LOCUS       NM_172243               1485 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus peptidylprolyl isomerase F (Ppif), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_172243
VERSION     NM_172243.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1485)
  AUTHORS   Shinohe,D., Kobayashi,A., Gotoh,M., Tanaka,K. and Ohta,Y.
  TITLE     Long-term inhibition of cyclophilin D results in intracellular
            translocation of calcein AM from mitochondria to lysosomes
  JOURNAL   Arch Biochem Biophys 613, 53-60 (2017)
   PUBMED   27864141
  REMARK    GeneRIF: cyclophilin D may modify mitochondrial features by
            inducing the translocation of molecules to the mitochondria through
            the mechanism associated with cellular energy metabolism
REFERENCE   2  (bases 1 to 1485)
  AUTHORS   Folda,A., Citta,A., Scalcon,V., Cali,T., Zonta,F., Scutari,G.,
            Bindoli,A. and Rigobello,M.P.
  TITLE     Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D
            Redox State
  JOURNAL   Sci Rep 6, 23071 (2016)
   PUBMED   26975474
  REMARK    GeneRIF: Data show that the redox state of cyclophilin D was
            stimulated by thioredoxin 1 and 2 and peroxiredoxin 3 in heart
            mitochondria.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1485)
  AUTHORS   Shanmughapriya,S., Rajan,S., Hoffman,N.E., Higgins,A.M., Tomar,D.,
            Nemani,N., Hines,K.J., Smith,D.J., Eguchi,A., Vallem,S., Shaikh,F.,
            Cheung,M., Leonard,N.J., Stolakis,R.S., Wolfers,M.P., Ibetti,J.,
            Chuprun,J.K., Jog,N.R., Houser,S.R., Koch,W.J., Elrod,J.W. and
            Madesh,M.
  TITLE     SPG7 Is an Essential and Conserved Component of the Mitochondrial
            Permeability Transition Pore
  JOURNAL   Mol Cell 60 (1), 47-62 (2015)
   PUBMED   26387735
REFERENCE   4  (bases 1 to 1485)
  AUTHORS   Vaseva,A.V., Marchenko,N.D., Ji,K., Tsirka,S.E., Holzmann,S. and
            Moll,U.M.
  TITLE     p53 opens the mitochondrial permeability transition pore to trigger
            necrosis
  JOURNAL   Cell 149 (7), 1536-1548 (2012)
   PUBMED   22726440
REFERENCE   5  (bases 1 to 1485)
  AUTHORS   Chinopoulos,C., Konrad,C., Kiss,G., Metelkin,E., Torocsik,B.,
            Zhang,S.F. and Starkov,A.A.
  TITLE     Modulation of F0F1-ATP synthase activity by cyclophilin D regulates
            matrix adenine nucleotide levels
  JOURNAL   FEBS J 278 (7), 1112-1125 (2011)
   PUBMED   21281446
REFERENCE   6  (bases 1 to 1485)
  AUTHORS   Li,Y., Johnson,N., Capano,M., Edwards,M. and Crompton,M.
  TITLE     Cyclophilin-D promotes the mitochondrial permeability transition
            but has opposite effects on apoptosis and necrosis
  JOURNAL   Biochem J 383 (Pt 1), 101-109 (2004)
   PUBMED   15233627
  REMARK    GeneRIF: The present study examines the effects of cyclophilin-D on
            mitochondrial permeability transition and lethal cell injury.
REFERENCE   7  (bases 1 to 1485)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1485)
  AUTHORS   Lin,D.T. and Lechleiter,J.D.
  TITLE     Mitochondrial targeted cyclophilin D protects cells from cell death
            by peptidyl prolyl isomerization
  JOURNAL   J Biol Chem 277 (34), 31134-31141 (2002)
   PUBMED   12077116
REFERENCE   9  (bases 1 to 1485)
  AUTHORS   Woodfield,K., Ruck,A., Brdiczka,D. and Halestrap,A.P.
  TITLE     Direct demonstration of a specific interaction between
            cyclophilin-D and the adenine nucleotide translocase confirms their
            role in the mitochondrial permeability transition
  JOURNAL   Biochem J 336 (Pt 2) (Pt 2), 287-290 (1998)
   PUBMED   9820802
REFERENCE   10 (bases 1 to 1485)
  AUTHORS   Connern,C.P. and Halestrap,A.P.
