LOCUS       NM_001191838            2436 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein phosphatase methylesterase 1 (Ppme1),
            mRNA.
ACCESSION   NM_001191838 XM_341891
VERSION     NM_001191838.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2436)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2436)
  AUTHORS   Lipina,C. and Hundal,H.S.
  TITLE     Carnosic acid stimulates glucose uptake in skeletal muscle cells
            via a PME-1/PP2A/PKB signalling axis
  JOURNAL   Cell Signal 26 (11), 2343-2349 (2014)
   PUBMED   25038454
  REMARK    GeneRIF: findings provide new insight into how CA may improve
            glucose homeostasis through enhancing peripheral glucose clearance
            in tissues such as skeletal muscle through a PME-1/PP2A/PKB
            signalling axis
REFERENCE   3  (bases 1 to 2436)
  AUTHORS   Sjostrom,M., Stenstrom,K., Eneling,K., Zwiller,J., Katz,A.I.,
            Takemori,H. and Bertorello,A.M.
  TITLE     SIK1 is part of a cell sodium-sensing network that regulates active
            sodium transport through a calcium-dependent process
  JOURNAL   Proc Natl Acad Sci U S A 104 (43), 16922-16927 (2007)
   PUBMED   17939993
REFERENCE   4  (bases 1 to 2436)
  AUTHORS   Ogris,E., Du,X., Nelson,K.C., Mak,E.K., Yu,X.X., Lane,W.S. and
            Pallas,D.C.
  TITLE     A protein phosphatase methylesterase (PME-1) is one of several
            novel proteins stably associating with two inactive mutants of
            protein phosphatase 2A
  JOURNAL   J Biol Chem 274 (20), 14382-14391 (1999)
   PUBMED   10318862
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XM_341891.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JAXUCZ010000001.1  164126975-164127220 c
            247-340             JAXUCZ010000001.1  164111955-164112048 c
            341-433             JAXUCZ010000001.1  164111396-164111488 c
            434-491             JAXUCZ010000001.1  164103330-164103387 c
            492-543             JAXUCZ010000001.1  164102983-164103034 c
            544-698             JAXUCZ010000001.1  164099261-164099415 c
            699-789             JAXUCZ010000001.1  164096806-164096896 c
            790-855             JAXUCZ010000001.1  164095210-164095275 c
            856-979             JAXUCZ010000001.1  164091835-164091958 c
            980-1109            JAXUCZ010000001.1  164088762-164088891 c
            1110-1154           JAXUCZ010000001.1  164087256-164087300 c
            1155-1219           JAXUCZ010000001.1  164085205-164085269 c
            1220-1287           JAXUCZ010000001.1  164082494-164082561 c
            1288-2436           JAXUCZ010000001.1  164080242-164081390 c
FEATURES             Location/Qualifiers
     source          1..2436
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2436
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /note="protein phosphatase methylesterase 1"
                     /db_xref="GeneID:361613"
                     /db_xref="RGD:1309683"
     exon            1..246
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1306
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /EC_number="3.1.1.89"
                     /codon_start=1
                     /product="protein phosphatase methylesterase 1"
                     /protein_id="NP_001178767.1"
                     /db_xref="GeneID:361613"
                     /db_xref="RGD:1309683"
                     /translation="MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFTPV
                     PWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISR
                     VQCRIVALDLRSHGETKVKNSEDLSAETMAKDVGNVVEAMYGDLPPPVMLIGHSMGGA
                     IAVHTAAANLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKS
                     GQIRNLESARVSMVGQVKQCEGITSPESSKSIVEGIIEEEEEDEEGSESVNKRKKEDD
                     METKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQ
                     MQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC"
     exon            247..340
