LOCUS       NM_001004215            1380 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus peptidylprolyl isomerase C (Ppic), mRNA.
ACCESSION   NM_001004215 XM_214534
VERSION     NM_001004215.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R,
            Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser
            EZ and Dhe-Paganon S.
  TITLE     Structural and biochemical characterization of the human
            cyclophilin family of peptidyl-prolyl isomerases
  JOURNAL   PLoS Biol 8 (7), e1000439 (2010)
   PUBMED   20676357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Shimizu T, Imai H, Seki K, Tomizawa S, Nakamura M, Honda F,
            Kawahara N and Saito N.
  TITLE     Cyclophilin C-associated protein and cyclophilin C mRNA are
            upregulated in penumbral neurons and microglia after focal cerebral
            ischemia
  JOURNAL   J Cereb Blood Flow Metab 25 (3), 325-337 (2005)
   PUBMED   15647740
REFERENCE   3  (bases 1 to 1380)
  AUTHORS   Montague JW, Hughes FM Jr and Cidlowski JA.
  TITLE     Native recombinant cyclophilins A, B, and C degrade DNA
            independently of peptidylprolyl cis-trans-isomerase activity.
            Potential roles of cyclophilins in apoptosis
  JOURNAL   J Biol Chem 272 (10), 6677-6684 (1997)
   PUBMED   9045699
REFERENCE   4  (bases 1 to 1380)
  AUTHORS   Friedman J and Weissman I.
  TITLE     Two cytoplasmic candidates for immunophilin action are revealed by
            affinity for a new cyclophilin: one in the presence and one in the
            absence of CsA
  JOURNAL   Cell 66 (4), 799-806 (1991)
   PUBMED   1652374
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078949.1.
            
            On Sep 10, 2004 this sequence version replaced XM_214534.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078949.1, EV768065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..1380
                     /gene="Ppic"
                     /note="peptidylprolyl isomerase C"
                     /db_xref="GeneID:291463"
                     /db_xref="RGD:1303221"
     exon            1..198
                     /gene="Ppic"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..720
                     /gene="Ppic"
                     /EC_number="5.2.1.8"
                     /note="peptidyl-prolyl cis-trans isomerase C"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase C precursor"
                     /protein_id="NP_001004215.1"
                     /db_xref="GeneID:291463"
                     /db_xref="RGD:1303221"
                     /translation="MSRGPRLLLPAVLFLGLGGLVSSSGSSGVRKRGPLVTDKVFFDV
                     RIGDKDVGRIVIGLFGKVVPRTVENFVTLATGEKGYGYKGSIFHRVIKDFMIQGGDFT
                     ARDGTGGMSIYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLTKPAWLDGKH
                     VVFGKVLDGMTVVHSIELQATDDHDRPLTDCTIVNSGKIDVKTPFVVEVPDW"
     exon            199..312
                     /gene="Ppic"
                     /inference="alignment:Splign:2.1.0"
     exon            313..406
                     /gene="Ppic"
                     /inference="alignment:Splign:2.1.0"
     exon            407..591
                     /gene="Ppic"
                     /inference="alignment:Splign:2.1.0"
     exon            592..1355
                     /gene="Ppic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcaggcg gccaagagtc ctgccacagt ccgggagctt aaggttgcgc ccgagccact
       61 gtcgccgttc catcgtgcac catgagccgg ggtcctcgtc tgctgctgcc cgcggtgctc
      121 ttcctggggc ttggaggcct cgtgtcttct tcggggtcat cgggcgtccg aaagcgaggt
      181 cccttggtga cggacaaggt cttctttgat gtgaggatcg gagacaaaga tgtgggtaga
      241 attgtgattg gcctctttgg aaaagttgta ccccggacgg tagaaaactt cgtgactctg
      301 gcaacaggag agaaaggcta cgggtacaag ggaagcatat tccaccgtgt catcaaggac
      361 ttcatgattc aaggagggga cttcacggct agagacggca ctggaggtat gagcatttat
      421 ggtgagacat ttcctgatga gaacttcaaa ctgaaacact atggcattgg gtgggtcagc
      481 atggccaatg ctggaccaga caccaatggt tcccaattct tcatcacctt gaccaagccc
      541 gcctggctgg atggcaaaca tgtggtattt ggaaaagttc tggatgggat gactgtggta
      601 cattccatag aacttcaagc aacggatgac catgaccgcc cacttaccga ctgcaccatt
      661 gtcaacagcg gcaagataga tgtgaaaaca ccctttgtgg ttgaggtccc tgactggtga
      721 cagaagtgga ggaaaacagg gaatgcactg gctggtccat gtgctcatct gctatccacc
      781 agctgtcttt tgactcttta gttacttaaa gttgtagtta aaaaaaattt ttttctcttt
      841 taatttccca gtctagattg caatgaagat ttaaaaatca accacacaac cagatgtctc
      901 aacaaacacc tgtcatccca gtatttggga ggtgcaggca ggaggatcag aagttcaagg
      961 ccagccttgg ctacatagtg agtttggggc tagccttgtc tatgtggaac cctgttcaaa
     1021 aaagcatacc aacaacaata aaaaccaact cctgcttagg tactttaatt gaatgacata
     1081 tccttctctt ctagtggtgc tattttcaaa tcagaaacct tctcattggc tatttgtttt
     1141 tacaaacatg gtcttttagt ctcacatggt ttcttgtgat ctccatttgg gtgatcagag
     1201 ggtttgtttg aggaaggtgg actataataa ggcttagcat tttctgttca aataattctt
     1261 gtcgggtaaa gggaaactgg agtagtatca aatgttgtgt atcaccagca ttttggggct
     1321 ttgatgttct ttatattaaa tactttttaa atgaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
