LOCUS       NM_001105968            1793 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus protoporphyrinogen oxidase (Ppox), mRNA.
ACCESSION   NM_001105968 XM_001054597 XM_213944
VERSION     NM_001105968.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1793)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1793)
  AUTHORS   Barupala,D.P., Dzul,S.P., Riggs-Gelasco,P.J. and Stemmler,T.L.
  TITLE     Synthesis, delivery and regulation of eukaryotic heme and Fe-S
            cluster cofactors
  JOURNAL   Arch Biochem Biophys 592, 60-75 (2016)
   PUBMED   26785297
  REMARK    Review article
REFERENCE   3  (bases 1 to 1793)
  AUTHORS   Ajioka,R.S., Phillips,J.D. and Kushner,J.P.
  TITLE     Biosynthesis of heme in mammals
  JOURNAL   Biochim Biophys Acta 1763 (7), 723-736 (2006)
   PUBMED   16839620
  REMARK    Review article
REFERENCE   4  (bases 1 to 1793)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1793)
  AUTHORS   Medlock,A.E., Meissner,P.N., Davidson,B.P., Corrigall,A.V. and
            Dailey,H.A.
  TITLE     A mouse model for South African (R59W) variegate porphyria:
            construction and initial characterization
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 48 (1), 71-78 (2002)
   PUBMED   11929050
REFERENCE   6  (bases 1 to 1793)
  AUTHORS   Ferreira,G.C., Andrew,T.L., Karr,S.W. and Dailey,H.A.
  TITLE     Organization of the terminal two enzymes of the heme biosynthetic
            pathway. Orientation of protoporphyrinogen oxidase and evidence for
            a membrane complex
  JOURNAL   J Biol Chem 263 (8), 3835-3839 (1988)
   PUBMED   3346226
REFERENCE   7  (bases 1 to 1793)
  AUTHORS   Li,F., Lim,C.K. and Peters,T.J.
  TITLE     An h.p.l.c. assay for protoporphyrinogen oxidase activity in rat
            liver
  JOURNAL   Biochem J 243 (3), 863-866 (1987)
   PUBMED   3663105
REFERENCE   8  (bases 1 to 1793)
  AUTHORS   Abraham,N.G., Camadro,J.M., Hoffstein,S.T. and Levere,R.D.
  TITLE     Effects of iron deficiency and chronic iron overloading on
            mitochondrial heme biosynthetic enzymes in rat liver
  JOURNAL   Biochim Biophys Acta 870 (2), 339-349 (1986)
   PUBMED   3955059
REFERENCE   9  (bases 1 to 1793)
  AUTHORS   Deybach,J.C., da Silva,V., Grandchamp,B. and Nordmann,Y.
  TITLE     The mitochondrial location of protoporphyrinogen oxidase
  JOURNAL   Eur J Biochem 149 (2), 431-435 (1985)
   PUBMED   3996415
REFERENCE   10 (bases 1 to 1793)
  AUTHORS   Kolarov,J., Nelson,B.D. and Kuzela,S.