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            341..433
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            434..491
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            492..543
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            544..698
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            699..789
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            790..855
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            856..979
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1109
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1154
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1219
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1287
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..2436
                     /gene="Ppme1"
                     /gene_synonym="PME-1; RGD1309683"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggcggt aggcggcgct gccggtggct ggttgctgtc caaaggcgac tgggcgtcgt
       61 tagaggagtg agctgtgacc ggttgtaccg cacgtatcgt gggacggacc ttgggccact
      121 gttttcgacg tgaggcctcc ctttgatgtc ggcccttgaa aaaagcatgc acctcggccg
      181 cttaccttct cgccctcctc tacccggcag cgggggcagt cagagcggag ccaagatgcg
      241 gatgggccct ggaaggaagc gggactttac ccctgttcca tggagtcagt acttcgagtc
      301 aatggaagat gtggaggtgg agaatgaaac tggcaaggat acttttcgag tttacaagag
      361 tggttccgag ggtccagtcc tgctgctgct tcatggagga ggccattctg ccctttcctg
      421 ggcagtattc acggcagcaa tcatcagtag agtacagtgt cggattgtgg ctctggatct
      481 acgaagccat ggagaaacta aagtcaagaa ttctgaagac ctgtcagcag aaacaatggc
      541 aaaagatgtt ggtaatgtgg tggaagccat gtatggcgac ctccctcctc ccgtcatgct
      601 gattgggcac agcatgggcg gtgccattgc agtacacaca gcagcagcta acctggtgcc
      661 aagccttttg ggtctttgta tgattgatgt tgtggaaggt acagccatgg atgcccttaa
      721 tagcatgcag aatttcttac ggggtcggcc caaaaccttc aagtctctgg agaatgctat
      781 tgaatggagt gtgaagagtg gccagattcg aaatctagaa tctgcccgtg tatccatggt
      841 cggccaagtc aaacagtgtg aaggaattac aagtccagaa agttccaaat ccatagtaga
      901 aggaatcata gaggaggagg aagaagatga agaaggaagt gagtcagtta acaagaggaa
      961 aaaggaagac gacatggaaa ccaagaagga tcatccatac acctggagaa ttgagctggc
     1021 aaaaacagag aagtactggg acggctggtt ccgaggctta tccaatctct ttcttagctg
     1081 tcctattcct aaactgctgc tcttggcagg tgttgataga ttggataaag atctgaccat
     1141 aggccagatg caggggaagt tccagatgca ggtcttaccc cagtgtggcc atgcagtcca
     1201 tgaggatgcc cctgacaagg tagctgaagc tgttgccact ttcctgatcc gacacaggtt
     1261 tgcagagccc atcggaggat tccagtgtgt gtttcctggc tgttagtgac ctgctgtcta
     1321 ctcctccctc tacattgaac tctgttgtaa atacatcgtt ccagaggcca ctgtgatgcc
     1381 gctgtctcct cctcaccatc ccgcccagcc atgtgacacc ggctcctgta gagggcatcc
     1441 ccagacgtac aaaccctttc ctgtataccc attgaaagca ttcttctcca gggcccttgt
     1501 ccagcagtgg cctatgcagt ctggggccca cagctcctcc tccccctcct gtgctccctg
     1561 ccttgcctag gatgaagcct ccagagctac tccctggccc tgtgcctggc atccggcagt
     1621 gtacccccag gctcagggat ctccattcct tgaggatgtt cttggcatgg ttctgccctt
     1681 cctcatggga tgggcaatgc acacactgac ccttattttt ccctttcaaa taaaacacca
     1741 gtcgggtacc tttatcccag tcttaactgt tccaagtctg gaagatccag agtaatgagg
     1801 attcagggag aggtagtgga tagcaagtat cccaagaaac caagctgtaa gccaggtcca
     1861 gccagtccaa gcacatggct tcccatctgg gcgagcccac tgtcccactc ccacatgtct
     1921 gggcacctgc cctgggctga ggccaggctg ctccaagggc ctcatgagcc ctcatctgcc
     1981 acagagcaac ccaggttaaa cacagcccat gcacaaagcc acaggctaaa ttctgtggaa
     2041 ttgtttttaa ggattgaatt taacattttc atagttggtt cctggaggtg tgccaagtgc
     2101 ccgcttgcct cttctagacc cacagcttct tgatccactt gtggtttcca tgtcactctg
     2161 tagaaacatc atggactagc atccccagtc tttgccctca tccagctgtc ccagcacagc
     2221 actggggcct ccctctgctg ctcacgggta ggggcagggc agcctcctga agcccatctt
     2281 tctgtgactg tcttaggtga ctgtgtagcc ctcttctgtt ttttcaccca acaacttcct
     2341 acccctgtcc tgctgcacgg tccagagtct gggaccgact ttgttctttg ttatttatga
     2401 tcttgtttaa agaaaataaa tatcccccaa ccttta
//
