LOCUS       NM_176075               3252 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus PPARG coactivator 1 beta (Ppargc1b), mRNA.
ACCESSION   NM_176075
VERSION     NM_176075.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Yin,Z., Zhao,Y., He,M., Li,H., Fan,J., Nie,X., Yan,M., Chen,C. and
            Wang,D.W.
  TITLE     MiR-30c/PGC-1beta protects against diabetic cardiomyopathy via
            PPARalpha
  JOURNAL   Cardiovasc Diabetol 18 (1), 7 (2019)
   PUBMED   30635067
  REMARK    GeneRIF: MiR-30c/PGC-1beta protects against diabetic cardiomyopathy
            via PPARalpha signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Liu,Y.C., Gao,X.X., Zhang,Z.G., Lin,Z.H. and Zou,Q.L.
  TITLE     PPAR Gamma Coactivator 1 Beta (PGC-1beta) Reduces Mammalian Target
            of Rapamycin (mTOR) Expression via a SIRT1-Dependent Mechanism in
            Neurons
  JOURNAL   Cell Mol Neurobiol 37 (5), 879-887 (2017)
   PUBMED   27631411
  REMARK    GeneRIF: Abeta increases the expression of mTOR and p-mTOR at the
            site of Ser2448, and the stimulation of Abeta is likely to depend
            on sirtuin 1, PPARgamma, and PGC-1beta pathway in regulating mTOR
            expression.
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Zhang,H., Li,Y., Hu,J., Shen,W.J., Singh,M., Hou,X., Bittner,A.,
            Bittner,S., Cortez,Y., Tabassum,J., Kraemer,F.B. and Azhar,S.
  TITLE     Effect of Creosote Bush-Derived NDGA on Expression of Genes
            Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats:
            Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic
            Steatosis
  JOURNAL   PLoS One 10 (9), e0138203 (2015)
   PUBMED   26394137
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Cho,Y., Hazen,B.C., Russell,A.P. and Kralli,A.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator 1
            (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in
            muscle 1 (Perm1) is a tissue-specific regulator of oxidative
            capacity in skeletal muscle cells
  JOURNAL   J Biol Chem 288 (35), 25207-25218 (2013)
   PUBMED   23836911
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Guo,Y., Fan,Y., Zhang,J., Chang,L., Lin,J.D. and Chen,Y.E.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator 1beta
            (PGC-1beta) protein attenuates vascular lesion formation by
            inhibition of chromatin loading of minichromosome maintenance
            complex in smooth muscle cells
  JOURNAL   J Biol Chem 288 (7), 4625-4636 (2013)
   PUBMED   23264620
  REMARK    GeneRIF: Peroxisome proliferator-activated receptor gamma
            coactivator 1beta (PGC-1beta) protein attenuates vascular lesion
            formation by inhibition of chromatin loading of minichromosome
            maintenance complex in smooth muscle cells
REFERENCE   6  (bases 1 to 3252)
  AUTHORS   Park,K.S., Shin,H.D., Park,B.L., Cheong,H.S., Cho,Y.M., Lee,H.K.,
            Lee,J.Y., Lee,J.K., Kim,H.T., Park,C.S., Han,B.G., Kimm,K. and
            Oh,B.
  TITLE     Putative association of peroxisome proliferator-activated receptor
            gamma co-activator 1beta (PPARGC1B) polymorphism with Type 2
            diabetes mellitus
  JOURNAL   Diabet Med 23 (6), 635-642 (2006)
   PUBMED   16759305
REFERENCE   7  (bases 1 to 3252)
  AUTHORS   Andersen,G., Wegner,L., Yanagisawa,K., Rose,C.S., Lin,J.,
            Glumer,C., Drivsholm,T., Borch-Johnsen,K., Jorgensen,T., Hansen,T.,
            Spiegelman,B.M. and Pedersen,O.
