LOCUS       NM_022951               4170 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 1, regulatory subunit 10
            (Ppp1r10), mRNA.
ACCESSION   NM_022951 XM_579471
VERSION     NM_022951.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4170)
  AUTHORS   Boon,R.A., Iekushi,K., Lechner,S., Seeger,T., Fischer,A., Heydt,S.,
            Kaluza,D., Treguer,K., Carmona,G., Bonauer,A., Horrevoets,A.J.,
            Didier,N., Girmatsion,Z., Biliczki,P., Ehrlich,J.R., Katus,H.A.,
            Muller,O.J., Potente,M., Zeiher,A.M., Hermeking,H. and Dimmeler,S.
  TITLE     MicroRNA-34a regulates cardiac ageing and function
  JOURNAL   Nature 495 (7439), 107-110 (2013)
   PUBMED   23426265
REFERENCE   2  (bases 1 to 4170)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   3  (bases 1 to 4170)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4170)
  AUTHORS   Lee,J.H., You,J., Dobrota,E. and Skalnik,D.G.
  TITLE     Identification and characterization of a novel human PP1
            phosphatase complex
  JOURNAL   J Biol Chem 285 (32), 24466-24476 (2010)
   PUBMED   20516061
REFERENCE   5  (bases 1 to 4170)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   6  (bases 1 to 4170)
  AUTHORS   Kim,Y.M., Watanabe,T., Allen,P.B., Kim,Y.M., Lee,S.J.,
            Greengard,P., Nairn,A.C. and Kwon,Y.G.
  TITLE     PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit.
            Characterization of its PP1- and RNA-binding domains and regulation
            by phosphorylation
  JOURNAL   J Biol Chem 278 (16), 13819-13828 (2003)
   PUBMED   12574161
  REMARK    GeneRIF: PNUTS has a role in protein kinase A-regulated targeting
            of PP1 to specific RNA-associated complexes in the nucleus
REFERENCE   7  (bases 1 to 4170)
  AUTHORS   Allen,P.B., Kwon,Y.G., Nairn,A.C. and Greengard,P.
  TITLE     Isolation and characterization of PNUTS, a putative protein
            phosphatase 1 nuclear targeting subunit
  JOURNAL   J Biol Chem 273 (7), 4089-4095 (1998)
   PUBMED   9461602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883048.1, BC134805.1 and BP477033.1.
            
            On Oct 16, 2009 this sequence version replaced NM_022951.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF040954.1, BC134805.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BX883048.1         136813-136839
            28-4157             BC134805.1         1-4130
            4158-4170           BP477033.1         3-15                c
FEATURES             Location/Qualifiers
     source          1..4170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..4170
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /note="protein phosphatase 1, regulatory subunit 10"
                     /db_xref="GeneID:65045"
                     /db_xref="RGD:620079"
     exon            1..27
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            28..545
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            546..663
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     CDS             557..3175
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /note="phosphatase 1 nuclear targeting subunit; MHC class
                     I region proline-rich protein CAT53; putative protein
                     phosphatase 1 nuclear targeting subunit"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 1
                     regulatory subunit 10"
                     /protein_id="NP_075240.1"
                     /db_xref="GeneID:65045"
                     /db_xref="RGD:620079"
                     /translation="MGSGPIDPKELLKGLDSFLTRDGEVKSVDGIAKIFSLMKEARKM
                     VSRCTYLNIILQTRAPEVLVKFIDVGGYKLLNSWLTYSKTTNNIPLLQQILLTLQHLP
