LOCUS       NM_001039010            1371 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus phosphopantothenoylcysteine synthetase (Ppcs),
            mRNA.
ACCESSION   NM_001039010 XM_216527
VERSION     NM_001039010.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Iuso A, Wiersma M, Schuller HJ, Pode-Shakked B, Marek-Yagel D,
            Grigat M, Schwarzmayr T, Berutti R, Alhaddad B, Kanon B, Grzeschik
            NA, Okun JG, Perles Z, Salem Y, Barel O, Vardi A, Rubinshtein M,
            Tirosh T, Dubnov-Raz G, Messias AC, Terrile C, Barshack I, Volkov
            A, Avivi C, Eyal E, Mastantuono E, Kumbar M, Abudi S, Braunisch M,
            Strom TM, Meitinger T, Hoffmann GF, Prokisch H, Haack TB, Brundel
            BJJM, Haas D, Sibon OCM and Anikster Y.
  TITLE     Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase,
            Cause Autosomal-Recessive Dilated Cardiomyopathy
  JOURNAL   Am J Hum Genet 102 (6), 1018-1030 (2018)
   PUBMED   29754768
REFERENCE   2  (bases 1 to 1371)
  AUTHORS   Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de
            Crecy-Lagard V and Osterman A.
  TITLE     Complete reconstitution of the human coenzyme A biosynthetic
            pathway via comparative genomics
  JOURNAL   J Biol Chem 277 (24), 21431-21439 (2002)
   PUBMED   11923312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK474267.1, BQ195046.1 and BG378487.1.
            
            On Jan 12, 2008 this sequence version replaced NM_001039010.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK474267.1, CK601952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-735               CK474267.1         40-774
            736-1353            BQ195046.1         20-637              c
            1354-1371           BG378487.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1371
                     /gene="Ppcs"
                     /gene_synonym="RGD1311399"
                     /note="phosphopantothenoylcysteine synthetase"
                     /db_xref="GeneID:298490"
                     /db_xref="RGD:1311399"
     CDS             1..936
                     /gene="Ppcs"
                     /gene_synonym="RGD1311399"
                     /EC_number="6.3.2.5"
                     /codon_start=1
                     /product="phosphopantothenate--cysteine ligase"
                     /protein_id="NP_001034099.2"
                     /db_xref="GeneID:298490"
                     /db_xref="RGD:1311399"
                     /translation="MAEMDLVAELPRPEGAARWAEVMARFAARLGEQGRRVVLVTSGG
                     TKVPLEARAVRFLDNFSSGRRGAASAEVFLAAGYGVLFLYRARSAFPYAHRFPPQAWL
                     SALRPSGPAQSGKLSLEAEENALPGFAAALQGYQEAAAAGTFLAVEFTTLADYLHLLQ
                     AAALALNPLGSSAMFYLAAAVSDFYIPVSEMPEHKIHSSGGPLQITMKMVPKMLSPLV
                     KDWAPKAFIVSFKLETDPDIIISRARNALEVYQHQVVVANILESIKSFVIIVTKDSET
                     KLLLSEDEVARGMVIEEKIVDDLRSRHTAFICDRN"
     exon            1..508
                     /gene="Ppcs"
                     /gene_synonym="RGD1311399"
                     /inference="alignment:Splign:2.1.0"
     exon            509..612
                     /gene="Ppcs"
                     /gene_synonym="RGD1311399"
                     /inference="alignment:Splign:2.1.0"
     exon            613..1353
                     /gene="Ppcs"
                     /gene_synonym="RGD1311399"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggaaa tggacctggt ggctgagttg ccgcgtcccg agggtgctgc gcgctgggcc
       61 gaggttatgg ctcgctttgc ggccaggctg ggcgagcagg gccggcgggt ggtgctggtc
      121 acgtctggag gcactaaggt tcctctggaa gcgcgagccg tgcgctttct ggacaacttc
      181 agcagcgggc gacgcggggc agcgtcggcg gaggtcttcc tggctgccgg ctatggggtc
      241 ttgttcttgt accgagcacg ctcggccttc ccctacgccc accgcttccc gccccaggcc
      301 tggctgtcag cccttcggcc ttctggccca gctcaatcgg gcaagctgag tctggaggcc
      361 gaagagaatg cactcccagg ctttgctgca gcgttgcagg gctaccaaga ggcagctgct
      421 gccggcacct tcctggctgt agagtttacc actttggcgg attacctgca tctgctgcag
      481 gctgcggccc tggctctcaa tccattaggc tcttctgcga tgttttacct ggccgcggca
      541 gtgtcagatt tctatattcc tgtctctgaa atgcctgaac acaagatcca ctcatctggt
      601 ggcccactgc agataacaat gaagatggtg ccgaagatgc tctctcctct ggttaaggac
      661 tgggctccca aagcatttat agtttcgttc aagctggaga cagacccgga catcatcatt
      721 agtcgggctc ggaatgctct ggaagtttac cagcatcaag tagtggtggc caatatcctg
      781 gagtcaataa agtcctttgt gattattgta accaaagact cagagacaaa gttactgctg
      841 tctgaggacg aggtagcaag aggcatggtg atagaagaga agatcgtaga cgaccttcgg
      901 tctcgacaca cagcgtttat atgtgacaga aactgaaggg atgctcccct agggttaaaa
      961 gccgggttct caccactgat gtgaactaaa gttaatcctt tgttaaggat aaacacagtg
     1021 aagaagtggc aaaaaacagt gtgcgggcaa aggcctgtga aacactggac accttgatct
     1081 ggaaagtgaa caagattcac aaagactgtg tgattgcgtg ttctgcagag cagacgggac
     1141 tggagctgct gtctgtcagc ctgctgtaca gtagaaagat cgtaggcgca tgaatggtca
     1201 tgctctgaag aagtacttat cgagtgccta ccctttgcca gggcctttgt gcgctgtgag
     1261 ggtctgaaag atgagcgagc gttgtctcgt ttgggacctg gatgtacaaa aatgtatgtg
     1321 caataaagtg tgtgcccata aagggacact tggaaaaaaa aaaaaaaaaa a
//
