LOCUS       NM_001419966            5412 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus diphosphoinositol pentakisphosphate kinase 2
            (Ppip5k2), mRNA.
ACCESSION   NM_001419966 XM_039084893
VERSION     NM_001419966.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5412)
  AUTHORS   Wang,H., Falck,J.R., Hall,T.M. and Shears,S.B.
  TITLE     Structural basis for an inositol pyrophosphate kinase surmounting
            phosphate crowding
  JOURNAL   Nat Chem Biol 8 (1), 111-116 (2011)
   PUBMED   22119861
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5412)
  AUTHORS   Fridy,P.C., Otto,J.C., Dollins,D.E. and York,J.D.
  TITLE     Cloning and characterization of two human VIP1-like inositol
            hexakisphosphate and diphosphoinositol pentakisphosphate kinases
  JOURNAL   J Biol Chem 282 (42), 30754-30762 (2007)
   PUBMED   17690096
REFERENCE   3  (bases 1 to 5412)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 24, 2023 this sequence version replaced XM_039084893.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1633737.1,
                                           SRR26643293.52423.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000009.1  105762535-105762734
            201-598             JAXUCZ010000009.1  105774478-105774875
            599-794             JAXUCZ010000009.1  105776814-105777009
            795-885             JAXUCZ010000009.1  105779104-105779194
            886-971             JAXUCZ010000009.1  105780110-105780195
            972-1126            JAXUCZ010000009.1  105780881-105781035
            1127-1228           JAXUCZ010000009.1  105783209-105783310
            1229-1390           JAXUCZ010000009.1  105784871-105785032
            1391-1512           JAXUCZ010000009.1  105785843-105785964
            1513-1614           JAXUCZ010000009.1  105786308-105786409
            1615-1701           JAXUCZ010000009.1  105787416-105787502
            1702-1777           JAXUCZ010000009.1  105788527-105788602
            1778-1887           JAXUCZ010000009.1  105789940-105790049
            1888-1973           JAXUCZ010000009.1  105790991-105791076
            1974-2099           JAXUCZ010000009.1  105793924-105794049
            2100-2221           JAXUCZ010000009.1  105794165-105794286
            2222-2404           JAXUCZ010000009.1  105794473-105794655
            2405-2546           JAXUCZ010000009.1  105799506-105799647
            2547-2770           JAXUCZ010000009.1  105800480-105800703
            2771-2898           JAXUCZ010000009.1  105803803-105803930
            2899-3013           JAXUCZ010000009.1  105804772-105804886
            3014-3121           JAXUCZ010000009.1  105806313-105806420
            3122-3238           JAXUCZ010000009.1  105806510-105806626
            3239-3403           JAXUCZ010000009.1  105811059-105811223
            3404-3476           JAXUCZ010000009.1  105814945-105815017
            3477-3617           JAXUCZ010000009.1  105821704-105821844
            3618-3743           JAXUCZ010000009.1  105823029-105823154
            3744-5412           JAXUCZ010000009.1  105826744-105828412
FEATURES             Location/Qualifiers
     source          1..5412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..5412
                     /gene="Ppip5k2"
                     /note="diphosphoinositol pentakisphosphate kinase 2"
                     /db_xref="GeneID:501194"
                     /db_xref="RGD:1590765"
     exon            1..200
