LOCUS       NM_017038               1604 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1A
            (Ppm1a), mRNA.
ACCESSION   NM_017038
VERSION     NM_017038.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1604)
  AUTHORS   Zhao,Y., Xiao,M., Sun,B., Zhang,Z., Shen,T., Duan,X., Yu,P.B.,
            Feng,X.H. and Lin,X.
  TITLE     C-terminal domain (CTD) small phosphatase-like 2 modulates the
            canonical bone morphogenetic protein (BMP) signaling and
            mesenchymal differentiation via Smad dephosphorylation
  JOURNAL   J Biol Chem 289 (38), 26441-26450 (2014)
   PUBMED   25100727
REFERENCE   2  (bases 1 to 1604)
  AUTHORS   Chida,T., Ando,M., Matsuki,T., Masu,Y., Nagaura,Y.,
            Takano-Yamamoto,T., Tamura,S. and Kobayashi,T.
  TITLE     N-Myristoylation is essential for protein phosphatases PPM1A and
            PPM1B to dephosphorylate their physiological substrates in cells
  JOURNAL   Biochem J 449 (3), 741-749 (2013)
   PUBMED   23088624
REFERENCE   3  (bases 1 to 1604)
  AUTHORS   Inoue,K., Matsui,I., Hamano,T., Fujii,N., Shimomura,A., Nakano,C.,
            Kusunoki,Y., Takabatake,Y., Hirata,M., Nishiyama,A.,
            Tsubakihara,Y., Isaka,Y. and Rakugi,H.
  TITLE     Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed
            kidneys by recruiting PPM1A/VDR complex to pSmad3
  JOURNAL   Lab Invest 92 (12), 1686-1697 (2012)
   PUBMED   22926646
  REMARK    GeneRIF: Maxacalcitol ameliorates tubulointerstitial fibrosis in
            obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3. This
            recruitment promoted the dephosphorylation of pSmad3 and attenuated
            the pSmad3-dependent production of TGF-beta1.
REFERENCE   4  (bases 1 to 1604)
  AUTHORS   Shohat,M., Ben-Meir,D. and Lavi,S.
  TITLE     Protein phosphatase magnesium dependent 1A (PPM1A) plays a role in
            the differentiation and survival processes of nerve cells
  JOURNAL   PLoS One 7 (2), e32438 (2012)
   PUBMED   22384250
  REMARK    GeneRIF: Protein phosphatase magnesium dependent 1A (PPM1A) plays a
            role in the differentiation and survival processes of nerve cells
REFERENCE   5  (bases 1 to 1604)
  AUTHORS   Samarakoon,R., Chitnis,S.S., Higgins,S.P., Higgins,C.E.,
            Krepinsky,J.C. and Higgins,P.J.
  TITLE     Redox-induced Src kinase and caveolin-1 signaling in
            TGF-beta1-initiated SMAD2/3 activation and PAI-1 expression
  JOURNAL   PLoS One 6 (7), e22896 (2011)
   PUBMED   21829547
REFERENCE   6  (bases 1 to 1604)
  AUTHORS   Komaki,K., Katsura,K., Ohnishi,M., Guang Li,M., Sasaki,M.,
            Watanabe,M., Kobayashi,T. and Tamura,S.
  TITLE     Molecular cloning of PP2Ceta, a novel member of the protein
            phosphatase 2C family
  JOURNAL   Biochim Biophys Acta 1630 (2-3), 130-137 (2003)
   PUBMED   14654243
REFERENCE   7  (bases 1 to 1604)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   8  (bases 1 to 1604)
  AUTHORS   Tan,K.M., Chan,S.L., Tan,K.O. and Yu,V.C.
  TITLE     The Caenorhabditis elegans sex-determining protein FEM-2 and its
            human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein
            kinase phosphatases that promote apoptosis
  JOURNAL   J Biol Chem 276 (47), 44193-44202 (2001)
   PUBMED   11559703
REFERENCE   9  (bases 1 to 1604)
  AUTHORS   Strovel,E.T., Wu,D. and Sussman,D.J.
  TITLE     Protein phosphatase 2Calpha dephosphorylates axin and activates
            LEF-1-dependent transcription
  JOURNAL   J Biol Chem 275 (4), 2399-2403 (2000)
   PUBMED   10644691
REFERENCE   10 (bases 1 to 1604)
  AUTHORS   Tamura,S., Lynch,K.R., Larner,J., Fox,J., Yasui,A., Kikuchi,K.,
            Suzuki,Y. and Tsuiki,S.
