LOCUS       NM_001270619            2587 bp    mRNA    linear   ROD 11-OCT-2020
DEFINITION  Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1B
            (Ppm1b), transcript variant 2, mRNA.
ACCESSION   NM_001270619
VERSION     NM_001270619.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2587)
  AUTHORS   Chida T, Ando M, Matsuki T, Masu Y, Nagaura Y, Takano-Yamamoto T,
            Tamura S and Kobayashi T.
  TITLE     N-Myristoylation is essential for protein phosphatases PPM1A and
            PPM1B to dephosphorylate their physiological substrates in cells
  JOURNAL   Biochem J 449 (3), 741-749 (2013)
   PUBMED   23088624
REFERENCE   2  (bases 1 to 2587)
  AUTHORS   Zhao Y, Liang L, Fan Y, Sun S, An L, Shi Z, Cheng J, Jia W, Sun W,
            Mori-Akiyama Y, Zhang H, Fu S and Yang J.
  TITLE     PPM1B negatively regulates antiviral response via dephosphorylating
            TBK1
  JOURNAL   Cell Signal 24 (11), 2197-2204 (2012)
   PUBMED   22750291
REFERENCE   3  (bases 1 to 2587)
  AUTHORS   Voss M, Paterson J, Kelsall IR, Martin-Granados C, Hastie CJ,
            Peggie MW and Cohen PT.
  TITLE     Ppm1E is an in cellulo AMP-activated protein kinase phosphatase
  JOURNAL   Cell Signal 23 (1), 114-124 (2011)
   PUBMED   20801214
  REMARK    Erratum:[Cell Signal. 2011 May;23(5):947]
REFERENCE   4  (bases 1 to 2587)
  AUTHORS   Sun W, Yu Y, Dotti G, Shen T, Tan X, Savoldo B, Pass AK, Chu M,
            Zhang D, Lu X, Fu S, Lin X and Yang J.
  TITLE     PPM1A and PPM1B act as IKKbeta phosphatases to terminate
            TNFalpha-induced IKKbeta-NF-kappaB activation
  JOURNAL   Cell Signal 21 (1), 95-102 (2009)
   PUBMED   18930133
REFERENCE   5  (bases 1 to 2587)
  AUTHORS   Kato S, Kobayashi T, Kusuda K, Nishina Y, Nishimune Y, Yomogida K,
            Yamamoto M, Sakagami H, Kondo H, Ohnishi M, Chida N, Yanagawa Y and
            Tamura S.
  TITLE     Differentiation-dependent enhanced expression of protein
            phosphatase 2Cbeta in germ cells of mouse seminiferous tubules
  JOURNAL   FEBS Lett 396 (2-3), 293-297 (1996)
   PUBMED   8915006
REFERENCE   6  (bases 1 to 2587)
  AUTHORS   Watanabe T, Ohnishi M, Kobayashi T, Oishi M and Tamura S.
  TITLE     The mouse protein phosphatase 2Cbeta (Ppm1b) gene maps to the
            distal part of mouse chromosome 17
  JOURNAL   Genomics 33 (1), 147-149 (1996)
   PUBMED   8617503
REFERENCE   7  (bases 1 to 2587)
  AUTHORS   Schafer K and Braun T.
  TITLE     Monoclonal anti-FLAG antibodies react with a new isoform of rat
            Mg2+ dependent protein phosphatase beta
  JOURNAL   Biochem Biophys Res Commun 207 (2), 708-714 (1995)
   PUBMED   7532404
REFERENCE   8  (bases 1 to 2587)
  AUTHORS   Wenk J, Trompeter HI, Pettrich KG, Cohen PT, Campbell DG and
            Mieskes G.
  TITLE     Molecular cloning and primary structure of a protein phosphatase 2C
            isoform
  JOURNAL   FEBS Lett 297 (1-2), 135-138 (1992)
   PUBMED   1312947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FN800175.1, AC111831.5, FM108050.1, FM075941.1, FM042005.1 and
            BQ780970.1.
            
            [WARNING] On Jun 29, 2023 this sequence was replaced by
            NM_001270619.2.