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            201..598
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..3856
                     /gene="Ppip5k2"
                     /EC_number="2.7.4.24"
                     /codon_start=1
                     /product="inositol hexakisphosphate and
                     diphosphoinositol-pentakisphosphate kinase 2"
                     /protein_id="NP_001406895.1"
                     /db_xref="GeneID:501194"
                     /db_xref="RGD:1590765"
                     /translation="MSEAPRFFVGPEDAEINAGNYRRFFHHADEEEEEEEESPPERQI
                     VVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEDVILNEPVGDWPLCDCLISFHS
                     KGFPLDKAVAYAKLRNPFVINDLNMQYHIQDRRDVYSILQAEGILLPRYAILNRDPNN
                     PKECSLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSR
                     SSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSE
                     GKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKY
                     YDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDR
                     TPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLMELGQNNDS
                     DIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDNRREEPSLLLV
                     LKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASD
                     EGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLH
                     EILQKDRDFTAEDYEKLTPSGSISVIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRME
                     DPKSADIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSL
                     KLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDT
                     VNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCDESKDEQWKRAMDY
                     LNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRP
                     ASRENEGRRSLRADDDEPHTSRRDEVDRAVMLFKPLVSEPIHIHRKSPLPRSRKMTSN
                     EVVSENTNYLRAPRALVEQKQNPTVGFELYSMVPSICPLETLHNALFLKQVDDFLASI
                     ASPSTEVLRKVPEMSSVASRSSPGIRRKISLNTYTPTKILPTPPAAVKSTKASSKAAA
                     GGPSLAMASHTSSRKKSLSSKTEGHEPKKSTGKKR"
     exon            599..794
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            795..885
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..971
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1126
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1228
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1390
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1512
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1614
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1701
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1777
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1887
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1973
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2099
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2221
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2404
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2546
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2770
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2898
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3013
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3121
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3238
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3403
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3476
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3617
