LOCUS       NM_031527               1392 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus protein phosphatase 1 catalytic subunit alpha
            (Ppp1ca), mRNA.
ACCESSION   NM_031527
VERSION     NM_031527.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1392)
  AUTHORS   Gao,J., Hu,X.D., Yang,H. and Xia,H.
  TITLE     Distinct Roles of Protein Phosphatase 1 Bound on Neurabin and
            Spinophilin and Its Regulation in AMPA Receptor Trafficking and LTD
            Induction
  JOURNAL   Mol Neurobiol 55 (9), 7179-7186 (2018)
   PUBMED   29383693
  REMARK    GeneRIF: PP1 bound on spinophilin, a close homolog of neurabin and
            another major synaptic PP1 anchoring protein, does not play a role
            in long term depression [LTD] induction, which suggests that
            neurabin plays a privileged role in nanodomain targeting of PP1 in
            LTD induction.
REFERENCE   2  (bases 1 to 1392)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1392)
  AUTHORS   Santos,M., Rebelo,S., Van Kleeff,P.J., Kim,C.E., Dauer,W.T.,
            Fardilha,M., da Cruz E Silva,O.A. and da Cruz E Silva,E.F.
  TITLE     The nuclear envelope protein, LAP1B, is a novel protein phosphatase
            1 substrate
  JOURNAL   PLoS One 8 (10), e76788 (2013)
   PUBMED   24116158
  REMARK    GeneRIF: Data indicate that the protein phosphatase 1 (PP1) and
            nuclear membrane protein lamina associated polypeptide 1B (LAP1B)
            LAP1B:PP1 complex can be immunoprecipitated from cerebral cortex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1392)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   5  (bases 1 to 1392)
  AUTHORS   Wurzenberger,C., Held,M., Lampson,M.A., Poser,I., Hyman,A.A. and
            Gerlich,D.W.
  TITLE     Sds22 and Repo-Man stabilize chromosome segregation by
            counteracting Aurora B on anaphase kinetochores
  JOURNAL   J Cell Biol 198 (2), 173-183 (2012)
   PUBMED   22801782
REFERENCE   6  (bases 1 to 1392)
  AUTHORS   Ouimet,C.C., da Cruz e Silva,E.F. and Greengard,P.
  TITLE     The alpha and gamma 1 isoforms of protein phosphatase 1 are highly
            and specifically concentrated in dendritic spines
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3396-3400 (1995)
   PUBMED   7724573
REFERENCE   7  (bases 1 to 1392)
  AUTHORS   Moorhead,G., MacKintosh,C., Morrice,N. and Cohen,P.
  TITLE     Purification of the hepatic glycogen-associated form of protein
            phosphatase-1 by microcystin-Sepharose affinity chromatography
  JOURNAL   FEBS Lett 362 (2), 101-105 (1995)
   PUBMED   7720853
REFERENCE   8  (bases 1 to 1392)
  AUTHORS   Kitamura,K., Mizuno,Y., Sasaki,A., Yasui,A., Tsuiki,S. and
            Kikuchi,K.
  TITLE     Molecular cloning and sequence analysis of cDNA for the catalytic
            subunit 1 alpha of rat kidney type 1 protein phosphatase, and
            detection of the gene expression at high levels in hepatoma cells
            and regenerating livers as compared to rat livers
  JOURNAL   J Biochem 109 (2), 307-310 (1991)
   PUBMED   1650776
REFERENCE   9  (bases 1 to 1392)
  AUTHORS   Wadzinski,B.E., Heasley,L.E. and Johnson,G.L.
  TITLE     Multiplicity of protein serine-threonine phosphatases in PC12
            pheochromocytoma and FTO-2B hepatoma cells
  JOURNAL   J Biol Chem 265 (35), 21504-21508 (1990)
   PUBMED   2174876
REFERENCE   10 (bases 1 to 1392)
  AUTHORS   Sasaki,K., Shima,H., Kitagawa,Y., Irino,S., Sugimura,T. and
            Nagao,M.
