LOCUS       NM_001108745            4986 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus PTPRF interacting protein alpha 2 (Ppfia2), mRNA.
ACCESSION   NM_001108745 XM_001080748 XM_343204
VERSION     NM_001108745.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4986)
  AUTHORS   Stucchi,R., Plucinska,G., Hummel,J.J.A., Zahavi,E.E., Guerra San
            Juan,I., Klykov,O., Scheltema,R.A., Altelaar,A.F.M. and
            Hoogenraad,C.C.
  TITLE     Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM
            Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to
            Postsynaptic Sites
  JOURNAL   Cell Rep 24 (3), 685-700 (2018)
   PUBMED   30021165
REFERENCE   2  (bases 1 to 4986)
  AUTHORS   Wong,M.Y., Liu,C., Wang,S.S.H., Roquas,A.C.F., Fowler,S.C. and
            Kaeser,P.S.
  TITLE     Liprin-alpha3 controls vesicle docking and exocytosis at the active
            zone of hippocampal synapses
  JOURNAL   Proc Natl Acad Sci U S A 115 (9), 2234-2239 (2018)
   PUBMED   29439199
REFERENCE   3  (bases 1 to 4986)
  AUTHORS   Wentzel,C., Sommer,J.E., Nair,R., Stiefvater,A., Sibarita,J.B. and
            Scheiffele,P.
  TITLE     mSYD1A, a mammalian synapse-defective-1 protein, regulates
            synaptogenic signaling and vesicle docking
  JOURNAL   Neuron 78 (6), 1012-1023 (2013)
   PUBMED   23791195
REFERENCE   4  (bases 1 to 4986)
  AUTHORS   Spangler,S.A., Schmitz,S.K., Kevenaar,J.T., de Graaff,E., de
            Wit,H., Demmers,J., Toonen,R.F. and Hoogenraad,C.C.
  TITLE     Liprin-alpha2 promotes the presynaptic recruitment and turnover of
            RIM1/CASK to facilitate synaptic transmission
  JOURNAL   J Cell Biol 201 (6), 915-928 (2013)
   PUBMED   23751498
  REMARK    GeneRIF: Depletion of liprin-alpha2 resulted in reduced turnover of
            RIM1 and CASK at presynaptic terminals, suggesting that
            liprin-alpha2 promotes dynamic scaffolding for molecular complexes
            that facilitate synaptic vesicle release.
REFERENCE   5  (bases 1 to 4986)
  AUTHORS   Zurner,M., Mittelstaedt,T., tom Dieck,S., Becker,A. and Schoch,S.
  TITLE     Analyses of the spatiotemporal expression and subcellular
            localization of liprin-alpha proteins
  JOURNAL   J Comp Neurol 519 (15), 3019-3039 (2011)
   PUBMED   21618221
REFERENCE   6  (bases 1 to 4986)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 4986)
  AUTHORS   Olsen,O., Moore,K.A., Fukata,M., Kazuta,T., Trinidad,J.C.,
            Kauer,F.W., Streuli,M., Misawa,H., Burlingame,A.L., Nicoll,R.A. and
            Bredt,D.S.
  TITLE     Neurotransmitter release regulated by a MALS-liprin-alpha
            presynaptic complex
  JOURNAL   J Cell Biol 170 (7), 1127-1134 (2005)
   PUBMED   16186258
REFERENCE   8  (bases 1 to 4986)
  AUTHORS   Wyszynski,M., Kim,E., Dunah,A.W., Passafaro,M., Valtschanoff,J.G.,
            Serra-Pages,C., Streuli,M., Weinberg,R.J. and Sheng,M.