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..3743
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..5412
                     /gene="Ppip5k2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcgtgt ccgaggttct cgaggtgtac ccgtgccagc cgttccgctg ttgctggaga
       61 ggaagattca ggtccacgcc tccgagagcg gcctctgtac gaacatccta tccttgtccc
      121 cgcaattaaa ggggaggaac cgaaacctgg atgggctcag gcatctgcca cagatcgctg
      181 gatgaccgca gccgtggcag gtgaaaagag gacatctgtt ccaaccctgg ggaagcagta
      241 gcctcattgt ccttgccatt ttaaactgca gcagcaactt ggagttcaac aatgaagcaa
      301 tgatatctga gaacaaagga gctcttgcca gctaaatgtc agcgcatctc atgtgattag
      361 ataaaacact gcagcagacc tgcgtgtcag ccagcacagt gaggatgtgt tcttctgaca
      421 ccttttgttg gaagcagctt taggatagat tatttaaact ttatgtatat gaaatccagt
      481 aaaaatgagc gaagccccca gattctttgt tgggcctgaa gatgcggaaa tcaatgctgg
      541 aaactaccgt cgcttcttcc accatgctga tgaagaggag gaggaggagg aggagtctcc
      601 accagaaagg cagattgtgg ttggaatatg ttccatggcc aagaaatcca aatccaaacc
      661 catgaaggaa attttggaac ggatctcctt gtttaagtac atcacagtcg tggtttttga
      721 ggaggacgtg atcttgaatg agcccgtggg tgactggcct ctgtgtgact gcctcatctc
      781 tttccactcg aaaggatttc cactggacaa agcagttgcc tatgcaaaac tcaggaatcc
      841 atttgtaatc aatgacttga atatgcagta tcacatacaa gatagaagag atgtttatag
      901 cattcttcaa gctgaaggca tcctacttcc tcggtatgca attctgaacc gtgatccaaa
      961 taacccgaaa gaatgcagcc tgattgaagg agaagatcac gtggaagtga atggggaagt
     1021 tttccaaaag ccatttgtgg aaaagccggt cagtgccgaa gaccacaatg tttacattta
     1081 ttacccgaca tctgccggag gtggaagtca gagacttttc aggaagatcg gcagtagaag
     1141 tagtgtgtat tccccagaaa gcagcgtgcg aaaaacgggg tcatatatat atgaagaatt
     1201 tatgcctaca gacggtactg acgttaaggt ttataccgtg ggtccagact acgctcatgc
     1261 tgaagctcga aagtctcccg ctcttgatgg caaggtagag cgagacagcg aagggaagga
     1321 agtaagatac cctgtcattc tcaatgcacg cgagaagctg atcgcatgga aagtctgcct
     1381 tgcttttaag caaacagtct gtggctttga tttgttacgc gccaacggac agtcctacgt
     1441 gtgcgacgtc aatggcttca gttttgtgaa aaattccatg aagtactatg atgactgtgc
     1501 aaaaatcctt ggcaatatcg tgatgcggga gcttgcgcca cagtttcata tcccctggtc
     1561 cataccgtta gaggctgaag acattccaat tgtgccaact acctctggaa cgatgatgga
     1621 gctccgatgt gtcatagctg tgatacgaca cggggatcgc acaccaaaac agaaaatgaa
     1681 aatggaagtg aggcatcaga agttttttga tctttttgaa aagtgtgatg gatataagtc
     1741 agggaagtta aagctcaaga agccaaaaca attacaggaa gtcctggata ttgcccggca
     1801 acttcttatg gagctgggac aaaacaatga ctctgacatc gaagaaaaca aatcaaagct
     1861 ggagcagctc aagactgtgc tagagatgta tggtcatttt tcaggaataa accgtaaggt
     1921 ccaattgacc tatctccctc atggttgtcc aaaaacatcc agtgaagagg aagataaccg
     1981 aagagaggag ccgtccttac ttttggttct aaaatgggga ggagaactga cccctgcggg
     2041 cagggttcag gctgaagagc tgggaagagc ttttcggtgt atgtaccctg gaggtcaagg
     2101 agattatgca ggatttcctg gttgtggttt actccgactg catagcacct acagacacga
     2161 cctcaaaata tatgcctctg atgaagggcg ggtccagatg acggcagctg ccttcgcaaa
     2221 gggtctcttg gctctagaag gagagcttac ccccattctg gttcagatgg tgaaaagtgc
     2281 aaatatgaac ggccttttgg acagcgacag tgactctttg agtagctgtc agcagcgtgt
     2341 gaaagcgagg cttcatgaga tacttcagaa agacagagat tttacagccg aagactacga
     2401 gaagcttact ccatctggaa gcatttctgt tatcaaatca atgcatctaa ttaaaaaccc
     2461 agtgaaaacc tgtgacaaag tatattccct gattcaaagt ttgacttccc aaatcagaca
     2521 tcggatggaa gatcccaaat cagctgatat tcagctctac catagtgaga cgctggaact
     2581 tatgctgcgt agatggtcca agttggagaa ggactttaaa acaaagaatg gaagatatga
