LOCUS       NM_001395726            1190 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus peptidylprolyl isomerase E (Ppie), transcript
            variant 1, mRNA.
ACCESSION   NM_001395726 XM_006238796
VERSION     NM_001395726.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1190)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   2  (bases 1 to 1190)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   3  (bases 1 to 1190)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1190)
  AUTHORS   Davis,T.L., Walker,J.R., Campagna-Slater,V., Finerty,P.J.,
            Paramanathan,R., Bernstein,G., MacKenzie,F., Tempel,W., Ouyang,H.,
            Lee,W.H., Eisenmesser,E.Z. and Dhe-Paganon,S.
  TITLE     Structural and biochemical characterization of the human
            cyclophilin family of peptidyl-prolyl isomerases
  JOURNAL   PLoS Biol 8 (7), e1000439 (2010)
   PUBMED   20676357
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1190)
  AUTHORS   Gaither,L.A., Borawski,J., Anderson,L.J., Balabanis,K.A., Devay,P.,
            Joberty,G., Rau,C., Schirle,M., Bouwmeester,T., Mickanin,C.,
            Zhao,S., Vickers,C., Lee,L., Deng,G., Baryza,J., Fujimoto,R.A.,
            Lin,K., Compton,T. and Wiedmann,B.
  TITLE     Multiple cyclophilins involved in different cellular pathways
            mediate HCV replication
  JOURNAL   Virology 397 (1), 43-55 (2010)
   PUBMED   19932913
REFERENCE   6  (bases 1 to 1190)
  AUTHORS   Mesa,A., Somarelli,J.A. and Herrera,R.J.
  TITLE     Spliceosomal immunophilins
  JOURNAL   FEBS Lett 582 (16), 2345-2351 (2008)
   PUBMED   18544344
  REMARK    Review article
REFERENCE   7  (bases 1 to 1190)
  AUTHORS   Wang,Y., Han,R., Zhang,W., Yuan,Y., Zhang,X., Long,Y. and Mi,H.
  TITLE     Human CyP33 binds specifically to mRNA and binding stimulates
            PPIase activity of hCyP33
  JOURNAL   FEBS Lett 582 (5), 835-839 (2008)
   PUBMED   18258190
REFERENCE   8  (bases 1 to 1190)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 1190)
  AUTHORS   Fair,K., Anderson,M., Bulanova,E., Mi,H., Tropschug,M. and
            Diaz,M.O.
  TITLE     Protein interactions of the MLL PHD fingers modulate MLL target
            gene regulation in human cells
  JOURNAL   Mol Cell Biol 21 (10), 3589-3597 (2001)
   PUBMED   11313484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 3, 2021 this sequence version replaced XM_006238796.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158560.1, SRR26360176.151268.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN09345238 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000005.1  140704294-140704347 c
            55-153              JAXUCZ010000005.1  140703268-140703366 c
            154-197             JAXUCZ010000005.1  140702241-140702284 c
            198-224             JAXUCZ010000005.1  140701587-140701613 c
            225-306             JAXUCZ010000005.1  140700158-140700239 c
            307-407             JAXUCZ010000005.1  140699636-140699736 c
            408-531             JAXUCZ010000005.1  140697633-140697756 c
            532-717             JAXUCZ010000005.1  140695124-140695309 c
            718-860             JAXUCZ010000005.1  140691795-140691937 c
            861-1190            JAXUCZ010000005.1  140691285-140691614 c
FEATURES             Location/Qualifiers
     source          1..1190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1190
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /note="peptidylprolyl isomerase E"
                     /db_xref="GeneID:298508"
                     /db_xref="RGD:1311411"
     exon            1..54
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..929
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidyl-prolyl cis-trans isomerase E; peptidylprolyl
                     isomerase E (cyclophilin E)"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase E isoform 1"
                     /protein_id="NP_001382655.1"
                     /db_xref="GeneID:298508"
                     /db_xref="RGD:1311411"
                     /translation="MATTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETE
                     KHRGFAFVEFELAEDAAAAIDNMNESELFGRTIRVNLAKPMRIKEGSSRPVWSDDDWL
                     KKFSGKTLEENKEEEGPEPPKAEAPEGEPAAKKARSNPQVYMDIKIGNKPAGRIQMLL
                     RSDVVPMTAENFRCLCTHEKGFGFKGSSFHRIIPQFMCQGGDFTNHNGTGGKSIYGKK
                     FDDENFILKHTGPGLLSMANSGPNTNGSQFFLTCDKTDWLDGKHVVFGEITDGLDVLR
                     QIEAQGSKDGKPKQKVIIADCGEYM"
     exon            55..153
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /inference="alignment:Splign:2.1.0"
     exon            154..197
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /inference="alignment:Splign:2.1.0"
     exon            198..224
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /inference="alignment:Splign:2.1.0"
     exon            225..306
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /inference="alignment:Splign:2.1.0"
     exon            307..407
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /inference="alignment:Splign:2.1.0"
     exon            408..531
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /inference="alignment:Splign:2.1.0"
     exon            532..717
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /inference="alignment:Splign:2.1.0"
     exon            718..860
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1190
                     /gene="Ppie"
                     /gene_synonym="Ab1-210"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggaaac gggcgcgagc aagatggcca ccaccaagcg tgtgctgtac gtgggtgggc
       61 tggcagaaga ggtggacgac aaagttcttc atgcggcttt tatccctttt ggagacatca
      121 cagatattca gattcctctg gattatgaaa cagaaaaaca ccgaggattt gcttttgtgg
      181 agtttgagtt ggcagaggat gctgcagcag ctatcgacaa catgaatgaa tctgaactct
      241 ttggacggac aattcgtgtc aatttggcca agccaatgag aattaaagag ggctcttcca
      301 ggccagtttg gtcagatgat gactggttga agaagttttc tgggaagact cttgaggaga
      361 ataaagaaga agaaggacct gagcctccca aagctgaagc cccagaggga gagcccgctg
      421 caaaaaaagc ccggtcaaat cctcaagtgt acatggacat caagattggg aacaagccag
      481 caggccgaat tcaaatgctc ctacggtctg acgttgtgcc catgacagca gagaacttcc
      541 gttgcctgtg cacccatgag aagggctttg gcttcaaggg aagcagcttc caccgcatca
      601 tcccccagtt catgtgccag ggcggtgact tcacaaacca caacggcaca gggggcaagt
      661 ccatctatgg caagaagttc gatgatgaaa acttcatcct taaacacaca gggccaggcc
      721 tcctctccat ggccaattct ggcccaaaca ccaatggctc ccagttcttc ctgacctgtg
      781 ataagacaga ttggctggac ggcaagcatg tggtgtttgg ggagatcacg gacggcctgg
      841 atgtcttgcg gcagattgag gcgcagggca gcaaggacgg gaaaccaaag cagaaggtga
      901 tcattgctga ctgtggagag tacatgtgag gctctgctca tctctgtagg acagggtgaa
      961 ccgcctggtg tctgccctgg tgctgagtgg ttcctgagaa gtgagctgtg tatagcgtgt
     1021 gcctttcctt ggggtcacct gccttagcag ccagtcgtct gcactgttgg gttcttcggt
     1081 cacagctctg cccgaaagcc agcatgggca cagtgctgcc gccacctgcc ctgaactgtg
     1141 tagctgctgg gtggcgtctt tgctaaaata aactggtttt ctgtaccatt
//
