LOCUS       NM_175755               1935 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1F
            (Ppm1f), mRNA.
ACCESSION   NM_175755
VERSION     NM_175755.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Luo,G., Chao,Y.L., Tang,B., Li,B.S., Xiao,Y.F., Xie,R., Wang,S.M.,
            Wu,Y.Y., Dong,H., Liu,X.D. and Yang,S.M.
  TITLE     miR-149 represses metastasis of hepatocellular carcinoma by
            targeting actin-regulatory proteins PPM1F
  JOURNAL   Oncotarget 6 (35), 37808-37823 (2015)
   PUBMED   26498692
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Phang,H.Q., Hoon,J.L., Lai,S.K., Zeng,Y., Chiam,K.H., Li,H.Y. and
            Koh,C.G.
  TITLE     POPX2 phosphatase regulates the KIF3 kinesin motor complex
  JOURNAL   J Cell Sci 127 (Pt 4), 727-739 (2014)
   PUBMED   24338362
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Ishida,A., Tsumura,K., Oue,M., Takenaka,Y., Shigeri,Y., Goshima,N.,
            Ishihara,Y., Hirano,T., Baba,H., Sueyoshi,N., Kameshita,I. and
            Yamazaki,T.
  TITLE     An active C-terminally truncated form of Ca (2+)
            /calmodulin-dependent protein kinase phosphatase-N (CaMKP-N/PPM1E)
  JOURNAL   Biomed Res Int 2013, 134813 (2013)
   PUBMED   23991411
  REMARK    GeneRIF: The truncated CaMKP-N may play an important physiological
            role in neuronal cells.
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Voss,M., Paterson,J., Kelsall,I.R., Martin-Granados,C.,
            Hastie,C.J., Peggie,M.W. and Cohen,P.T.
  TITLE     Ppm1E is an in cellulo AMP-activated protein kinase phosphatase
  JOURNAL   Cell Signal 23 (1), 114-124 (2011)
   PUBMED   20801214
  REMARK    Erratum:[Cell Signal. 2011 May;23(5):947]
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   Susila,A., Chan,H., Loh,A.X., Phang,H.Q., Wong,E.T., Tergaonkar,V.
            and Koh,C.G.
  TITLE     The POPX2 phosphatase regulates cancer cell motility and
            invasiveness
  JOURNAL   Cell Cycle 9 (1), 179-187 (2010)
   PUBMED   20016286
REFERENCE   6  (bases 1 to 1935)
  AUTHORS   Harvey,B.P., Banga,S.S. and Ozer,H.L.
  TITLE     Regulation of the multifunctional Ca2+/calmodulin-dependent protein
            kinase II by the PP2C phosphatase PPM1F in fibroblasts
  JOURNAL   J Biol Chem 279 (23), 24889-24898 (2004)
   PUBMED   15140879
REFERENCE   7  (bases 1 to 1935)
  AUTHORS   Koh,C.G., Tan,E.J., Manser,E. and Lim,L.
  TITLE     The p21-activated kinase PAK is negatively regulated by POPX1 and
            POPX2, a pair of serine/threonine phosphatases of the PP2C family
  JOURNAL   Curr Biol 12 (4), 317-321 (2002)
   PUBMED   11864573
REFERENCE   8  (bases 1 to 1935)
  AUTHORS   Tan,K.M., Chan,S.L., Tan,K.O. and Yu,V.C.
  TITLE     The Caenorhabditis elegans sex-determining protein FEM-2 and its
            human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein
            kinase phosphatases that promote apoptosis
  JOURNAL   J Biol Chem 276 (47), 44193-44202 (2001)
   PUBMED   11559703
REFERENCE   9  (bases 1 to 1935)
  AUTHORS   Kameshita,I., Ishida,A. and Fujisawa,H.
  TITLE     Phosphorylation and activation of Ca2+/calmodulin-dependent protein
            kinase phosphatase by Ca2+/calmodulin-dependent protein kinase II
  JOURNAL   FEBS Lett 456 (2), 249-252 (1999)
   PUBMED   10456318
REFERENCE   10 (bases 1 to 1935)
  AUTHORS   Kitani,T., Ishida,A., Okuno,S., Takeuchi,M., Kameshita,I. and
            Fujisawa,H.
  TITLE     Molecular cloning of Ca2+/calmodulin-dependent protein kinase
            phosphatase
  JOURNAL   J Biochem 125 (6), 1022-1028 (1999)
   PUBMED   10348902
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB023634.1.
