LOCUS       NM_001107681            8924 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1L
            (Ppm1l), mRNA.
ACCESSION   NM_001107681 XM_001066833 XM_227247
VERSION     NM_001107681.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8924)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   2  (bases 1 to 8924)
  AUTHORS   Saito S, Matsui H, Kawano M, Kumagai K, Tomishige N, Hanada K,
            Echigo S, Tamura S and Kobayashi T.
  TITLE     Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral
            membrane protein that dephosphorylates the ceramide transport
            protein CERT to enhance its association with organelle membranes
  JOURNAL   J Biol Chem 283 (10), 6584-6593 (2008)
   PUBMED   18165232
  REMARK    GeneRIF: CERT is a physiological substrate of PP2Cepsilon and that
            dephosphorylation of CERT by PP2Cepsilon may play an important role
            in the regulation of ceramide trafficking from the ER to the Golgi
            apparatus.
REFERENCE   3  (bases 1 to 8924)
  AUTHORS   Imanaka-Yoshida K, Matsumoto K, Hara M, Sakakura T and Yoshida T.
  TITLE     The dynamic expression of tenascin-C and tenascin-X during early
            heart development in the mouse
  JOURNAL   Differentiation 71 (4-5), 291-298 (2003)
   PUBMED   12823230
REFERENCE   4  (bases 1 to 8924)
  AUTHORS   Li MG, Katsura K, Nomiyama H, Komaki K, Ninomiya-Tsuji J, Matsumoto
            K, Kobayashi T and Tamura S.
  TITLE     Regulation of the interleukin-1-induced signaling pathways by a
            novel member of the protein phosphatase 2C family (PP2Cepsilon)
  JOURNAL   J Biol Chem 278 (14), 12013-12021 (2003)
   PUBMED   12556533
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000069.1.
            
            [WARNING] On Mar 29, 2024 this sequence was replaced by
            NM_001107681.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001107681.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132265,
                              SAMD00132271 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               JACYVU010000069.1  20039073-20039517
            446-620             JACYVU010000069.1  20234392-20234566
            621-782             JACYVU010000069.1  20299935-20300096
            783-8924            JACYVU010000069.1  20303713-20311854
FEATURES             Location/Qualifiers
     source          1..8924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..8924
                     /gene="Ppm1l"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent, 1L"
                     /db_xref="GeneID:310506"
                     /db_xref="RGD:1305220"
     exon            1..445
                     /gene="Ppm1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1129
                     /gene="Ppm1l"
                     /EC_number="3.1.3.16"
                     /codon_start=1
                     /product="protein phosphatase 1L"
                     /protein_id="NP_001101151.1"
                     /db_xref="GeneID:310506"
