LOCUS       NM_001270985            4643 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus PTPRF interacting protein alpha 3 (Ppfia3), mRNA.
ACCESSION   NM_001270985 XM_341856
VERSION     NM_001270985.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4643)
  AUTHORS   Wong,M.Y., Liu,C., Wang,S.S.H., Roquas,A.C.F., Fowler,S.C. and
            Kaeser,P.S.
  TITLE     Liprin-alpha3 controls vesicle docking and exocytosis at the active
            zone of hippocampal synapses
  JOURNAL   Proc Natl Acad Sci U S A 115 (9), 2234-2239 (2018)
   PUBMED   29439199
REFERENCE   2  (bases 1 to 4643)
  AUTHORS   Joshi,C.S., Suryawanshi,A.R., Khan,S.A., Balasinor,N.H. and
            Khole,V.V.
  TITLE     Liprin alpha3: a putative estrogen regulated acrosomal protein
  JOURNAL   Histochem Cell Biol 139 (4), 535-548 (2013)
   PUBMED   23124857
  REMARK    GeneRIF: study reports the presence of Liprin alpha3 in testicular
            and epididymal tissue as well as in sperm acrosome and describes
            its immunochemical characterization
REFERENCE   3  (bases 1 to 4643)
  AUTHORS   Zurner,M., Mittelstaedt,T., tom Dieck,S., Becker,A. and Schoch,S.
  TITLE     Analyses of the spatiotemporal expression and subcellular
            localization of liprin-alpha proteins
  JOURNAL   J Comp Neurol 519 (15), 3019-3039 (2011)
   PUBMED   21618221
REFERENCE   4  (bases 1 to 4643)
  AUTHORS   Wang,Y. and Sudhof,T.C.
  TITLE     Genomic definition of RIM proteins: evolutionary amplification of a
            family of synaptic regulatory proteins
  JOURNAL   Genomics 81 (2), 126-137 (2003)
   PUBMED   12620390
REFERENCE   5  (bases 1 to 4643)
  AUTHORS   Wyszynski,M., Kim,E., Dunah,A.W., Passafaro,M., Valtschanoff,J.G.,
            Serra-Pages,C., Streuli,M., Weinberg,R.J. and Sheng,M.
  TITLE     Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA
            receptor targeting
  JOURNAL   Neuron 34 (1), 39-52 (2002)
   PUBMED   11931740
REFERENCE   6  (bases 1 to 4643)
  AUTHORS   Schoch,S., Castillo,P.E., Jo,T., Mukherjee,K., Geppert,M., Wang,Y.,
            Schmitz,F., Malenka,R.C. and Sudhof,T.C.
  TITLE     RIM1alpha forms a protein scaffold for regulating neurotransmitter
            release at the active zone
  JOURNAL   Nature 415 (6869), 321-326 (2002)
   PUBMED   11797009
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 19, 2014 this sequence version replaced NM_001270985.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.2867.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000001.1  104982143-104982278 c
            137-391             JAXUCZ010000001.1  104976796-104977050 c
            392-493             JAXUCZ010000001.1  104975758-104975859 c
            494-658             JAXUCZ010000001.1  104975294-104975458 c
            659-733             JAXUCZ010000001.1  104974518-104974592 c
            734-808             JAXUCZ010000001.1  104974277-104974351 c
            809-1030            JAXUCZ010000001.1  104973161-104973382 c
            1031-1177           JAXUCZ010000001.1  104971924-104972070 c
            1178-1312           JAXUCZ010000001.1  104971693-104971827 c
            1313-1396           JAXUCZ010000001.1  104971520-104971603 c
            1397-1528           JAXUCZ010000001.1  104970523-104970654 c
            1529-1591           JAXUCZ010000001.1  104970242-104970304 c
            1592-1668           JAXUCZ010000001.1  104970073-104970149 c
            1669-1813           JAXUCZ010000001.1  104968691-104968835 c
            1814-2001           JAXUCZ010000001.1  104966791-104966978 c
            2002-2221           JAXUCZ010000001.1  104964490-104964709 c
            2222-2385           JAXUCZ010000001.1  104962585-104962748 c
