LOCUS       NM_001270983            1493 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus protein phosphatase 1 catalytic subunit gamma
            (Ppp1cc), transcript variant 2, mRNA.
ACCESSION   NM_001270983
VERSION     NM_001270983.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1493)
  AUTHORS   Liu,X., Huang,S., Liu,C., Liu,X., Shen,Y. and Cui,Z.
  TITLE     PPP1CC is associated with astrocyte and microglia proliferation
            after traumatic spinal cord injury in rats
  JOURNAL   Pathol Res Pract 213 (11), 1355-1364 (2017)
   PUBMED   29033188
  REMARK    GeneRIF: that PPP1CC promoted astrocyte and microglia proliferation
            after inflammation
REFERENCE   2  (bases 1 to 1493)
  AUTHORS   Buren,S., Gomes,A.L., Teijeiro,A., Fawal,M.A., Yilmaz,M.,
            Tummala,K.S., Perez,M., Rodriguez-Justo,M., Campos-Olivas,R.,
            Megias,D. and Djouder,N.
  TITLE     Regulation of OGT by URI in Response to Glucose Confers
            c-MYC-Dependent Survival Mechanisms
  JOURNAL   Cancer Cell 30 (2), 290-307 (2016)
   PUBMED   27505673
REFERENCE   3  (bases 1 to 1493)
  AUTHORS   Hafver,T.L., Hodne,K., Wanichawan,P., Aronsen,J.M., Dalhus,B.,
            Lunde,P.K., Lunde,M., Martinsen,M., Enger,U.H., Fuller,W.,
            Sjaastad,I., Louch,W.E., Sejersted,O.M. and Carlson,C.R.
  TITLE     Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium
            Exchanger 1 Regulates Its Activity by Dephosphorylating Serine
            68-phosphorylated Phospholemman
  JOURNAL   J Biol Chem 291 (9), 4561-4579 (2016)
   PUBMED   26668322
  REMARK    GeneRIF: Data suggest that Ncx1 (sodium-calcium exchanger 1) is
            substrate-specifying Pp1c regulator protein, regulating Ncx1
            activity via Ser-68-phospholemman (Plm) dephosphorylation in
            cardiomyocytes; Plm/Ncx1/Pp1c complex is up-regulated in heart
            failure.
REFERENCE   4  (bases 1 to 1493)
  AUTHORS   Santos,M., Rebelo,S., Van Kleeff,P.J., Kim,C.E., Dauer,W.T.,
            Fardilha,M., da Cruz E Silva,O.A. and da Cruz E Silva,E.F.
  TITLE     The nuclear envelope protein, LAP1B, is a novel protein phosphatase
            1 substrate
  JOURNAL   PLoS One 8 (10), e76788 (2013)
   PUBMED   24116158
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1493)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   6  (bases 1 to 1493)
  AUTHORS   Allen,P.B., Ouimet,C.C. and Greengard,P.
  TITLE     Spinophilin, a novel protein phosphatase 1 binding protein
            localized to dendritic spines
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9956-9961 (1997)
   PUBMED   9275233
REFERENCE   7  (bases 1 to 1493)
  AUTHORS   Ouimet,C.C., da Cruz e Silva,E.F. and Greengard,P.
  TITLE     The alpha and gamma 1 isoforms of protein phosphatase 1 are highly
            and specifically concentrated in dendritic spines
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3396-3400 (1995)
   PUBMED   7724573
REFERENCE   8  (bases 1 to 1493)
  AUTHORS   .
  TITLE     Identification of members of the protein phosphatase 1 gene family
            in the rat and enhanced expression of protein phosphatase 1 alpha
            gene in rat hepatocellular carcinomas
  JOURNAL   Jpn J Cancer Res 82 (7), 873 (1991)
   PUBMED   1653777
  REMARK    Correction to:[Jpn J Cancer Res. 1990 Dec;81(12):1272-80. doi:
            10.1111/j.1349-7006.1990.tb02690.x.. PMID: 2177460]
REFERENCE   9  (bases 1 to 1493)
  AUTHORS   Wadzinski,B.E., Heasley,L.E. and Johnson,G.L.
  TITLE     Multiplicity of protein serine-threonine phosphatases in PC12
            pheochromocytoma and FTO-2B hepatoma cells
  JOURNAL   J Biol Chem 265 (35), 21504-21508 (1990)
   PUBMED   2174876
REFERENCE   10 (bases 1 to 1493)
  AUTHORS   Sasaki,K., Shima,H., Kitagawa,Y., Irino,S., Sugimura,T. and
            Nagao,M.
