LOCUS       NM_001108992            4067 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus periphilin 1 (Pphln1), mRNA.
ACCESSION   NM_001108992 XM_001057366 XM_345865
VERSION     NM_001108992.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4067)
  AUTHORS   Tchasovnikarova,I.A., Timms,R.T., Douse,C.H., Roberts,R.C.,
            Dougan,G., Kingston,R.E., Modis,Y. and Lehner,P.J.
  TITLE     Hyperactivation of HUSH complex function by Charcot-Marie-Tooth
            disease mutation in MORC2
  JOURNAL   Nat Genet 49 (7), 1035-1044 (2017)
   PUBMED   28581500
REFERENCE   2  (bases 1 to 4067)
  AUTHORS   Tchasovnikarova,I.A., Timms,R.T., Matheson,N.J., Wals,K.,
            Antrobus,R., Gottgens,B., Dougan,G., Dawson,M.A. and Lehner,P.J.
  TITLE     GENE SILENCING. Epigenetic silencing by the HUSH complex mediates
            position-effect variegation in human cells
  JOURNAL   Science 348 (6242), 1481-1485 (2015)
   PUBMED   26022416
REFERENCE   3  (bases 1 to 4067)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4067)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474027.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345865.3, XM_001057366.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132264,
                              SAMD00132266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4067
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..4067
                     /gene="Pphln1"
                     /note="periphilin 1"
                     /db_xref="GeneID:366975"
                     /db_xref="RGD:1306207"
     exon            1..268
                     /gene="Pphln1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1431
                     /gene="Pphln1"
                     /codon_start=1
                     /product="periphilin-1"
                     /protein_id="NP_001102462.1"
                     /db_xref="GeneID:366975"
                     /db_xref="RGD:1306207"
                     /translation="MANLWPAQTTKLHIPVVLGYRPRLASTRDEMWSEGRYDYERLPR
                     ERVPPRSHPSDGYHRVVNVVPKRPPLLDKRPPLLDKRPPLLARPDEGYNRYYTHVDCR
                     VCNEGRSFSHDRRSGPSHRGDEFGYRWTRDDHSTSRQSDYRDMRDGFRRKSFYSSHYS
                     RDRSPHKRDAPFFRESPVGRKDSPHSRSGSSVSSRSYSPERSRTHTFHQSQHRKSSRV
                     GASYKRQNEATRGRGKERSIQSLKTSRDTSPSSSSAVSSSKALDKPSRLTEKELAEAE
                     SKWAADTLERSDENNLGEISEFEAGSAAPLFIDQTEEPESNTTDGTEMYEDSQLSSRS
                     KAIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIGERCVEEL
                     KHFITEYDNSTQDFGDPF"
     exon            269..360
                     /gene="Pphln1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..564
                     /gene="Pphln1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..626
                     /gene="Pphln1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..838
                     /gene="Pphln1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..895
                     /gene="Pphln1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..975
                     /gene="Pphln1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1095
                     /gene="Pphln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1236
                     /gene="Pphln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..4067
                     /gene="Pphln1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacatacag accaggcctg taactactcc ctgggaacct gcgtgtcagc agcccggagc
       61 ccagagcctg tcgtggagcc tgcacaatca atcctgactg aagcggaggg ccgaagtgca
      121 atccacccag ggcgcagctg agttttgaga ggcattaatt ccttggcgtc caccaaggga
      181 ccactgggac taattctcat ggcaaacttg tggccagccc aaactaccaa gcttcacatt
      241 ccggttgtgc ttggttatcg cccaagattg gcttccacaa gagatgaaat gtggtctgag
      301 ggacgctatg actacgagcg acttccgaga gaacgagtgc ctccccggag ccatcccagt
      361 gatggctacc atagagtagt taatgttgtg ccaaagagac cacctctcct agacaagaga
      421 ccacctctcc tagacaagag accacctctg ctagccagac ccgatgaagg ctacaataga
      481 tattacactc atgttgattg ccgagtatgt aacgagggcc gcagtttttc tcatgatcga
      541 agaagtggcc catctcacag aggagatgaa tttggctaca gatggacaag agatgatcat
      601 tccacaagcc ggcagtctga ctacagggat atgagagatg gctttagaag aaagagtttc
      661 tactcttccc attattcaag agaccgctct ccccataaaa gggacgctcc gttcttcaga