  TITLE     Evidence of an association between genetic variation of the
            coactivator PGC-1beta and obesity
  JOURNAL   J Med Genet 42 (5), 402-407 (2005)
   PUBMED   15863669
REFERENCE   8  (bases 1 to 3252)
  AUTHORS   Lin,J., Tarr,P.T., Yang,R., Rhee,J., Puigserver,P., Newgard,C.B.
            and Spiegelman,B.M.
  TITLE     PGC-1beta in the regulation of hepatic glucose and energy
            metabolism
  JOURNAL   J Biol Chem 278 (33), 30843-30848 (2003)
   PUBMED   12807885
REFERENCE   9  (bases 1 to 3252)
  AUTHORS   Meirhaeghe,A., Crowley,V., Lenaghan,C., Lelliott,C., Green,K.,
            Stewart,A., Hart,K., Schinner,S., Sethi,J.K., Yeo,G., Brand,M.D.,
            Cortright,R.N., O'Rahilly,S., Montague,C. and Vidal-Puig,A.J.
  TITLE     Characterization of the human, mouse and rat PGC1 beta
            (peroxisome-proliferator-activated receptor-gamma co-activator 1
            beta) gene in vitro and in vivo
  JOURNAL   Biochem J 373 (Pt 1), 155-165 (2003)
   PUBMED   12678921
REFERENCE   10 (bases 1 to 3252)
  AUTHORS   Kressler,D., Schreiber,S.N., Knutti,D. and Kralli,A.
  TITLE     The PGC-1-related protein PERC is a selective coactivator of
            estrogen receptor alpha
  JOURNAL   J Biol Chem 277 (16), 13918-13925 (2002)
   PUBMED   11854298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 3, 2020 this sequence version replaced NM_176075.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.57765.1,
                                           SRR26643285.52442.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000018.1  57131356-57131466   c
            112-285             JAXUCZ010000018.1  57052888-57053061   c
            286-498             JAXUCZ010000018.1  57046267-57046479   c
            499-615             JAXUCZ010000018.1  57042285-57042401   c
            616-1711            JAXUCZ010000018.1  57040494-57041589   c
            1712-1748           JAXUCZ010000018.1  57039705-57039741   c
            1749-1810           JAXUCZ010000018.1  57039087-57039148   c
            1811-2612           JAXUCZ010000018.1  57037281-57038082   c
            2613-2688           JAXUCZ010000018.1  57034241-57034316   c
            2689-2810           JAXUCZ010000018.1  57032146-57032267   c
            2811-2965           JAXUCZ010000018.1  57030382-57030536   c
            2966-3252           JAXUCZ010000018.1  57029264-57029550   c
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3252
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /note="PPARG coactivator 1 beta"
                     /db_xref="GeneID:291567"
                     /db_xref="RGD:727948"
     exon            1..111
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..3066
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /note="PGC-1-beta; PPARGC-1-beta; PPAR-gamma coactivator
                     1-beta; peroxisome proliferative activated receptor,
                     gamma, coactivator 1 beta; peroxisome
                     proliferator-activated receptor gamma coactivator
                     1beta-2a"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator 1-beta"
                     /protein_id="NP_788264.2"
                     /db_xref="GeneID:291567"
