LOCUS       NM_198773               2743 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1E
            (Ppm1e), mRNA.
ACCESSION   NM_198773 XM_340873
VERSION     NM_198773.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2743)
  AUTHORS   Chida,T., Ando,M., Matsuki,T., Masu,Y., Nagaura,Y.,
            Takano-Yamamoto,T., Tamura,S. and Kobayashi,T.
  TITLE     N-Myristoylation is essential for protein phosphatases PPM1A and
            PPM1B to dephosphorylate their physiological substrates in cells
  JOURNAL   Biochem J 449 (3), 741-749 (2013)
   PUBMED   23088624
REFERENCE   2  (bases 1 to 2743)
  AUTHORS   Voss,M., Paterson,J., Kelsall,I.R., Martin-Granados,C.,
            Hastie,C.J., Peggie,M.W. and Cohen,P.T.
  TITLE     Ppm1E is an in cellulo AMP-activated protein kinase phosphatase
  JOURNAL   Cell Signal 23 (1), 114-124 (2011)
   PUBMED   20801214
  REMARK    Erratum:[Cell Signal. 2011 May;23(5):947]
REFERENCE   3  (bases 1 to 2743)
  AUTHORS   Ishida,A., Sueyoshi,N., Shigeri,Y. and Kameshita,I.
  TITLE     Negative regulation of multifunctional Ca2+/calmodulin-dependent
            protein kinases: physiological and pharmacological significance of
            protein phosphatases
  JOURNAL   Br J Pharmacol 154 (4), 729-740 (2008)
   PUBMED   18454172
  REMARK    Review article
REFERENCE   4  (bases 1 to 2743)
  AUTHORS   Kitani,T., Okuno,S., Nakamura,Y., Tokuno,H., Takeuchi,M. and
            Fujisawa,H.
  TITLE     Post-translational excision of the carboxyl-terminal segment of CaM
            kinase phosphatase N and its cytosolic occurrence in the brain
  JOURNAL   J Neurochem 96 (2), 374-384 (2006)
   PUBMED   16269004
  REMARK    GeneRIF: CaM kinase phosphatase N is involved in the regulation of
            not only CaM kinase IV but also CaM kinases II and I.
REFERENCE   5  (bases 1 to 2743)
  AUTHORS   Ishida,A., Tada,Y., Nimura,T., Sueyoshi,N., Katoh,T., Takeuchi,M.,
            Fujisawa,H., Taniguchi,T. and Kameshita,I.
  TITLE     Identification of major Ca(2+)/calmodulin-dependent protein kinase
            phosphatase-binding proteins in brain: biochemical analysis of the
            interaction
  JOURNAL   Arch Biochem Biophys 435 (1), 134-146 (2005)
   PUBMED   15680915
  REMARK    GeneRIF: The results suggest that CaMKP regulates the
            phosphorylation level of GAPDH in the CaMKP-GAPDH complex by
            dephosphorylating and deactivating CaMKs that are responsible for
            the phosphorylation of GAPDH.
REFERENCE   6  (bases 1 to 2743)
  AUTHORS   Kitani,T., Okuno,S., Takeuchi,M. and Fujisawa,H.
  TITLE     Subcellular distributions of rat CaM kinase phosphatase N and other
            members of the CaM kinase regulatory system
  JOURNAL   J Neurochem 86 (1), 77-85 (2003)
   PUBMED   12807427
  REMARK    GeneRIF: CaM kinase phosphatase N occurs inside the cellular
            nucleus of PC-12 cells [Ppm1e].
REFERENCE   7  (bases 1 to 2743)
  AUTHORS   Koh,C.G., Tan,E.J., Manser,E. and Lim,L.
  TITLE     The p21-activated kinase PAK is negatively regulated by POPX1 and
            POPX2, a pair of serine/threonine phosphatases of the PP2C family
  JOURNAL   Curr Biol 12 (4), 317-321 (2002)
   PUBMED   11864573
REFERENCE   8  (bases 1 to 2743)
  AUTHORS   Takeuchi,M., Ishida,A., Kameshita,I., Kitani,T., Okuno,S. and
            Fujisawa,H.