                     /db_xref="RGD:1305220"
                     /translation="MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDE
                     VKTIVKSSRDAVKMVKGKVAEIMQNDRLGGLDVLEAEFSKTWEFKSHNVAVYSIQGRR
                     DHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKEN
                     SVLTYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLC
                     DKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLN
                     VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQ
                     SFYRGCPDNITVMVVKFRNSSKTEEQ"
     exon            446..620
                     /gene="Ppm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            621..782
                     /gene="Ppm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            783..8924
                     /gene="Ppm1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcggggcgc gcgttgctgc tgctggtcgg gctctaggga taataaatga tagaggatac
       61 aatgactttg ctgtctctgc tgggtcgcat catgcgctac ttcttactga gacccgagac
      121 gctttttctg ctgtgcatca gcttggctct gtggagttac ttcttccaca cggacgaagt
      181 gaagaccatc gtcaagtcca gccgggacgc ggtgaagatg gtgaagggca aggtggccga
      241 gattatgcag aacgatcgtc ttggaggact tgatgtgctg gaggccgagt tttccaagac
      301 ctgggaattc aagagccata atgttgcggt gtactccatc cagggccgga gagaccacat
      361 ggaagatcgc ttcgaagttc taacggatct ggccaacaag acgcacccgt ccatcttcgg
      421 aatctttgac ggtcacggcg gcgagactgc agcggagtat gtaaagtctc gactcccaga
      481 ggctcttaag cagcaccttc aggattatga gaaggacaaa gaaaacagtg tcctgaccta
      541 ccagaccatc ctcgagcagc agatcttgtc aatcgaccga gaaatgctgg aaaagttgac
      601 agtgtcctac gacgaagcag gaacaacgtg tttgatcgct ctactctcag ataaagacct
      661 caccgtggcc aacgtgggtg actctcgagg agtcttgtgt gacaaagatg gcaatgccat
      721 tcccttgtct cacgatcaca agccttacca gctgaaggag aggaagagga taaagagagc
      781 tggtgggttc atcagcttta atggctcctg gagggtccag gggatcctag ccatgtctcg
      841 atccctggga gattatccgc tgaaaaatct caacgtggtc atcccagacc cagacatctt
      901 gacctttgac ctggacaagc tgcagcctga gttcatgatc ttagcgtcgg atggcctgtg
      961 ggatgctttt agcaatgaag aagcagttcg attcatcaag gagcgcttgg atgagccgca
     1021 ctttggggcc aaaagcatcg tcctgcagtc cttttacaga ggctgccctg acaatattac
     1081 agtcatggtg gtgaagttca ggaatagtag caaaacggaa gagcagtgag ccctacagga
     1141 tctcagctgt cccaaactag aggacgctca acatactgtt ctcttcatgt agtaaacagt
     1201 gtgggaatta taattaggat catgcatccc aacacagaac ccccttccct gatggccttg
     1261 aatccctttg gagtgctgag ctgagggttc cctggctgac atcgaagaga ggctgctagg
     1321 tttgtgctcc cccagccctt ctatcagtgt ttgaaatgca tacataggta gccgtagatc
     1381 ccacgtgtga ggcaaaagaa agacaggcca tgtattttcc tttttaatgt acttttcatg
     1441 atctctttcc tggtccttca ggaacctgcc ttggtgtcct ctcctgcacc tgggaagggc
     1501 gagccggtgt tgcccgtcca tcaccgtgat gatgtggtag ccacgctctc tgcctcaaag
     1561 tagttccctc agaaatgctc tccccttctg agcgttggcc tttagtactc cagcagcctg
     1621 gaaggagacg tgcaacactt agtcatgtgt tgcctgctcc tagagactga ggcacggaaa
