LOCUS       NM_001004279            1353 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus peptidylprolyl isomerase D (Ppid), mRNA.
ACCESSION   NM_001004279 XM_342265
VERSION     NM_001004279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1353)
  AUTHORS   Barreto-Torres,G., Hernandez,J.S., Jang,S., Rodriguez-Munoz,A.R.,
            Torres-Ramos,C.A., Basnakian,A.G. and Javadov,S.
  TITLE     The beneficial effects of AMP kinase activation against oxidative
            stress are associated with prevention of PPARalpha-cyclophilin D
            interaction in cardiomyocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 308 (7), H749-H758 (2015)
   PUBMED   25617357
  REMARK    GeneRIF: In cardiomyocytes the protective effects of
            metformin-induced AMPK activation against oxidative stress converge
            on mitochondria and are mediated, at least in part, through the
            dissociation of PPARalpha-CypD interactions.
REFERENCE   2  (bases 1 to 1353)
  AUTHORS   Jandova,J., Janda,J. and Sligh,J.E.
  TITLE     Cyclophilin 40 alters UVA-induced apoptosis and mitochondrial ROS
            generation in keratinocytes
  JOURNAL   Exp Cell Res 319 (5), 750-760 (2013)
   PUBMED   23220213
REFERENCE   3  (bases 1 to 1353)
  AUTHORS   Bourke,C.H., Raees,M.Q., Malviya,S., Bradburn,C.A., Binder,E.B. and
            Neigh,G.N.
  TITLE     Glucocorticoid sensitizers Bag1 and Ppid are regulated by
            adolescent stress in a sex-dependent manner
  JOURNAL   Psychoneuroendocrinology 38 (1), 84-93 (2013)
   PUBMED   22647578
  REMARK    GeneRIF: Ppid expression was predicted by plasma estradiol & 34%
            lower in control adolescent females than males. After chronic
            adolescent stress, females had elevated hippocampal Ppid expression
            that was not seen in males.
REFERENCE   4  (bases 1 to 1353)
  AUTHORS   Anderson,L.J., Lin,K., Compton,T. and Wiedmann,B.
  TITLE     Inhibition of cyclophilins alters lipid trafficking and blocks
            hepatitis C virus secretion
  JOURNAL   Virol J 8, 329 (2011)
   PUBMED   21711559
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1353)
  AUTHORS   Wang,H., Zhang,Y., Wang,T., You,H. and Jia,J.
  TITLE     N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver
            fibrosis in rats by interacting with cyclophilin B and D
  JOURNAL   J Gastroenterol Hepatol 26 (3), 558-567 (2011)
   PUBMED   21332552
  REMARK    GeneRIF: NIM811 attenuates liver fibrosis in a CCl(4)-induced rat
            liver fibrosis model, which may be related to binding with
            cyclophilin B and D.
REFERENCE   6  (bases 1 to 1353)
  AUTHORS   Pirkl,F. and Buchner,J.
  TITLE     Functional analysis of the Hsp90-associated human peptidyl prolyl
            cis/trans isomerases FKBP51, FKBP52 and Cyp40
  JOURNAL   J Mol Biol 308 (4), 795-806 (2001)
   PUBMED   11350175
REFERENCE   7  (bases 1 to 1353)
  AUTHORS   Mark,P.J., Ward,B.K., Kumar,P., Lahooti,H., Minchin,R.F. and
            Ratajczak,T.
  TITLE     Human cyclophilin 40 is a heat shock protein that exhibits altered
            intracellular localization following heat shock
  JOURNAL   Cell Stress Chaperones 6 (1), 59-70 (2001)
   PUBMED   11525244
REFERENCE   8  (bases 1 to 1353)
  AUTHORS   Young,J.C., Obermann,W.M. and Hartl,F.U.
  TITLE     Specific binding of tetratricopeptide repeat proteins to the
            C-terminal 12-kDa domain of hsp90
  JOURNAL   J Biol Chem 273 (29), 18007-18010 (1998)
   PUBMED   9660753
REFERENCE   9  (bases 1 to 1353)
  AUTHORS   Whitesell,L., Sutphin,P.D., Pulcini,E.J., Martinez,J.D. and
            Cook,P.H.
  TITLE     The physical association of multiple molecular chaperone proteins
            with mutant p53 is altered by geldanamycin, an hsp90-binding agent
  JOURNAL   Mol Cell Biol 18 (3), 1517-1524 (1998)
   PUBMED   9488468
REFERENCE   10 (bases 1 to 1353)
  AUTHORS   Leverson,J.D. and Ness,S.A.
