LOCUS       NM_013065               2942 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus protein phosphatase 1 catalytic subunit beta
            (Ppp1cb), mRNA.
ACCESSION   NM_013065
VERSION     NM_013065.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Law,N.C. and Hunzicker-Dunn,M.E.
  TITLE     Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating
            Hormone to Phosphatidylinositol 3-Kinase Activation
  JOURNAL   J Biol Chem 291 (9), 4547-4560 (2016)
   PUBMED   26702053
  REMARK    GeneRIF: Data suggest FSH and IGF1 (insulin-like growth factor-1)
            PI3K signaling pathways in granulosa cells converge at IRS1
            (insulin receptor substrate 1), requiring PKA (cyclic AMP-dependent
            protein kinase) and PP1 (protein phosphatase 1) to regulate IRS1.
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   3  (bases 1 to 2942)
  AUTHORS   Lee,H.M., Chen,R., Kim,H., Etchegaray,J.P., Weaver,D.R. and Lee,C.
  TITLE     The period of the circadian oscillator is primarily determined by
            the balance between casein kinase 1 and protein phosphatase 1
  JOURNAL   Proc Natl Acad Sci U S A 108 (39), 16451-16456 (2011)
   PUBMED   21930935
REFERENCE   4  (bases 1 to 2942)
  AUTHORS   Yger,M. and Girault,J.A.
  TITLE     DARPP-32, Jack of All Trades em leader Master of Which?
  JOURNAL   Front Behav Neurosci 5, 56 (2011)
   PUBMED   21927600
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2942)
  AUTHORS   Hardie,D.G., Carling,D. and Gamblin,S.J.
  TITLE     AMP-activated protein kinase: also regulated by ADP?
  JOURNAL   Trends Biochem Sci 36 (9), 470-477 (2011)
   PUBMED   21782450
  REMARK    Review article
REFERENCE   6  (bases 1 to 2942)
  AUTHORS   Hirano,K., Ito,M. and Hartshorne,D.J.
  TITLE     Interaction of the ribosomal protein, L5, with protein phosphatase
            type 1
  JOURNAL   J Biol Chem 270 (34), 19786-19790 (1995)
   PUBMED   7649987
REFERENCE   7  (bases 1 to 2942)
  AUTHORS   Moorhead,G., MacKintosh,C., Morrice,N. and Cohen,P.
  TITLE     Purification of the hepatic glycogen-associated form of protein
            phosphatase-1 by microcystin-Sepharose affinity chromatography
  JOURNAL   FEBS Lett 362 (2), 101-105 (1995)
   PUBMED   7720853
REFERENCE   8  (bases 1 to 2942)
  AUTHORS   .
  TITLE     Identification of members of the protein phosphatase 1 gene family
            in the rat and enhanced expression of protein phosphatase 1 alpha
            gene in rat hepatocellular carcinomas
  JOURNAL   Jpn J Cancer Res 82 (7), 873 (1991)
   PUBMED   1653777
  REMARK    Correction to:[Jpn J Cancer Res. 1990 Dec;81(12):1272-80. doi:
            10.1111/j.1349-7006.1990.tb02690.x.. PMID: 2177460]
REFERENCE   9  (bases 1 to 2942)
  AUTHORS   Wadzinski,B.E., Heasley,L.E. and Johnson,G.L.
  TITLE     Multiplicity of protein serine-threonine phosphatases in PC12
            pheochromocytoma and FTO-2B hepatoma cells
  JOURNAL   J Biol Chem 265 (35), 21504-21508 (1990)
   PUBMED   2174876
REFERENCE   10 (bases 1 to 2942)
  AUTHORS   Sasaki,K., Shima,H., Kitagawa,Y., Irino,S., Sugimura,T. and
            Nagao,M.
  TITLE     Identification of members of the protein phosphatase 1 gene family
            in the rat and enhanced expression of protein phosphatase 1 alpha
            gene in rat hepatocellular carcinomas
  JOURNAL   Jpn J Cancer Res 81 (12), 1272-1280 (1990)
   PUBMED   2177460
  REMARK    Erratum:[Jpn J Cancer Res. 1991 Jul;82(7):873.. PMID: 1653777]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062033.1.