  TITLE     Identification of members of the protein phosphatase 1 gene family
            in the rat and enhanced expression of protein phosphatase 1 alpha
            gene in rat hepatocellular carcinomas
  JOURNAL   Jpn J Cancer Res 81 (12), 1272-1280 (1990)
   PUBMED   2177460
  REMARK    Erratum:[Jpn J Cancer Res. 1991 Jul;82(7):873.. PMID: 1653777]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D00859.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D00859.1, FQ233040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1392
                     /gene="Ppp1ca"
                     /gene_synonym="PP1alpha"
                     /note="protein phosphatase 1 catalytic subunit alpha"
                     /db_xref="GeneID:24668"
                     /db_xref="RGD:3375"
     exon            1..123
                     /gene="Ppp1ca"
                     /gene_synonym="PP1alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1061
                     /gene="Ppp1ca"
                     /gene_synonym="PP1alpha"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase-1d; PP-1A; Protein phosphatase
                     type 1 alpha, catalytic subunit; protein phosphatase 1,
                     catalytic subunit, alpha isozyme"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PP1-alpha
                     catalytic subunit"
                     /protein_id="NP_113715.1"
                     /db_xref="GeneID:24668"
                     /db_xref="RGD:3375"
                     /translation="MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSRE
                     IFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLE
                     TICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLP
                     IAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGE
                     NDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEF
                     DNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK"
     exon            124..255
                     /gene="Ppp1ca"
                     /gene_synonym="PP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            256..486
                     /gene="Ppp1ca"
                     /gene_synonym="PP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            487..591
                     /gene="Ppp1ca"
                     /gene_synonym="PP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            592..815
                     /gene="Ppp1ca"
                     /gene_synonym="PP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            816..950
                     /gene="Ppp1ca"
                     /gene_synonym="PP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1392
                     /gene="Ppp1ca"
                     /gene_synonym="PP1alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaggctgc aagagggcgg gaggcaggag agggcccgga gctggtgggc cggagcggcg
       61 gcgccgccat gtccgacagc gagaagctca acctggattc catcatcggg cgcctgctgg
      121 aagtgcaggg ctcacggcct ggaaagaatg tgcagctgac agagaacgag atccgtggtc
      181 tttgcctcaa atcccgggag attttcctga gccagcctat tcttctggag cttgaggcgc
      241 ctctcaagat ctgtggtgac atccatggcc agtactatga ccttctacgg ctgttcgagt
      301 atggtggctt ccctccagag agcaactacc tcttcttggg ggactatgtg gatcggggaa
      361 agcagtcttt ggagaccatc tgcttgttgc tggcctataa gatcaaatac ccggagaatt
      421 tctttctact acgtgggaac catgagtgtg ccagcatcaa ccgcatctat ggcttctatg
      481 atgaatgcaa gagacgatac aacatcaaac tgtggaagac tttcaccgac tgcttcaact
      541 gcctgcccat tgcagccatt gtagatgaga agatcttctg ctgccacgga ggcctgtctc
      601 cagacttgca atccatggag cagattagac gtattatgcg gcccacggac gtgcctgacc
      661 agggcctgtt gtgtgatctg ctgtggtctg accctgacaa ggatgttcaa ggctggggcg
      721 agaatgaccg tggagtctcc tttacctttg gggccgaggt tgtagccaag ttcctgcaca
      781 agcatgattt ggacctcatc tgcagagcac atcaggttgt agaagatggc tatgagttct
      841 ttgccaagag gcagctggtg acactcttct cagctcccaa ctactgtggc gagtttgaca
      901 acgctggcgc catgatgagt gtggacgaga cactcatgtg ttccttccag atcctcaagc
      961 ccgctgataa gaataagggg aagtatgggc agttcagtgg cctgaacccc ggaggccgtc
     1021 ccatcactcc accccgcaat tctgccaaag ccaagaaata gcctccatgt gctgccctct
     1081 gccccagatg acggattatt tgtacagaaa tcatgctgcc atgggtcaca ctggcctctc
     1141 aggcccaccc atcatgggga acacagcgtt aagtgtcttt cctttatttt ttaaagaatc
     1201 aatagcagca tctaattccc cagggctccc tcccaccagc acctgtggtg gctgcaagtg
     1261 gaatcctggg gccaaggctg cagctcaggg caatggcaga ccagattgtg ggtctccagc
     1321 cttgcatggc tggcagccag atcctggggc aacccatctg gtctcttgaa taaaggtcaa
     1381 agctggattc tc
//
