LOCUS       NP_001100446            1754 aa            linear   ROD 26-FEB-2024
DEFINITION  periplakin [Rattus norvegicus].
ACCESSION   NP_001100446 XP_001079075 XP_220174
VERSION     NP_001100446.1
DBSOURCE    REFSEQ: accession NM_001106976.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1754)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1754)
  AUTHORS   Pyle AL, Li B, Maupin AB, Guzman RJ, Crimmins DL, Olson S, Atkinson
            JB and Young PP.
  TITLE     Biomechanical stress induces novel arterial intima-enriched genes:
            implications for vascular adaptation to stress
  JOURNAL   Cardiovasc Pathol 19 (2), e13-e20 (2010)
   PUBMED   19211270
REFERENCE   3  (residues 1 to 1754)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (residues 1 to 1754)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (residues 1 to 1754)
  AUTHORS   Murdoch H, Feng GJ, Bachner D, Ormiston L, White JH, Richter D and
            Milligan G.
  TITLE     Periplakin interferes with G protein activation by the
            melanin-concentrating hormone receptor-1 by binding to the proximal
            segment of the receptor C-terminal tail
  JOURNAL   J Biol Chem 280 (9), 8208-8220 (2005)
   PUBMED   15590649
  REMARK    GeneRIF: Periplakin interferes with G protein activation by the
            melanin-concentrating hormone receptor-1 by binding to the proximal
            segment of the receptor C-terminal tail
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474017.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001079075.1, XP_220174.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132293 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     Protein         1..1754
                     /product="periplakin"
                     /calculated_mol_wt=204017
     Region          213..387
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            317..322
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          388..451
                     /region_name="SH3_10"
                     /note="SH3 domain; pfam17902"
                     /db_xref="CDD:407754"
     Region          <583..>1134
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          902..1638
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <1655..1683
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     CDS             1..1754
                     /gene="Ppl"
                     /coded_by="NM_001106976.1:78..5342"
                     /db_xref="GeneID:302934"
                     /db_xref="RGD:1305511"
ORIGIN      
        1 mhslfrkknk gkysptvqtr sisnkelsdl ieqlqknadq vernivdtea kmqsdlarmq
       61 dgqlpehrda tlqnvsdsek llyvleadsa iakhmkhpqg dmiaedirql kervtnlrgk
      121 hkqmyslavr eadpkvnwda lvdekldkls sqsfgtdlpl vdsqveqhni fhnevkaigp
      181 hlakdkeqns elqakyqkll aasqarqqhl sslqdymqrc tnelywldqq akgriqydws
      241 drnldypsrr rqyenfinrn leakeerink lhtegdqllt aehpgrnsie ahmeavhaew
      301 keylnllice eshlkymedy hqfhkdmkda qellrkvdsd lnqkyspdfk dryqielllr
      361 elddqekald kyedvvrglq krgqqvlplk yrretplkpi pvealcdfeg dqglisrgys
      421 ytlqknnges weltdstgkk lmapavcfii pptdpealal sdslgsqyrs vrqkaagskh
      481 alqqrhevlr tenpgdasdl qgrqllagld qvasdldrqe kaitgilrpp leqgraieds
      541 aerakhlkni tnellqiepe kiqrtaecea fvqalpgsgt tpllktrved tnqkykrlvq
      601 lleaaqekvd vanrlenslq rgrellashe nrlmqddtip esdymldskr qeleamasel
      661 qaqksllgev eqnlqvakqc ssslasrfqe hcpdlerqea evhklnqrfn nlnqqverra
      721 qslqsarday seycrgydhv lqflvktpsy epqetdslsq metklknqkn lldeiasmeq
      781 gaqkvyadsq qyqqavkdye leaeklrsll dlengrnshv nkrarlqspa akvkeeeaal
      841 aakftevnai nrqrlqnlef alnllrqqpe agvthetlqg reqgsgmeet wkiqkeleee
      901 merrqqlene vksaqeeiqt lkdqgpqesl vrkevlkkvp dpaleesfqq lqqtlaeeqh
      961 knqllqeelg alqlrlqale qetrdggqey vvkevlriep draqedevlq lreeleglrr
     1021 qkgareaevl llqqrvaala aeksrvqekv terevvklqn dpqleaeyrr lqeehqregt
     1081 lrekqeeels flqaklrrle keramaegki tvkevlkvek dtaaerevnd lsrqyedeas
     1141 kartsqrekt ellrkiwale eenakvvvqe kvreivrpdp kaesevanlr lelveqerkf
     1201 rgaeeqlksy qselealrnr gpqvevkevt kevikyttdp eteqelqrlr eeimdktrli
     1261 ercdleiyql kqeiqilkdt kpqvqtrevv qeilqfqedp qtkkeveslr iqlseekkkl
     1321 vdlegeqasq eekikrkeee laqgkerivr qevvqyedep dlraevtaft dsidvelrqi
     1381 dklcvelrrl qhrraelerq leelererqa rraaelevqr lqqrlaaleq eeaktgekvt
     1441 htqkvvlqqd pqqtrehall raqleeerhr rqllegelep lrrklaalek teikekvvfs
     1501 esvqvekgdt eqeiqrlkks leeesrskre ldsevtrlea klselefyns ksskeldflr
     1561 eenhklqler qnlqletrrl qseiemaate trdlknitmv dsgthlnsrl wslekelddl
     1621 kkmskdkdle idelqrrlgs vavkreqren hlrrsivvid pdtgrelspe eahraglidw
     1681 kmfvklrsqe cdweeisvkg pngessvihd rksgkkfsie dalqsgrltp aqydryvnkd
     1741 msiqelavlv sgqk
//
