LOCUS       NM_172011                742 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory (inhibitor)
            subunit 14D (Ppp1r14d), mRNA.
ACCESSION   NM_172011
VERSION     NM_172011.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 742)
  AUTHORS   Karthik,D. and Ravikumar,S.
  TITLE     Characterization of the brain proteome of rats with diabetes
            mellitus through two-dimensional electrophoresis and mass
            spectrometry
  JOURNAL   Brain Res 1371, 171-179 (2011)
   PUBMED   21112318
  REMARK    GeneRIF: Brain PPP1R14D is upregulated in alloxan diabetes. It
            inhibits the function of PP1, switches-on glycogen breakdown and
            switches-off glycogen synthesis due to lack of insulin.
REFERENCE   2  (bases 1 to 742)
  AUTHORS   Kawamoto,E.M., Munhoz,C.D., Lepsch,L.B., de Sa Lima,L., Glezer,I.,
            Markus,R.P., de Silva,C.L., Camarini,R., Marcourakis,T. and
            Scavone,C.
  TITLE     Age-related changes in cerebellar phosphatase-1 reduce Na,K-ATPase
            activity
  JOURNAL   Neurobiol Aging 29 (11), 1712-1720 (2008)
   PUBMED   17537548
  REMARK    GeneRIF: PP-1 activity due to a decrease in cyclic GMP-PKG
            modulation plays a role for the age-related reduction of
            alpha(2/3)-Na,K-ATPase activity in rat cerebellum.
REFERENCE   3  (bases 1 to 742)
  AUTHORS   Liu,Q.R., Zhang,P.W., Lin,Z., Li,Q.F., Woods,A.S., Troncoso,J. and
            Uhl,G.R.
  TITLE     GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory
            protein, is activated by PKC and inactivated by PKA
  JOURNAL   Biochem J 377 (Pt 1), 171-181 (2004)
   PUBMED   12974676
  REMARK    GeneRIF: A gastrointestinal- and brain-specific PP1 inhibitory
            protein (GBPI-1)is activated by PKC phosphorylation. A longer
            GBPI-2 splice variant mRNA is found in testis.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_172011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ204010.1, AY122322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               JAXUCZ010000003.1  126672832-126673132 c
            302-385             JAXUCZ010000003.1  126659645-126659728 c
            386-418             JAXUCZ010000003.1  126659412-126659444 c
            419-742             JAXUCZ010000003.1  126658886-126659209 c
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..742
                     /gene="Ppp1r14d"
                     /gene_synonym="Gbpi"
                     /note="protein phosphatase 1, regulatory (inhibitor)
                     subunit 14D"
                     /db_xref="GeneID:259226"
                     /db_xref="RGD:628891"
     exon            1..301
                     /gene="Ppp1r14d"
                     /gene_synonym="Gbpi"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..484
                     /gene="Ppp1r14d"
                     /gene_synonym="Gbpi"
                     /note="GBPI-1; gastrointestinal and brain-specific
                     PP1-inhibitory protein 1; gastrointestinal- and
                     brain-specific PKC-activated PP1 inhibitor"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 14D"
                     /protein_id="NP_742008.1"
                     /db_xref="GeneID:259226"
                     /db_xref="RGD:628891"
                     /translation="MLSSSAASCTSPNPDTDNPDKKVRWSSEKRRRASSTDSESKTHL
                     DISKLPRSRRPSRLTVKYDRGHLQRWLEMEQWVDAQVQELFQGQADTSEPEIDLEALM
                     ELSTDEQRTQLEAILQDCPGNREPFISELLSQLKRLRRLSRPSK"
     exon            302..385
                     /gene="Ppp1r14d"
                     /gene_synonym="Gbpi"
                     /inference="alignment:Splign:2.1.0"
     exon            386..418
                     /gene="Ppp1r14d"
                     /gene_synonym="Gbpi"
                     /inference="alignment:Splign:2.1.0"
     exon            419..742
                     /gene="Ppp1r14d"
                     /gene_synonym="Gbpi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactggcagt ttcccccagc tccttgcaca gtccgatctt tccatgctgt cgtcaagcgc
       61 tgcttcctgt acatctccca accctgacac agacaaccca gacaagaagg tccgctggtc
      121 ttctgagaag agaaggaggg catcatccac agactcagag tcaaagactc acttggacat
      181 ttctaagttg cccaggtccc ggagacccag ccggctgacg gtgaagtatg accggggtca
      241 tctgcagcgc tggctggaga tggagcaatg ggtagatgct caggttcagg aactcttcca
      301 gggtcaagca gatacttctg agcccgagat cgatctggaa gctctaatgg aattgtccac
      361 agacgagcaa aggactcagc tggaggccat tctccaagac tgcccaggca acagagagcc
      421 ttttatctct gagctactca gtcaactcaa gagacttcgg agactcagca ggccttcgaa
      481 ataatcttgg agggaccatc ttctgtagcc tcagcactgc caggatccac aggattctgg
      541 ccaccatcta cagccctgac ctggatactg gctgaaaggc ctttgatata gaaaagggct
      601 gcagaagaca gagagagaca cttgtatagc ccatgtatga gggcacccac agttggcttt
      661 catctgggct ctctgggggt cagttgtggc tattgtccaa tgttttcctt ggcagccaag
      721 ataaaacctt tgggagccca ga
//