                     /db_xref="RGD:727948"
                     /translation="MAGNDCGALLDEELSSFFLNYLSDTQGGESGEEQLCADLPELDL
                     SQLDASDFDSATCFGELQWCPETSETEPSQYSPDDSEFFQIDSENEALLAALTKTLDD
                     IPEDDVGLAAFPGLDEGDTPSCTPASPAPLSVPPSPALERLLSPVSEVDELSLLQKLL
                     LATSSPTASSDALKDGATWSQTSLSSRSQRPCVKVDGTQDKKTPMLRSQSRPCTELHK
                     HLTSVLPCPRGKACSPPPHPSPQLLSKEDEEVGEDCPSPWPAPASPQDSLGQDTANPN
                     SAQVPKDDVRAMVQLIRYMHTYCLPQRKLPQRASEPIPQSCSSPLRKVPPRSRQTPKA
                     FWTEFSILRELLAQDILCDVSKPYRLATPVYASLTPQSRTRPPKDSQASPAHSAMAEE
                     VRITASPKSTGPRPSLRPLRLEVKRDVNKPARQKREEDEEEEEEEEEEEEKEDEEEEW
                     GRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCLATET
                     HDLEEELGGLTDSSQGQQLPLGSQIPTLESPCESGCGDTDEDPSCPRPPSRDSPRCLM
                     LALSQSDPLGKKSFEESLTVELCGTAGLTPPTTPPYKPMEEDPFKQDTKHSPGQDTAP
                     SLPSPETLQLTATPGASHKLPKRHPERSELLSHLQHATTQPVSQAGQKRPFSCSFGDH
                     DYCQVIRPEAALQRKVLRSWEPIKVHLEDLAHQGATLPVETKTPRREADQNCDPTPKD
                     SMQLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLLEEE
                     EEEGGEEDDEGEDSGVSPPCSDHCPYQSPPSKASRQLCSRSRSSSGSSSCSSWSPATR
                     KNFRLESRGPCSDGTPSARHAKKRREKAIGEGRVVYIRNLSGDMSSRELKKRFEVFGE
                     IVECQVLRRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEPSFHLSYGGLRHFRWP
                     RYTDYDPTSEESLPSSGKSKYEAMDFDSLLKEAQQSLH"
     exon            112..285
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            286..498
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            499..615
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            616..1711
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1748
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1810
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..2612
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2688
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2810
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2965
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3252
                     /gene="Ppargc1b"
                     /gene_synonym="Perc; PGC1beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactccgccg cacgctgcag ccgcggctgg aagatggcgg ggaacgactg cggcgcgctg
       61 ctggatgaag agctctcgtc cttcttcctc aactatctct ctgacacgca gggtggggag
      121 tctggagagg aacagttatg tgctgacttg ccagagctcg acctctccca gctggatgcc
      181 agtgacttcg actcagccac gtgctttggg gagctgcagt ggtgcccaga gacctcagag
      241 acagagccca gccagtatag ccctgatgat tccgagttct tccagattga cagtgagaat
      301 gaagctctct tggctgcgct taccaagacc ctggatgaca tccccgaaga cgatgtgggg
      361 ctggctgcct tcccaggact ggatgaaggc gacacaccct cctgcacccc agcttcacct
      421 gctcctttat ctgtgccccc cagccccgcc ttggagaggc ttctgtcccc agtgtctgaa
      481 gtggatgagc tttcactgct gcagaagctc ctcctggcca catcctcccc aacagcaagc
      541 tctgatgctc tgaaggacgg ggccacctgg tcgcagacca gcctcagttc cagaagtcag
      601 cggccttgtg tcaaggtgga tggcacccag gacaagaaga cccccatgct acggtctcag
      661 agccggcctt gtacagaact gcataagcac ctcacttcgg tgctgccctg ccccagggga