     2641 tatcagtaag atccctgata tatatgactg catcaaatac gatgttcagc ataacggttc
     2701 cttgaagtta gaaaatacaa tggaactata caggctttca aaggcattag cagatattgt
     2761 tatccctcag gaatatggta taacaaaagc tgaaaaactg gagattgcca aagggtactg
     2821 tactccacta gttagaaaaa tccgatcaga tcttcagagg acacaagatg atgacactgt
     2881 caataaactc catcctgtgt attctagagg cgttctgtct cccgaaaggc acgtccgcac
     2941 cagattgtac tttaccagtg agagtcatgt gcattcctta ctgtccattc tccgctatgg
     3001 cgccttgtgc gatgaatcga aggatgagca gtggaaacga gcgatggatt atctaaacgt
     3061 tgtcaatgag ctcaactaca tgacacagat cgttatcatg ctctacgagg atcctaacaa
     3121 ggatctgtcc tcagaggagc gctttcatgt tgagttacac tttagtcctg gggccaaagg
     3181 ctgtgaagaa gataagaatc tgccgtccgg ctacgggtac cggccggctt ccagggagaa
     3241 cgaaggcagg aggtctttaa gagctgatga tgacgagcct cacacttcta gaagagatga
     3301 agtggatcgg gctgtgatgc tgtttaaacc attggtgtca gagccaattc atatccacag
     3361 gaagtcacca cttccgaggt ccaggaagat gacttccaat gaagtggttt ctgaaaacac
     3421 caactatctc cgagcaccca gagctcttgt ggaacagaag cagaacccta ccgtaggctt
     3481 tgagctgtat tccatggtac catccatctg tcctctagaa acccttcaca atgccctgtt
     3541 tttaaagcaa gtggatgact ttcttgcttc tattgcttct ccatcaactg aagttctccg
     3601 caaggtccct gaaatgtcat ctgtggcctc acggtccagt ccaggaataa gaagaaagat
     3661 ttccctaaat acatacacac ctacgaagat cctcccaaca ccgcctgctg ctgtaaagag
     3721 caccaaagca agcagcaaag cagcagctgg cggaccgtct ctggcaatgg cttctcatac
     3781 ctcatctcgg aagaagagct taagtagcaa aactgagggg catgaaccca agaaaagcac
     3841 tgggaagaaa agatgagcac acagcagaac tggaagttcc catgcttaga aagggacttg
     3901 ttgcttagta aaggatttgc aggaaacctt gactgactga agctggtccg agccagtgac
     3961 tcacatgttg ccctgcttta ctttatccat ctgtgtatgt ctttaaacac cccggaagct
     4021 agagaccttc tgtttttatt cagacaagga gctttggcag gatgtagaaa tgctcaaaat
     4081 aatgtctgtc cgctttgtgt aatgaattca tgacaactgc tatggctgtc actgtgagat
     4141 tgccatgtgc ctatggcaga gacaaaggac acagagatcc ggctgaccat tacccaagtg
     4201 ccctgtctca ggtgcctctt gacaccacgc tcgcatttcg acaggattgc acgtactgac
     4261 attggacagg caagaccaca cgtcgatgac tgttttaaaa gtacatttcc aaagagatct
     4321 cgttgaccat ttacattaga atttttttgt catttttaca gtaacatatg ctgcaatatt
     4381 tattgactgg attatataga ccatgaatta ttttttcaat ttgtgctttg aattttttat
     4441 tgtgaattat ttaaaatctt acaaatccaa gtgggagaac tataccttta tacacataaa
     4501 tttacaagtt aatctgtaga aaatattttc tttatacatt tctttaccat gaagaaaaat
     4561 ttcttggttc atcaagaaaa aatttttctg tattagcaag agaggcattt ttagagtttc
     4621 tttttttatg aactgtaact gctaaattcg taaatcttat gcttgatttt ctgagttttc
     4681 cgtgagacct atggactcag atctaaaacg ggcaggcatt ctgctgttgg tgtcatccat
     4741 ggtatatttc ttgtgttctc attcttatgt ctagtgtatt cattgatttc accaagaaaa
     4801 ctcaaaaggt tgaacatttg cagtaagtaa atggtgttta caaatgatga gatttggaag
     4861 aaagattgag atgactatag taattttatc taatattaaa aaaaaaagaa ggaaatcatt
     4921 ctccttggta ctttttctcc ttgatgcata agtaattgtt tgaaacattt gaaatggctt
     4981 acaaactaaa cagcctgcta aaaaaaaatc ccagacactg gatgtgatgt aacttaaggt
     5041 agtgagctgt agcttcaagc ttgtgtttag aagttctgag cccttattgt ataaatactt
     5101 cattgtaatt cttcaaaaga gacttctaac cttaaatcat cctctatgaa ctgacttcta
     5161 gagaatagac gtattatctt ggttgtttaa aaagggatgg atggggtaca gaagttccaa
     5221 atatatacat gtagataagt tcatctactt cacttgaatg tcaatggatt acatggtgac
     5281 aaatcttgta aacaattgaa tgtacgtaca ttttctgtat gtgaatatgt gcttaatgta
     5341 ctcattatgg ggggtgagga gactaccttt attttttaag tggaatgaat taaaatcctt
     5401 tgtagaataa ga
//