  TITLE     Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA
            receptor targeting
  JOURNAL   Neuron 34 (1), 39-52 (2002)
   PUBMED   11931740
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343204.3, XM_001080748.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4986
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..4986
                     /gene="Ppfia2"
                     /note="PTPRF interacting protein alpha 2"
                     /db_xref="GeneID:362876"
                     /db_xref="RGD:1305021"
     exon            1..255
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..506
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..4013
                     /gene="Ppfia2"
                     /note="protein tyrosine phosphatase, receptor type, f
                     polypeptide (PTPRF), interacting protein (liprin), alpha
                     2"
                     /codon_start=1
                     /product="liprin-alpha-2"
                     /protein_id="NP_001102215.1"
                     /db_xref="GeneID:362876"
                     /db_xref="RGD:1305021"
                     /translation="MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDR
                     LLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLTGSKGADPPE
                     FAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ
                     AQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVA
                     LREQNVHIQRKMVSSEGSTESEHLDGMEPGQKVHEKRLSNGSIDSTDDTSQIVELQEL
                     LEKQNYEMAQMKDRLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKE
                     DMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELA
                     EQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQR
                     ARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNL
                     EESLHDKERLAEEIEKLRSELDQMKMRTGSLIEPTISRTHLDTSAELRYSVGSLVDSQ
                     SDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLGSHPFESDTEMSDID
                     DDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIE
                     NRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPSGHSTPKLTPRSPAREMDRMG
                     VMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPRAIRMTHTLPSSYHNEARS
                     SLSASLEPDRLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGKKEKARLGQLRGFMETE
                     AAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMP
                     AWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPT
                     SRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQTLAYGDMNHEWIGNEWLPSLGLPQ
                     YRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERR
                     REASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIALDENFDYSSLAL
                     LLQIPTQNTQARQILEREYNNLLALGTERRLDESDDKNFRRGSTWRRQFPPREVHGIS
                     MMPGSSETLPAGFRLTTTSGQSRKMTTDVASSRLQRLDNSTVRTYSC"
     exon            507..560
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..662
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..827
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..902
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1019
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1241
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1388
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1523
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1607
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1739
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1802
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1894
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2030
