LOCUS       NM_017101                743 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus peptidylprolyl isomerase A (Ppia), mRNA.
ACCESSION   NM_017101
VERSION     NM_017101.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 743)
  AUTHORS   Kalinina,A., Tilova,L., Kirsanov,K., Lesovaya,E., Zhidkova,E.,
            Fetisov,T., Ilyinskaya,G., Yakubovskaya,M., Kazansky,D. and
            Khromykh,L.
  TITLE     Secreted cyclophilin A is non-genotoxic but acts as a tumor
            promoter
  JOURNAL   Toxicology 500, 153675 (2023)
   PUBMED   37993081
  REMARK    GeneRIF: Secreted cyclophilin A is non-genotoxic but acts as a
            tumor promoter.
REFERENCE   2  (bases 1 to 743)
  AUTHORS   Demir,B., Kersin,B., Gojayeva,F., Arman,A. and Binnetoglu,A.
  TITLE     Concentrations of Serum Cyclophilin A in Patients With Bell Palsy
  JOURNAL   J Craniofac Surg 31 (4), e368-e370 (2020)
   PUBMED   32149981
REFERENCE   3  (bases 1 to 743)
  AUTHORS   Bouybayoune,I., Comerio,L., Pasetto,L., Bertani,I., Bonetto,V. and
            Chiesa,R.
  TITLE     Cyclophillin A deficiency accelerates RML-induced prion disease
  JOURNAL   Neurobiol Dis 130, 104498 (2019)
   PUBMED   31181281
REFERENCE   4  (bases 1 to 743)
  AUTHORS   Liu,L., Zuo,L., Yang,J., Xin,S., Zhang,J., Zhou,J., Li,G., Tang,J.
            and Lu,J.
  TITLE     Exosomal cyclophilin A as a novel noninvasive biomarker for
            Epstein-Barr virus associated nasopharyngeal carcinoma
  JOURNAL   Cancer Med 8 (6), 3142-3151 (2019)
   PUBMED   31063269
REFERENCE   5  (bases 1 to 743)
  AUTHORS   Tian,H., Yu,D., Hu,Y., Zhang,P., Yang,Y., Hu,Q. and Li,M.
  TITLE     Angiotensin II upregulates cyclophilin A by enhancing ROS
            production in rat cardiomyocytes
  JOURNAL   Mol Med Rep 18 (5), 4349-4355 (2018)
   PUBMED   30221707
  REMARK    GeneRIF: the action of Ang II was primarily dependent on the
            angiotensin type 2 receptor (AT2R), not the type 1 receptor. These
            results provided an insight into the role of the AT2R signaling
            pathway in Ang IIinduced myocardial hypertrophy
REFERENCE   6  (bases 1 to 743)
  AUTHORS   Braaten,D. and Luban,J.
  TITLE     Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene
            targeting in human T cells
  JOURNAL   EMBO J 20 (6), 1300-1309 (2001)
   PUBMED   11250896
REFERENCE   7  (bases 1 to 743)
  AUTHORS   Connern,C.P. and Halestrap,A.P.
  TITLE     Purification and N-terminal sequencing of peptidyl-prolyl
            cis-trans-isomerase from rat liver mitochondrial matrix reveals the
            existence of a distinct mitochondrial cyclophilin
  JOURNAL   Biochem J 284 (Pt 2) (Pt 2), 381-385 (1992)
   PUBMED   1599421
REFERENCE   8  (bases 1 to 743)
  AUTHORS   Lad,R.P., Smith,M.A. and Hilt,D.C.
  TITLE     Molecular cloning and regional distribution of rat brain
            cyclophilin
  JOURNAL   Brain Res Mol Brain Res 9 (3), 239-244 (1991)
   PUBMED   1851525
REFERENCE   9  (bases 1 to 743)
  AUTHORS   Danielson,P.E., Forss-Petter,S., Brow,M.A., Calavetta,L.,
            Douglass,J., Milner,R.J. and Sutcliffe,J.G.
  TITLE     p1B15: a cDNA clone of the rat mRNA encoding cyclophilin
  JOURNAL   DNA 7 (4), 261-267 (1988)
   PUBMED   3293952
REFERENCE   10 (bases 1 to 743)
  AUTHORS   Theodor,L., Peleg,D. and Meyuhas,O.
  TITLE     P31, a mammalian housekeeping protein encoded by a multigene family
            containing a high proportion of pseudogenes
  JOURNAL   Biochim Biophys Acta 826 (2-3), 137-146 (1985)
   PUBMED   2996604
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M19533.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M19533.1, FQ241390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..743
                     /gene="Ppia"
                     /gene_synonym="CYCA; CyP-A; p1B15; p31"
                     /note="peptidylprolyl isomerase A"
                     /db_xref="GeneID:25518"
                     /db_xref="RGD:3372"
     exon            1..111
                     /gene="Ppia"
                     /gene_synonym="CYCA; CyP-A; p1B15; p31"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..537
                     /gene="Ppia"
                     /gene_synonym="CYCA; CyP-A; p1B15; p31"
                     /EC_number="5.2.1.8"
                     /note="PPIase A; rotamase A; cyclophilin A; cyclosporin
                     A-binding protein"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase A"
                     /protein_id="NP_058797.1"
                     /db_xref="GeneID:25518"
                     /db_xref="RGD:3372"
                     /translation="MVNPTVFFDITADGEPLGRVCFELFADKVPKTAENFRALSTGEK
                     GFGYKGSSFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMAN
                     AGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMSIVEAMERFGSRNGKTSKKITISD
                     CGQL"
     exon            112..142
                     /gene="Ppia"
                     /gene_synonym="CYCA; CyP-A; p1B15; p31"
                     /inference="alignment:Splign:2.1.0"
     exon            143..231
                     /gene="Ppia"
                     /gene_synonym="CYCA; CyP-A; p1B15; p31"
                     /inference="alignment:Splign:2.1.0"
     exon            232..404
                     /gene="Ppia"
                     /gene_synonym="CYCA; CyP-A; p1B15; p31"
                     /inference="alignment:Splign:2.1.0"
     exon            405..743
                     /gene="Ppia"
                     /gene_synonym="CYCA; CyP-A; p1B15; p31"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttgcagac gccgctgtct cttttcgccg cttgctgcag acatggtcaa ccccaccgtg
       61 ttcttcgaca tcacggctga tggcgagccc ttgggtcgcg tctgcttcga gctgtttgca
      121 gacaaagttc caaagacagc agaaaacttt cgtgctctga gcactgggga gaaaggattt
      181 ggctataagg gttcctcctt tcacagaatt attccaggat tcatgtgcca gggtggtgac
      241 ttcacacgcc ataatggcac tggtggcaag tccatctacg gagagaaatt tgaggatgag
      301 aacttcatcc tgaagcatac aggtcctggc atcttgtcca tggcaaatgc tggaccaaac
      361 acaaatggtt cccagttttt tatctgcact gccaagactg agtggctgga tggcaagcat
      421 gtggtctttg ggaaggtgaa agaaggcatg agcattgtgg aagccatgga gcgttttggg
      481 tccaggaatg gcaagaccag caagaagatc accatctccg actgtggaca actctaattt
      541 ctttgacttg cgggcatttt acccatcaaa ccattccttc tgtagctcag gagagcaccc
      601 ccaccccatc tgctcgcaat accctgtaat ctctgctctc actgaagttc tttgggttcc
      661 atattttcct cattcccctt caagtctagc aggattgcaa agttaagttt atgattatga
      721 ataaaaacta aatgagaagt gtt
//
