LOCUS       NM_001107210            3245 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase with EF-hand domain 2
            (Ppef2), mRNA.
ACCESSION   NM_001107210 XM_001071302 XM_223273
VERSION     NM_001107210.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3245)
  AUTHORS   Kutuzov,M.A., Bennett,N. and Andreeva,A.V.
  TITLE     Protein phosphatase with EF-hand domains 2 (PPEF2) is a potent
            negative regulator of apoptosis signal regulating kinase-1 (ASK1)
  JOURNAL   Int J Biochem Cell Biol 42 (11), 1816-1822 (2010)
   PUBMED   20674765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 28, 2023 this sequence version replaced NM_001107210.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643289.34567.1, SRR22582424.1270620.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               JAXUCZ010000014.1  16081706-16081957
            253-374             JAXUCZ010000014.1  16089113-16089234
            375-502             JAXUCZ010000014.1  16091231-16091358
            503-560             JAXUCZ010000014.1  16091471-16091528
            561-736             JAXUCZ010000014.1  16092523-16092698
            737-851             JAXUCZ010000014.1  16094062-16094176
            852-898             JAXUCZ010000014.1  16095085-16095131
            899-1065            JAXUCZ010000014.1  16096593-16096759
            1066-1102           JAXUCZ010000014.1  16097286-16097322
            1103-1252           JAXUCZ010000014.1  16097405-16097554
            1253-1642           JAXUCZ010000014.1  16102880-16103269
            1643-1828           JAXUCZ010000014.1  16105642-16105827
            1829-1971           JAXUCZ010000014.1  16107537-16107679
            1972-2078           JAXUCZ010000014.1  16110252-16110358
            2079-2242           JAXUCZ010000014.1  16111834-16111997
            2243-2330           JAXUCZ010000014.1  16113521-16113608
            2331-3245           JAXUCZ010000014.1  16114989-16115903
FEATURES             Location/Qualifiers
     source          1..3245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3245
                     /gene="Ppef2"
                     /note="protein phosphatase with EF-hand domain 2"
                     /db_xref="GeneID:305246"
                     /db_xref="RGD:1307093"
     exon            1..252
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            253..374
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..2584
                     /gene="Ppef2"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase, EF hand calcium-binding domain
                     2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase with
                     EF-hands 2"
                     /protein_id="NP_001100680.1"
                     /db_xref="GeneID:305246"
                     /db_xref="RGD:1307093"
                     /translation="MGSSSSTQHHFAFQNAEKAFKAAALIQRWYRRYMARLEMRRRCT
                     WNIFQSIEYAGQQDQVKLHEFFSYLVDHFTPSSHHERDFLNRMFTEERFAQDVETEEG
                     GDFESIEVPDSYTGPRLSFPLLPDHATALVEAFRLRQQLHARYVLNLLYETRRHLAQL
                     PNINRVSTCYSEEVTVCGDLHGQLDDLIFIFYKNGLPSPERAYVFNGDFVDRGKDSVE
                     VLMVLFAFMLVYPKEFHLNRGNHEDHLVNLRYGFTKEVMHKYKIHGKKILRTLQDVFC
                     WLPLATLVDEKVLVLHGGVSDKTDLELLAKLDRHKIVSTMRCKTRKESENLEEQKRKD
                     NQTSSAQKPTPWFLPQSRSLPSSPFHLGSGFKAYKACRSCSIPCGSAVSKELSRQGQV
                     RRSMDLELELCRQQAGFLGIREKRESLPLADCDADAGGMLKPTPEEWKQVVDILWSDP
                     MAQEGCKANTVRGGGCYFGPDVTEQLMEKYKLQFLIRSHECKPEGYEFCHNRKVLTIF
                     SASNYYEVGSNRGAYVKLGPALTPHIVQYQANKATHRLTMRQRISRVEESALRALRQK
                     LFAHSSDLLVEFRKRDPDESGVITLSDWAVAVEAVLHLGLPWRMLRPQLVNSSADNVL
                     EYKSWLDSLAKEQLSRENIQSSLLEKLYRNRSNLETIFRIIDSDHSGFISLDEFRQTW
                     KLFSSHMNIDITDDGICDLARSIDFNKDGHIDINEFLEAFRLVEQSCSEGQASACPQS
                     TDTGESGRSSPGPC"
     exon            375..502
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..560
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..736
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            737..851
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..898
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1065
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1102
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1252
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1642
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1828