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2251
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2489
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2519
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2650
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2805
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2899
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2981
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3182
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3245
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3275
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3451
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3549
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3725
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3794
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3954
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            3955..4046
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..4986
                     /gene="Ppfia2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catttttccg atggaccttt ctccttttgg ctgctgacgg agccacggga agatgccgaa
       61 ctgctgccac gttaaggagc cagggcacgt tccaagagaa cgcaggggct cgccagtgtc
      121 taagctgcct ttctcctccc gttgctaggg aaatggtcca ggactgctgg gtgtgagcct
      181 cacctctcct ccagccgaga gactgcggtt gtcattgaca attgaagaaa caggacctga
      241 gataagagac cttagcaatg atgtgcgaag tgatgcccac gattaatgag gacaccccaa
      301 tgagccaacg ggggtcccaa agtagtggct ctgactcgga ctcccacttt gagcaactga
      361 tggtcaatat gctagatgaa agggaccgtt tactggacac acttcgagag actcaggaaa
      421 gcctctcgct tgcccagcaa agactccagg atgtcatcta cgaccgagat tcactccaga
      481 gacagcttaa ttcagccctg cctcaggaca tcgaatctct aacaggaggg ctgactggtt
      541 ctaagggggc tgatccaccg gagtttgctg cactgactaa agagctgaat gcttgccgtg
      601 agcaacttct agaaaaggaa gaagagattt cagagctaaa agctgaaaga aacaacacaa
      661 gactgttgct ggaacacttg gagtgccttg tgtcccgaca tgaaaggtca ctaagaatga
      721 cagtggtcaa gcggcaagca cagtctccct ctggagtgtc cagtgaagtg gaggttctca
      781 aggcactgaa atctttgttt gagcaccaca aagccttgga tgaaaaggta agggagcgac
      841 tgagggtttc tttagaaaga gtctctgcac tggaagagga actagctgca gctaatcagg
      901 agattgttgc cttgcgtgag caaaatgttc atattcaaag aaaaatggta tcgagtgagg
      961 ggtccacgga gtcagaacat cttgacggga tggaaccagg ccagaaagtc catgaaaagc
     1021 gtctatccaa tggctccata gattccacag atgacaccag ccagatcgtc gagctgcaag
     1081 aattgcttga aaagcaaaac tatgaaatgg cccaaatgaa agaccgctta gcagctcttt
     1141 cttcccgagt gggagaagtg gaacaagaag ccgagacggc aagaaaggac ctcattaaaa
     1201 cagaagaaat gaacaccaaa tatcaaaggg acatccgaga ggccatggct cagaaggaag
     1261 atatggaaga aagaatcaca actctggaga agcgttacct gagtgcccag agagaatcta
     1321 cctccattca cgacatgaat gataaactag aaaatgagtt ggcaaacaag gaagccatct
     1381 tgcggcagat ggaagagaaa aacaggcaat tgcaagagcg tcttgagctg gctgagcaaa
     1441 agttacagca gaccatgagg aaagctgaaa ctttacctga agtagaggca gaacttgctc
     1501 agagaattgc agccctaaca aaggctgaag agagacatgg aaatattgaa gagcgtatga
     1561 gacacctaga gggtcaactt gaagagaaga atcaagaact tcaaagagct aggcaaaggg
     1621 agaaaatgaa tgaagagcat aacaagagat tatctgacac cgtggacagg cttctgacag
     1681 aatccaatga gcgcctgcag ctgcacctaa aggaaaggat ggctgccttg gaagagaaga
     1741 atgttttgat tcaagaatca gaaaccttca gaaaaaatct tgaagagtcc ttacatgata
     1801 aggaaagact agcagaagaa atagagaagt tgaggtctga acttgaccaa atgaaaatga
     1861 gaactggctc tctaattgaa ccaactatat cgagaactca tctagacacc tccgctgagt
     1921 tgcggtattc agttgggtcc ctcgtagaca gccagtctga ttacagaacc actaaagtaa
     1981 tacgaagacc aaggagaggc cgcatgggtg tgcgaagaga tgagccaaag gtgaaatccc
