LOCUS       NM_001106320            4789 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus PTPRF interacting protein alpha 1 (Ppfia1), mRNA.
ACCESSION   NM_001106320 XM_001067102 XM_238162
VERSION     NM_001106320.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4789)
  AUTHORS   Stucchi,R., Plucinska,G., Hummel,J.J.A., Zahavi,E.E., Guerra San
            Juan,I., Klykov,O., Scheltema,R.A., Altelaar,A.F.M. and
            Hoogenraad,C.C.
  TITLE     Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM
            Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to
            Postsynaptic Sites
  JOURNAL   Cell Rep 24 (3), 685-700 (2018)
   PUBMED   30021165
  REMARK    GeneRIF: liprin-alpha and TANC2 are not part of the KIF1A-cargo
            complex but capture dense core vesicles at dendritic spines.
REFERENCE   2  (bases 1 to 4789)
  AUTHORS   Huang,H., Lin,X., Liang,Z., Zhao,T., Du,S., Loy,M.M.T., Lai,K.O.,
            Fu,A.K.Y. and Ip,N.Y.
  TITLE     Cdk5-dependent phosphorylation of liprinalpha1 mediates neuronal
            activity-dependent synapse development
  JOURNAL   Proc Natl Acad Sci U S A 114 (33), E6992-E7001 (2017)
   PUBMED   28760951
  REMARK    GeneRIF: findings collectively demonstrate that the Cdk5-dependent
            phosphorylation of liprinalpha1 is important for the postsynaptic
            organization during activity-dependent synapse development.
            Erratum:[Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9425-E9426.
            doi: 10.1073/pnas.1717049114. PMID: 29078422]
REFERENCE   3  (bases 1 to 4789)
  AUTHORS   Sakamoto,S., Ishizaki,T., Okawa,K., Watanabe,S., Arakawa,T.,
            Watanabe,N. and Narumiya,S.
  TITLE     Liprin-alpha controls stress fiber formation by binding to mDia and
            regulating its membrane localization
  JOURNAL   J Cell Sci 125 (Pt 1), 108-120 (2012)
   PUBMED   22266902
REFERENCE   4  (bases 1 to 4789)
  AUTHORS   Nomura,H., Tadokoro,S. and Hirashima,N.
  TITLE     Liprin-alpha is involved in exocytosis and cell spreading in mast
            cells
  JOURNAL   Immunol Lett 139 (1-2), 110-116 (2011)
   PUBMED   21683737
  REMARK    GeneRIF: liprin-alpha1 facilitates exocytosis and cell spreading,
            and these events might have correlated each other in mast cells.
REFERENCE   5  (bases 1 to 4789)
  AUTHORS   Yin,H., Wang,L., Xiao,F., Huang,Z., Huang,Y., Zhou,C., Han,Y.,
            Tao,S., Yang,H. and Wang,X.
  TITLE     Upregulation of liprin-alpha1 protein in the temporal neocortex of
            intractable epileptic patients and experimental rats
  JOURNAL   Synapse 65 (8), 742-750 (2011)
   PUBMED   21157931
  REMARK    GeneRIF: expression of Liprin-alpha1 in animals in the experimental
            group gradually increased from Days 1 to 30 postseizure induction
            and reached a stable level when spontaneous recurrent seizures
            (SRS) appeared
REFERENCE   6  (bases 1 to 4789)
  AUTHORS   Dickinson,B.A., Jo,J., Seok,H., Son,G.H., Whitcomb,D.J.,
            Davies,C.H., Sheng,M., Collingridge,G.L. and Cho,K.
  TITLE     A novel mechanism of hippocampal LTD involving muscarinic
            receptor-triggered interactions between AMPARs, GRIP and
            liprin-alpha
  JOURNAL   Mol Brain 2, 18 (2009)
   PUBMED   19534762
  REMARK    GeneRIF: These data indicate a novel mechanism of synaptic
            plasticity in which activation of M1 receptors results in AMPA
            receptor endocytosis, via a mechanism involving interactions
            between GluA2, GRIP and liprin-alpha.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4789)
  AUTHORS   Hoogenraad,C.C., Feliu-Mojer,M.I., Spangler,S.A., Milstein,A.D.,
            Dunah,A.W., Hung,A.Y. and Sheng,M.
