LOCUS       NM_001271079            2794 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1H
            (Ppm1h), mRNA.
ACCESSION   NM_001271079 XM_002729796
VERSION     NM_001271079.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2794)
  AUTHORS   Biesemann,C., Gronborg,M., Luquet,E., Wichert,S.P., Bernard,V.,
            Bungers,S.R., Cooper,B., Varoqueaux,F., Li,L., Byrne,J.A.,
            Urlaub,H., Jahn,O., Brose,N. and Herzog,E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   2  (bases 1 to 2794)
  AUTHORS   Lee-Hoeflich,S.T., Pham,T.Q., Dowbenko,D., Munroe,X., Lee,J.,
            Li,L., Zhou,W., Haverty,P.M., Pujara,K., Stinson,J., Chan,S.M.,
            Eastham-Anderson,J., Pandita,A., Seshagiri,S., Hoeflich,K.P.,
            Turashvili,G., Gelmon,K.A., Aparicio,S.A., Davis,D.P.,
            Sliwkowski,M.X. and Stern,H.M.
  TITLE     PPM1H is a p27 phosphatase implicated in trastuzumab resistance
  JOURNAL   Cancer Discov 1 (4), 326-337 (2011)
   PUBMED   22586611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Sep 20, 2014 this sequence version replaced NM_001271079.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.17995.1,
                                           SRR26643292.29539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               JAXUCZ010000007.1  60224087-60224398
            313-475             JAXUCZ010000007.1  60323257-60323419
            476-820             JAXUCZ010000007.1  60347090-60347434
            821-933             JAXUCZ010000007.1  60356377-60356489
            934-1018            JAXUCZ010000007.1  60401515-60401599
            1019-1137           JAXUCZ010000007.1  60419686-60419804
            1138-1201           JAXUCZ010000007.1  60446238-60446301
            1202-1309           JAXUCZ010000007.1  60448739-60448846
            1310-1461           JAXUCZ010000007.1  60467579-60467730
            1462-2794           JAXUCZ010000007.1  60483615-60484947
FEATURES             Location/Qualifiers
     source          1..2794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2794
                     /gene="Ppm1h"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent, 1H"
                     /db_xref="GeneID:314897"
                     /db_xref="RGD:1309528"
     exon            1..312
                     /gene="Ppm1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1609
                     /gene="Ppm1h"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 1H (PP2C domain containing)"
                     /codon_start=1
                     /product="protein phosphatase 1H"
                     /protein_id="NP_001258008.1"
                     /db_xref="GeneID:314897"
                     /db_xref="RGD:1309528"
                     /translation="MLTRVKSAVANFMGGIMAGSSGSEHGGSGCGGSDLPLRFPYGRP
                     EFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLT
                     VKKKVGTITSTPNRNSKRRSSLPNGEGLQLKENSESEGISCHYWSLFDGHAGSGAAVV
                     ASRLLQHHITQQLQDIVEILKNSAILPPTCLGEEPESTPAHGRTLTRAASLRGGVGAP
                     GSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSAYNISGGCTALIVVCL
                     LGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEF
                     PRRVQRKELGKKMLYRDFNMTGWAYKTIEDDDLKFPLIYGEGKKARVMATIGVTRGLG
                     DHDLKVHDSNIYIKPFLSSAPEVRVYDLSKYEHGADDVLILATDGLWDVLSNEEVAEA
                     ITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIH
                     GNKLS"
     exon            313..475
                     /gene="Ppm1h"
                     /inference="alignment:Splign:2.1.0"
     exon            476..820
                     /gene="Ppm1h"
                     /inference="alignment:Splign:2.1.0"
     exon            821..933
                     /gene="Ppm1h"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1018
                     /gene="Ppm1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1137