     1681 gtcagtgcag cttcctgtac accagacctc ccccttcccc ttgcttcctt cattagttaa
     1741 gagagtcagg atgcagttaa ccagccccta tgtctctcct cctggaggta acctcaccat
     1801 gttcacacct tacagggtgg aaagcacatc acagtacagt gcccttccgc cctgaaggag
     1861 gaatagggct gggatgattc tcaatgtgct tgagaatcgc tgtccaccct ggagaggagg
     1921 gcaggagtcc tggggtcacc agctcacact caccagccgc tggtttctgc acggcccttc
     1981 tcgagcccgt tctaccaagt agctttcctg tctcccaaac agtgctggga gaaactgcag
     2041 cctagaatca cccacaagtg ctgttcccag ctagcaccgc aagttggtat ttggtggcaa
     2101 actactggga catgcttcct ggcaagagaa agacctttca tgttcaattg caaataccca
     2161 tacccaggca aatgtgaact gtctgctgtg acctggaggg agaacggcag actggctcct
     2221 ggggacctgc gtgcactggt ggcagagctg gttgggaaga gaaccctcag agacaagcag
     2281 cagagtcatt tgggggctag agggctagat tactgctcct aacaccaaag ttatgggggg
     2341 gggggggtcc cagtctatat actttgtaag ttaatttata ggacatatta ggttgtcctt
     2401 tttgattgat tgaaccagcc ccaaagagcc aaggttatcg ttgtgaacac gctccgagcc
     2461 cgcctggctt tgtcctctca gagggtgttt gtcagcatgg cttctcaggg cctgctcctt
     2521 agctacccct tccccactgc caagccctct gtccttcagc tgcagggctt gtaggtggag
     2581 aatggcagac ttggactcct cggacgcaca ctgtcttgat tccgctggga actcgctttc
     2641 ctctgactgc atcaagaatt aataatggcc tcccagaaaa atcacttact tttgtatctt
     2701 gtgtcttcaa cattggaatt agggtctttt ctgcttttca gaatgtttta gtacaaaata
     2761 cattctatca tgttagagtg gagcgttggc ttgtggagat gcgggctgac ggtgttcatt
     2821 atggctctag tggaagggga gtggaggagg caggtgtggg gttaaccagt gctgggatgg
     2881 gcctgtccac ttcggatgct cttactctag agtgcccgaa gcccttcctc tagctaaagg
     2941 tccagattga cagaagagag tcaactcttt tctgtatttg cctaacacag aagtatataa
     3001 caagaggaaa gaaaagtaat tcgagacaca aatgtttccg taaagaaaaa aaaaaaaaaa
     3061 gactttgcta tcaaattagt cggttggtat tccttgagca agcagggtct ttaaaccagc
     3121 atggctgact acactggcta cagagccttc tgatcgaggt ttatggatat gtcttgtaaa
     3181 ttttgctttg gagaagaaac ttatttaacc aaataggaaa aaaaaaatta tatatatata
     3241 tatatctcct ttctggcctc ttccccttcc catggcttgt atactttttt aaagatagaa
     3301 attctaggca aaatggtagt attttgataa gtagttacac ataaaacaag agtagccctt
     3361 taccttctcc ccctcctgga atgccccttc ctgatctgtg cccagccatg gcgagtctac
     3421 agttaggtgt gggctctgca tcctggccac tccccttctc tggcggcttc agaagggtga
     3481 atctagctgc aagagaaacg gatttgagag agtaagtgtg aaacttccat aaacagcact
     3541 gccaaagcct tgggcccatc ccaaaggctc cccggactcc ctacctagcc tgagttctaa
     3601 ttgccaatag tccccacagt gccaaagttg ggagagtttt acagtgtttt aggagtagag
     3661 ctgatgccag cccagccccc caggcccctt acctgtgctg ctgcttccct ggcgatttct
     3721 actcttcagg tgggataggg tgggagggtg gggcaggatt ttaaagaact cactgcattt
     3781 gcagttgttt aatcataaaa ataaattata caaacccaga acagtccaaa gctagttccc
     3841 aagagctgtt tctaaaatgt gatcagctca gccaagccag tctggatcac tgttcgaccc
     3901 catggtgtgt gcactcactc ccggtagcca ggtactctct gctccttgct gtgaatggaa
     3961 gggactggcc tcttgaatct ggtatttgtc aaaaacaaga cccagagaag gttctagtac
     4021 acagcttccc cggcttggca actgtgattt ggacagtttg cacagatgca gaagaaggca
     4081 gggagtgcta gcactgatgt tctaatcctc tcaggaggct ctagggagct gactgcactc