     2041 ttggggatca tgaatggaac aggactcagc aaattggagt actaggcagt cacccattcg
     2101 aaagtgacac tgaaatgtca gatattgatg atgacgacag agaaacgatt ttcagctcaa
     2161 tggatcttct ctctccaagt ggccattctg atgcccagac gctagctatg atgcttcaag
     2221 aacaactgga tgcaatcaac aaagaaataa ggctaatcca ggaagaaaag gaatctacag
     2281 aattgcgtgc tgaagaaatc gagaataggg tggctagtgt aagcttggaa ggtctgaact
     2341 tggcaagggt ccatcctggt acctccatca ctgcttctgt tacagcttca tcactggcca
     2401 gttcatctcc cccaagtgga cactcaacgc caaagcttac accaagaagc ccggccaggg
     2461 aaatggaccg tatgggagtc atgaccctgc caagtgatct aaggaaacat cggagaaaga
     2521 ttgcagtggt ggaagaagat gggcgggaag ataaagcaac aattaaatgt gaaacttctc
     2581 ctcccccaac acccagagcc atcagaatga ctcacaccct accttcttcc taccacaatg
     2641 aggcccggag cagtttatct gcctctcttg agccagatag acttgggctt ggcagtgcca
     2701 atagcagcca ggactctctt cacaaagccc cgaagaagaa aggaatcaag tcttcaattg
     2761 ggcgtttgtt tggtaaaaaa gagaaggctc gacttgggca gcttcgaggc ttcatggaga
     2821 cagaagctgc agcacaggaa tcgctgggct taggcaaact tggcactcaa gctgaaaagg
     2881 acagaaggct gaagaaaaag catgaacttc ttgaagaagc tcgtagaaaa ggattaccct
     2941 ttgcccagtg ggacggacct actgtggttg cgtggctgga gctctggctg ggaatgcctg
     3001 cttggtatgt ggcagcatgc agagccaacg tgaaaagtgg tgccatcatg tcggctttat
     3061 cagacactga aatccaaagg gagattggaa tcagcaaccc tctgcaccgc ttaaagctca
     3121 gactagccat ccaggagatg gtttccctca caagcccttc agctcctccg acatcgcgaa
     3181 ctccttcagg caatgtctgg gtgacccatg aagaaatgga aaacctcgca gctccagcaa
     3241 aaacgaaaga atctgaggaa ggaagctggg cccagaccct ggcttatgga gatatgaacc
     3301 atgagtggat cgggaacgaa tggcttccca gcctcggatt accgcaatac cgaagttact
     3361 ttatggaatg cttggttgat gcaagaatgt tagatcacct cacaaaaaag gatcttcgtg
     3421 tccatttaaa aatggtggat agtttccatc gaacaagttt acagtatggg attatgtgct
     3481 tgaaaagatt gaattatgat aggaaagagc tagagagaag acgagaagca agtcaacatg
     3541 aaataaaaga tgttttagtg tggagcaatg atcgagttat tcgctggatc caagcgattg
     3601 gacttcggga atatgccaat aacattcttg agagtggagt gcatggctca ctcatagccc
     3661 tggatgagaa ctttgactac agcagcctag ctctactgct gcagattccc acgcagaaca
     3721 cccaggcaag gcagattctt gaacgcgagt ataataacct cttggctctg ggaactgagc
     3781 ggcgactgga tgaaagtgat gacaagaatt tcagacgcgg atcaacctgg cgaaggcagt
     3841 tccctcctcg cgaggtacac ggaatcagca tgatgcctgg atcctcagaa acattaccag
     3901 ctggattcag gttgaccaca acatctgggc agtccagaaa aatgacgaca gatgttgctt
     3961 catcaagact gcagaggtta gacaactcca ctgttcgcac atactcatgt tgacaagtca
     4021 ctcaaaggag gcagcactga cctgctatgt cgtcttttct gtctacacga cctaaagtgc
     4081 actactgcct aagaagacaa atggagaagt ctttgtgaag actgaactct aaaggaataa
     4141 tataagtaac gatttaccaa acgttaaata tgtgactctg gggggagttg ggtcttgggt
     4201 ttgattagtt tactatgatt gtaataaaat gtttaagtca tctgatgtaa gagcatcatc
     4261 cacgtcataa attctgaaca tctgatgctt ttatgagatg gaaccactcg tttttttcat
     4321 gttgtaatat aataggcatt tatgtattac tgtgtatcat ttctttttaa aggtgtaagt
     4381 cttctgtaaa tggatataaa tatgattttt ttaaaaaaat aaaatatatg gttcatggag
     4441 tctcgagtgc aaacattgaa caattccaag tactgtttgt attttaccat ttcaccattt
     4501 atacggtttt tgaactgtaa cagtcaatca atatgtttct tagaagtgtg tttcatgctt
     4561 cgacatgctt ctccttcaag tctgtcatac tttaaagctg aacacctgcc tctgatcatg
     4621 tgatttaacc tggagcccaa aatgaccttt aaaggcaatc agggatgtga taccctctct
     4681 ctctctctct ctttacaaat gcactgtgat ggctcaatct gttttaaaag aaaacaaagc
     4741 caaactgttt acaagagtca aatgcaatga ttttaaaaat ttatattaag aaaaccatta
     4801 cctaatcgtg ttgcctgtgg accaagaaac acacacacac acacacacac acacacacac
     4861 acacacacac acacacattt tattaagaac tacacgttca tagaaacacc ctgaacttcc
     4921 agccagcact ggacagtgaa tgtcaatcat tgtagagtct gaggtccatt tccactaggg
     4981 gtgggg
//
