LOCUS       NP_001102215            1251 aa            linear   ROD 24-JUN-2024
DEFINITION  liprin-alpha-2 [Rattus norvegicus].
ACCESSION   NP_001102215 XP_001080748 XP_343205
VERSION     NP_001102215.1
DBSOURCE    REFSEQ: accession NM_001108745.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1251)
  AUTHORS   Stucchi,R., Plucinska,G., Hummel,J.J.A., Zahavi,E.E., Guerra San
            Juan,I., Klykov,O., Scheltema,R.A., Altelaar,A.F.M. and
            Hoogenraad,C.C.
  TITLE     Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM
            Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to
            Postsynaptic Sites
  JOURNAL   Cell Rep 24 (3), 685-700 (2018)
   PUBMED   30021165
REFERENCE   2  (residues 1 to 1251)
  AUTHORS   Wong,M.Y., Liu,C., Wang,S.S.H., Roquas,A.C.F., Fowler,S.C. and
            Kaeser,P.S.
  TITLE     Liprin-alpha3 controls vesicle docking and exocytosis at the active
            zone of hippocampal synapses
  JOURNAL   Proc Natl Acad Sci U S A 115 (9), 2234-2239 (2018)
   PUBMED   29439199
REFERENCE   3  (residues 1 to 1251)
  AUTHORS   Wentzel,C., Sommer,J.E., Nair,R., Stiefvater,A., Sibarita,J.B. and
            Scheiffele,P.
  TITLE     mSYD1A, a mammalian synapse-defective-1 protein, regulates
            synaptogenic signaling and vesicle docking
  JOURNAL   Neuron 78 (6), 1012-1023 (2013)
   PUBMED   23791195
REFERENCE   4  (residues 1 to 1251)
  AUTHORS   Spangler,S.A., Schmitz,S.K., Kevenaar,J.T., de Graaff,E., de
            Wit,H., Demmers,J., Toonen,R.F. and Hoogenraad,C.C.
  TITLE     Liprin-alpha2 promotes the presynaptic recruitment and turnover of
            RIM1/CASK to facilitate synaptic transmission
  JOURNAL   J Cell Biol 201 (6), 915-928 (2013)
   PUBMED   23751498
  REMARK    GeneRIF: Depletion of liprin-alpha2 resulted in reduced turnover of
            RIM1 and CASK at presynaptic terminals, suggesting that
            liprin-alpha2 promotes dynamic scaffolding for molecular complexes
            that facilitate synaptic vesicle release.
REFERENCE   5  (residues 1 to 1251)
  AUTHORS   Zurner,M., Mittelstaedt,T., tom Dieck,S., Becker,A. and Schoch,S.
  TITLE     Analyses of the spatiotemporal expression and subcellular
            localization of liprin-alpha proteins
  JOURNAL   J Comp Neurol 519 (15), 3019-3039 (2011)
   PUBMED   21618221
REFERENCE   6  (residues 1 to 1251)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (residues 1 to 1251)
  AUTHORS   Olsen,O., Moore,K.A., Fukata,M., Kazuta,T., Trinidad,J.C.,
            Kauer,F.W., Streuli,M., Misawa,H., Burlingame,A.L., Nicoll,R.A. and
            Bredt,D.S.
  TITLE     Neurotransmitter release regulated by a MALS-liprin-alpha
            presynaptic complex
  JOURNAL   J Cell Biol 170 (7), 1127-1134 (2005)
   PUBMED   16186258
REFERENCE   8  (residues 1 to 1251)
  AUTHORS   Wyszynski,M., Kim,E., Dunah,A.W., Passafaro,M., Valtschanoff,J.G.,
            Serra-Pages,C., Streuli,M., Weinberg,R.J. and Sheng,M.
  TITLE     Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA
            receptor targeting
  JOURNAL   Neuron 34 (1), 39-52 (2002)
   PUBMED   11931740
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_343205.3, XP_001080748.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     Protein         1..1251
                     /product="liprin-alpha-2"
                     /note="protein tyrosine phosphatase, receptor type, f
                     polypeptide (PTPRF), interacting protein (liprin), alpha
                     2"
                     /calculated_mol_wt=142507
     Region          49..>427
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <269..>589
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          895..965
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1013..1078
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1098..1169
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1251
                     /gene="Ppfia2"
                     /coded_by="NM_001108745.1:258..4013"
                     /db_xref="GeneID:362876"
                     /db_xref="RGD:1305021"
ORIGIN      
        1 mmcevmptin edtpmsqrgs qssgsdsdsh feqlmvnmld erdrlldtlr etqeslslaq
       61 qrlqdviydr dslqrqlnsa lpqdiesltg gltgskgadp pefaaltkel nacreqllek
      121 eeeiselkae rnntrllleh leclvsrher slrmtvvkrq aqspsgvsse vevlkalksl
      181 fehhkaldek vrerlrvsle rvsaleeela aanqeivalr eqnvhiqrkm vssegstese
      241 hldgmepgqk vhekrlsngs idstddtsqi velqellekq nyemaqmkdr laalssrvge
      301 veqeaetark dlikteemnt kyqrdiream aqkedmeeri ttlekrylsa qrestsihdm
      361 ndklenelan keailrqmee knrqlqerle laeqklqqtm rkaetlpeve aelaqriaal
      421 tkaeerhgni eermrhlegq leeknqelqr arqrekmnee hnkrlsdtvd rlltesnerl
      481 qlhlkermaa leeknvliqe setfrknlee slhdkerlae eieklrseld qmkmrtgsli
      541 eptisrthld tsaelrysvg slvdsqsdyr ttkvirrprr grmgvrrdep kvkslgdhew
      601 nrtqqigvlg shpfesdtem sdiddddret ifssmdllsp sghsdaqtla mmlqeqldai
      661 nkeirliqee kestelraee ienrvasvsl eglnlarvhp gtsitasvta sslassspps
      721 ghstpkltpr sparemdrmg vmtlpsdlrk hrrkiavvee dgredkatik cetsppptpr
      781 airmthtlps syhnearssl saslepdrlg lgsanssqds lhkapkkkgi kssigrlfgk
      841 kekarlgqlr gfmeteaaaq eslglgklgt qaekdrrlkk khelleearr kglpfaqwdg
      901 ptvvawlelw lgmpawyvaa cranvksgai msalsdteiq reigisnplh rlklrlaiqe
      961 mvsltspsap ptsrtpsgnv wvtheemenl aapaktkese egswaqtlay gdmnhewign
     1021 ewlpslglpq yrsyfmeclv darmldhltk kdlrvhlkmv dsfhrtslqy gimclkrlny
     1081 drkelerrre asqheikdvl vwsndrvirw iqaiglreya nnilesgvhg slialdenfd
     1141 ysslalllqi ptqntqarqi lereynnlla lgterrldes ddknfrrgst wrrqfpprev
     1201 hgismmpgss etlpagfrlt ttsgqsrkmt tdvassrlqr ldnstvrtys c
//
