LOCUS       NM_001106976            6281 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus periplakin (Ppl), mRNA.
ACCESSION   NM_001106976 XM_001079075 XM_220174
VERSION     NM_001106976.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6281)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6281)
  AUTHORS   Pyle AL, Li B, Maupin AB, Guzman RJ, Crimmins DL, Olson S, Atkinson
            JB and Young PP.
  TITLE     Biomechanical stress induces novel arterial intima-enriched genes:
            implications for vascular adaptation to stress
  JOURNAL   Cardiovasc Pathol 19 (2), e13-e20 (2010)
   PUBMED   19211270
REFERENCE   3  (bases 1 to 6281)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 6281)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 6281)
  AUTHORS   Murdoch H, Feng GJ, Bachner D, Ormiston L, White JH, Richter D and
            Milligan G.
  TITLE     Periplakin interferes with G protein activation by the
            melanin-concentrating hormone receptor-1 by binding to the proximal
            segment of the receptor C-terminal tail
  JOURNAL   J Biol Chem 280 (9), 8208-8220 (2005)
   PUBMED   15590649
  REMARK    GeneRIF: Periplakin interferes with G protein activation by the
            melanin-concentrating hormone receptor-1 by binding to the proximal
            segment of the receptor C-terminal tail
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474017.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001079075.1, XM_220174.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132293 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6281
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..6281
                     /gene="Ppl"
                     /note="periplakin"
                     /db_xref="GeneID:302934"
                     /db_xref="RGD:1305511"
     exon            1..139
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..5342
                     /gene="Ppl"
                     /codon_start=1
                     /product="periplakin"
                     /protein_id="NP_001100446.1"
                     /db_xref="GeneID:302934"
                     /db_xref="RGD:1305511"
                     /translation="MHSLFRKKNKGKYSPTVQTRSISNKELSDLIEQLQKNADQVERN
                     IVDTEAKMQSDLARMQDGQLPEHRDATLQNVSDSEKLLYVLEADSAIAKHMKHPQGDM
                     IAEDIRQLKERVTNLRGKHKQMYSLAVREADPKVNWDALVDEKLDKLSSQSFGTDLPL
                     VDSQVEQHNIFHNEVKAIGPHLAKDKEQNSELQAKYQKLLAASQARQQHLSSLQDYMQ
                     RCTNELYWLDQQAKGRIQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHTEGD
                     QLLTAEHPGRNSIEAHMEAVHAEWKEYLNLLICEESHLKYMEDYHQFHKDMKDAQELL
                     RKVDSDLNQKYSPDFKDRYQIELLLRELDDQEKALDKYEDVVRGLQKRGQQVLPLKYR
                     RETPLKPIPVEALCDFEGDQGLISRGYSYTLQKNNGESWELTDSTGKKLMAPAVCFII
                     PPTDPEALALSDSLGSQYRSVRQKAAGSKHALQQRHEVLRTENPGDASDLQGRQLLAG
                     LDQVASDLDRQEKAITGILRPPLEQGRAIEDSAERAKHLKNITNELLQIEPEKIQRTA
                     ECEAFVQALPGSGTTPLLKTRVEDTNQKYKRLVQLLEAAQEKVDVANRLENSLQRGRE
                     LLASHENRLMQDDTIPESDYMLDSKRQELEAMASELQAQKSLLGEVEQNLQVAKQCSS
                     SLASRFQEHCPDLERQEAEVHKLNQRFNNLNQQVERRAQSLQSARDAYSEYCRGYDHV
                     LQFLVKTPSYEPQETDSLSQMETKLKNQKNLLDEIASMEQGAQKVYADSQQYQQAVKD
                     YELEAEKLRSLLDLENGRNSHVNKRARLQSPAAKVKEEEAALAAKFTEVNAINRQRLQ
                     NLEFALNLLRQQPEAGVTHETLQGREQGSGMEETWKIQKELEEEMERRQQLENEVKSA
