LOCUS       NM_057198               4065 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus phosphoribosyl pyrophosphate amidotransferase
            (Ppat), mRNA.
ACCESSION   NM_057198 XM_001076038 XM_579602
VERSION     NM_057198.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4065)
  AUTHORS   Camici,M., Micheli,V., Ipata,P.L. and Tozzi,M.G.
  TITLE     Pediatric neurological syndromes and inborn errors of purine
            metabolism
  JOURNAL   Neurochem Int 56 (3), 367-378 (2010)
   PUBMED   20005278
  REMARK    Review article
REFERENCE   2  (bases 1 to 4065)
  AUTHORS   Iwahana,H., Honda,S., Tsujisawa,T., Takahashi,Y., Adzuma,K.,
            Katashima,R., Yamaoka,T., Moritani,M., Yoshimoto,K. and Itakura,M.
  TITLE     Rat genomic structure of amidophosphoribosyltransferase, cDNA
            sequence of aminoimidazole ribonucleotide carboxylase, and cell
            cycle-dependent expression of these two physically linked genes
  JOURNAL   Biochim Biophys Acta 1261 (3), 369-380 (1995)
   PUBMED   7742366
REFERENCE   3  (bases 1 to 4065)
  AUTHORS   Iwahana,H., Yamaoka,T., Mizutani,M., Mizusawa,N., Ii,S.,
            Yoshimoto,K. and Itakura,M.
  TITLE     Molecular cloning of rat amidophosphoribosyltransferase
  JOURNAL   J Biol Chem 268 (10), 7225-7237 (1993)
   PUBMED   8463258
REFERENCE   4  (bases 1 to 4065)
  AUTHORS   Tsuchiya,M., Yoshikawa,H., Itakura,M. and Yamashita,K.
  TITLE     Increased de novo purine synthesis by insulin through selective
            enzyme induction in primary cultured rat hepatocytes
  JOURNAL   Am J Physiol 258 (5 Pt 1), C841-C848 (1990)
   PUBMED   2185659
REFERENCE   5  (bases 1 to 4065)
  AUTHORS   Kunjara,S., Beardsley,S.J. and Greenbaum,A.L.
  TITLE     Renal hypertrophy in experimental diabetes. The activity of the 'de
            novo' and salvage pathways of purine [corrected] synthesis
  JOURNAL   Biochem J 249 (3), 911-914 (1988)
   PUBMED   2451505
  REMARK    Erratum:[Biochem J 1988 Jun 15;252(3):935]
REFERENCE   6  (bases 1 to 4065)
  AUTHORS   Itakura,M., Maeda,N., Tsuchiya,M. and Yamashita,K.
  TITLE     Increased rate of de novo purine synthesis and its mechanism in
            regenerating rat liver
  JOURNAL   Am J Physiol 251 (5 Pt 1), G585-G590 (1986)
   PUBMED   2430469
REFERENCE   7  (bases 1 to 4065)
  AUTHORS   Natsumeda,Y., Prajda,N., Donohue,J.P., Glover,J.L. and Weber,G.
  TITLE     Enzymic capacities of purine de Novo and salvage pathways for
            nucleotide synthesis in normal and neoplastic tissues
  JOURNAL   Cancer Res 44 (6), 2475-2479 (1984)
   PUBMED   6327016
REFERENCE   8  (bases 1 to 4065)
  AUTHORS   Denton,J.E., Lui,M.S., Aoki,T., Sebolt,J. and Weber,G.
  TITLE     Rapid in vivo inactivation by acivicin of CTP synthetase,
            carbamoyl-phosphate synthetase II, and
            amidophosphoribosyltransferase in hepatoma
  JOURNAL   Life Sci 30 (13), 1073-1080 (1982)
   PUBMED   7078346
REFERENCE   9  (bases 1 to 4065)
  AUTHORS   Prajda,N., Morris,H.P. and Weber,G.
  TITLE     Glutamine-phosphoribosylpyrophosphate amidotransferase
            (amidophosphoribosyltransferase, EC 2.4.2.14) activity in normal,
            differentiating, and neoplastic kidney
  JOURNAL   Cancer Res 39 (10), 3909-3914 (1979)
   PUBMED   476627
REFERENCE   10 (bases 1 to 4065)
  AUTHORS   Tsuda,M., Katunuma,N. and Weber,G.
  TITLE     Rat liver glutamine 5-phosphoribosyl-1-pyrophosphate
            amidotransferase [EC 2.4.2.14]. Purification and properties
  JOURNAL   J Biochem 85 (5), 1347-1354 (1979)
   PUBMED   447621
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086999.1.