  TITLE     Point mutations in v-Myb disrupt a cyclophilin-catalyzed negative
            regulatory mechanism
  JOURNAL   Mol Cell 1 (2), 203-211 (1998)
   PUBMED   9659917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076386.1.
            
            On Sep 10, 2004 this sequence version replaced XM_342265.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076386.1, FQ214826.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q33"
     gene            1..1353
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /note="peptidylprolyl isomerase D"
                     /db_xref="GeneID:361967"
                     /db_xref="RGD:1303174"
     exon            1..145
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1173
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /EC_number="5.2.1.8"
                     /note="40 kDa peptidyl-prolyl cis-trans isomerase;
                     cyclophilin-40; PPIase D; rotamase D; Cyclophilin D"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase D"
                     /protein_id="NP_001004279.1"
                     /db_xref="GeneID:361967"
                     /db_xref="RGD:1303174"
                     /translation="MSHPSPAGKPSNSKNPRVFFDVDIGGERVGRIVLELFADIVPKT
                     AENFRALCTGEKGTGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEK
                     FEDENFHYKHDREGLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGQVIKGLGVAR
                     MLENVEVNGEKPAKLCVIAECGELKEGDEWGIFPKDGSGDSHPDFPEDADIDLKDVDK
                     ILLISEDLKNIGNTFFKSQNWEMAIKKYAKVLRYLDSSKAVIEKADVSRLQPIALSCV
                     LNIGACKLKMSNWQGAIDSCLEALEMDPSNTKALYRKAQGWQGLKEYDQALADLKKAQ
                     EIAPGDKAIQAELLKVKQMIKAQKDKEKAVYAKMFA"
     exon            146..286
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            287..393
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            394..582
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            583..705
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            706..812
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            813..954
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1041
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1084
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1331
                     /gene="Ppid"
                     /gene_synonym="Cyp-40; CypD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttgagccc ctctcgtgca cgaggcactt gtgtcctgct ttccagcgcc tgcagtgaag
       61 atgtcccacc catccccagc aggcaagccc tccaattcca agaacccgcg agtcttcttt
      121 gacgtggaca tcggcgggga gcgagttgga cgaattgttt tagaattgtt tgcagatatt
      181 gttcctaaaa ctgcagaaaa ttttcgtgca ttgtgtacag gagaaaaggg cactggaccg
      241 acaactggga aacctctgca ttttaaagga tgccctttcc accgaattat taagaaattt
      301 atgattcagg gtggagactt ctcaaatcag aatgggacag gtggagaaag tatttatggt
      361 gaaaaatttg aagatgagaa ttttcattat aagcatgatc gggagggttt gctgagcatg
      421 gcaaatgcag gccccaatac aaatggttct cagttcttta tcacaacagt tccaactcct
      481 catttggatg ggaaacatgt ggtatttggt caagtaataa aaggactagg tgtggcaagg
      541 atgcttgaaa atgtagaagt gaatggtgaa aaacctgcca aactctgtgt tattgcagaa
      601 tgtggagaat tgaaggaagg ggatgaatgg ggaatattcc ccaaagatgg ctctggggat
      661 agtcatccag atttccctga ggatgcagac atagacttaa aggatgtaga taaaatttta
      721 ttaatatctg aagacttaaa aaacattgga aatacttttt tcaagtctca aaactgggag
      781 atggctatta aaaaatatgc aaaggtttta aggtacttgg atagttcaaa ggctgttatt
      841 gagaaagcag atgtatccag actgcaaccc atagccttaa gttgtgtgct gaatattggt
      901 gcttgtaaat tgaagatgtc aaattggcag ggggcaattg acagttgctt ggaggctctt
      961 gaaatggacc cttcaaacac taaagcacta taccgaaaag cacaaggatg gcaaggattg
     1021 aaagaatatg atcaagcatt ggctgatctt aagaaggcgc aggagatagc cccaggagat
     1081 aaagctatcc aggcagaatt gcttaaagtc aaacaaatga taaaggcaca gaaagataaa
     1141 gagaaggcag tgtatgcaaa aatgtttgct taataaggat taaagtttcc ttaactatta
     1201 tacattgatt atataaagga caatgtatat tactgtctac ataatccctg atgtgtttcc
     1261 cttgatcttt gtcattgttt acatagcagt gctgacatcg gttccttaat aaagttacga
     1321 attacagtga aaaaaaaaaa aaaaaaaaaa aaa
//