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1971
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2078
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2242
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2330
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..3245
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccccagg actcattcga cccaggctgc tgtcctgagc ttgaaggtgg atactgtgaa
       61 tgtcacatgg catttgaaat gcatagccag ggtagtccgt gtcctcccac cctctgagaa
      121 gacatcagac aaaggtggca tcagatttgt tagacccaca gatccataag gcagttccac
      181 ccaccaacct tgaagatgga tgggttaggt gcctgcctcc tcgggcttca gagtcagcaa
      241 agcgcctaga agcaaacccc tcccttccct cggatccgga tccactgtct gtcccgcagg
      301 agctctctgc ctctcaacca tgggaagcag ctcgtccacc cagcaccact ttgcgtttca
      361 gaatgcggag aaagccttca aggcagcagc cctgatccag agatggtacc gacgctacat
      421 ggcccgcctg gagatgaggc ggcgatgtac ctggaacatc ttccagtcta tagagtatgc
      481 tggacagcaa gatcaggtca agctccatga attcttcagc taccttgtgg accacttcac
      541 tcccagcagt caccacgaga gagatttcct gaaccgaatg ttcactgagg agagattcgc
      601 ccaggatgtg gagacagagg agggcggcga ttttgaatcc atagaggtgc ccgacagcta
      661 cacggggcca cgcctctcct tcccccttct tcctgaccat gccactgcct tggtggaagc
      721 tttcaggctg agacaacagc tccatgctcg ctacgtcttg aatcttttgt atgagaccag
      781 aagacacctg gcccagctgc ccaacatcaa ccgagtctct acctgctaca gcgaggaggt
      841 cacagtgtgt ggagatctac atggccagtt ggatgactta atatttatat tttacaagaa
      901 cggtctaccg tcaccagaga gagcatacgt gttcaacggt gacttcgtgg atcgaggcaa
      961 ggactctgta gaggtcctga tggttctgtt tgccttcatg ttggtgtacc ccaaagagtt
     1021 tcatcttaac agaggaaacc atgaggacca tctagtgaac ttacgatacg gcttcaccaa
     1081 ggaagtgatg cataaataca agatacatgg gaagaaaatc ctaaggacgc ttcaagatgt
     1141 cttctgctgg cttccactgg ccactctggt tgatgagaaa gtccttgttc ttcatggcgg
     1201 ggtctcagac aagacggacc tggaacttct ggctaaacta gataggcaca agattgtttc
     1261 taccatgcga tgcaaaacaa gaaaggaaag tgagaatctg gaggagcaga agagaaaaga
     1321 taaccagaca agctctgcac agaaaccgac tccgtggttt cttcctcaga gccgctctct
     1381 tccctcttcg ccttttcacc tgggctctgg gtttaaggcc tacaaagcct gcaggtcctg
     1441 cagcatcccc tgtggctcgg ctgtcagcaa agagctgtcc cggcaggggc aggtgcggcg
     1501 ctccatggac ctggagctgg aactgtgccg gcagcaagcc ggcttcctgg ggatccgaga
     1561 gaagagggag tctttgccct tggccgactg tgatgctgat gcaggaggga tgctgaagcc
     1621 cactcctgag gagtggaagc aggttgtaga tattctgtgg agcgatccca tggctcagga
     1681 gggctgcaag gccaacactg tccgaggagg aggctgttac tttgggcctg atgtgacaga
     1741 acagttgatg gagaaataca agctacaatt cctgatccga tcacatgagt gcaaacctga
     1801 aggctatgaa ttctgccaca accgcaaggt gttaaccatt ttttctgcct ctaactacta
     1861 tgaagttggc agcaacaggg gagcctacgt caaactggga ccagccctga ctccacatat
     1921 cgtgcagtac caagctaaca aggcgaccca caggctgacc atgaggcaaa ggatcagcag
     1981 agtggaggag tcggccctca gagccctgcg acaaaaatta tttgctcatt cctcggacct
     2041 gcttgttgag tttaggaagc gcgacccgga tgagagcggt gtaatcaccc tgagtgactg
     2101 ggcagtcgcc gtagaggctg tgctgcacct ggggctgcca tggaggatgc tgcggccaca
     2161 actggtcaat agttcagcag ataacgtgtt ggagtacaag tcctggttgg acagcttggc
     2221 caaagagcag ctgagccgag agaatattca gtcgagtctg ctggaaaagc tctatcgaaa
     2281 ccgatccaac ttggagacca tttttaggat catagacagc gaccattcag ggttcatctc
     2341 cctggacgag ttcagacaga cttggaagct cttcagctct catatgaaca tcgacatcac
     2401 agatgatggc atctgtgacc ttgccagaag catcgacttc aacaaggacg gccacatcga
     2461 tatcaatgag ttcctggagg ccttccgcct cgtggagcag tcctgctcgg agggccaggc
     2521 ctctgcttgc ccacagtcca cagacacggg ggagagtggt cgtagcagtc caggcccatg
     2581 ttgaggatag cctggtctat tcactcaaag tgccaacagg cgatgccaag ctcatgactc
     2641 cacatggact tggggacttc atgctaagaa tttgccagca tcaagaatca cctgtgtgta
     2701 cgccggtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta
     2761 gtggtcccaa cctcatttca gaagtcaggt ttaggaatgt ttaaactctc aaatctactc
     2821 tagttgtcac tgatatttta acaccctcag gtttttattt cttatatttt atttattgtt
     2881 ttaaaatgtc accagtaaaa gaaagttttt ttaagggttg ggaatttagc tcagtggtag
     2941 agcgcttgcc tagcaagcgc aaggccctgg gttcagtccc cagctccaaa aaaagaaaaa
     3001 aaaagttttt ttaattatat ataatcctat gaccccaaat ataccttttt cattatgtac
     3061 tcctccttct tatgtattta gagttttctt tttaaaataa atttacattt aattgtacat
     3121 actttcacat gctgctgtat aattttcaca actatcattt aatggccata tagttttctt
     3181 tcaaattaat gtactataat ccatttggtt cctagttaat aaacagacgt gttgcttagt
     3241 ttttc
//