            
            On or before Oct 23, 2008 this sequence version replaced
            XM_001076038.1, XM_579602.2, NM_057198.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086999.1, D10853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..4065
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /note="phosphoribosyl pyrophosphate amidotransferase"
                     /db_xref="GeneID:117544"
                     /db_xref="RGD:620237"
     exon            1..688
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
     CDS             561..2114
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /EC_number="2.4.2.14"
                     /note="GPAT; glutamine phosphoribosylpyrophosphate
                     amidotransferase"
                     /codon_start=1
                     /product="amidophosphoribosyltransferase"
                     /protein_id="NP_476546.1"
                     /db_xref="GeneID:117544"
                     /db_xref="RGD:620237"
                     /translation="MELEESGIREECGVFGCIASGDWPTQLDVPHVITLGLVGLQHRG
                     QESAGIVTSDGSSVPKFRVHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCEL
                     ENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPP
                     QEQDDTPDWVARIKNLMKEAPAAYSLVIMHRDVIYAVRDPYGNRPLCIGRLMPVSDIN
                     DKEKKSSETEGWVVSSESCSFLSIGARYCHEVKPGEIVEISRHGVRTLDIIPRSNGDP
                     VAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAVEAPVEADLVSTVPESATPAALG
                     YATKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLIDDSI
                     VRGNTISPIIKLLKESGAKEVHIRVASPPIKHPCFMGINIPTKEELIANKPEFEYLAE
                     YLGANSVVYLSVEGLVSSVQQEIKFKKQKVKKRDITIQENGNGLEYFEKTGHCTACLT
                     GQYPVDLEW"
     exon            689..755
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
     exon            756..962
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1075
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1221
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1294
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1446
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1574
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1796
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1917
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..4036
                     /gene="Ppat"
                     /gene_synonym="Atase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctggctg ctcagggcag gaaccgcgtc cccaggcttc cctccacgca ggcgtactga
       61 cgcgaccccg cttccggcgg cccctccccc gcagtccgcg aaaagtggcg cgcaggctgc
      121 gggcccccgc cggccggaga ggtttctggg ttggatcgga ccaagtcctg atggccgggg
      181 gacggcgtga gaccagggac acgcacggct cagactttct gagggaccaa cgcgattaac
      241 tacgctactc tcatcaccta cgccttggga gcgggaaaat aacggagtct cccacgtgca
      301 gggaaaagca gcgatcctga cctctgccgc ggagaattaa ccccagtccc ttgactccat
      361 agctccgccc ccgtcccgtg tcctagctga ttggcccgga gctggagggc gccgccgcag
      421 tagcgagata ctagccggcg gggaaggagg aggcagtctg tagctcgagc ctgtgaggcg
      481 ctctatagcg gagcggacag ctggttggcg cttggaccac gccgcagcag caggtccctc
      541 cacgtgcttt cggcggcgcc atggaactgg aggagtcggg gatccgtgag gaatgtggtg
      601 tgttcgggtg catcgcttct ggagactggc ccacgcagct agatgtgcca catgtgatca
      661 ctctgggact cgtggggctt cagcaccgag gtcaggagag cgctggtatt gtgaccagtg
      721 atgggagttc agtgcctaaa ttcagggtgc ataagggaat gggccttgta aatcatgttt
      781 ttaccgaaga caatttgaag aaattgtatg tctcaaatct tggaatcgga catacgcggt
      841 acgccaccac agggaagtgt gagctggaaa attgccagcc gtttgttgtt gagactctgc
      901 atgggaaaat agctgtggcc cataacggag agctggtgaa cgcagctcgg ctgaggaaga
      961 agcttctgcg gcatggtatt gggctttcca catcctccga tagtgaaatg attacccagt
     1021 tactcgcata tacccctcct caggaacaag atgatactcc agactgggta gcaagaatta