                     LTVDHLKQNNTAKLVKQLSKSSEDEELRKLASVLVSDWMAVIRSQSSTQPAEKDKKKR
                     KEEGKSRTTLPERPLTEVKAETRAEEAPEKKKEKPKSLRTTAPSHAKFRSTGLELDTP
                     SLVPVKKNSSTVVVSDKYNLKPIPLKRQSATAAPGDAAPPAEKKYKPLNTTPNTTKEI
                     KVKIIPPQPMEGLGFLDALNSAPVPGIKIKKKKKVLSPTAAKPSPFEGKTSTEPSTAK
                     PSSPEPAAPAEPMDTDRPGTPVPAVEVPELMDAASSEPGALDAKPVESPGDPNQLTRK
                     GRKRKTVTWPEEGKLREYFYFELDETERVNVNKIKDFGEAAKREILSDRHAFETARRL
                     SHDNMEEKVPWVCPRPLVLPSPLVIPGSNSQERYIQAEREKGILQELFLNKESPHEPD
                     PEPYEPIPPKLIPLDEECAMDETPYVETLEPGGSGGSPDGAGGSKLPPVLANLMGSMG
                     AGKSPQGPGGGGINVQEILTSIMGSPNNHPSEELLKQPDYSDKLKQMLVPHGLLGPGP
                     VANGFPPGGPGGPKGMQHFPPGPGGPMPGPHGGPGGPVGPRLLGPPPPSRGGDPFWDG
                     PGDPMRGGPMRGGPGPGPGPYHRGRGGRGGNEPPPPPPFRGARGGRSGGGPPNGRGGP
                     GGGGMVGGGGHRPHEGPGGSMGSGHRSHEGPGGSMGSGHRSHEGPGHGGPHGHRPHDV
                     PSHRGHDHRGPPPHEHRGHDGHGGGGHRGHDGGHSHGGDMSNRPVCRHFMMKGNCRYE
                     NNCAFYHPGVNGPPLP"
     exon            664..750
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            751..886
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            887..938
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1016
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1190
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1296
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1409
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1510
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1658
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1817
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2064
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2128
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2323
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2399
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2513
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..3065
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..4170
                     /gene="Ppp1r10"
                     /gene_synonym="Fb19; Pnuts"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgccatt ctggggttcg tttagaggtt gaattttctc ggagaaagac aggccggcca
       61 tcaggaaaac aaacaagcct cagcaacatc taaacccttg aaaggatcct gagagagggg
      121 ggaaagggaa aacagcagcc accagcccaa ccacttgtgt cttctgcccc tccccaccta
      181 tcttgcccac cccaccagcc cacgctgctt gggacttgaa atctgtggcc gaaggaccgt
      241 caccacataa cttcaaaaat aatcaaccac cctccctacc caaacccacc caatctcact
      301 catccagcat ttcctttttg gagtccactc agaatttttt tcaacgaccc cctctcccta
      361 atggagttgg gtggggggaa aatgaaaact gagttggtct ttactttttt aagagacttt
      421 ttgatccaat gaggccccac aagtaactga gtttgggtcc tggttggttg ttttattttt
      481 tttcctccaa aattttaccc ctcccccctg agcccgaggt gctgacgtcg caaaaaaatt
      541 ggataaagcc accatcatgg gttcaggacc catagacccc aaagaacttc tcaagggcct
      601 agatagcttc cttactcggg atggagaagt gaagagtgtg gatggaattg ccaagatctt
      661 cagtctaatg aaggaggcac gaaagatggt gagtcgatgc acgtacttga atattatcct
      721 gcagacccgg gcgccggagg tgctagtcaa gtttattgac gtcggcggct acaagcttct
      781 gaacagttgg ttaacgtatt caaagacgac caacaacatt cctctcctac agcagattct
      841 gctgactctg cagcacctcc cactgactgt ggaccacctc aagcagaaca acacagcgaa
      901 gctagtgaag cagctcagca agtcaagcga ggacgaagag ctccggaaat tggcatcagt
      961 ccttgtcagt gactggatgg ctgtcatccg ctcccagagt agcacccagc ctgcagagaa
     1021 agataagaag aaaaggaagg aagaggggaa aagtcgaacc acgcttcctg agcggccttt
     1081 gactgaagtg aaggctgaaa cccgggctga ggaagcccca gagaagaaga aggagaagcc
     1141 caagtcactt agaactacgg cacccagtca tgccaagttc cgttctactg gactggagct