                     QEEIQTLKDQGPQESLVRKEVLKKVPDPALEESFQQLQQTLAEEQHKNQLLQEELGAL
                     QLRLQALEQETRDGGQEYVVKEVLRIEPDRAQEDEVLQLREELEGLRRQKGAREAEVL
                     LLQQRVAALAAEKSRVQEKVTEREVVKLQNDPQLEAEYRRLQEEHQREGTLREKQEEE
                     LSFLQAKLRRLEKERAMAEGKITVKEVLKVEKDTAAEREVNDLSRQYEDEASKARTSQ
                     REKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKFRGAE
                     EQLKSYQSELEALRNRGPQVEVKEVTKEVIKYTTDPETEQELQRLREEIMDKTRLIER
                     CDLEIYQLKQEIQILKDTKPQVQTREVVQEILQFQEDPQTKKEVESLRIQLSEEKKKL
                     VDLEGEQASQEEKIKRKEEELAQGKERIVRQEVVQYEDEPDLRAEVTAFTDSIDVELR
                     QIDKLCVELRRLQHRRAELERQLEELERERQARRAAELEVQRLQQRLAALEQEEAKTG
                     EKVTHTQKVVLQQDPQQTREHALLRAQLEEERHRRQLLEGELEPLRRKLAALEKTEIK
                     EKVVFSESVQVEKGDTEQEIQRLKKSLEEESRSKRELDSEVTRLEAKLSELEFYNSKS
                     SKELDFLREENHKLQLERQNLQLETRRLQSEIEMAATETRDLKNITMVDSGTHLNSRL
                     WSLEKELDDLKKMSKDKDLEIDELQRRLGSVAVKREQRENHLRRSIVVIDPDTGRELS
                     PEEAHRAGLIDWKMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEDALQSG
                     RLTPAQYDRYVNKDMSIQELAVLVSGQK"
     exon            140..239
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            240..394
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            395..515
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            516..635
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            636..677
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            678..839
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            840..947
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1043
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1166
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1313
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1465
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1563
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1721
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1900
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2039
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2233
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2384
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2468
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2585
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2678
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..6281
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctgagccc gccgccggct ttcggtgcgc gccgggcccg tagccgcgtt ccaggtccct
       61 ccgtccccag cgccaccatg cactcgctct tcaggaagaa aaacaaaggc aaatacagcc
      121 caacggtgca gacgcggagc atctccaaca aggaactctc agatctgatt gagcagctgc
      181 agaagaatgc ggaccaggtg gaaaggaaca ttgtggacac cgaggccaag atgcagagtg
      241 acttggcccg gatgcaagac gggcagctcc ctgagcaccg ggacgcgacc ctgcagaatg
      301 tgtctgactc agaaaagctg ctgtacgtac tggaggcaga ctcagccatc gccaagcaca
      361 tgaagcaccc acagggggac atgatcgccg aggacatccg ccagctgaaa gagcgtgtga
      421 ccaacctgcg gggcaaacac aagcagatgt acagcctggc agtgagagag gctgacccga
      481 aggtcaactg ggatgcactg gtggatgaga aactggacaa gctgagcagc cagagttttg
      541 ggactgacct tcctctggtg gacagccagg tggagcaaca caacatcttc cacaatgaag
      601 tcaaagccat cgggccccac ctggccaagg acaaggagca gaacagcgaa ctccaagcca
      661 agtatcagaa gttgctggca gcatcacagg ctcggcagca gcacctgagc tcgctgcagg
      721 attacatgca gcgctgcacc aatgagctgt actggctgga ccagcaagcc aagggccgca
