LOCUS       NM_153721                352 bp    mRNA    linear   ROD 06-OCT-2023
DEFINITION  Rattus norvegicus pro-platelet basic protein (Ppbp), mRNA.
ACCESSION   NM_153721
VERSION     NM_153721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 352)
  AUTHORS   Zabczyk M, Natorska J, Matusik PT, Molek P, Wojciechowska W, Rajzer
            M, Rajtar-Salwa R, Tokarek T, Lenart-Migdalska A, Olszowska M and
            Undas A.
  TITLE     Neutrophil-activating Peptide 2 as a Novel Modulator of Fibrin Clot
            Properties in Patients with Atrial Fibrillation
  JOURNAL   Transl Stroke Res, 1-11 (2023) In press
   PUBMED   37294500
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 352)
  AUTHORS   Hua S, Shi F, Xie Z, Wu L, Dai M, Zhang Y, Xu X, Zhu Y and Jiang J.
  TITLE     Di-n-butyl phthalate induces oversecretion of vascular
            endothelium-derived NAP-2 and promotes epithelial-mesenchymal
            transition of urothelial cells in newborn hypospadias rats
  JOURNAL   Ecotoxicol Environ Saf 256, 114892 (2023)
   PUBMED   37059017
REFERENCE   3  (bases 1 to 352)
  AUTHORS   Mansanguan C and Maneerat Y.
  TITLE     PPBP gene as a biomarker for coronary heart disease risk in
            postmenopausal Thai women
  JOURNAL   PeerJ 10, e13615 (2022)
   PUBMED   35734636
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 352)
  AUTHORS   Su Y, Chen Y, Zhang W, Liu L, Cao X and Wu J.
  TITLE     Platelet factor 4 and beta-thromboglobulin mRNAs in circulating
            microparticles of trauma patients as diagnostic markers for deep
            vein thrombosis
  JOURNAL   J Thromb Thrombolysis 50 (3), 525-532 (2020)
   PUBMED   32347511
REFERENCE   5  (bases 1 to 352)
  AUTHORS   Horioka K, Tanaka H, Isozaki S, Okuda K, Asari M, Shiono H, Ogawa K
            and Shimizu K.
  TITLE     Hypothermia-induced activation of the splenic platelet pool as a
            risk factor for thrombotic disease in a mouse model
  JOURNAL   J Thromb Haemost 17 (10), 1762-1771 (2019)
   PUBMED   31237986
REFERENCE   6  (bases 1 to 352)
  AUTHORS   Oda M, Haruta H, Nagao M and Nagata Y.
  TITLE     Isolation and characterization of mouse homolog of the neutrophil
            activating peptide-2
  JOURNAL   Biochem Biophys Res Commun 290 (2), 865-868 (2002)
   PUBMED   11785982
REFERENCE   7  (bases 1 to 352)
  AUTHORS   Krijgsveld J, Zaat SA, Meeldijk J, van Veelen PA, Fang G, Poolman
            B, Brandt E, Ehlert JE, Kuijpers AJ, Engbers GH, Feijen J and
            Dankert J.
  TITLE     Thrombocidins, microbicidal proteins from human blood platelets,
            are C-terminal deletion products of CXC chemokines
  JOURNAL   J Biol Chem 275 (27), 20374-20381 (2000)
   PUBMED   10877842
REFERENCE   8  (bases 1 to 352)
  AUTHORS   Cohen AB, Stevens MD, Miller EJ, Atkinson MA, Mullenbach G, Maunder
            RJ, Martin TR, Wiener-Kronish JP and Matthay MA.
  TITLE     Neutrophil-activating peptide-2 in patients with pulmonary edema
            from congestive heart failure or ARDS
  JOURNAL   Am J Physiol 264 (5 Pt 1), L490-L495 (1993)
   PUBMED   8498526
REFERENCE   9  (bases 1 to 352)
  AUTHORS   Yamauchi,K., Furui,H., Taniguchi,N. and Sotobata,I.
  TITLE     Plasma beta-thromboglobulin and platelet factor 4 concentrations in
            patients with atrial fibrillation
  JOURNAL   Jpn Heart J 27 (4), 481-487 (1986)
   PUBMED   2946878
REFERENCE   10 (bases 1 to 352)
  AUTHORS   Tu,C.M.
  TITLE     Effects of pesticide seed treatments on Rhizobium japonicum and its
            symbiotic relationship with soybean
  JOURNAL   Bull Environ Contam Toxicol 18 (2), 190-199 (1977)
   PUBMED   70252
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF349115.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF349115.1, AW921515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680444
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..352
                     /gene="Ppbp"
                     /gene_synonym="Cxcl7; Nap-2"
                     /note="pro-platelet basic protein"
                     /db_xref="GeneID:246358"
                     /db_xref="RGD:70548"
     exon            1..119
                     /gene="Ppbp"
                     /gene_synonym="Cxcl7; Nap-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..340
                     /gene="Ppbp"
                     /gene_synonym="Cxcl7; Nap-2"
                     /note="neutrophil activating peptide-2; platelet basic
                     protein; chemokine (C-X-C motif) ligand 7"
                     /codon_start=1
                     /product="platelet basic protein precursor"
                     /protein_id="NP_714943.1"
                     /db_xref="GeneID:246358"
                     /db_xref="RGD:70548"
                     /translation="MGFRLRPTSSCTRASSLRNLQVLLSLLLVALVPLAVGKPDNNEP
                     FIELRCRCTNTLSGIPLNSISRVNVFRPGAHCDNVEVIATLKNGKEVCLDPTAPMIKK
                     IVKKILEGY"
     exon            120..249
                     /gene="Ppbp"
                     /gene_synonym="Cxcl7; Nap-2"
                     /inference="alignment:Splign:2.1.0"
     exon            250..352
                     /gene="Ppbp"
                     /gene_synonym="Cxcl7; Nap-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccatgggc ttcagactca gacctacatc ctcctgcacc agggccagct ctcttcgtaa
       61 cctacaggtg ctgctgagcc tgcttctcgt tgcgctggtt ccccttgcag ttggaaaacc
      121 tgataacaac gagccattta tcgaattgcg ctgcagatgt acgaatacac tctctggaat
      181 cccactgaac tctatctccc gtgtgaatgt gttccggcca ggagcgcact gtgacaatgt
      241 ggaagtgata gccacactga agaatggaaa ggaagtgtgc ctggacccga ctgcccctat
      301 gatcaagaaa atcgtcaaga agatattgga aggttattga ccagctgctt cg
//