            2386-2513           JAXUCZ010000001.1  104962366-104962493 c
            2514-2607           JAXUCZ010000001.1  104961651-104961744 c
            2608-2689           JAXUCZ010000001.1  104961364-104961445 c
            2690-2890           JAXUCZ010000001.1  104960690-104960890 c
            2891-2953           JAXUCZ010000001.1  104958162-104958224 c
            2954-2980           JAXUCZ010000001.1  104957974-104958000 c
            2981-3156           JAXUCZ010000001.1  104956790-104956965 c
            3157-3254           JAXUCZ010000001.1  104956178-104956275 c
            3255-3430           JAXUCZ010000001.1  104955575-104955750 c
            3431-3499           JAXUCZ010000001.1  104955425-104955493 c
            3500-3671           JAXUCZ010000001.1  104955068-104955239 c
            3672-3743           JAXUCZ010000001.1  104954662-104954733 c
            3744-4643           JAXUCZ010000001.1  104953598-104954497 c
FEATURES             Location/Qualifiers
     source          1..4643
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..4643
                     /gene="Ppfia3"
                     /note="PTPRF interacting protein alpha 3"
                     /db_xref="GeneID:140591"
                     /db_xref="RGD:620054"
     exon            1..136
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            137..391
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..3730
                     /gene="Ppfia3"
                     /note="protein tyrosine phosphatase receptor type f
                     polypeptide-interacting protein alpha-3; protein tyrosine
                     phosphatase, receptor type, f polypeptide (PTPRF),
                     interacting protein (liprin), alpha 3"
                     /codon_start=1
                     /product="liprin-alpha-3"
                     /protein_id="NP_001257914.1"
                     /db_xref="GeneID:140591"
                     /db_xref="RGD:620054"
                     /translation="MMCEVMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLE
                     TLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEE
                     IAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLF
                     EHHKALDEKVRERLRMALERVAVLEEELELSNQEALNLRDQLSRRRSGLEEPGKDGDG
                     QTLANGLGPVGESSRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRE
                     LGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELA
                     SKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERH
                     GNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLK
                     ERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSYSRSL
                     PGSALELRYSQAPTLPSGAPLDPYGAGSGRAGKRGRWSGAKDESSKDWDRSTPAGSIP
                     PPFPGELDGSDEEETEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKE
                     TTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPS
                     PARETDKTNHVPKDEAGVPRGEGPAIPGDTPPPTPRSARLERMTQALALQAGSLEDGA
                     PPRGSESTPDSLHKAPKRKSIKSSIGRLFGKKEKGRMGPPGRESVSLAGTPSDETLAT
                     DPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYV
                     AACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTP
                     TGNVWMTHEEMESLTAATKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYF
                     MESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQ
                     TQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIP
                     TQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDSAE
                     MLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC"
     exon            392..493
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            494..658