      721 gaatcacctg taggccggaa ggactcccca cacagcaggt ccggctccag tgtcagcagt
      781 agaagctatt ctccagaacg aagcaggaca cacaccttcc atcagtctca gcacagaaaa
      841 tcctcgcgtg tcggtgcttc ctacaaacgg cagaatgaag ccactcgagg aagaggtaaa
      901 gagagatcca tccagtcttt gaaaacttca agagacactt caccctcaag ttcgtcagca
      961 gtttcttcat ccaaggcgtt agacaagccc agcaggctca ctgagaagga actcgctgag
     1021 gctgagagca agtgggctgc cgacacacta gagagatccg atgaaaacaa cctgggtgaa
     1081 atttctgagt ttgaggcggg atccgcggca cccttattta ttgaccagac agaggaaccc
     1141 gagtcaaaca caacggacgg cacagaaatg tatgaagaca gccagctcag cagccgctct
     1201 aaagccatcg catcaaaaac caaagagatc gagcaggttt accgacaaga ctgtgagact
     1261 ttcgggatgg tggtgaaaat gctgattgaa aaagatccct cgttagaaaa gtctatccag
     1321 tttgcactga ggcagaactt acatgaaata ggtgagcgct gtgttgaaga actcaagcat
     1381 ttcattaccg agtacgataa ttctactcaa gattttggag acccttttta gaagaagtag
     1441 tgcccaggtc aagaaaattt ttttagattt tttttttctc cttggattgt gtaaatcctt
     1501 actattttgt gatgaagaga aatactttat gctagctgac cacatttcta gtattaaata
     1561 aacatctaca atagctttta aagtatctta attagaatat ttcccctatg tgtagaatat
     1621 tcttctccat cttcaaatac ttcctccctc caaaataatg ttcagttatt ttaatgttca
     1681 aaaaagcagt tctggagagc agctttctga gttcaacttg tgttccacag tcttccatga
     1741 tgtttcagga tgatcctctt gtgtcccggg taaaggccga ctttgtatgt tggtttctgt
     1801 gcagagagct gagtactgtt gggacttcgg tattgtcact ctaatttctc agcagcttct
     1861 tagttgtaaa cattctcctc catcaccttc tgattggtct aataaagcct gtaggtcggg
     1921 agaggaaagc agggcatctg ggcagagaga ggaactatgg gaagaatttg tgtagggaat
     1981 ttaccaccca gacacaaagg aagtctggct tcagggactg aatgagagat aacagaccac
     2041 gtgacaaacg tgaaccaaaa taaattaagt tataggaact agttgagaac aagcctaagc
     2101 tataaggcct aggcattcat aaataataaa aaaaagtctg tgtccttgtt gggctggtgg
     2161 atccaaacag tctgatagtg agcgtttagt ctcagctgtt taatttgtag ttaagatcat
     2221 tccagtttgc atataatagt ggcactgtta gcattttgag ttggtgatgt caaaatatgc
     2281 tatcttaatg ggtcagaacc ttgctattgt atatttgctt tgatatttct tattcaatat
     2341 agaaaaaagc acttgaaaat ctgtaaggtt gtaagatttt agaacaaaat ctttcactca
     2401 agtcagtgaa cttagtttat ctcttctaca aagtgctctt ggggctccta actgttcttt
     2461 ctatagacta acaggagggg tcatctgaga tacgagataa attgaagttt ggatgtctca
     2521 gaaacccttc tgatggctat agtaaaggtc agaatatcca gagcacttaa gttttgtttg
     2581 aggcccacac tgtatcaaaa ggggacctga caaggcactc gtgcttgggt taagttacag
     2641 attactctgt tagtctcgtg atctcagtgc tgtaggttta gaggggacct gacaaggcac
     2701 ttgtgcttgg ttaagttaca gattactctg ttagtctcgt gatctcagtg ctggagggtt
     2761 agagggtctc ttccttcata agtgacctca ggaaaatgaa gcagaaaaca gtgaggccag
     2821 cacagccacc gtaaataagt aaagagacaa ttaggactct cgctcacttc ctggtccctt
     2881 ccagcagttc attgaggcaa aatacataat tcatgacatt aggcacctta aaaatcactg
     2941 ttttaatcac tgcctgatcc tgttatctac tattttttca agttagggcc atacagtata
     3001 gccctagcta gcctgaatat ctctgtagac caggctaggc cttgaactca cagaaatctt
     3061 cccacctcta cctcttgcaa gctggcatta aaccctgtgt caccatgctt aggatccttt
     3121 tggtttggtt tgatttcatt ttcattcagt tctgtccttt acactcttta atttgagaca
     3181 gggtcttact gtgtattcta ggctggcttc aaactttccg ctttggcctt tttaactctt
     3241 gggattcctg cctcagcttt cctgagttag aggtgtgaac cccaacgctt gccattacgt
     3301 tccgtggcct ctatgatcct gtctgcagag atactcctaa atcgcataca gatgatattt
     3361 aaactagaaa tggcagtatg agtaatttta atgagccctg caatgggagt gcaaagatat
     3421 tattatgcca ttttgaaaat taaaaactaa ttgatgacat tttaagttcc ttaagtgaga
     3481 acactggagt tattccaggc attgcgattc tatgcacacc tcttctaagc acgtgtggtc
     3541 aatgctggtc gcttcagcaa gaccgcatgt catttttcct tttttttttt ttttttttct
     3601 tccaccaatt ctcagctctt caaatcaagt tgttaacaaa cataactata aaatttgaga
     3661 agctaccagg gcaaataaat tgttcacttg gtagaaatcc atttaaaaaa gagtcttact
     3721 agtagattta tttaaatgaa ggtccaacca gtgaccttcc ctcaaatcat attcagcatt
     3781 tgaagctatt tccagcttgc cgtcagcgat gttctgctag gcttgtcagt gttaaatgtt
     3841 ttgtttacca ttttttaaaa aatgcttcaa catctaaaat tcatgtgtac tagaatatgt
     3901 attttataaa tgtttttgat tctaagagat gtgtttgtaa attatccact gtttttcagt
     3961 atactgaatt cgtgtgttat gttttcattg tctcaccata aggccttgat gatcaatatg
     4021 ggggaagcag acactgtaaa atgcaaaata aagcgcccag tactaag
//
