LOCUS       NM_022536                838 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus peptidylprolyl isomerase B (Ppib), mRNA.
ACCESSION   NM_022536
VERSION     NM_022536.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 838)
  AUTHORS   Wang,Q., Xu,B., Fan,K., Wu,J. and Wang,T.
  TITLE     CypB-CD147 Signaling Is Involved in Crosstalk between Cartilage and
            FLS in Collagen-Induced Arthritis
  JOURNAL   Mediators Inflamm 2020, 6473858 (2020)
   PUBMED   32908452
  REMARK    GeneRIF: CypB-CD147 Signaling Is Involved in Crosstalk between
            Cartilage and FLS in Collagen-Induced Arthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 838)
  AUTHORS   Lan,X., Fu,H., Li,G., Zeng,W., Lin,X., Zhu,Y., Liu,M. and Chen,P.
  TITLE     TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with
            the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic
            Domain
  JOURNAL   Sci Rep 8 (1), 9917 (2018)
   PUBMED   29967478
  REMARK    GeneRIF: Cyclophilin B in the hepatocyte proliferation.TMUB1
            interfered with the binding of CAML to cyclophilin B in
            hepatocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 838)
  AUTHORS   Jansen,G., Maattanen,P., Denisov,A.Y., Scarffe,L., Schade,B.,
            Balghi,H., Dejgaard,K., Chen,L.Y., Muller,W.J., Gehring,K. and
            Thomas,D.Y.
  TITLE     An interaction map of endoplasmic reticulum chaperones and foldases
  JOURNAL   Mol Cell Proteomics 11 (9), 710-723 (2012)
   PUBMED   22665516
REFERENCE   4  (bases 1 to 838)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 838)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 838)
  AUTHORS   Rycyzyn,M.A., Reilly,S.C., O'Malley,K. and Clevenger,C.V.
  TITLE     Role of cyclophilin B in prolactin signal transduction and nuclear
            retrotranslocation
  JOURNAL   Mol Endocrinol 14 (8), 1175-1186 (2000)
   PUBMED   10935542
REFERENCE   7  (bases 1 to 838)
  AUTHORS   Kainer,D.B. and Doris,P.A.
  TITLE     Cyclophilin B expression in renal proximal tubules of hypertensive
            rats
  JOURNAL   Hypertension 35 (4), 958-964 (2000)
   PUBMED   10775569
REFERENCE   8  (bases 1 to 838)
  AUTHORS   Arber,S., Krause,K.H. and Caroni,P.
  TITLE     s-cyclophilin is retained intracellularly via a unique
            COOH-terminal sequence and colocalizes with the calcium storage
            protein calreticulin
  JOURNAL   J Cell Biol 116 (1), 113-125 (1992)
   PUBMED   1530944
REFERENCE   9  (bases 1 to 838)
  AUTHORS   Hasel,K.W., Glass,J.R., Godbout,M. and Sutcliffe,J.G.
  TITLE     An endoplasmic reticulum-specific cyclophilin
  JOURNAL   Mol Cell Biol 11 (7), 3484-3491 (1991)
   PUBMED   1710767
REFERENCE   10 (bases 1 to 838)
  AUTHORS   Iwai,N. and Inagami,T.
  TITLE     Molecular cloning of a complementary DNA to rat cyclophilin-like
            protein mRNA
  JOURNAL   Kidney Int 37 (6), 1460-1465 (1990)
   PUBMED   2194066
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF071225.1.
            
            On Feb 21, 2013 this sequence version replaced NM_022536.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF071225.1, BC061971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-838               AF071225.1         1-838
FEATURES             Location/Qualifiers
     source          1..838
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WKY"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..838
                     /gene="Ppib"
                     /gene_synonym="CypB; Scylp"
                     /note="peptidylprolyl isomerase B"
                     /db_xref="GeneID:64367"
                     /db_xref="RGD:620312"
     exon            1..133
                     /gene="Ppib"
                     /gene_synonym="CypB; Scylp"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..649
                     /gene="Ppib"
                     /gene_synonym="CypB; Scylp"
                     /EC_number="5.2.1.8"
                     /note="peptidyl-prolyl cis-trans isomerase B; CYP-S1;
                     S-cyclophilin; PPIase B; rotamase B; cyclophilin B;
                     S-cyclophylin"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase B precursor"
                     /protein_id="NP_071981.1"
                     /db_xref="GeneID:64367"
                     /db_xref="RGD:620312"
                     /translation="MKVLFAAALIVGSVVFLLLPGPSVANDKKKGPKVTVKVYFDFQI
                     GDEPVGRVTFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRG
                     DGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTSWLDGKHVV
                     FGKVLEGMDVVRKVENTKTDSRDKPLKDVIIVDCGKIEVEKPFAIAKE"
     exon            134..247
                     /gene="Ppib"
                     /gene_synonym="CypB; Scylp"
                     /inference="alignment:Splign:2.1.0"
     exon            248..341
                     /gene="Ppib"
                     /gene_synonym="CypB; Scylp"
                     /inference="alignment:Splign:2.1.0"
     exon            342..526
                     /gene="Ppib"
                     /gene_synonym="CypB; Scylp"
                     /inference="alignment:Splign:2.1.0"
     exon            527..838
                     /gene="Ppib"
                     /gene_synonym="CypB; Scylp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgcctc tcggagcgca atatgaaggt gctcttcgcc gccgccctca tcgtgggctc
       61 cgttgtcttc cttttgctgc ctggaccctc cgtggccaac gataagaaga agggacctaa
      121 agtcacagtc aaggtatact ttgatttcca aattggagac gaacctgtag gacgagtgac
      181 ctttggactc tttggaaaga ctgttccaaa aacagtggat aattttgtag ccttagctac
      241 aggagagaaa ggatttggct ataagaacag caagttccat cgtgtcatca aggacttcat
      301 gatccagggt ggagacttca ccaggggaga tggcacagga ggaaagagca tctatggtga
      361 gcgcttccca gatgagaact tcaagctgaa gcactatggg cccggatggg tgagcatggc
      421 caatgcaggc aaagacacca atggctccca gttcttcata actacagtca agacctcctg
      481 gctagacggc aagcacgtgg ttttcggcaa agttctggaa ggcatggatg tggtacggaa
      541 ggtggagaac accaagacgg acagccggga caagcccctg aaggatgtga tcattgtaga
      601 ctgtggcaag atcgaagtgg agaaaccctt tgccattgcc aaggagtaga gagagcctcg
      661 gggacctcat ccctctaaac agctgtctgt gcgggtcctg tcgattccct cacaggtgaa
      721 agcagccagt cacaaggctc tgtgcggctc tggctccagt gcttccatcc gacggggtgg
      781 ccacacccct cacattccac aggcctgatt tttatataaa actcctacca atgctgat
//