  TITLE     Liprinalpha1 degradation by calcium/calmodulin-dependent protein
            kinase II regulates LAR receptor tyrosine phosphatase distribution
            and dendrite development
  JOURNAL   Dev Cell 12 (4), 587-602 (2007)
   PUBMED   17419996
REFERENCE   8  (bases 1 to 4789)
  AUTHORS   Shin,H., Wyszynski,M., Huh,K.H., Valtschanoff,J.G., Lee,J.R.,
            Ko,J., Streuli,M., Weinberg,R.J., Sheng,M. and Kim,E.
  TITLE     Association of the kinesin motor KIF1A with the multimodular
            protein liprin-alpha
  JOURNAL   J Biol Chem 278 (13), 11393-11401 (2003)
   PUBMED   12522103
REFERENCE   9  (bases 1 to 4789)
  AUTHORS   Ko,J., Kim,S., Valtschanoff,J.G., Shin,H., Lee,J.R., Sheng,M.,
            Premont,R.T., Weinberg,R.J. and Kim,E.
  TITLE     Interaction between liprin-alpha and GIT1 is required for AMPA
            receptor targeting
  JOURNAL   J Neurosci 23 (5), 1667-1677 (2003)
   PUBMED   12629171
REFERENCE   10 (bases 1 to 4789)
  AUTHORS   Wyszynski,M., Kim,E., Dunah,A.W., Passafaro,M., Valtschanoff,J.G.,
            Serra-Pages,C., Streuli,M., Weinberg,R.J. and Sheng,M.
  TITLE     Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA
            receptor targeting
  JOURNAL   Neuron 34 (1), 39-52 (2002)
   PUBMED   11931740
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On May 29, 2008 this sequence version replaced NM_001106320.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               JAXUCZ010000001.1  209146306-209146569 c
            265-366             JAXUCZ010000001.1  209113064-209113165 c
            367-531             JAXUCZ010000001.1  209112725-209112889 c
            532-606             JAXUCZ010000001.1  209111905-209111979 c
            607-708             JAXUCZ010000001.1  209111497-209111598 c
            709-927             JAXUCZ010000001.1  209111111-209111329 c
            928-1074            JAXUCZ010000001.1  209109464-209109610 c
            1075-1209           JAXUCZ010000001.1  209107847-209107981 c
            1210-1293           JAXUCZ010000001.1  209106212-209106295 c
            1294-1425           JAXUCZ010000001.1  209104318-209104449 c
            1426-1488           JAXUCZ010000001.1  209102141-209102203 c
            1489-1568           JAXUCZ010000001.1  209101271-209101350 c
            1569-1704           JAXUCZ010000001.1  209099052-209099187 c
            1705-1928           JAXUCZ010000001.1  209096970-209097193 c
            1929-2160           JAXUCZ010000001.1  209095821-209096052 c
            2161-2312           JAXUCZ010000001.1  209091184-209091335 c
            2313-2485           JAXUCZ010000001.1  209090037-209090209 c
            2486-2579           JAXUCZ010000001.1  209089655-209089748 c
            2580-2661           JAXUCZ010000001.1  209086199-209086280 c
            2662-2862           JAXUCZ010000001.1  209085909-209086109 c
            2863-3038           JAXUCZ010000001.1  209079570-209079745 c
            3039-3136           JAXUCZ010000001.1  209079380-209079477 c
            3137-3312           JAXUCZ010000001.1  209076775-209076950 c
            3313-3381           JAXUCZ010000001.1  209076232-209076300 c
            3382-3547           JAXUCZ010000001.1  209074883-209075048 c
            3548-4789           JAXUCZ010000001.1  209070608-209071849 c
FEATURES             Location/Qualifiers
     source          1..4789