  TITLE     Identification of members of the protein phosphatase 1 gene family
            in the rat and enhanced expression of protein phosphatase 1 alpha
            gene in rat hepatocellular carcinomas
  JOURNAL   Jpn J Cancer Res 81 (12), 1272-1280 (1990)
   PUBMED   2177460
  REMARK    Erratum:[Jpn J Cancer Res. 1991 Jul;82(7):873.. PMID: 1653777]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB740494.1, BC078825.1 and DV727747.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region compared to variant 1. The resulting
            protein (isoform 2) is longer and has a distinct C-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078825.1, D90166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                CB740494.1         59-131
            74-1487             BC078825.1         1-1414
            1488-1493           DV727747.1         821-826
FEATURES             Location/Qualifiers
     source          1..1493
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1493
                     /gene="Ppp1cc"
                     /gene_synonym="PP-1G; Ppp1cc1"
                     /note="protein phosphatase 1 catalytic subunit gamma"
                     /db_xref="GeneID:24669"
                     /db_xref="RGD:3377"
     exon            1..308
                     /gene="Ppp1cc"
                     /gene_synonym="PP-1G; Ppp1cc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1267
                     /gene="Ppp1cc"
                     /gene_synonym="PP-1G; Ppp1cc1"
                     /EC_number="3.1.3.16"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine-protein phosphatase PP1-gamma catalytic
                     subunit; protein serine-threonine phosphatase catalytic
                     subunit PP-1b; protein phosphatase 1C catalytic subunit;
                     protein phosphatase 1, catalytic subunit, gamma isozyme"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PP1-gamma
                     catalytic subunit isoform 2"
                     /protein_id="NP_001257912.1"
                     /db_xref="GeneID:24669"
                     /db_xref="RGD:3377"
                     /translation="MADIDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSRE
                     IFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLE
                     TICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLP
                     IAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGE
                     NDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEF
                     DNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRVGSGLNPSIQKASNYRNNTV
                     LYE"
     exon            309..440
                     /gene="Ppp1cc"
                     /gene_synonym="PP-1G; Ppp1cc1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..671
                     /gene="Ppp1cc"
                     /gene_synonym="PP-1G; Ppp1cc1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..776
                     /gene="Ppp1cc"
                     /gene_synonym="PP-1G; Ppp1cc1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1000
                     /gene="Ppp1cc"
                     /gene_synonym="PP-1G; Ppp1cc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1135
                     /gene="Ppp1cc"
                     /gene_synonym="PP-1G; Ppp1cc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1196
                     /gene="Ppp1cc"
                     /gene_synonym="PP-1G; Ppp1cc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1493
                     /gene="Ppp1cc"
                     /gene_synonym="PP-1G; Ppp1cc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcgcatc cgtgcgccgc ccgaggctgg cctgaggagt cggcggccat tttgttcttc
       61 tcgtggttcc agtggcgaga ggaggaggaa gccgggagcg gggcggctgg gggggggacc
      121 cgccgcggct gctgctgcca ccgccgccgc caccaccgct cgtggggctc gtggcgtgaa
      181 gaaggaggac gagtgagacc cgggcgcgag ccggcggcgg cgccgctgcg ggagggtcgg
      241 cggcgggacg gcgatggcgg atatcgataa actcaacatc gacagtatca tccaacggct
      301 gctggaagtg agagggtcca agccaggcaa gaatgtccag ctccaggaga atgaaatccg
      361 gggactgtgc ttgaagtctc gggagatctt cctcagtcag cctatccttt tagaacttga
      421 agcaccactc aagatatgtg gtgacatcca cgggcagtac tatgatttgc tccgtctgtt
      481 tgaatacggt ggctttcctc cagaaagcaa ctatttgttt ctcggggact atgtggacag
      541 gggcaaacag tcactagaga cgatctgcct cttgctggcc tacaaaatca agtatccgga
      601 gaactttttt cttcttagag ggaaccatga gtgtgccagc atcaatagaa tctacggatt
      661 ttatgatgag tgtaagagaa gatacaacat taagctgtgg aaaacgttca cagactgttt
      721 taactgctta ccgatagcag ccatcgtgga cgagaagata ttctgctgtc atggaggttt
      781 atcaccagat cttcaatcta tggagcagat tcggcgaatt atgagaccaa ctgatgtacc
      841 agatcaaggt cttctttgtg atcttttgtg gtctgacccc gataaagatg tcttaggctg
      901 gggtgaaaat gacagaggag tgtccttcac atttggtgca gaagtggttg caaaatttct
      961 ccataagcat gatttggatc ttatatgtag agcccatcag gtggttgaag atggatatga
     1021 gttttttgca aagaggcagt tagtcactct gttttctgca cccaactact gtggcgagtt
     1081 tgacaatgcg ggcgccatga tgagtgtgga tgagaccctc atgtgctcct tccagatttt
     1141 aaagcctgca gagaaaaaga agcccaatgc cacgagacct gtcacaccgc cacgggttgg
     1201 atcaggcctg aacccgtcca ttcagaaagc ttcaaattat agaaacaaca ctgtcctata
     1261 cgagtgatcg ataatgcttt ctttggctac attctttatt ctgcggtgac attgaggctt
     1321 ataaatcaaa aggaactaac ttgccgtcca ccggtttata cagaactcac agtatctatg
     1381 acttttttaa actacgacct gttaaaatga atctgtttcc acagatgccc gtgtacaatg
     1441 ccatgtgcta agaatgattt cagacttatt aaatgcgagc ttgttaacct gtc
//