  TITLE     Purification and N-terminal sequencing of peptidyl-prolyl
            cis-trans-isomerase from rat liver mitochondrial matrix reveals the
            existence of a distinct mitochondrial cyclophilin
  JOURNAL   Biochem J 284 (Pt 2) (Pt 2), 381-385 (1992)
   PUBMED   1599421
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_172243.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U68544.1, BC086977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000016.1  1264001-1264221
            222-252             JAXUCZ010000016.1  1265329-1265359
            253-341             JAXUCZ010000016.1  1265838-1265926
            342-438             JAXUCZ010000016.1  1267797-1267893
            439-514             JAXUCZ010000016.1  1268513-1268588
            515-1485            JAXUCZ010000016.1  1269752-1270722
FEATURES             Location/Qualifiers
     source          1..1485
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1485
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CypD; PPIase"
                     /note="peptidylprolyl isomerase F"
                     /db_xref="GeneID:282819"
                     /db_xref="RGD:628670"
     exon            1..221
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..650
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CypD; PPIase"
                     /EC_number="5.2.1.8"
                     /note="peptidyl-prolyl cis-trans isomerase F,
                     mitochondrial; PPIase F; rotamase F; cyclophilin D;
                     cyclophilin F"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase F,
                     mitochondrial precursor"
                     /protein_id="NP_758443.1"
                     /db_xref="GeneID:282819"
                     /db_xref="RGD:628670"
                     /translation="MLALRCGPRLLGLLSGPRSAPLLLSTTRTCSDGGARGANSSSQN
                     PLVYLDVGADGQPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPAFM
                     CQAGDFTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKT
                     DWLDGKHVVFGHVKEGMDVVKKIESFGSKSGKTSKKIVITDCGQLS"
     exon            222..252
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            253..341
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            342..438
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            439..514
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            515..1485
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcgccct cgcccgaccc gtgacagcga tgctagctct gcgctgcggt ccccgcctgc
       61 tcggtctgct ctccggcccg cgctccgcgc cgctcctcct ctccacgacc cgtacctgca
      121 gcgacggcgg agcccgaggc gcgaactctt cctcccaaaa cccgctcgtg tacttggacg
      181 tgggcgccga cggacagccg ctcggccgcg tggtgctgga gttaaaggca gatgtcgtgc
      241 caaagacagc agagaacttc agagccctgt gcactggtga gaagggcttt ggctacaaag
      301 gctccacctt ccacagggtc atcccagcct tcatgtgcca ggctggcgac ttcaccaatc
      361 acaatggcac gggagggaag tccatctacg gaagccgctt tcctgacgag aacttcacac
      421 tgaagcacgt gggaccaggt gtcctgtcca tggcaaacgc aggccccaac accaatggct
      481 ctcagttctt tatctgcaca ataaagacag actggctgga tggcaagcat gttgtgtttg
      541 gccatgtcaa agagggcatg gatgttgtga agaaaataga atctttcggc tcaaaaagtg
      601 ggaagacatc taagaagatt gtcatcacag actgtggcca gttgagctaa gtcacagcca
      661 aggtgctagg acagcagcag gcagccatgt cttggttcac ccaggtactc caaagaactg
      721 tttgtaccca cttctactga gtatgaggaa ggccacttgg gcacatggtc ccccacagga
      781 ccaggctgct ctcaactgtc catccttcct cagatccatt tctgggcatc agcatggcca
      841 ctgggccatg tatccttagc aagtgtctcg gtgattgcca ttgtgtgtgc cttggacatc
      901 ggcaatgctg accagttagt cagagaaggc tcctgccttt ttccttgacc agcggggaca
      961 gcagttgcta tttaatgttg tcttcctcat tgcaataatt taacaagatc tcataggaac
     1021 aaagctacta cactaactgc actgtcctat gtgtgacctg agttggcaca agccacagac
     1081 accccaccac caccaccacc accaccacca ccacctcccc gcctggcttc tgaaacataa
     1141 ctcagggctc ttgtgaaagt cccaccatca atgcctctcc ttctggtcac tgtgaatcct
     1201 gctggttggc tgctgtgatt ttctgaaagg agcctgtgaa atagaagcag ctggacctgg
     1261 ggacagacct gtgagccagg cctgtctgct caatgtgaat tcctgtgttg aaaacttaca
     1321 gaaactgcct gaattcatgc tctcctcaag agggaagtgt tttctggtag gctttgcttt
     1381 ttctgtatgt taaatcaatc aatcaatgat atatatgtag aagatttctg aacagtcctc
     1441 tgtgttcatc tcaaatgtga taaataaatc ctattttcta taaaa
//