  TITLE     Identification and characterization of CaMKP-N, nuclear
            calmodulin-dependent protein kinase phosphatase
  JOURNAL   J Biochem 130 (6), 833-840 (2001)
   PUBMED   11726284
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB081729.1.
            
            On Dec 17, 2003 this sequence version replaced XM_340873.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB081729.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132265,
                                           SAMD00132269 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2743
                     /gene="Ppm1e"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent, 1E"
                     /db_xref="GeneID:360593"
                     /db_xref="RGD:735028"
     exon            1..575
                     /gene="Ppm1e"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2373
                     /gene="Ppm1e"
                     /EC_number="3.1.3.16"
                     /note="calmodulin-dependent protein kinase phosphatase N;
                     caMKN; caMKP-N; caMKP-nucleus; partner of PIXA; partner of
                     PIX 1; partner of PIX-alpha; ca(2+)/calmodulin-dependent
                     protein kinase phosphatase N; protein phosphatase 1E (PP2C
                     domain containing)"
                     /codon_start=1
                     /product="protein phosphatase 1E"
                     /protein_id="NP_942068.1"
                     /db_xref="GeneID:360593"
                     /db_xref="RGD:735028"
                     /translation="MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPESEPEPEPE
                     AELVAAEAAEASGEDPGEDAATVEAAEEGVQDQDPEPEEEAVEEEAAAEGEEEEEEEE
                     AAAPGHSAVPPPQPQLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAA
                     ALARATSDEVLQSDLSAHCIPKETDGTEGTVEIETVKLARSVFSKLHEICCNWVKDFP
                     LRRRPQIYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVD
                     AAIYASVHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFI
                     RGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNG
                     SLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDH
                     LKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGG
                     QEDGGDDKENHGECKRPWPQHQCSAPADLGYEGRVDSFTDRTSLSPGPQINVLEDPDY
                     LDLTQIETSKPHSTQFLPPVEMIGPGAPKKAYVNELIMEESSVTPSQPERSGAGELLV
                     SFNLGSTGQQICRMENLSPVYSGLENEQFKSPGKRASRLYHLRHHYSKRQRGFRFNPK
                     FYSFFSAQESSRKIGISLSSLTRSGKRNKMLRSSLPWRENSWEGYSGNMAIRKRNNIS
                     CPDLPWDYKI"
     exon            576..694
                     /gene="Ppm1e"
                     /inference="alignment:Splign:2.1.0"
     exon            695..894
                     /gene="Ppm1e"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1083
                     /gene="Ppm1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1227
                     /gene="Ppm1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1321
                     /gene="Ppm1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..2743
                     /gene="Ppm1e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggtgccg gtgcggccgt tccccctccg tagcgggagg cgaggctccg aagcagcccc
       61 ctcctcctcc tgggttcacc tcccaccccc ttcccggtgg acctcggggc atgagcaacg