                     /gene="Ppm1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1201
                     /gene="Ppm1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1309
                     /gene="Ppm1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1461
                     /gene="Ppm1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..2794
                     /gene="Ppm1h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgcgctg cacctcggcc ggccgccgcc tcctgctcgc tcagcggctg cccggcgccg
       61 gagtaatatg ctcactcggg tgaaatctgc cgtggccaat ttcatgggcg gcatcatggc
      121 tggcagctcc ggctccgagc acggcggcag cggctgcgga ggctcggacc tgcccctgcg
      181 cttcccgtac gggcggccag agttcctcgg gctgtctcag gatgaggtgg agtgcagcgc
      241 agaccacatc gcccgcccca tcctcatcct caaggagacc cggcggctgc cctgggccac
      301 gggctacgca gaggttatta atgctggaaa gagcacacac aatgaggacc aagccagctg
      361 cgaggtgctc acagtgaaga agaaagttgg gaccattact tccaccccga acagaaattc
      421 caagcgaagg tcatcccttc ccaacgggga aggcctgcag ttaaaggaga actctgagtc
      481 tgagggcatc tcctgccact actggtccct gtttgatggc cacgcaggct caggtgctgc
      541 tgtggtggca tcgcgcctgc tgcagcacca catcacacaa cagctgcagg acatcgtgga
      601 gatcctgaag aactccgcca tccttccccc gacctgccta ggggaggagc cagagagcac
      661 gccggcccat ggcaggaccc taacccgcgc agcctcactg cgtggagggg tgggtgcccc
      721 cggctccccc agcacaccac ccacgcgctt cttcacggag aagaagattc ctcatgagtg
      781 tttggtcatc ggggccctgg agagcgcctt caaggaaatg gaccttcaaa ttgaacggga
      841 gaggagtgca tataatatat ccggtggctg cacggccctc atcgtggttt gccttctggg
      901 gaagctctac gtggcaaatg caggtgacag cagggccata atcatccgaa atggagaaat
      961 catccccatg tcttccgaat tcacccctga gactgagcgt cagagacttc agtacctggc
     1021 gttcatgcag cctcacttgc tgggaaatga gttcacacac ttggagtttc caaggagagt
     1081 acagaggaaa gaactcggga agaagatgct gtaccgggac tttaacatga caggctgggc
     1141 atacaaaacc attgaggatg atgacttgaa gtttcccctt atatatggag aaggcaagaa
     1201 ggcccgggta atggcaacta ttggagtgac aaggggactt ggggaccatg acctgaaggt
     1261 tcatgactcc aacatctaca taaaaccatt cctgtcttca gctccagagg tcagagtcta
     1321 cgatctctcc aaatacgagc acggagcgga tgacgtgctg atcctggcta ctgatggact
     1381 ctgggatgtc ttatcaaatg aagaagtagc ggaagcaatc actcagtttc ttcctaactg
     1441 tgatccagat gaccctcaca ggtacacact ggcagctcag gacctggtga tgcgtgcccg
     1501 aggcgtcctg aaggaccgag gatggcggat atcaaatgac cgactgggct caggagatga
     1561 catttctgta tacgtcattc ctttaataca cggaaacaaa ctgtcatgaa agtgacccag
     1621 gggactagga agacagaaga agggaagaaa actggggtgc ctccaagcag ggcgggactg
     1681 gggagtaagt acctgggctg gattccaggt gacgcacatt ttccccagcc caggtgggga
     1741 atttgctgcc aaaaggcctc tggctttgct tcaaggagac ccttgggttt ccgtttcttc
     1801 tttggtaaca ggtctggaca ctgaataaga gcaaaacgca cagcctgcta ctgagggtta
     1861 catctctctt ggtttctaca gtagggctcc taggcggcag cagcctattt ggggcgcagg
     1921 cacacgttta tttattttac ctagaatagc agggacagcc attccgggtg taactggtaa
     1981 aagacttctc agcctgtcaa gctgccagca tctctccagg agaagagcca cattgaaaag
     2041 ttgggggacc atacctcaga aagtacgagc agtcatctca ttgtgtgttc cagttatttc
     2101 agggatcctt cctgcccccc atttcctgcc ccctccgttt ctctatattc ttttgtggtg
     2161 atggtggggt gaggcagagt ttttttgggt ttttttttgt tttgtttttg tttttttgac
     2221 atttctccca tctttcccat ttccctccac cgggactttc caaattgtca ctggacagtt
     2281 tccagatcag aaaccagccc attctgacta gtcccatgtt ctgtgcccca tagttttgtc
     2341 cagagcaatg tctaaggtga cggtctgtct ttgttgtgta acatttaccc cggggttctg
     2401 tttttctccc caaatagata tgtttgcttc aaaacatggg tgtttcattg gaccagtggt
     2461 tcctgggtta tctttaaggc ccctctgtgt gtctggaggc tctgccacga gaggctgggt
     2521 ttgcggttct ggattggcga tactccccgc cttctgtgtc ctggagaggc ataggaagca
     2581 gcgtccagca ccacggctaa gcaggctctt gtatccagca cttgaccatg tttccttagg
     2641 gaagggggtg tgggattcag gctccttggt cgctgactgt tctccaggca caggaggatc
     2701 gagtgtcaca gctcagctaa gcagcagctc ttcctgacac ctttgtgcaa ggataactag
     2761 gatgacactt gaataaaagt gaatttgaat tgca
//