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..733
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            734..808
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1030
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1177
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1312
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1396
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1528
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1591
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1668
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1813
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2001
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2221
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2385
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2513
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2607
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2689
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2890
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..2953
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..2980
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3156
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3254
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3430
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3499
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3671
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3743
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..4643
                     /gene="Ppfia3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgctagc ggcgtagaca gggctccaga tctccagatc cgggccccgg ccgtcgccag
       61 gggccccgcc cggtgcccct accccacccc gcgtccctcc tgcagcccag ctcctcccgc
      121 agtcgtcgcg gaccaggccg gcaccgccgc catgatgtgc gaggtgatgc ctaccatcag
      181 cgaggatggc cggcggggct cggcgctggg cccggacgag gccggcggcg agctggagcg
      241 cctcatggtc acgatgctca cggagcgcga gcgcctgctg gagacgctgc gagaggcgca
      301 ggacgggttg gcgacagcgc agctacgact gcgcgagctc ggccacgaga aggactcgct
      361 gcagcggcag ctcagcattg ctctgcctca ggagtttgcg gctctgacga aggagcttaa
      421 cttatgtcgg gaacagcttc tggagaggga agaagaaatc gcagagctga aggcggagcg
      481 aaacaacacc cggctacttc tggaacacct cgagtgccta gtgtccaggc acgagcgttc
      541 cctacgaatg actgtggtga aacgccaagc ccaatctcct ggaggagtct cctctgaggt
      601 ggaagtgctc aaggctctaa aatccctctt tgagcaccac aaggccctgg atgagaaggt
      661 ccgggaaaga ttgcggatgg cactggagag ggtagcagtg ctcgaggagg agctggaact
      721 gagcaatcag gaggccctga accttcgaga ccagctatct agaaggcggt caggactgga
      781 ggagccgggc aaggatgggg atggacagac ccttgccaat ggcctgggtc ccgttggaga
      841 atccagccgg cgcacggcag agctggagga ggcactggag cggcagcgtg cagaggtgtg
      901 ccagctgagg gagcgcctgg cggtgctgtg ccgtcagatg agccagctgg aggaggagct
      961 gggcactgct caccgcgagc tgggtaaggc ggaggaagct aactccaagc tgcagcgcga
     1021 cctcaaggag gccctggctc agcgggaaga tatggaagaa cgcatcacca cactggaaaa
     1081 gcgctatctg agtgcccagc gtgaggccac atctctacat gatgccaacg ataagctgga
     1141 gaatgagctg gccagcaaag agtccctgta cagacagagt gaagagaaga gccgtcagct
     1201 ggccgagtgg ctggatgacg ccaagcagaa gctgcagcag accctgcaga aggcagagac
     1261 cttgcctgag attgaggctc agctggcaca gagagtggct gctctgaaca aggctgagga
     1321 acgccatggg aactttgagg agaggcttcg gcagctggag gcacagctgg aggagaagaa
     1381 ccaggagctg cagagggccc ggcagaggga gaagatgaac gatgaccaca ataaacgact
     1441 atcagaaacg gtggacaagc tgctaagtga atccaatgaa cggttacagc ttcacctcaa
     1501 ggaacgtatg ggggcactgg aggagaagaa ctcactgagt gaggagattg ctaacatgaa
     1561 gaagcttcaa gatgagctgc tcctgaataa ggagcagctc ttggctgaga tggaacggat
     1621 gcagatggag atcgaccagc tacgggggag gccgccctcc tattccaggt ccctccctgg