      781 tacagtatga ctggagtgac cgcaacctcg actaccccag ccgccggcgc cagtacgaga
      841 atttcatcaa ccggaacctg gaggccaaag aagagagaat caacaaactg cacactgaag
      901 gcgaccagct gctgacagcc gagcacccgg ggaggaactc cattgaggca cacatggagg
      961 cggtgcacgc ggagtggaag gagtacctga acctgctcat ctgtgaggag agccacctga
     1021 aatacatgga agactatcac caatttcaca aagatatgaa ggatgctcag gaactgctgc
     1081 gcaaggtgga ctcagacttg aaccagaaat acagccctga cttcaaagac cgatatcaga
     1141 tagagctgtt gcttcgggag ctggatgacc aggagaaggc tctggacaag tatgaggatg
     1201 tggtgcgggg gctgcagaag cgagggcagc aagtgctgcc actcaagtac cggcgtgaga
     1261 cgccactcaa gcccatccct gtggaggccc tctgtgactt tgagggtgac cagggcctaa
     1321 tctcccgggg ctacagctac acgctgcaga agaacaacgg ggagagctgg gagctgacag
     1381 acagcactgg gaagaagctg atggccccag ctgtctgctt catcattccc cccaccgacc
     1441 ccgaggcctt ggctctctcg gacagcctgg gcagccagta ccggagtgtg cggcagaagg
     1501 cggccgggag caaacacgcg ctccagcagc ggcatgaggt gctaaggaca gagaaccctg
     1561 gagatgcctc cgatcttcag gggcgacagc tgctggctgg cttggaccaa gtggccagtg
     1621 acctggaccg gcaggagaag gctatcacgg ggatcctacg gccacccctt gagcagggac
     1681 gggcaataga agatagtgct gagcgggcca agcacctcaa gaacattacc aatgagctgc
     1741 tacagattga gccagagaag atacagcgca cagctgagtg tgaggccttc gtgcaggccc
     1801 tcccgggcag tggcaccaca cccttgctga agacccgggt ggaagatacc aaccagaaat
     1861 ataagcgact ggtacagctg ctagaagcag cccaggagaa ggtggatgtt gccaaccgcc
     1921 tggagaacag tctgcaacgg ggcagggagc tgctggcctc ccacgagaac aggctgatgc
     1981 aggatgacac aatacctgaa agtgactaca tgttggacag caagaggcag gagctagagg
     2041 ccatggcttc tgagctgcag gcccagaagt ccctcctggg tgaggtggaa cagaacctgc
     2101 aggtggccaa gcagtgctcc agctcactgg ccagccgctt ccaagagcac tgccctgacc
     2161 tggagcgcca ggaggctgag gtacacaagc tcaaccagcg tttcaacaac ctcaatcagc
     2221 aggtggaacg cagggcccag agcctgcaga gtgccaggga tgcctacagt gaatactgcc
     2281 gaggttatga ccatgtgctt cagttcttgg tcaagactcc cagttatgag ccccaggaga
     2341 cagacagcct cagccagatg gagaccaaac tgaagaacca gaagaacttg cttgatgaga
     2401 tagcaagcat ggaacaaggg gcgcagaagg tctacgcaga ctcccaacag taccagcaag
     2461 cagtgaagga ctatgagctt gaagcagaga agctaaggtc cctgctggac ctggagaacg
     2521 gacggaacag ccatgtgaac aagagagcca ggctgcagtc tcctgctgcc aaagtgaagg
     2581 aagaggaagc tgctcttgct gccaagttca cagaagttaa tgccatcaac agacagaggc
     2641 tacaaaattt ggagtttgca ctgaatctct tgagacagca accagaggca ggagtgaccc
     2701 atgagactct gcaagggaga gagcaaggct ctggcatgga ggaaacatgg aagattcaga
     2761 aggaactgga ggaggagatg gagcgaaggc aacagttgga aaatgaggtc aagagtgccc
     2821 aggaagaaat ccagaccctg aaggatcagg gtcctcagga atcattggtg aggaaggagg
     2881 tgctgaagaa ggtgccagac cctgccctgg aggagagctt ccagcagctg cagcagaccc
     2941 tggctgagga acagcacaag aaccagctgt tgcaggagga gctgggagca ctgcagctcc
     3001 ggctgcaggc cctagaacag gagaccaggg atgggggaca agagtatgtg gtcaaggagg
     3061 tcttgcgcat tgagccagac agagcccagg aggatgaggt tttacagctt cgggaggagc
     3121 tggagggact acggcgccag aaaggtgccc gagaggctga ggtactactc ttacagcagc
     3181 gcgtagcagc cctagctgct gagaagagca gggtacagga aaaggtcact gagagagagg
     3241 tggtaaagct acagaatgac cctcagctgg aggcagaata ccggaggcta caggaggaac
     3301 accaacggga aggtacactc agggagaagc aggaagagga gctgagtttc ctacaggcca
     3361 agctcaggag actggagaaa gaacgagcca tggcagaagg caagatcact gtcaaagagg
     3421 tgctcaaagt agagaaagat acagctgcag agagggaagt caatgacctc agccgccagt
     3481 atgaggatga ggcttccaag gctcgcacta gccagcggga gaagacagag cttctcagaa
