inducible gene
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9125-9130 (1997)
   PUBMED   9256446
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1997 Oct 28;94(22):12241]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and BC072513.1.
            
            On Dec 7, 2013 this sequence version replaced NM_133546.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072513.1, SRR22399484.1288634.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 19131336
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                JAXUCZ010000001.1  105139579-105139596 c
            19-2051             BC072513.1         1-2033
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2051
                     /gene="Ppp1r15a"
                     /gene_synonym="Gadd34; Myd116; Peg-3; RGD1624209"
                     /note="protein phosphatase 1, regulatory subunit 15A"
                     /db_xref="GeneID:171071"
                     /db_xref="RGD:621526"
     exon            1..216
                     /gene="Ppp1r15a"
                     /gene_synonym="Gadd34; Myd116; Peg-3; RGD1624209"
                     /inference="alignment:Splign:2.1.0"
     regulatory      122..202
                     /regulatory_class="uORF"
                     /gene="Ppp1r15a"
                     /gene_synonym="Gadd34; Myd116; Peg-3; RGD1624209"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:19131336]"
                     /note="this uORF is predicted to encode a 26 aa peptide
                     (PMID:19131336)"
     exon            217..1611
                     /gene="Ppp1r15a"
                     /gene_synonym="Gadd34; Myd116; Peg-3; RGD1624209"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1962
                     /gene="Ppp1r15a"
                     /gene_synonym="Gadd34; Myd116; Peg-3; RGD1624209"
                     /note="progression elevated gene 3 protein; growth arrest
                     and DNA damage-inducible protein GADD34; myeloid
                     differentiation primary response protein MyD116 homolog;
                     myeloid differentiation primary response gene 116; protein
                     phosphatase 1, regulatory (inhibitor) subunit 15A"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 15A"
                     /protein_id="NP_598230.2"
                     /db_xref="GeneID:171071"
                     /db_xref="RGD:621526"
                     /translation="MAPSPRPQHVLHWKEAHSFYLLSPLMGFLSRAWSRLRGPEVSEA
                     WLAETVAGANQIEADALLTPPPVSENHLPLRETEGNGTPEWSKAAQRLCLDVEAQSSP
                     PKTWGLSDIDEHNGKPGQDGLREQEVEHTAGLPTLQPLHLQGADKKVGEVVAREEGVS
                     ELAYPTSHWEGGPAEDEEDTETVKKAHQASAASIAPGYKPSTSVYCPGEAEHRATEEK
                     GTDNKAEPSGSHSRVWEYHTRERPKQEGETKPEQHRAGQSHPCQNAEAEEGGPETSVC
                     SGSAFLKAWVYRPGEDTEEEEDSDLDSAEEDTAHTCTTPHTSAFLKAWVYRPGEDTEE
                     EDDGDWDSAEEDTAQSCTTPHTSAFLKAWVYRPGEDTEEEDDSENVAPVDSETVDSCQ
                     STQHCLPVEKTKGCGEAEPPPFQVAFYLPGQKPAPPWAAPKLPLRLQKRLRSFKAPAR
                     NQDPEIPLKGRKVHFSEKVTVHFLAVWAGPAQAARRGPWEQFARDRSRFARRIAQAEE
                     QLGPYLTPAFRARAWTRLRNLPLPLSSSSLPLPEPCSSTEATPLSQDVTTPSPLPSEI
                     PPPSLDLGGRRG"
     exon            1612..2029
                     /gene="Ppp1r15a"
                     /gene_synonym="Gadd34; Myd116; Peg-3; RGD1624209"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcgcagc ttgtggaaga ttacatgcga gaccccgcgc gactccgcat ccctttgccg
       61 ggacagcctt tgcgacagcc cgtgagacat cacgtccccg agccccacgc ctgagggcga
      121 catgaacgcg ctggccttga gagcaatccg gacccacgac cgcttttggc aaaccgaacc
      181 ggacctccag cccccggggt gacgcgcagc ccgccggcca gacacatggc cccaagccca
      241 agaccccagc atgtcctgca ctggaaggaa gcccactctt tctacctcct gtctccactg
      301 atgggcttcc tcagccgggc ctggagccgc ctgagggggc ccgaggtctc agaggcctgg
      361 ttggcagaaa cagtagcagg agcaaaccag atagaggctg atgctctgtt gacgcctccc
      421 ccggtctctg aaaatcacct acctctccga gagactgaag gaaatggaac tcctgaatgg
      481 agtaaagcag cccagaggct ctgccttgat gtggaagccc aaagttcccc tcctaaaact
      541 tggggacttt cagatattga tgaacataat gggaagccag gacaagatgg ccttagagag
      601 caagaagtgg agcacacagc tggcctgcct acactacagc cccttcacct gcaaggggca
      661 gataagaaag ttggggaggt ggtggctaga gaagagggtg tgtccgagct ggcttatccc
      721 acatcacact gggagggtgg tccagctgag gatgaagagg atacagaaac cgtgaagaag
      781 gctcaccagg cctctgctgc ttccatagct ccaggatata aacccagcac ttctgtgtat
      841 tgcccagggg aggcagaaca tcgagccacg gaggaaaaag gaacagacaa taaggctgaa
      901 ccctcaggct cccactccag agtctgggag taccacacta gagagaggcc taagcaggag
      961 ggagaaacta agccagagca acacagggca gggcagagtc acccttgtca gaatgcagag
     1021 gctgaggaag gaggacctga gacttctgtc tgttctggca gtgccttcct gaaggcctgg
     1081 gtgtatcgcc caggagagga cacagaggag gaagaagaca gtgatttgga ttcagctgag
     1141 gaagacacag ctcatacctg taccaccccc catacaagtg ccttcctgaa ggcctgggtc
     1201 tatcgcccag gagaggacac agaagaggaa gatgacggtg attgggattc agctgaggaa
     1261 gacacagctc agagctgtac caccccccat acaagtgcct tcctgaaggc ctgggtctat
     1321 cgcccaggag aggacacaga agaggaagac gacagtgaga atgtggcccc agttgactca
     1381 gaaacagttg actcttgcca gagtacccag cattgtctac cagtagagaa gaccaaggga
     1441 tgtggagaag cagagccccc tcccttccag gtggccttct atttacctgg acagaagcca
     1501 gcaccacctt gggctgcccc taagctgccc cttcgactgc agaagcggct cagatctttc
     1561 aaagcccccg cccggaatca ggaccctgag attcctctga agggtagaaa ggtgcacttc
     1621 tctgagaaag ttacagtcca tttccttgct gtctgggcag gaccagccca ggctgctcgt
     1681 cgaggcccct gggagcagtt tgcacgagat cgaagccgct ttgctcgacg cattgcccag
     1741 gcagaggagc agctgggtcc ttaccttacc cctgctttca gggccagagc atggacacgc
     1801 cttagaaacc taccccttcc tctgtcgtcc tcgtctcttc cactgcctga gccttgctct
     1861 tccactgagg ccacacccct cagccaagat gtgaccactc cctctcccct tcccagtgaa
     1921 atccctcctc ccagcctgga cttgggagga aggcggggct aagcctgagt agttttttgt
     1981 tatttattta ttttaatacg aaataaagcc ttttgatttg tagtgataaa aaaaaaaaaa
     2041 aaaaaaaaaa a
//