            
            On Dec 20, 2003 this sequence version replaced NM_013065.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062033.1, D90164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2942
                     /gene="Ppp1cb"
                     /gene_synonym="PP1B; PP1beta"
                     /note="protein phosphatase 1 catalytic subunit beta"
                     /db_xref="GeneID:25594"
                     /db_xref="RGD:3376"
     exon            1..316
                     /gene="Ppp1cb"
                     /gene_synonym="PP1B; PP1beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1248
                     /gene="Ppp1cb"
                     /gene_synonym="PP1B; PP1beta"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.53"
                     /note="protein phosphatase-1a; PP-1B; protein phosphatase
                     1, catalytic subunit, beta isozyme"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PP1-beta
                     catalytic subunit"
                     /protein_id="NP_037197.1"
                     /db_xref="GeneID:25594"
                     /db_xref="RGD:3376"
                     /translation="MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREI
                     FLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLET
                     ICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPI
                     AAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGEN
                     DRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFD
                     NAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR"
     exon            317..448
                     /gene="Ppp1cb"
                     /gene_synonym="PP1B; PP1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            449..679
                     /gene="Ppp1cb"
                     /gene_synonym="PP1B; PP1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            680..784
                     /gene="Ppp1cb"
                     /gene_synonym="PP1B; PP1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            785..856
                     /gene="Ppp1cb"
                     /gene_synonym="PP1B; PP1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1008
                     /gene="Ppp1cb"
                     /gene_synonym="PP1B; PP1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1143
                     /gene="Ppp1cb"
                     /gene_synonym="PP1B; PP1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..2928
                     /gene="Ppp1cb"
                     /gene_synonym="PP1B; PP1beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctggggtc tgacgcggcc cggttcgtgg gggcccgctt gtttatttat ttatttctag
       61 tgggtgccgc cggcgtgtgc gcgcgctctc gctgctcggc ggggaggggg tggggggagg
      121 gccggcgccc ggggggagtt ggagccgggg tcgaaacgcc gcgtgactcg taggtgagaa
      181 cgccgagcta ccaccgccgc cgccgctgcc gccgcggaga agcccttgtt cccgctgcgg
      241 ggaggagagt ctggtgccta caagatggcg gacggggagc tgaacgtgga cagcctcatc
      301 acccgcctgc tggaggtacg aggatgtcgt ccgggaaaaa ttgtgcagat gactgaagca
      361 gaagtccgag gactgtgtat caagtctcgt gaaatctttc ttagccagcc tattcttttg
      421 gaattggaag cgccactgaa gatttgtgga gatattcatg gacagtatac agacttactg
      481 agattatttg aatatggagg ttttccacca gaagccaact atcttttctt aggagattat
      541 gtggacagag gaaagcagtc tttggaaacc atctgtttgc tattggctta caaaatcaaa
      601 tacccagaga acttctttct tctacgagga aaccatgagt gtgctagcat caaccgcatt
      661 tatggattct atgatgagtg caaacgaaga tttaatatta aattgtggaa gacattcact
      721 gattgtttta attgtctgcc tatagctgct attgttgatg agaaaatctt ctgctgtcat
      781 ggaggactgt caccagacct acagtctatg gaacagattc ggagaattat gagacccact
      841 gacgtacctg atacaggttt gctttgtgat ttactgtggt ccgacccaga taaggatgta
      901 caaggctggg gagaaaatga tcgtggtgtt tcttttactt ttggagctga tgtagtcagt
      961 aaatttctga atcgtcatga tttggacttg atttgtcgag cccatcaggt ggtagaagat
     1021 ggatatgaat tttttgctaa acgacaattg gtaactttat tttctgcccc aaattactgc
     1081 ggcgagtttg acaatgctgg tggtatgatg agtgtggatg aaactttgat gtgttcattc
     1141 cagatattga aaccatctga aaagaaagct aagtaccagt atggtgggct gaattctgga
     1201 cgtcctgtca ctccgcctcg aacagctaat ccaccgaaga aaaggtgaag acaggaattc
     1261 cggaaagaga aaccatcaga tttgttaagg acatacttca taatatataa gtgtgcactg
     1321 taaaaccatc cagccattcg acacccttta tgatgtcaca cctttaactt aaggagacgg
     1381 gtaaaggatc ttaaattttt ttctaataga aagatgtgct acactgtatt gtaataagta
     1441 tactctgtta taatattcaa caaagttaaa tccaaattca aaagtatcca ttaaagttct
     1501 atcttctcat atcacagttt ttaaagttga aagcatccca gttaaactag ctgcgttagt
     1561 tacccagatg agagcatgaa gatccatctg tgtaatgtgg ctttagtgtt gcttggttgt
     1621 ttctttattt tgggcttgtt ttgttttgtt tgtttttgct agaataatgg catctacttt
     1681 tcctattttt ccctaaccat tttaaaaagt gaaaatggga agagctttaa agacattcac
     1741 caactattct tttccttcac ttatctactt aaggaactgt tggatcttac taagaaaact
     1801 tacgcctcat aataaaaagg aactttagag gccgataggt tttaaaaata tacaaactat
     1861 ttgatccaat gattttaatc aaacagtttg actgggcaaa ctttgcagct gataatgact
     1921 atttcgcttt ttacaaattg ccactgattt ggatttgtgc actctaacct ttaatttatt
     1981 gatgctctat tgtgcagtag catttcattt aagataaggc tcatatagta ctatccaaaa
     2041 ctagttggta atgtgattat gtggtacctt ggctttaggt tttaattcgc acgaaacacc
     2101 ttttggcatg cttaactttc tggtattatc ctcacctgca ttggttttgt tttttggggt
     2161 ttttgttgtt gtttgtttgt ttgtttttag atccacagaa catgagaatc ctttttgaca
     2221 agccttggaa agctggctct tctttccctc tctatgtgaa ggatgtattt aaatgaacac
     2281 tggtcagtgg gacattgtca gctctgagta ttgggtgctt cactgtctaa taattgccat
     2341 gtgaatgttg tttttgactg taaggctatg tcactaaaga tttttactct gcgttttcat
     2401 aatcaaaggt catgatgtgt atagacatgc tttgtagtga agtatagtag caataatttc
     2461 tgcacatgat caagagttta ttgcagcatt tctttccctg ttctctcttt tttaagggtt
     2521 agcattaaca aatgtcaagg aatagcaaag tcaacaaaga ctttaggagg tggaattaag
     2581 aacacacaga tttgtgattc tttggatgtg acacttattg gatgttattc taaagtctta
     2641 ttgaacattg tcaaatttgt aagcttcatg gggatggaca taatgtttat ataatgccct
     2701 tcttatgtgt taccatagat gtgaaacctt atattgtctt tgaaaatgtt aaattgagaa
     2761 ctctgttaac attttatgga ttggcacatt atattactgc aagaaacatt tgattttcag
     2821 cacagtgcaa aagttcttta aaatgcatat gtcttttttt ctaattcaat tttgtttaaa
     2881 gcacatttta aatgtagttt tctcatttag taaaagttgt ctaattgaaa aaaaaaaaaa
     2941 aa
//