            
            Transcript Variant: This variant (2) contains an alternate 3'
            terminal exon compared to variant 1, which results in a longer
            isoform (2) with a distinct C-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061986.1, AJ271834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00052296, SAMD00052297
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               FN800175.1         1-629
            630-846             AC111831.5         96848-97064
            847-1286            FM108050.1         2-441
            1287-1538           FM075941.1         27-278
            1539-1786           FM042005.1         6-253
            1787-1787           AC111831.5         117082-117082
            1788-2142           FM042005.1         255-609
            2143-2587           BQ780970.1         1-445               c
FEATURES             Location/Qualifiers
     source          1..2587
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..2587
                     /gene="Ppm1b"
                     /gene_synonym="Pp2c2"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent, 1B"
                     /db_xref="GeneID:24667"
                     /db_xref="RGD:3374"
     exon            1..390
                     /gene="Ppm1b"
                     /gene_synonym="Pp2c2"
                     /inference="alignment:Splign:2.0.8"
     exon            391..1250
                     /gene="Ppm1b"
                     /gene_synonym="Pp2c2"
                     /inference="alignment:Splign:2.0.8"
     CDS             405..1802
                     /gene="Ppm1b"
                     /gene_synonym="Pp2c2"
                     /EC_number="3.1.3.16"
                     /note="isoform 2 is encoded by transcript variant 2;
                     PP2C-beta"
                     /codon_start=1
                     /product="protein phosphatase 1B isoform 2"
                     /protein_id="NP_001257548.1"
                     /db_xref="GeneID:24667"
                     /db_xref="RGD:3374"
                     /translation="MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVV
                     GIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAADKSGFALEPSVENV
                     KTGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPTHIYFINCGDSRAVLCRNG
                     QVCFSTQDHKPCNPMEKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQ
                     LVSPEPEVYEILRAEEDEFVVLACDGIWDVMSNEELCEFVNSRLEVSDDLENVCNWVV
                     DTCLHKGSRDNMSIVLVCFANAPKVSDEAVKRDLELDKHLESRVEEIMQKSGEEGMPD
                     LAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPNKDNDGASEEAEESGSQGKL
                     VEALRQMRVNHRGNYRQLLEEMLTSYRLAKVEGEESPAGPAAATASSNSDAGNPVAVQ
                     ERHTESGPAELDSPK"
     exon            1251..1368
                     /gene="Ppm1b"
                     /gene_synonym="Pp2c2"
                     /inference="alignment:Splign:2.0.8"
     exon            1369..1480
                     /gene="Ppm1b"
                     /gene_synonym="Pp2c2"
                     /inference="alignment:Splign:2.0.8"
     exon            1481..1538
                     /gene="Ppm1b"
                     /gene_synonym="Pp2c2"
                     /inference="alignment:Splign:2.0.8"
     exon            1539..2570
                     /gene="Ppm1b"
                     /gene_synonym="Pp2c2"
                     /inference="alignment:Splign:2.0.8"