     4141 ttggcttggg catctggaaa tgtgtgaagg agtcacaaaa gcagtgacct ctttttcctt
     4201 tgccaggtgc actttgattt tcctgtttgt tctcatcctc ctcttcctga tttcacagat
     4261 ctttttcctc ctttgaccca ggattacaca tagcttctct ctggaatagt cacccaaagt
     4321 accctgtgtt tgtttaacca gcactcctga ttcagctctg gacaagatgg cggtcagata
     4381 ctggggaagg agggaggtga actccgaacc atgaactgcc tttgggcaaa tcggatgcat
     4441 cttgcaggaa cagaggaatc tagcagccct caacacaggg aacacatata ctagaaatgt
     4501 ttttagatac atggttttat tgtcagagga ggtggggagc catacttcat ggtgcgaaat
     4561 aaattcacaa ccaagctgaa tgtcatagag gagaggagaa aatcacatac aacacagtgt
     4621 ctgcaaactt cttgtttttc atattagctt gatcacaggt ctgaataacc cctcctgaca
     4681 ggccaatggg atcctaggaa ttacggtttg taagtcagaa gcactgagca ttcatctgca
     4741 aggctggctt aggatagaaa cagtattgga atgcgatgat ttgatatgac caacggtctc
     4801 cattgacagc agaaggccag caggcacatt gaaacattct gaaaggcctc cctccttttc
     4861 tgtaagaagc aagggcttcg ccatgctggg cttctcggct gggctacctc agcgctcagt
     4921 cgtttctctg cagctttctt tgctttccaa attaaaccaa gatgtttttc cctcatcact
     4981 gacacacacc aagaaagaaa ggaaggagga aggaaggaaa gaaggaagga aggaaggcag
     5041 gcaaacaagc aagcgggaaa atacacactt gattgacatt gtaactaatg tgtaatagga
     5101 atgtcaactg ttaatattga cacactatta tcttttctct cttcacacca gactctttga
     5161 aataatttgc aatctagaac tcatatatcc tgaaattcat agcctatgtc atcctgtctt
     5221 tacacatgtg cacacacgcg cgcgcgcgcg cacacacaca cacacacaca cacacacaca
     5281 cacacacaca cacagacagt taagtctggc aacttaaaag gcttgcccat atctatctcc
     5341 ctagccatta tcaattgggg gagggggaac aggcagctgt aacaagtaac ccaaaactat
     5401 gggtgaaaca cagaatagaa taaatctggg gtacagtcac taatttaaaa ctgcatctga
     5461 tattttgggg aatatgccac ctatataata caaaatagta aaaagtaaaa caaagctaag
     5521 aatagcatcc cttaaactaa gccgtagatc ggaaaaggac aaggacagtt ggtacggtgg
     5581 gatccttagg tccgtttcta aatgtcccct aatacataag cgtttgcagt cttagtaacg
     5641 ctgctgctct gtccgtcgtt tggtcggttt actactgccg aggggcatac tgtcaaccca
     5701 gtgttatatc atgtacatgt ataatcatgt acatgtacac ccatgtacag tctgggttaa
     5761 ggtcacctct gagacgcgtg tgtgctgttc atctccacaa atcatcatag gcgcgtttgc
     5821 tgttcagaat ttcactaaga agcaaacatg cagcaaagga gtagttcata ttcaggggcc
     5881 tattttcatt tattctaagt cttgtattgt ttaaccacag aatcttgtac attcgccacg
     5941 tctaaataca tttttgaaag cttccaaaga ccagcctcct tcttcttggc ataaggacat
     6001 tatttaatgg ttctggcggc agcttggggc tagcaggttt taaggaaggg caggaaaatc
     6061 tacctgaccc tcacagtgct catgaggaac tctagcagcc acacattatc acaacattcc
     6121 cgacaatcca gatctttaaa taggagagtt acatcctttc agaccattta attgcccatt
     6181 catatctgaa gtgtgttcac acagaggcaa agggagaagc cttggtccag gactggggtg
     6241 aaagtggtca agcctgggtt tccagatgcc tgtgcacatg cagctttgga tacaaacttc
     6301 caactcctgt acgaagcatc gtacaagagg tgctagtgta gacatttgct gattctttaa
     6361 aaaggaaccc tcattttcaa cagcaaagtt gaactgttgt aaactgagtc ccaatcccct
     6421 ttctccccag tggggtctgg taggtgtggg ctcacccagc atggccctag caaggcacca
     6481 gctcattctc ttcctgccca aaccctggat gtggcttttc ttagaatgtt tgcattttca