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..4789
                     /gene="Ppfia1"
                     /note="PTPRF interacting protein alpha 1"
                     /db_xref="GeneID:293645"
                     /db_xref="RGD:1309009"
     CDS             1..3573
                     /gene="Ppfia1"
                     /note="protein tyrosine phosphatase, receptor type, f
                     polypeptide (PTPRF), interacting protein, alpha 1;
                     liprin-alpha-1-like; protein tyrosine phosphatase,
                     receptor type, f polypeptide (PTPRF), interacting protein
                     (liprin), alpha 1"
                     /codon_start=1
                     /product="liprin-alpha-1"
                     /protein_id="NP_001099790.2"
                     /db_xref="GeneID:293645"
                     /db_xref="RGD:1309009"
                     /translation="MMCEVMPTISEAEGPPGGGGSHGSGSPSQPDADSHFEQLMVSML
                     EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCRE
                     QLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEV
                     LKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNSQKKALTE
                     GMLDGNHEQENAPSTNGKRSSDGSLSHEDLAKVLELQEVIDRQAREQSQMKERLASLS
                     SHAAELEEDLDTARKDLIKSEEMNTKLQREVREAMAQKEDMEERITTLEKRYLAAQRE
                     ATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEA
                     ELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTV
                     DKLLSESNERLQLHLKERMAALEDKNSLLREVENAKKQLEETQHDKDQLVLNIEALKA
                     ELEQMRLRGSSLHHGRPHLGSVPDFRFSVADGHVDAYSTSAVLRRPQKGRLAALRDEP
                     SKVQTLNEQDWERAQQASVLANVAQAFESDVDVSDGEDDRDTLLSSVDLLSPSGQADA
                     QTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPP
                     YPASSLAGSSPPGSGRSTPRRVPHSPAREVDRLGVMTLLPASREEVRDDKTTIKCETS
                     PPSSPRPLRLDRLHKGALHTVSHEDIRDLRNSTGSQDGPVSNPSSSNSSQDSLHKAPK
                     KKGIKSSIGRLFGKKEKGRPGPLGKESPGQAGVSETENSSQDALGLSKLGGQAEKNRK
                     LQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALS
                     DTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLP
                     SLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDR
                     KELERKREESQNETRDVLVWSNDRVIRWILSIGLKEFANNLIESGVHGALLALDETFD
                     FSALALLLQIPTQNTQARAVLEREFNNLLVTGTDRRFDEDDDKSFRRAPSWRKKFRPK
                     DIRGLASGSAETLPANFRVTSSMSSPSMQPKKVQMDVYPHYFYR"
     exon            1..264
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..366
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..531
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..606
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..708
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..927
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1074
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1209
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1293
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1425
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1488
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1568
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1704
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1928
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2160