            
            On Jun 3, 2003 this sequence version replaced NM_175755.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1935
                     /gene="Ppm1f"
                     /gene_synonym="CaMKPase"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent, 1F"
                     /db_xref="GeneID:287931"
                     /db_xref="RGD:631363"
     exon            1..27
                     /gene="Ppm1f"
                     /gene_synonym="CaMKPase"
                     /inference="alignment:Splign:2.1.0"
     exon            28..296
                     /gene="Ppm1f"
                     /gene_synonym="CaMKPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1446
                     /gene="Ppm1f"
                     /gene_synonym="CaMKPase"
                     /EC_number="3.1.3.16"
                     /note="CaM-kinase phosphatase; partner of PIX 2;
                     ca(2+)/calmodulin-dependent protein kinase phosphatase;
                     calcium/calmodulin-dependent protein kinase phosphatase;
                     protein phosphatase 1F (PP2C domain containing)"
                     /codon_start=1
                     /product="protein phosphatase 1F"
                     /protein_id="NP_786931.1"
                     /db_xref="GeneID:287931"
                     /db_xref="RGD:631363"
                     /translation="MASGAPQNSSQMACDGEIPGFLDTLLQDFPAPLSLESPLPWKVP
                     GTVLGQEEVEAELTELAMGFLGSRNAPPAVAAAVTHEAISQLLQTDLSEFKRLPEQEE
                     EEEEEEERVLTTLLDAKGLSRSFFNCLWEVCSQWQKRVPLTAQAPQRKWLVSIHAIRN
                     TRRKMEDRHVSLPAFNHLFGLSDSVHRAYFAVFDGHGGVDAARYASVHVHTNASHQPE
                     LLTDPAAALKEAFRHTDQMFLQKAKRERLQSGTTGVCALITGAALHVAWLGDSQVILV
                     QQGQVVKLMEPHKPERQDEKSRIEALGGFVSLMDCWRVNGTLAVSRAIGDVFQKPYVS
                     GEADAASRELTGLEDYLLLACDGFFDVVPHHEIPGLVHGHLLRQKGSGMHVAEELVAV
                     ARDRGSHDNITVMVVFLRDPLELLEGGGQGAGGAQADVGSQDLSTGLSELEINTSQRS
                     "
     exon            297..436
                     /gene="Ppm1f"
                     /gene_synonym="CaMKPase"
                     /inference="alignment:Splign:2.1.0"
     exon            437..639
                     /gene="Ppm1f"
                     /gene_synonym="CaMKPase"
                     /inference="alignment:Splign:2.1.0"
     exon            640..828
                     /gene="Ppm1f"
                     /gene_synonym="CaMKPase"
                     /inference="alignment:Splign:2.1.0"
     exon            829..972
                     /gene="Ppm1f"
                     /gene_synonym="CaMKPase"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1066
                     /gene="Ppm1f"
                     /gene_synonym="CaMKPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1935
                     /gene="Ppm1f"
                     /gene_synonym="CaMKPase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggggagca ttgcggcagg ctggcagagt aaagacttga ctgaagacca tctcacccca
       61 gcctagctgc aagccccccg gaatgcactg ggcatggcct ctggagcccc acagaacagc
      121 agccagatgg cctgtgacgg cgagatccca ggtttcctgg acacactcct ccaagacttc
      181 ccagccccac tgagcctgga gagccctttg ccatggaagg tcccagggac agtcctgggc
      241 caggaggagg tggaggctga gctgacggag ctggcaatgg gtttcctggg cagcaggaat
      301 gcacccccag cagttgctgc ggctgtgacc cacgaggcaa tttcccagct gcttcagaca
      361 gacctctctg aatttaagag gttgcctgaa caagaggaag aggaggagga ggaggaagag
      421 agagtcctca cgaccctact ggatgccaaa ggcctgtccc ggagcttctt taactgtctt
      481 tgggaagtat gcagccagtg gcagaaacgg gtgccactga ctgcccaggc ccctcagcgc
      541 aagtggctgg tctctatcca tgccatccgg aacacacgac gaaagatgga ggatcgacac
      601 gtgtcccttc ctgctttcaa ccacctcttc ggcttgtctg actccgtgca ccgcgcctac
      661 ttcgctgtgt ttgatggtca tggaggtgtg gatgcagcac ggtatgcctc tgtccacgtg
      721 cacaccaacg cctctcacca gccagagctg ctcacagacc ctgcagcagc tctcaaagaa
      781 gccttccggc atactgacca gatgtttctc cagaaagcca agcgagagcg actgcagagc
      841 ggtaccacag gtgtgtgtgc gctcatcaca ggagcagccc tgcatgttgc ctggcttgga
      901 gactcccagg tcatcctggt acagcaagga caggtagtga agctgatgga gccacacaaa
      961 ccggaacgac aggatgagaa atcacgcatt gaagcgctgg gcggctttgt ttctctcatg
     1021 gactgctgga gagtcaacgg gaccctggca gtgtccagag ccattgggga tgtcttccag
     1081 aagccttatg tgtctggcga ggcagatgca gcatccagag agctgacagg cttggaggac
     1141 tacctgctgc ttgcctgtga cggtttcttc gatgtcgtcc cccaccatga aatcccgggt
     1201 cttgtccatg gccacttgct caggcagaag ggcagtggga tgcacgttgc tgaggagctg
     1261 gtggctgtag cccgtgaccg gggttcccat gacaacatta cagtcatggt ggttttcctt
     1321 agggaccccc tggagctgct ggagggtggg gggcaggggg cagggggtgc ccaggcagat
     1381 gtaggaagtc aggacttgtc cactggcctc tcagaacttg agatcaatac ctcacagaga
     1441 agctaagtgg tccaggcccc caggccccat ccctctgccc ttgtgaccct ccccttcaaa
     1501 gaccttagat ccaacaggta tagtgggcag gggtgcacac cctcacagca ttcccttagc
     1561 accccagccc ttcatgttgc ctgccacagc ctgttctcat ggctgcagaa ctgtaggcac
     1621 caatggatct caaggaagca taggaaaatg acctcacaaa agaatagatg gctgaggtga
     1681 tcagggcagg acaggtctgg ggacagaaac cacaggcacc tgctggcagc ctaaccaaaa
     1741 gcataggtca agtcttagga accctcacac agaccctggg gtaggatcca gcccagactg
     1801 tggcttctca ctgtccccaa gtgaggaggg tttggtctgt actaacacac aagctcacag
     1861 tcctgcttga ctgctggctt cccaaagaag ttgacattgg tcttgctggg aggagcacca
     1921 ggagagtggc cactg
//