     1081 agaacttaat gaaggaagcg cccgcagcct actccctggt cataatgcac agggacgtca
     1141 tttacgcagt gcgagatcca tacggaaatc gtcctctatg catcggccgt cttatgccag
     1201 tttctgacat aaatgacaaa gagaaaaagt cttcagagac tgaaggatgg gtggtgtcct
     1261 cagagtcttg cagcttttta tctattggtg cgagatattg ccatgaagtg aagcctgggg
     1321 aaattgtaga aatatccaga catggtgtca gaactcttga tataattcca aggtctaatg
     1381 gagacccagt ggctttttgt atcttcgaat atgtttattt tgcaagacca gatagtatgt
     1441 ttgaagacca gatggtttat acggtaaggt accggtgtgg ccagcagctg gcagttgaag
     1501 caccagtgga ggcggacctg gtcagcacag ttccagaatc tgccacgcct gcggccctgg
     1561 ggtatgcgac aaagtgtggg ctgccatatg tggaggtgct gtgtaagaac cggtatgtag
     1621 gaagaacctt cattcagcca aacatgaggc taagacaact tggggttgca aagaaattcg
     1681 gcgtgttgtc tgacaacttt aaaggcaaaa gaattgttct catagatgat tccattgtga
     1741 gaggcaatac tatctcaccc atcataaaac tcctcaaaga atccggtgca aaggaggtac
     1801 acattcgagt cgcttcgcca ccaataaaac atccgtgctt catgggaata aacattccta
     1861 caaaagaaga gcttatagcc aataagcccg aatttgagta tcttgcagag taccttggag
     1921 caaacagcgt tgtgtatctg tcagtggaag gactagtttc gtctgtgcaa caagaaataa
     1981 agttcaagaa gcagaaagtt aaaaagcgtg atatcacaat tcaagaaaat ggaaatggtc
     2041 tggagtattt tgagaagacg ggacactgta cggcttgcct cactggccag taccctgtgg
     2101 atctggaatg gtagctgcct ggaccgatgt gctgcttcca gactgaaagg tcatcaagaa
     2161 gtggtttaca tgtgttcctc agttggtaca aaatggacac cacttgctta tgtattatac
     2221 cttaagtttt gagattttct gaggtcactg aattgctata attgaatcat aaagattaca
     2281 tgtaatgcga catgtgggga ttctttttgt ataaggactg acttttcacc caagagaagg
     2341 caggaagtgg catttcccag acccatgctt gaatggttct aaagaggtga gatagggagg
     2401 ttgtgtgccc aggacaggaa gctttataaa gtttcatgaa aagcttgaat tcattgtgcc
     2461 ccatatgtat ctagtctatg cagtcaagtc tgcagttatg gccttggtct ttgattcttc
     2521 caccccatac acacatgtat ggctctgggg accagtgtac aactcctaaa aaatgaaaac
     2581 ctatgtggaa agctgaggca ggagagtcct gagttcaagg ccaacctggg ttttcctgtc
     2641 tcaagataaa gaacctcttt ctgtgcctcg gactccacat ctgtttccta agtcattcat
     2701 aaacttaatg cttagcggga acttgtgtgt ttgtctggga ggcttagagc tgccgtttta
     2761 cccctgcttc tttaccatgc atggtcagta gcttcagaag ctaatggtaa ttagctttca
     2821 ctaaattagt tttcagtttc cttgtgatgg aggtttgcag accttttcca tctctttggg
     2881 atataccaga acgactgaga aatctatctg gagccctgtt tttctacact tgacagaaaa
     2941 tatttagcct agcaaataac ttagtaagta cattggaaag agaaaatttt aatttcaagt
     3001 aagcctttat ccttgatttg attaaacttg gctgtttgaa tgagtgcttg atcatttaca
     3061 gaactgtgta cttgtataca tgtatgcatt tggtttaaac agagggaata gagacacagt
     3121 agggccgatt ttgtttaaag gctgagggga cagccactgt ttggggaatt agattgcctg
     3181 tacccaagcg ttagctcatg atcatgtttt ttctaatttt ttttgttagg tctagtgaca
     3241 tttttaattt ttttatgatg cagatttagt ggattgaggt gatttactaa ctcctgtttg
     3301 tgtgggattt ttcacatgga aaaataattg tctctatatt gccaaaattt gctactttcc
     3361 aaacccactt agaaatataa tatttattaa aaactgaaat cattagtcca catttggtat
     3421 atagtgtggt gtgtcacata tggcaggtca aaataaactg ttaggacttc gaggtcatgt
     3481 gctgcgtgcg gtgcctgagg ttgtcctgtg gcatagacac aggctggcct ttcacagccc
     3541 tggggccatt ttagtgggtg caacctcctg tgttacatgc attgtgtgta atggcggcgt
     3601 ggaggggtaa ggccgttagg tcagttttta aatggcctta tttaaatttg atgttttaca
     3661 aagaaactca gggaaggtac tacaaccaaa atctctaatt tgacttttgt gttccacagt
     3721 ttttattttg ttttattgga atacttttat aaagggaaat aataaccatg gtcgtttgta
     3781 caactttctt aattatttct tcattgttac cttttatttt acaagtttct gaatatggat
     3841 taaattaaca ttttaccagt ttcaagcctt attttatctg ctttaaatgt atataactag
     3901 agtactatat gctgaaaaga tgaaaaatgt gtttgaagac agttaacgtc ctaaactaat
     3961 gtaagcctac tttttgtttt gtatgtgcct gtgtggtttt ttgttttttt gcaacaaata
     4021 tatgtaataa acgtgtaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