  TITLE     Molecular cloning of rat type 2C (IA) protein phosphatase mRNA
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1796-1800 (1989)
   PUBMED   2538815
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017038.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04503.1, SRR26643295.25634.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000006.1  97179143-97179209
            68-921              JAXUCZ010000006.1  97205249-97206102
            922-1039            JAXUCZ010000006.1  97208418-97208535
            1040-1148           JAXUCZ010000006.1  97212405-97212513
            1149-1206           JAXUCZ010000006.1  97214803-97214860
            1207-1604           JAXUCZ010000006.1  97215732-97216129
FEATURES             Location/Qualifiers
     source          1..1604
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1604
                     /gene="Ppm1a"
                     /gene_synonym="Pp2c1"
                     /note="protein phosphatase, Mg2+/Mn2+ dependent, 1A"
                     /db_xref="GeneID:24666"
                     /db_xref="RGD:3373"
     exon            1..67
                     /gene="Ppm1a"
                     /gene_synonym="Pp2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            68..921
                     /gene="Ppm1a"
                     /gene_synonym="Pp2c1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1236
                     /gene="Ppm1a"
                     /gene_synonym="Pp2c1"
                     /EC_number="3.1.3.16"
                     /note="IA; PP2C-alpha; protein phosphatase IA"
                     /codon_start=1
                     /product="protein phosphatase 1A"
                     /protein_id="NP_058734.1"
                     /db_xref="GeneID:24666"
                     /db_xref="RGD:3373"
                     /translation="MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVI
                     GLPSGLETWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIR
                     TGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFF
                     TQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPE
                     PEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCL
                     YKGSRDNMSVILICFPNAPKVSAEAVKKEAELDKYLENRVEEIIKKQGEGVPDLVHVM
                     RTLASENIPSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSASTDDMW"
     exon            922..1039
                     /gene="Ppm1a"
                     /gene_synonym="Pp2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1148
                     /gene="Ppm1a"
                     /gene_synonym="Pp2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1206
                     /gene="Ppm1a"
                     /gene_synonym="Pp2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1604
                     /gene="Ppm1a"
                     /gene_synonym="Pp2c1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcccggccg ccgtcgccac cgccgccccg gccgaccgag ggacccgccc gcccgcggct
       61 gctccggatc tagaggatca agtcataatg ggagcatttt tagacaagcc aaagatggaa
      121 aagcataatg cccagggcca gggcaacggg ttgcgatacg gcctgagcag catgcaaggt
      181 tggcgagttg aaatggagga tgcacatacg gctgtgatcg gtttgccaag tggactcgag
      241 acatggtcat tctttgctgt atatgatggg catgctggtt ctcaggttgc caaatactgc
      301 tgtgagcact tgttagatca catcaccaat aaccaggatt ttaaaggctc tgcaggagca
      361 ccttctgtgg aaaacgtaaa gaacggaatc agaacaggtt ttctggagat tgatgaacac
      421 atgagagtta tgtcagagaa gaaacacggt gcagatagaa gtgggtcaac agctgtgggt
      481 gtcttaattt ctccccaaca tacttatttc attaactgtg gggactcaag aggtttactt
      541 tgtagaaata gaaaagttca cttcttcact caagaccata aaccaagtaa tcctctggaa
      601 aaagaacgaa ttcagaatgc agggggctct gtgatgattc agcgtgtcaa tggctctctg
      661 gctgtatcaa gagctcttgg ggattttgat tacaaatgtg tccatggaaa aggtcccaca
      721 gagcagcttg tctcgccaga gcctgaagtc catgatattg aaaggtctga agaagatgac
      781 cagttcatca ttcttgcatg tgatggcatc tgggacgtca tgggcaacga agagctctgt
      841 gactttgtga gatccagact tgaagtcact gatgaccttg agaaagtttg caatgaagta
      901 gtcgacacct gtttgtataa gggaagtcga gacaacatga gtgtgatttt gatctgcttt
      961 ccaaacgcgc ctaaagtctc agcagaggcg gtgaagaagg aggcagagct ggacaagtac
     1021 ctggagaaca gagtagaaga aatcataaag aagcaggggg aaggcgtccc tgacttagtc
     1081 catgtgatgc gcacgttagc cagtgagaac atccccagcc tcccaccagg gggtgaactg
     1141 gcaagcaagc ggaatgtaat tgaagccgtt tacaatagac tgaaccctta caaaaacgac
     1201 gacactgatt ctgcgtcaac tgatgatatg tggtaaagct gctcatctag ccatggtttc
     1261 acctttgcct ccaagggaga gagatcagcg catccttgct gagcctttaa catccatcac
     1321 cgacttaagg aaggggtccg acatgggtga gggactacag cttcagcgat ggaacagcca
     1381 gcccagaatg gatttttttt tttttttatt gtaaatttga gacttatgta agcgtgattt
     1441 caaaccgtaa ttcatgttgt aaatcagact ccagcaattt ttgttgtatg attttggttt
     1501 tttgtaaagt gtaattgtcc ttgtacaaag tgctcatatt taattatgaa ctgctttaaa
     1561 atcactatca atgataaagg aaatttggct tgttgtgtgg caca
//