      721 aaagcctgtt ccccacctcc ccacccaagt cctcagctcc tctccaaaga ggatgaggag
      781 gtgggagagg attgcccaag cccctggcca gctccagcgt ctccccaaga ctcactagga
      841 caggacacgg ccaaccccaa cagtgcccaa gttcccaagg acgacgtgag ggccatggta
      901 cagctcattc gctacatgca tacctactgc ctgcctcaga ggaagctgcc ccaacgggcc
      961 tcagagccaa tcccccagtc ctgcagcagc cccttgagga aggtcccacc ccgatcccgg
     1021 caaaccccca aagccttctg gactgagttc tccatcctaa gggaacttct ggcccaagat
     1081 atcctctgtg atgttagcaa gccctaccgc ctggccacac ctgtctatgc ttctctcaca
     1141 ccccagtcca gaaccaggcc ccccaaagac agtcaggcct cccctgccca ctctgccatg
     1201 gcagaagagg tgagaatcac tgcttccccc aagagcactg gacctagacc cagcctccgt
     1261 cctctgaggc tagaggtgaa acgggatgtc aacaagcctg caaggcaaaa gcgggaggaa
     1321 gatgaggagg aggaagagga agaagaagag gaagaagaaa aagaggatga agaagaggag
     1381 tggggcagga agagaccagg tcgtggcctg ccatggacca aactagggag gaagatggac
     1441 agctctgtgt gccctgtgcg gcgctccagg agactgaatc cagagctggg cccttggctg
     1501 acattcactg atgagcccct aggtgctcta ccctcgatgt gcctggctac agagacccac
     1561 gacctggaag aagagctggg cggcctcaca gacagtagtc aaggccagca gctccccctg
     1621 ggatcccaga tccccaccct ggaaagcccc tgtgaaagtg ggtgtgggga cacagatgaa
     1681 gatccaagct gcccgcggcc cccttccaga gactccccca ggtgcctcat gctggccttg
     1741 tcacaaagtg accctcttgg caagaagagc tttgaggagt ccttgacagt ggagctttgt
     1801 ggcacagcag gactcactcc acccaccaca cctccatata agcccatgga ggaggacccc
     1861 ttcaagcagg acaccaagca cagcccaggc caagacacag ctcccagcct cccttcccct
     1921 gagactcttc agctcacagc caccccaggg gcttcccaca agctgcccaa gaggcacccg
     1981 gagcgaagtg agctcctgtc tcatctgcaa catgccacaa cccagccagt ctcacaggct
     2041 ggccagaagc gtcccttctc ctgctccttt ggagaccatg actactgcca ggtgatcagg
     2101 ccagaggctg ccctgcagag gaaggtgctg cggtcctggg agccaatcaa ggtccacctt
     2161 gaagacttgg cccaccaggg tgcaaccctg ccagtggaaa caaagacccc taggagggag
     2221 gcagaccaga actgtgaccc cacccccaag gacagcatgc agctaagaga ccatgagatc
     2281 cgtgccagcc tcacaaagca ctttgggctg ctggaaaccg ctctggagga ggaagacttg
     2341 gcttcatgta aaagcccgga gtatgacacc gtatttgagg acagcagcag cagcagtggc
     2401 gagagcagct tcctgctaga ggaggaggaa gaggagggag gggaagagga cgatgaagga
     2461 gaggactcag gggtcagccc tccctgctcc gaccactgcc cctaccagag cccacccagt
     2521 aaggccagtc ggcagctctg ttcccgaagc cgctccagtt ctggctcctc atcctgtagc
     2581 tcctggtcac cagctacccg gaagaacttc agacttgaga gcagagggcc ctgttcagat
     2641 ggaaccccaa gcgcccggca tgccaagaag cggcgggaaa aggccatcgg tgaaggtcgt
     2701 gtggtataca tccgaaatct ctccggtgac atgagctctc gggaactaaa gaagcgcttc
     2761 gaggtgtttg gtgagatagt cgagtgccag gtgctgagga gaagtaagag aggccagaag
     2821 cacggtttta ttaccttccg gtgttcggag catgccgccc tgtccgtgag gaacggcgct
     2881 accctgagaa aacgcaatga gccctccttc cacctgagct atggagggct ccggcacttc
     2941 cgctggccca gatacaccga ctatgatccc acgtctgaag agtcccttcc ctcgtctggg
     3001 aaaagcaagt acgaagccat ggattttgac agcttactga aagaggccca gcagagcctg
     3061 cattaatatc agccttaacc ttcgaggaat acctcaatac ctcagacaag gcccttccaa
     3121 tatgtttacg ttttcaaaga aatgagtata tgaggaggag agcaagccaa tgagcgagcg
     3181 agcgagcgag cgtgagagaa cacacaggag agagagactt gaatctgctg tcgtttcctt
     3241 taaaaaaaaa aa
//