      121 atggcgggct gcatccctga ggagaaaact taccggcgct tcctggagct gttcctgggc
      181 gagttccgcg gaccgtgcgg cggcggcgag ccagagcccg aacccgaatc cgagcccgag
      241 cccgagcccg aagcggagct ggtcgcggct gaggcggccg aggcttcggg ggaggacccg
      301 ggggaggacg ctgcgacggt agaggcggcc gaggaggggg tgcaggacca agacccggag
      361 cccgaagagg aggcggtgga agaggaggcg gcggccgagg gcgaggagga ggaggaagag
      421 gaggaagcgg ctgccccggg gcactcggcc gtgccgccgc cgcagcccca gctgccgccg
      481 ctgcccccgc tcccgcggcc gctgtcggag cgcatcaccc gagaggaggt ggagggcgag
      541 agcctggacc tgtgcctgca gcagctctac aaatataact gcccttcctt tctggctgcc
      601 gctttagcca gagccacatc agatgaagtc ctccagagtg acctttctgc tcactgtatc
      661 ccaaaggaga cggacggcac agaagggact gtggaaattg agacagtgaa attagcccgt
      721 tctgtcttca gcaaactaca cgagatttgc tgcaattggg tgaaggactt ccctctacgc
      781 aggaggccac agatttatta tgagacgtca atccatgcca tcaagaacat gcgaaggaaa
      841 atggaggaca aacatgtctg catccctgac tttaacatgc tcttcaacct agaggaccag
      901 gaggaacaag catactttgc agtgtttgat ggccatgggg gagtggatgc tgctatatat
      961 gcctcggttc acctacacgt taacttagtg cgccaggaga tgtttcccca tgaccctgct
     1021 gaggctctct gccgggcctt ccgtgtcaca gatgagcggt ttgtgcagaa ggcagccagg
     1081 gagagtttac gatgtgggac cacaggagta gtgactttta tcagaggcaa catgctccat
     1141 gtggcatggg tgggcgactc ccaggtcatg ctggtaagaa agggccaagc tgttgaactc
     1201 atgaagcctc acaagccaga cagagaggat gaaaagcagc gaattgaggc ccttggaggt
     1261 tgtgtggttt ggtttggtgc ctggagggtg aatggaagcc tgtccgtctc cagagccatc
     1321 ggagatgctg aacacaagcc atatatctgt ggagatgcag attctgcctc cactgttctg
     1381 gatgggactg aagactacct cattctggcc tgtgatggct tctatgatac cgtgaaccct
     1441 gatgaggcag tgaaggttgt gtctgaccac ttgaaagaga ataatggaga cagcagcatg
     1501 gttgcccaca aattagtagc atcagctcgt gatgcggggt caagtgataa catcactgtt
     1561 attgtggtat tcctgaggga catgaacaaa gctgtaaatg ttagtgagga atcagattgg
     1621 acagagaact cttttcaagg agggcaagaa gatggtgggg atgataagga gaatcatgga
     1681 gagtgcaaac gcccttggcc acagcaccag tgctcagcac cagccgatct aggctatgag
     1741 gggcgtgtgg attcattcac tgatagaact agcctgagcc cagggcccca aatcaacgtg
     1801 ctggaagatc cagactactt agatctcaca caaatagaaa caagcaaacc tcacagtacc
     1861 caatttttgc caccagttga gatgattggt cctggtgcac caaagaaagc atatgttaat
     1921 gagctaataa tggaggagag ctcagtcacg ccatcacagc ctgaacggag tggtgctgga
     1981 gagcttctgg tttcttttaa tttgggttca acagggcaac agatatgcag aatggagaac
     2041 ttgtcccctg tctattctgg gttggaaaat gaacagttca aatccccggg gaaaagagcg
     2101 tctagattgt atcatttacg ccaccactac tccaaaaggc agcgtggatt caggtttaat
     2161 ccaaagtttt attcattttt ttctgctcaa gagtcttctc gaaaaatagg cattagcctc
     2221 tcctcactta ctcgaagtgg gaagagaaac aagatgttaa gaagttcttt gccatggagg
     2281 gaaaatagtt gggaaggata tagtggaaac atggcgatca gaaagcgtaa taatatttca
     2341 tgcccagacc ttccctggga ctataaaatt taagactttt tcttcaatgt aggctagcta
     2401 gttctctcaa aaatataact atcagagtag aaacaaggta gacattttta acgtacatgt
     2461 gcttcattat gaatccacgg atggctcaac cctcaaatgt acatagatct ttaggaaact
     2521 caaaatagcg ttttcaatct aatcaaaagt attggcggtt tcactagaaa aattattcaa
     2581 ctggtccctg tgatgtgtct ccacacctac atacagcccc tctccaccat cccttcacgt
     2641 cactagtgga agcttgaaag ttattccagt cagaatatat ggtatagaaa tcgcaactat
     2701 ctggtctgat gtgcctaatc taaaggaaac aatgcagaat taa
//