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2312
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2485
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2579
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2661
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2862
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3038
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3136
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3312
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3381
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3547
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
     exon            3548..4789
                     /gene="Ppfia1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatgtgcg aggtgatgcc gaccattagt gaagcggaag gacccccagg aggaggtggg
       61 agccatgggt caggctcccc ttcccagcca gacgctgatt cgcattttga gcagctcatg
      121 gtttccatgc tggaagagcg agaccgcctt ctggacacac tgagagagac acaagaaacg
      181 ctggcattaa cccaggggaa gttgcatgaa gttggtcatg aaagagattc tttgcagagg
      241 cagctcaaca ctgcacttcc acaggagttt gctgcactca cgaaggaact caatgtgtgt
      301 cgggagcagc ttctggagag agaggaagaa attgctgagc tgaaggcaga gaggaacaac
      361 actaggctgc tgttggagca cctagagtgc cttgtctcca ggcacgagcg ctctctacgt
      421 atgacagtgg tgaagaggca ggcacagtca cctgcgggcg tgtccagtga ggtggaggtt
      481 ctgaaagccc tgaagtcact gtttgagcac cacaaagcct tggatgagaa ggtacgagag
      541 cgattacgag tagctctgga gagatgcagc ttgttagaag aggagctagg tgccacccac
      601 aaagagctaa tgattcttaa agaacagaac agtcagaaga aagcactaac agagggaatg
      661 cttgatggga accacgaaca ggaaaatgca ccgagcacca acggcaagag atcttccgat
      721 ggctccttga gccatgagga tcttgccaaa gtgctggagc tgcaggaagt catagacagg
      781 caggctcgag agcagagcca gatgaaggag cgcctggcct ccctgtccag tcatgcagca
      841 gagctggaag aggatctgga cacagctaga aaagacctca tcaagtctga agagatgaat
      901 acgaaactgc agcgagaagt ccgagaagca atggcccaga aggaggatat ggaggagaga
      961 atcaccaccc ttgagaaacg ctacctcgcc gcacagcgtg aagccacgtc tgtgcatgac
     1021 ctcaatgaca aacttgaaaa tgaaattgca aataaagact ccatgcaccg acagacagag
     1081 gacaagaacc gccagttgca agaacgtctg gaattggcag agcagaagct gcagcagacc
     1141 ctgcgcaaag ctgagacgct gccagaggtg gaggctgagc tggcccagag ggtggctgca
     1201 ctctccaagg ctgaggagag acatggcaac attgaagaga ggctgcggca gatggaggca
     1261 cagctggagg agaagaatca ggagctgcag cgggcaagac agagagaaaa gatgaatgag
     1321 gaacataata agcgcctgtc tgacactgtg gacaagttgc tctcagaatc caatgagagg
     1381 ctgcagctgc atctgaagga gagaatggcg gcgctggagg acaagaattc tctgctaagg
     1441 gaagttgaaa atgcaaagaa gcaactagaa gagacccagc atgataagga ccaacttgtc
     1501 ttgaatattg aagccctgaa ggctgagctg gagcagatga gactgagagg ttcttcactt
     1561 catcatggcc gaccccattt gggcagtgtc ccggacttca ggttctctgt ggcagacggg
     1621 catgtggatg cttacagcac cagtgcagtg ttgcggcgcc cccagaaggg ccggctggca
     1681 gcgctgcggg acgagccctc caaggtgcag accctcaatg aacaggactg ggaacgggcc
     1741 caacaagcca gcgtcttggc aaatgtggca caggcatttg agagtgatgt ggatgtgtct
     1801 gatggtgaag atgaccgaga cactctgctc agctcagttg atctgctgtc acccagtggg
     1861 caagctgatg cccagaccct ggccatgatg cttcaggaac agctggatgc gatcaacaaa
     1921 gagatcagac tgatccaaga agagaaggag aatacagagc agcgggcaga ggagatcgag
     1981 agcagagtgg gcagtggaag cttggacaat cttggtcgtt ttagatcaat gagctccata
     2041 cccccctacc ctgcttcctc gcttgccggc tcctctcctc caggcagtgg tcggtccaca