     3541 agatatgggc cctggaagaa gaaaatgcca aggtggtggt acaggagaag gtccgagaga
     3601 ttgtgcggcc agatcccaag gcagagagtg aagtggccaa cctccgcctg gagctggtgg
     3661 agcaggagcg caaattcaga ggtgctgagg agcagctgaa gagctaccag agtgagctgg
     3721 aggccctacg gaaccgcggg ccacaagtag aagtcaaaga ggtgaccaaa gaggtcatta
     3781 aatacacaac tgacccagag acggagcagg aactccagcg actcagggag gagatcatgg
     3841 acaagaccag gttaatagaa aggtgtgact tagagattta tcagctgaag caggagatcc
     3901 aaatcctgaa agacaccaag ccacaggtgc agactagaga ggtggtccag gagatcctgc
     3961 agttccagga agacccccaa accaagaagg aggtagagtc tctgcgtata cagctgtcag
     4021 aagaaaagaa gaaactggtg gacctggaag gggagcaggc atcccaggaa gagaagatca
     4081 aacgcaagga ggaagagctg gcccagggta aggaaaggat tgtacgccag gaggtggtac
     4141 agtatgaaga tgagccagat ttgcgggctg aggtgactgc cttcacagac agcattgatg
     4201 ttgagctgag gcagattgat aaactgtgtg tggagctacg gcggctacag catcgcagag
     4261 cagagctgga gaggcagctg gaggagctgg agcgtgagag gcaggcacgt agggcagctg
     4321 agctggaggt gcagaggctg caacagcggc tggctgcact ggagcaagag gaggccaaga
     4381 ctggtgagaa agtgacccac acacaaaagg tggtgctgca gcaggaccca cagcaaacca
     4441 gggaacatgc cctgctccga gcccagctgg aggaagagcg acaccggagg cagctactgg
     4501 agggtgagct tgagcccctg cgtagaaagt tggctgccct ggagaagaca gagatcaaag
     4561 aaaaggtggt cttctccgag agtgtccagg tagaaaaggg tgacactgag caagagatcc
     4621 agcggctcaa gaagagcctg gaagaggaga gccggagcaa gagggagcta gattcagagg
     4681 tgacccggct ggaagccaag ttatctgagc tagaattcta caattccaag tcatccaagg
     4741 aactggattt cctgagagaa gaaaaccaca agctacagct agagcggcaa aacctgcagc
     4801 tagagacccg gagactccaa tcagagattg agatggccgc aacagaaact cgagatctga
     4861 agaacataac catggtagac tctggaaccc acctaaactc taggctgtgg tccctagaga
     4921 aggaactgga tgacctcaag aagatgtcca aggacaagga tctggagatc gatgaactgc
     4981 agaggcgtct gggctctgta gccgtcaaga gggagcagag ggagaaccac ctgaggcgct
     5041 ccatagtggt cattgaccct gacacaggtc gtgagctgtc cccagaggag gcccaccggg
     5101 ctgggctcat cgactggaaa atgttcgtga agctcagaag ccaggagtgt gactgggaag
     5161 agatatcagt gaaaggtcct aatggggagt catcagtaat ccatgacagg aagtctggca
     5221 agaagttttc cattgaggat gctctgcaga gtggcaggct aacccctgct caatatgacc
     5281 gctatgtcaa caaggatatg tccattcagg agctggcagt cttggtgtct gggcagaagt
     5341 agatccagcc cttctgcctg gcttttcttg gaggtggttg gctaactcgt tctcagcaac
     5401 ttcctgggtg tcttctgctc cctagcccta atacagactt ctgagctgtt ttgtcctcac
     5461 tgtatcaggc tgcttatagt gcagctattg taataccagc agataccagc tgagtatata
     5521 ctcagtcagt ctgagtgacc tgctcccacc tctgatgact taatagcctt ggtatcttct
     5581 ctctctttcc tacatgttcc catcaccagt gccacagctg gaaaccacag caggagaaaa
     5641 tagacacact caacaagaca gcatgggctt ttgtggtatc acatgacact gaaggcagac
     5701 tacctccttt ctgcctcttt caactcaaga ctggtccact ggggctgctg accttccttc
     5761 ttgccattcc attttcctga ctgggatcca actatcagca gtgcttgctc agtagtgatt
     5821 cttctcattg aacagactgg gctctacact agaacatgtg tccagaatcc acaatgcctg
     5881 gctcgtggtg ctagaataac tagccaggat gtgccagaaa gacaggcacc aacaactgtc
     5941 tgctagctct gaaatgaaaa gagcttggta ctggatggtg tgctagtctt actttcagtg
     6001 cctcacaggt cttcattatc tcattggcac ttagatatac aaaagctgat tgttcaccaa
     6061 atgaatttct gcttctctgt atttcatgta ttatgtaaga aaatgggagt gatagggaac
     6121 tttatttatg gcatgaaaat aaaaatctgg tggcttgatt ctaactcaaa gcaagtatga
     6181 atcctttaca catgaggctg atccttggct ctcacaccag ggctccactg cactgaagaa
     6241 tcacttgcaa atacaatggc aatgaaaaat gaggaaagac a
//