     6541 aagtaatgtc cctttttata ctttttaaag atgctaatgg agatgaaatg gtttgaacat
     6601 gctggtgatt ttccagatgt cagctgtcaa caaggaaagc agtgactgcc tggttgataa
     6661 caggcaggtt cacggaaata atttcactgt gcaataattt agcatttttt tatgtaatac
     6721 agtcacacta ctctcataat ttttaattag cctgatagaa agcatgtatt agacatcttt
     6781 aagttgggag gattatgtcc tatgtaaatt ttaaatttgc ctcaacctat gtaaggacga
     6841 atagggactg cttagaacac tgcacacagt tctgtcacac agggagaatc taaaccatgg
     6901 aacagtagac aatgctctct acaggctcca aggctccatc cagtagtttc tctgtgtgtt
     6961 tttcatcgga tccttttacc tgaaaaccca aagttgggaa attgccacga catcatttca
     7021 gagcagtaga gggctcctac attcttaact tctgtttgtt cttttaaaac tggctctgtg
     7081 aaagagattg ggactatctg cctgtgtcct cccttagaga ggaaggcaaa gttggaatgg
     7141 agagcattta gggaccagga cggggtgggg gggcaggacc accccaatgg agggaatgga
     7201 acctgcattt ggttaaagtc ggatcactca catttctggt cactagcgtt tacatgttta
     7261 ccgtctggtt gtcctgagtg ctgtccctct ccgcggtcct tggctgttag gcttacctct
     7321 gtttctgtgt gaacatcctt ttgacaatgg attgtctaaa atagaacact gtgacaacgc
     7381 acggcaccgt gtttgccatc tacactgcct tctcacagga ggttgagaga gaatgtgcct
     7441 gagtcgtccc cgacgtgaca ggggacatgc atggcctcag cagtggtctg gtagaagcca
     7501 ggcttcctgt cctccagaga gaatgggaag gaatggtaac cttgtaccat gtggatttgt
     7561 gtttttcttt ctatttttgg tcctaagaga tgataaattg taatgcccca agagcaaacc
     7621 caggactaag aatgtttatc atccgtctcc taacaatgtg gatggcaaat ttgtcatttg
     7681 gaaggctagc atatttcagg aatacaatta cttaacttca aatgcaagca aacacgaaat
     7741 gtcagatttt tttaaacaac aaaaatggtc tcttagcatt ccacattcta aacatgattt
     7801 atgttttgta ctttgaacaa gaatagcaaa atctattttc tgtatggggg ggggacctaa
     7861 atatcagctg tgggtttttt aaccaaagaa gcaaaggctt ttaacctctg ccagccccat
     7921 cttccctaag ctatttgagc cccactgggt tacactcctc tgcttactca gaataaacta
     7981 acaagaaaaa agcacctcac agtagtatgg agtcagcact tgcagaagaa atctcacgag
     8041 tttctgacac aatcaagacc acagggctgg gggcggggat aatacagaaa ggaggaagag
     8101 gaaaggaaag agggaaggga ccactgtcat agctgagtgg tagtctctgt gaatggtagc
     8161 atagctcaga ggtcctgagc ttgtcctgag ccgtcactgg aagtgctggc tttgtataag
     8221 ttctttatat ccacctgaca tcatgaaatc ctttcccttg gcagtgtgtc ctttctactt
     8281 taaacatcag ctcgggttgt ttctcagaac ataccaagat ccataatgta tcagccatgt
     8341 ttaaaaactc ttgacatgtt taatgatctc acagatcaac caggcttctg actcagtccc
     8401 ccaaacccat ctgtacatca gagccttgct gaaaccggtg cacttggacc tacttagggc
     8461 gtttcatttc tacagtctac acttgtctct accagacgtg agaaaccaca atgctgcagg
     8521 gggtttgggt agaggtcaga gccggtggca atgcagtcac tcaagatgca tggcgtgtca
     8581 tttggtccct ttgatgtgca gggtagagtt ggcattgtag agactgctgt gttcatgcaa
     8641 ccactagttc tatgttgtac acaaaatgaa cagctaaagg agaaaaagta aacccattaa
     8701 agctattaaa atatatgttc ctactcttct tttccttgaa ctaaactcat ttctgtttgg
     8761 aagatacgtg gttttgagtt ctgatggctt gggattctgc tcaagtggca gaaaattcac
     8821 aggtggagga cacctaaaca tagtagaagc cagagggagg agctggtggc actttggatc
     8881 aggaatgagc ctgacacatt taaaaataaa agttttcaaa tgca
//