     2101 cccagaaggg tccctcacag tcctgcccgg gaggtggaca ggctgggtgt catgactctg
     2161 ttgccagctt ccagagaaga ggtacgagac gacaagacga cgataaaatg tgaaacctcc
     2221 cccccatcct ccccaaggcc tctgcgctta gacaggctgc acaagggtgc gctgcacacg
     2281 gtcagccatg aggacatcag ggatctgagg aactccacag gctcccagga tggtcccgtg
     2341 agcaacccta gcagcagcaa tagtagccag gactccctcc acaaagcccc aaagaagaag
     2401 ggcatcaaat cctccattgg ccgcttattt gggaagaagg aaaagggccg gcctggtccg
     2461 ctgggcaagg agtcaccagg gcaagctggt gtttcagaga cagaaaattc atctcaagat
     2521 gccttgggac tcagcaaact gggagggcaa gctgagaaaa accggaaact tcagaaaaag
     2581 catgagctgc tggaggaggc ccgcaggcaa ggcttgcctt tcgcacagtg ggatgggcca
     2641 actgtggtgg tgtggctaga gctctgggtt gggatgcctg cctggtatgt ggctgcttgc
     2701 cgagcaaacg tcaagagtgg tgccattatg tcagccctgt cagacactga gatccagcgg
     2761 gagattggca tcagcaaccc cttgcacagg ctgaagctgc ggctggctat ccaagagata
     2821 atgtcactga ctagcccttc tgctccaccc acatctagga cgacgctagc atatggggac
     2881 atgaaccacg agtggattgg caacgagtgg ctgcccagct tgggcctgcc gcagtaccgc
     2941 agctacttca tggagtgcct tgtcgatgcc cggatgctgg atcacctgac caagaaagac
     3001 cttcgagggc agctgaagat ggtcgacagc ttccatagaa acagtttcca gtgtggaatt
     3061 atgtgcctga gaaggttgaa ttatgatcga aaagaactgg aaagaaaacg agaagagagt
     3121 cagaatgaga caagagatgt gcttgtttgg agcaatgatc gggtgattcg ctggatcctg
     3181 tcgatcggcc ttaaagagtt tgccaacaac ctaatagaga gcggtgttca cggcgcactt
     3241 ctggccttgg acgagacgtt cgatttcagc gccctggcac tcttgttaca gattccaaca
     3301 cagaatacac aggctcgcgc tgtcttggaa agagaattca acaacctttt ggtcaccggg
     3361 actgatcgga ggtttgatga ggatgatgac aaaagcttca ggagggcacc ttcctggagg
     3421 aagaagttca gaccaaagga catccgtggc ttggcttctg gctctgcaga gacgttgcct
     3481 gccaacttcc gggtcacctc ctctatgtca tctccctcta tgcagccaaa gaaggttcag
     3541 atggacgttt acccacacta cttctacaga tgacgcacgc cactgcggca cagcggtgca
     3601 gagttcgtgg agccccatct ggcaactctt gctatatgga cccaagatat tttattacag
     3661 agtttttaaa ctagtgaaga gaaaaacaaa tcacaaatac catagagaaa atattttaga
     3721 attgaccgtt tcttatattt atgtacactt acacctcctc atttatacag ctacttactc
     3781 ttccatgtat agctaggcta taaatatcct tttgagtcaa ttcatgttct tatacctaat
     3841 tttagtcttt taaatgaatg tactgtaatg cttgtgtgta aatctgagca aatatagggc
     3901 ttttgtaaat tatgcattta ctgtaattat tcctgtttaa tttttttaat gatgaacctg
     3961 acagaggaaa gaattttgct acgtttataa agtcatcatg atacaagcca tgtgcgatct
     4021 cctctctgca gctctgcaac aatcattctg aaagaagcag actttatttc cagacgtttt
     4081 ccgtcatatt ttcatgactg actctaaccg tactttatct gacataaatc tcggcttcca
     4141 ttgggcttga gactgatggt caggactctg tgaacggccc ttacccctga ccacatccct
     4201 ggccctgctc tggacatggg tggattgtct ccagaggctg agcagtatgt tgagctggga
     4261 gcagcactct actggggcag ggtggcagct gatggagcct tgcagccacc ccaccccccc
     4321 tactcttcaa ggaccaatca cgggcggggc aggtgctcgt tccctggttg gggcagagca
     4381 ggtgaaagca agagacctcg gtggagcggg cagcctgcaa ctccaataaa ggccttattt
     4441 ttcttgtgta aaccgtctta catttatttg taactgttgt aagagtggac ctagttctac
     4501 actcagctgt cctggcagcc tcctgactga cttcagtgaa ctaagaagcc acagggccca
     4561 ggcacaaatg tgcatattta ttgtgtagct gatgagggag aggcttttat atttgctttg
     4621 tgcttttaat tcatctggac agttggttgt tctgtttttc tgttaatcgt ttgtgaccct
     4681 cctgattata taacaaagtc tgtgcagtca acttctgaac tgtttttatc acagtgttat
     4741 ttattgcttt ttttcaataa agtccccagc attttccact gccagttaa
//