     regulatory      2543..2548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1b"
                     /gene_synonym="Pp2c2"
     polyA_site      2570
                     /gene="Ppm1b"
                     /gene_synonym="Pp2c2"
ORIGIN      
        1 aaggagcgga gcggccgctg ctcaatggcg gaaaagccgc tggtactctg accgcctggt
       61 cccccctggc agttgcgggg gagtttcctg ccggcgcggc tggagtctct gtttctctgt
      121 gtccggtggc tggaagatgc tccagagaga tcaggctgcg gcggaggagg tggcggcggc
      181 cgagtcggca gcggcgctgg gttggagaga aggcggcggc ggcggcgtga ggggccggac
      241 ggtgtaaaca gctcgggcgg cggcggtggc cgagcccccg agggcgaagc ggcggcggag
      301 gcggtgtcgc gtctcgggag aaagccgggg gccgcgggcg gctgtgcggc gggcaagccc
      361 gcgagacctt gccttccacc ttcgccccag attcgttact aaacatgggt gcatttttgg
      421 ataaacccaa aactgaaaag cacaatgctc acggtgcagg gaacggtctg cgttacggtc
      481 tgagcagtat gcaaggatgg agagtagaaa tggaagacgc acacactgct gttgtgggaa
      541 ttcctcacgg cttggaggac tggtcgtttt ttgcagtcta tgatggtcat gctggatccc
      601 gagtggcaaa ttactgttca acacatctat tagaacacat cactaccaat gaagacttta
      661 gggcagctga caaatcaggc tttgctcttg agccgtcagt ggaaaatgtt aagactggta
      721 tccgaactgg ctttttgaaa attgatgaat atatgcgtaa cttttcagac ctgaggaacg
      781 ggatggacag gagcggctct accgcagtgg gcgtgatgat ttcaccgaca cacatctact
      841 ttatcaactg cggtgactcg agagctgttc tgtgtaggaa tggacaagtc tgcttttcta
      901 cccaggatca caaaccttgt aatccaatgg aaaaggagcg catccaaaat gcaggaggca
      961 gtgtaatgat acagcgtgtg aatgggtcgt tagcagtgtc tcgtgctctg ggggactatg
     1021 attacaagtg tgttgatggc aagggcccca cagagcagct tgtttctcca gagcctgagg
     1081 tttatgagat tctaagagca gaagaggatg aatttgtcgt cctggcttgt gatgggatct
     1141 gggatgtgat gagcaatgag gagctctgtg agtttgttaa ctctaggctt gaggtgtcag
     1201 acgacctgga gaatgtgtgc aattgggtag tggacacttg tttacataag ggaagtcgag
     1261 ataacatgag tattgtgtta gtttgctttg caaatgcccc caaggtctca gatgaagccg
     1321 tgaaaagaga tttagagttg gacaagcact tggaatcacg ggtggaagaa atcatgcaga
     1381 agtctggaga ggaaggaatg cctgatcttg cccatgtgat gcgcattttg tctgcagaaa
     1441 atatcccaaa tttacctccc gggggaggcc tcgctggcaa gcgcaatgtt attgaagctg
     1501 tttatagtag acttaatcca aacaaagaca atgatggggc ctccgaggaa gcagaggaaa
     1561 gtggatcaca ggggaaattg gtggaagctc tcaggcaaat gagagttaac cataggggca
     1621 actaccgaca actgctggag gagatgctga ctagttacag gctagctaaa gtagagggag
     1681 aagagagccc ggctggccca gctgctgcaa ctgcttcttc gaacagtgat gctggaaacc
     1741 cagtggcagt gcaggagaga cacactgaaa gtggtcctgc tgaattagac agccctaaat
     1801 gaagatgcag ggacaaagac gagtgctgaa acaatatgac ctttttgggg taatattttt
     1861 gtgatcttga tttgacagtt tttacttagg aagtatactg tgtgcattta tataaccatt
     1921 ttgttatttg aatcttggaa aactagtttt cttatattcc tatagccttg ttttttctaa
     1981 aggcctttaa atacaccttt atgatagttt aagattgact atttatagta actttgattt
     2041 aatgaagttt tatgtcattt caccttgtat cccagaaaat aggttgtcat tattaatttc
     2101 agtagcttaa ttcttactag ctaggatata gattactgat tggaaagaca gctgtacact
     2161 gtggaaagaa ctgttactgt agaattgaca ctgcttattt tatatcaaac ccgccatagt
     2221 tagctttgta atacctgtgt gttcacttgc tattttagtt ctttaaagaa tggctagagc
     2281 tggcccataa cttttctttc agagttgata atctgtgttt ttaattgttt ctattttaca
     2341 tttctgtagc cttactttta gaatttattg agatattgga tgtgtggtta cttttccttt
     2401 ctctgtattc tttatgaaaa atttttaaag aactatgtac ttttcatata gctttcatat
     2461 gtatattctg tatagcctac tatacactta aaaatgtatg tcaaccgcgt gtttagaatg
     2521 aaatgatcag tgtttaagtc caaataaagc atgtgatgtg gaatcatcta aaaaaaaaaa
     2581 aaaaaaa
//
