LOCUS       NM_172045                745 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory (inhibitor)
            subunit 14B (Ppp1r14b), mRNA.
ACCESSION   NM_172045 XM_001074638
VERSION     NM_172045.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 745)
  AUTHORS   Tountas,N.A. and Brautigan,D.L.
  TITLE     Migration and retraction of endothelial and epithelial cells
            require PHI-1, a specific protein-phosphatase-1 inhibitor protein
  JOURNAL   J Cell Sci 117 (Pt 24), 5905-5912 (2004)
   PUBMED   15522888
  REMARK    GeneRIF: PHI-1 participates in regulatory events at the trailing
            edge of migrating cells and modulates retraction of endothelial and
            epithelial cells
REFERENCE   2  (bases 1 to 745)
  AUTHORS   Liu,Q.R., Zhang,P.W., Lin,Z., Li,Q.F., Woods,A.S., Troncoso,J. and
            Uhl,G.R.
  TITLE     GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory
            protein, is activated by PKC and inactivated by PKA
  JOURNAL   Biochem J 377 (Pt 1), 171-181 (2004)
   PUBMED   12974676
REFERENCE   3  (bases 1 to 745)
  AUTHORS   Deng,J.T., Sutherland,C., Brautigan,D.L., Eto,M. and Walsh,M.P.
  TITLE     Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and
            PHI-1, by integrin-linked kinase
  JOURNAL   Biochem J 367 (Pt 2), 517-524 (2002)
   PUBMED   12144526
  REMARK    GeneRIF: ILK may activate smooth-muscle contraction both directly,
            via phosphorylation of myosin, and indirectly, via phosphorylation
            and activation of CPI-17 and PHI-1, leading to inhibition of myosin
            light-chain phosphatase.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY122323.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001074638.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY122323.1, AW918183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..745
                     /gene="Ppp1r14b"
                     /gene_synonym="PHI-1"
                     /note="protein phosphatase 1, regulatory (inhibitor)
                     subunit 14B"
                     /db_xref="GeneID:259225"
                     /db_xref="RGD:628702"
     exon            1..266
                     /gene="Ppp1r14b"
                     /gene_synonym="PHI-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..452
                     /gene="Ppp1r14b"
                     /gene_synonym="PHI-1"
                     /note="phosphatase holoenzyme inhibitor 1; ubiquitous
                     PKC-potentiated PP1 inhibitor; protein phosphatase 1,
                     regulatory (inhibitor) 5 subunit 14B"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 14B"
                     /protein_id="NP_742042.1"
                     /db_xref="GeneID:259225"
                     /db_xref="RGD:628702"
                     /translation="MADSGPAGGAALAAPAPGPGSGSTGPRVYFQSPPGAAGEGPGGA
                     DDDGPVRRQGKVTVKYDRKELRKRLNLEEWILEQLTRLYDCQEEEIPELEIDVDELLD
                     MESDDTRAARVKELLVDCYKPTEAFISGLLDKIRGMQKLSTPQKK"
     exon            267..350
                     /gene="Ppp1r14b"
                     /gene_synonym="PHI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..383
                     /gene="Ppp1r14b"
                     /gene_synonym="PHI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..722
                     /gene="Ppp1r14b"
                     /gene_synonym="PHI-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      721
                     /gene="Ppp1r14b"
                     /gene_synonym="PHI-1"
ORIGIN      
        1 cggccgccat ggcggatagc ggccccgcgg ggggcgcggc gttggctgcc ccggcccccg
       61 gaccgggtag tggcagcaca gggccccgag tctacttcca gagtccccct ggggccgcag
      121 gcgaaggccc ggggggcgcg gatgatgatg gcccggtgag acggcaaggg aaggtcaccg
      181 tcaagtacga ccgcaaggag ctgcggaagc gcctcaacct ggaggagtgg attttagaac
      241 agctcacgcg actctacgac tgccaggagg aggagatccc agagctggag atcgatgtgg
      301 atgaactctt ggacatggaa agtgatgata ctcgggctgc tagagtcaag gagctgctag
      361 ttgactgtta caaacccact gaggccttca tctctggcct gctggacaag atccggggca
      421 tgcagaagct gagcacaccc cagaagaagt aagggtcctg actcagatga ccatggctcc
      481 cacaggacaa tcgctgcccc ccaacctagt agcaacagca atactggggg accctgcagc
      541 caggcctggt gccatgggca gggatccctg tgccccgcct aggggctgtt ccctcgccct
      601 cagttttcca ttttggggtt ttttattgtt attaaactga tgggactttt tgtgttttta
      661 tattgactct gcggcgcagg ccctttgaaa ataaagctag gatacagcct ttggagcagc
      721 taaaaaaaaa aaaaaaaaaa aaaaa
//