     1681 cagtgccctg gagctccggt actcccaggc accaacctta ccttctggtg cccctctgga
     1741 tccttatggg gcaggcagtg gccgggcagg caagaggggc cgctggtcgg gggccaagga
     1801 cgagtcttcc aaggactggg accggtctac ccctgctgga tccattccac cccctttccc
     1861 tggagagcta gatggctcag atgaggagga gaccgagggg atgttcgggg ctgaactgct
     1921 gtcccccagt gggcaagctg atgtgcagac actggccatc atgctccagg agcaattgga
     1981 agccatcaac aaggaaatca agctaattca agaagagaaa gaaacgacag agcagcgtgc
     2041 agaggagctg gagagccggg tgtccagttc tggcctcgac tctctgggcc ggtaccgcag
     2101 cagctgttca ctaccgccct ccctcaccac ctccaccctc gccagcccct cacctcccag
     2161 ctccggacac tccacccctc gtctggcacc tcccagtcct gcccgggaga ccgacaagac
     2221 caatcatgtc cccaaggacg aagccggtgt tccacgaggg gagggtccag ccattccagg
     2281 agacacccca ccacccactc cccgctctgc ccgtcttgag aggatgaccc aggctttggc
     2341 actgcaagcg gggtcactgg aagatggggc acctccccgg ggaagtgaga gcaccccaga
     2401 ttccctccac aaagccccca agaggaagag catcaagtca tccatcggtc ggctcttcgg
     2461 caagaaagag aagggccgga tgggaccccc aggccgggaa agtgtttctc tggctgggac
     2521 accgtctgat gaaacactgg ccactgaccc tctgggacta gccaagctga ctggtccagg
     2581 agataaggac aggaggaaca agagaaagca tgaacttcta gaagaggcct gtcgacaagg
     2641 cctgcctttt gctgcctggg acggccccac cgtggtctcc tggctggagc tctgggtggg
     2701 catgcctgca tggtacgtgg ccgcctgccg ggccaatgtc aagagcggcg ccatcatggc
     2761 caacctgtca gacacggaga tccagcggga aatcggcatc agcaatccac tgcacaggct
     2821 caaactgcgc cttgccattc aggagatggt atcactcaca tcaccctctg ctcctgcctc
     2881 ctcacgcacg cccacaggaa acgtgtggat gacacacgag gagatggagt ctctgactgc
     2941 agctacaaaa cccgagacca aggagatcag ctgggagcag atcctggcat atggcgacat
     3001 gaaccacgag tgggtgggca acgactggct gcccagcctt gggctgcccc agtaccgaag
     3061 ctacttcatg gagtcgctag ttgatgctcg gatgttggac catctgaaca agaaagaact
     3121 gcgaggccaa ctcaagatgg tggacagctt ccacagggtt agtctgcact atggtatcat
     3181 gtgcttgaaa cggctcaact atgaccggaa ggatctggag cgaaggaggg aagaaagcca
     3241 gacccaaatc agagatgtga tggtgtggtc caacgaacgg gtcatgggtt gggtgtctgg
     3301 tcttggcctg aaggagtttg ctacgaatct caccgagagt ggggtgcacg gagccctgtt
     3361 ggctctggat gaaaccttcg actactccga cctggccttg cttctacaaa tacctacaca
     3421 gaatgcacaa gctcggcaac tgctggagaa agaattcagt aacctcatct ccctaggaac
     3481 agacagacgg ctggatgagg acagtgccaa gtccttcagc cgctccccat cctggaggaa
     3541 gatgttccgt gagaaggacc tccggggtgt aacccccgat tcagccgaga tgttaccccc
     3601 caactttcgt tcagctgcag caggagccct aggctcaccg ggactcccac tccgcaaact
     3661 gcagcctgaa ggccagactt ctgggagttc acgagcagac ggtgtttcgg tccggactta
     3721 ctcctgctag tgtgcacctc cagagtattg tctagccaga gaccgccgtg agggagctcg
     3781 cccctgcgga ctgcaccacc tacacatacc agccgggtgt gcgtgttccc gcctcccaaa
     3841 tggactgggc ctggaccaaa ccacaagaaa tggacttaaa gggggcagcc gaagaagagg
     3901 acaggaagaa atcccacccc aaacttccgc ctcccttttc tctactttgt aatttattaa
     3961 tccgtttcga atgggagcca ggcgccctgc acctgtggaa agggggcggg gcttccctct
     4021 cgggccgcat gcggggagat gccacccctc ccctttctat tgcccagtcg cggggcccaa
     4081 gtcttccttt tccgtccgct aggaggggag gggagactcg ctgctacaag cctcgccccc
     4141 agcccctccc cccatgccac tcagccctgc cccgctgcgt cttgtcgcca gtcctcgggg
     4201 tcatctgcaa gcggggttcc ctgaccctcc tccctgtctc gtgttctccg aggcctcccc
     4261 gcccccgtgc tatggcggtg tctgtgccca agggtcaggg accagggacg cagcacagcg
     4321 ttcctatttc ccctctgact ccggggtttg catgggaaaa tccctctgtc aactatgccg
     4381 ctggcgatgt ggctggggag aggacggaca atggggagcc cccaccccga ctcggcctcc
     4441 tggctccagg cgttactcag tgatcacggg taaagaccta gtgtttccaa aagctctggt
     4501 gttgaccagc ctttttttga gacagggtct cactttgtag tcctggctgg cctggaactc
     4561 actgtgtaga ctaggctagc ctcgaactca cagagatccg cctgcctctg cctctgcact
     4621 gagattaaag gtgtgtgcca cca
//