  TITLE     Rat liver protoporphyrinogen IX oxidase: site of synthesis and
            factor influencing its activity
  JOURNAL   Biochem Biophys Res Commun 116 (2), 383-387 (1983)
   PUBMED   6316951
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_213944.4, XM_001054597.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1793
                     /gene="Ppox"
                     /note="protoporphyrinogen oxidase"
                     /db_xref="GeneID:289219"
                     /db_xref="RGD:1310543"
     exon            1..308
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            309..403
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..1750
                     /gene="Ppox"
                     /EC_number="1.3.3.4"
                     /codon_start=1
                     /product="protoporphyrinogen oxidase"
                     /protein_id="NP_001099438.1"
                     /db_xref="GeneID:289219"
                     /db_xref="RGD:1310543"
                     /translation="MARTVIVLGGGISGLAASYHLTRSPSPPKVILVEGSKRLGGWIR
                     SVRGSDGAIFELGPRGIRPAGALGARTLLLVSELGLESEVLPVRGDHPAAQNRFLYVG
                     GALHPLPSGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVAS
                     LAMDSLCRGVFAGNSQELSIRSCFPSLFQAEQTHGSMLLGLLLGAGQTPQPNSSLIRQ
                     ARAERWSQWSLRGGLEMLPQALHNYLTSKGVTILSGQPACGLSLQPEGHWKVSLGDSS
                     LEADHIISTIPASVLSKLLPAEAAPLAHILSTIQAVSVAVVNLQYKGACLPVQGFGHL
                     VPSSEDPTVLGIVYDSVAFPEQDGNPPGLRLTVMLGGYWLQKLKANGHELSPELFQRA
                     AQEAAATQLGLKEQPSHCLVHLHKNCIPQYTLGHWQKLDSALQFLTAQRLPLTLAGAS
                     YEGVAVNDCIESGRQAAIAVLGTESNS"
     exon            404..538
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            539..654
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            655..787
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            788..932
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1123
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1184
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1303
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1414
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1564
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1607
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1793
                     /gene="Ppox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgacggag agccggaggg accgtaaaag ttaggggcgg ggataccaga gttgaaccta
       61 gtcaccagct gaggctggaa aaaccgagtg ctgcagttct ggcctgtgga gggcttgacc
      121 tggcgagata gcgtgggcgt gggccttatc tgcacacgga caggatggac tggtcctagg
      181 gcctctatat cactcactcg ctttctcggg ttccccctat ctcgtgggta ggtcctggcc
      241 tctgaacaaa gacttcactc ttccaccagc acgtacacgc gcgttttgca ttagttgctc
      301 attaatcagc cttacgatgg cccggactgt gatagtgctt ggcggaggta tcagcggatt
      361 ggccgcaagt tatcatctga cccgaagccc cagtcctcct aaggtgatct tagtggaggg
      421 cagcaaacgt ttgggaggct ggatccgttc agtccgagga tcagatggtg cgatctttga
      481 acttggacct cgaggaatta ggccggctgg agccctggga gcccggaccc tgctcctggt
      541 ttctgaactt ggcttggaat ccgaagtctt gcctgtccga ggggatcatc cagctgccca
      601 gaaccggttc ctgtatgtag gcggtgccct gcacccccta ccctctggcc tcagggggct
      661 acttcgtcct tcacccccct tctcaaaacc tctattttgg gctggactga gggagttgac
      721 gaagcccagg ggcaaagagc ctgatgagac tgtgcacagt tttgcccagc gccgccttgg
      781 acctgaggtg gcgtctctgg ctatggacag cctttgcaga ggagtgtttg ctggcaacag
      841 ccaagagctc agcatccggt cctgctttcc cagtctcttc caagctgaac aaacccacgg
      901 gtccatgtta ctggggctgc tgctgggggc agggcagact ccacagccca attcctcatt
      961 aattcgtcag gcccgcgctg agcgatggag tcagtggtca ctccgtggag ggctggagat
     1021 gttgccccag gcccttcata actacctaac aagtaaaggg gtcactatcc tcagtggtca
     1081 gccagcctgc gggctcagcc ttcagccaga agggcactgg aaggtgtctc taggggacag
     1141 cagtctggag gctgaccaca ttataagcac cattccagct tcagtgctca gcaagctgct
     1201 ccctgccgag gctgcacctc tggctcacat cctgagtacc atccaagctg tgtctgtggc
     1261 cgtggtgaat ctgcagtaca aaggagcttg tctgcctgtg cagggatttg gacatctggt
     1321 gccatcctca gaagacccga ccgtcctggg aatcgtgtat gactcggttg cttttcctga
     1381 gcaggatggg aaccccccag gcctcagact gactgtgatg ttgggaggtt actggttaca
     1441 gaagctgaaa gccaatggcc atgaattgtc tccagagcta ttccaacgag cagcacagga
     1501 agcggctgcc acacagttag gactgaaaga gcaaccaagc cattgcttgg tccatctaca
     1561 caaaaactgt atccctcagt atacactagg ccactggcaa aaactagact cagctctgca
     1621 attcctgacg gcccagaggt tgcccctgac tttggctggg gcctcctatg agggggtagc
     1681 tgtcaatgac tgtatagaga gtgggcgcca ggcagcaatt gctgtcctgg gcacagaatc
     1741 gaacagctga cccccactct cctactcatg aaagtaaaag ttgatggagc ttg
//