     1201 ggacacccca tctttggtgc ctgtgaagaa gaactccagc actgtggttg tgtcagacaa
     1261 gtacaacctg aagcccatcc ccctcaagcg gcagagtgcc acagctgctc caggcgatgc
     1321 tgccccgcct gcagagaaga agtacaagcc cctcaacaca acccccaata ccaccaaaga
     1381 aattaaagtg aagatcatcc ccccacagcc catggagggc ctcggttttc tggatgctct
     1441 caattccgcc cctgtcccag gcatcaaaat taagaagaag aagaaggttc tatcacctac
     1501 tgctgccaag cccagccctt ttgaagggaa aacaagcact gagccaagca cagccaaacc
     1561 ttcctcccca gagcctgcag cccccgctga gcccatggac acagaccgtc ctggcacccc
     1621 tgtccccgct gtggaagtcc cggagctcat ggatgcagcc tcttcggagc caggagctct
     1681 ggatgcaaag cctgtggaaa gccctggaga tcccaaccag ctgactcgaa agggcagaaa
     1741 gagaaaaact gtgacgtggc ctgaggaggg caagctgagg gagtatttct acttcgaact
     1801 ggatgaaact gagcgagtga atgtgaacaa gatcaaggac tttggggagg ctgctaagcg
     1861 tgagatactg tcggaccgac atgcttttga gacagcccgg cgactaagcc atgacaatat
     1921 ggaggagaaa gtgccctggg tatgtcccag gcctctggtt ctgccctcac ctcttgtcat
     1981 ccctggaagc aacagccagg agcgatacat ccaggctgag cgggagaagg gcatccttca
     2041 ggagctcttc ctgaacaagg agagtcctca cgagcctgat cctgagccgt atgaacccat
     2101 tcctcccaaa ctcatcccct tggatgagga gtgcgccatg gatgagactc cgtatgttga
     2161 gaccctggag cctggagggt ctggtggctc acctgatgga gcaggaggct ccaagctgcc
     2221 tccagttctg gccaatctta tggggagcat gggagcaggg aagagccccc agggccctgg
     2281 aggcggtggc atcaatgttc aggagatcct cacttccata atgggcagtc caaacaacca
     2341 cccttcagag gagctgctga aacagccaga ctactcagac aagctgaagc agatgctggt
     2401 gccacatggg ctcctaggtc ctggtcctgt agccaatggc ttcccaccag gaggccctgg
     2461 gggccccaag ggtatgcagc atttcccccc tggtcctgga gggcccatgc caggtcccca
     2521 tggaggccct ggtggaccag tgggtccacg tctcctgggt cccccaccac cttctcgggg
     2581 aggtgatcca ttctgggatg gcccaggtga ccccatgcga ggtggcccaa tgcgtggggg
     2641 tccaggacct ggtcctggac cataccacag aggccgaggg ggtcgtggag gaaatgaacc
     2701 gccaccaccc cctccattcc gaggagccag aggaggtcgt tctggaggag gccccccaaa
     2761 tggccgaggg ggtcctggtg gaggtggcat ggttggaggt ggtgggcacc gcccccatga
     2821 aggccctgga gggagcatgg gcagtggaca tcggtctcat gagggccctg gagggagcat
     2881 gggcagtgga catcggtctc atgaaggccc tggacacggg ggaccccatg gccaccggcc
     2941 acatgacgtc cctagccatc gaggccacga ccatcgaggg ccaccacctc atgaacaccg
     3001 cggtcatgat ggccatgggg gaggcggcca ccgagggcat gatggaggcc acagtcacgg
     3061 aggagacatg tcaaaccgcc ctgtctgccg acacttcatg atgaagggca actgccgcta
     3121 tgagaacaac tgtgccttct accacccagg ggtcaacggg cccccactgc cctaggcctg
     3181 cctgccctac ccgcacccct gtggactgca gctttgctcc ttccacttgg ttatggcttc
     3241 tgtgaggccc actttccttt tccccagctg atgaggagcc ggccccctca gttcccacct
     3301 ggttgggttt ctgggggttt ctgattcctg gtgtgcattg atgtacatat tccctccagt
     3361 ctggagcgga gaggagagag actggactgc tgagacggct ggcttcactt tgtgaggaga
     3421 tttgccctgt gccccaaacc ccttccagta ttagccccga tgcctgagaa cctgaagccg
     3481 gccaccctgg agacctctgc tctccacatg cacacggaac tgagttggtc agctgcactt
     3541 aggaaaccgt ccaagctaag ctcattatct tcacagggtg agggggtggt gaggggtacc
     3601 atatatccca ctgcactgag ggctcaagct ggctgaagct gagttctgga actacccccc
     3661 acttgtgccc cacatgggcc agtcactgtt gagtcctttc tcaagaagga ctgcaactgt
     3721 tacttcccag gtcatcgtgg gtctgctagg ttcagtgatg gcacattcat atctgtgtcc
     3781 agtggaagtt gtatctggca gaggggtggc ctgtagtgtt gggccactct tgcctacagc
     3841 cattttcgag actccgtgag gccagctttc attaacttta gccgggtata ccgggcctga
     3901 cgcactacat gcactgcctt tgggagtggg ctggctcctt accccgtaag gagccctgtc
     3961 agtgaggctt cctgggtaga ctcagcagga ggggcccttc ccagtcctct cctccccctg
     4021 tcttggcatc agttgttttc tatgaaaaca gtgggttggt tttgtgcagg gtcttgggtt
     4081 agaaccaatg gatttgagga gttttttctt ttggttttgt atattttgta cattaataat
     4141 aaacagtgga aagagaagca gctcatttaa
//
