LOCUS       NM_031347               2440 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus PPARG coactivator 1 alpha (Ppargc1a), mRNA.
ACCESSION   NM_031347
VERSION     NM_031347.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2440)
  AUTHORS   Tian,Z., Li,J., Tang,H., Liu,W., Hou,H., Wang,C., Li,D., Chen,G.,
            Xia,T. and Wang,A.
  TITLE     ZLN005 alleviates PBDE-47 induced impairment of mitochondrial
            translation and neurotoxicity through PGC-1alpha/ERRalpha axis
  JOURNAL   J Hazard Mater 471, 134331 (2024)
   PUBMED   38677116
  REMARK    GeneRIF: ZLN005 alleviates PBDE-47 induced impairment of
            mitochondrial translation and neurotoxicity through
            PGC-1alpha/ERRalpha axis.
REFERENCE   2  (bases 1 to 2440)
  AUTHORS   Figarola-Centurion,I., Escoto-Delgadillo,M.,
            Gonzalez-Enriquez,G.V., Gutierrez-Sevilla,J.E., Vazquez-Valls,E.,
            Cardenas-Bedoya,J. and Torres-Mendoza,B.M.
  TITLE     HIV-1 Tat Induces Dysregulation of PGC1-Alpha and Sirtuin 3
            Expression in Neurons: The Role of Mitochondrial Biogenesis in
            HIV-Associated Neurocognitive Disorder (HAND)
  JOURNAL   Int J Mol Sci 24 (24), 17566 (2023)
   PUBMED   38139395
  REMARK    GeneRIF: HIV-1 Tat Induces Dysregulation of PGC1-Alpha and Sirtuin
            3 Expression in Neurons: The Role of Mitochondrial Biogenesis in
            HIV-Associated Neurocognitive Disorder (HAND).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2440)
  AUTHORS   Hoshino,D., Wada,R., Mori,Y., Takeda,R., Nonaka,Y., Kano,R.,
            Takagi,R. and Kano,Y.
  TITLE     Cooling of male rat skeletal muscle during endurance-like
            contraction attenuates contraction-induced PGC-1alpha mRNA
            expression
  JOURNAL   Physiol Rep 11 (21), e15867 (2023)
   PUBMED   37962014
  REMARK    GeneRIF: Cooling of male rat skeletal muscle during endurance-like
            contraction attenuates contraction-induced PGC-1alpha mRNA
            expression.
REFERENCE   4  (bases 1 to 2440)
  AUTHORS   Zou,Y., Wu,S., Wen,F., Ge,Y. and Luo,S.
  TITLE     PGC-1alpha Inhibits Schwann Cell Dedifferentiation and Delays
            Peripheral Nerve Degeneration by Targeting PON1
  JOURNAL   Cell Mol Neurobiol 43 (7), 3767-3781 (2023)
   PUBMED   37526811
  REMARK    GeneRIF: PGC-1alpha Inhibits Schwann Cell Dedifferentiation and
            Delays Peripheral Nerve Degeneration by Targeting PON1.
REFERENCE   5  (bases 1 to 2440)
  AUTHORS   Mu,N., Zhang,T., Zhu,Y., Lu,B., Zheng,Q. and Duan,J.
  TITLE     The mechanism by which miR-494-3p regulates PGC1-alpha-mediated
            inhibition of mitophagy in cardiomyocytes and alleviation of
            myocardial ischemia-reperfusion injury
  JOURNAL   BMC Cardiovasc Disord 23 (1), 204 (2023)
   PUBMED   37085803
  REMARK    GeneRIF: The mechanism by which miR-494-3p regulates
            PGC1-alpha-mediated inhibition of mitophagy in cardiomyocytes and
            alleviation of myocardial ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2440)
  AUTHORS   Louet,J.F., Hayhurst,G., Gonzalez,F.J., Girard,J. and Decaux,J.F.
  TITLE     The coactivator PGC-1 is involved in the regulation of the liver
            carnitine palmitoyltransferase I gene expression by cAMP in
            combination with HNF4 alpha and cAMP-response element-binding
            protein (CREB)
  JOURNAL   J Biol Chem 277 (41), 37991-38000 (2002)
   PUBMED   12107181
  REMARK    GeneRIF: Results show that CREB and HNF4alpha bind the CPT
            promoter, that PGC-1 is involved in liver carnitine
            palmitoyltransferase I (CPT) gene activation by cylic AMP, and that
            PGC-1 acts to coordinate the process of metabolic adaptation in the
            liver.
REFERENCE   7  (bases 1 to 2440)
  AUTHORS   Lane,R.H., MacLennan,N.K., Hsu,J.L., Janke,S.M. and Pham,T.D.
  TITLE     Increased hepatic peroxisome proliferator-activated receptor-gamma
            coactivator-1 gene expression in a rat model of intrauterine growth
            retardation and subsequent insulin resistance
  JOURNAL   Endocrinology 143 (7), 2486-2490 (2002)
   PUBMED   12072378
  REMARK    GeneRIF: increased PGC-1 expression and subsequent hepatic glucose
            production contribute to the insulin resistance observed in the
            intrauterine growth retardation juvenile rat
REFERENCE   8  (bases 1 to 2440)
  AUTHORS   Oberkofler,H., Esterbauer,H., Linnemayr,V., Strosberg,A.D.,
            Krempler,F. and Patsch,W.
  TITLE     Peroxisome proliferator-activated receptor (PPAR) gamma
            coactivator-1 recruitment regulates PPAR subtype specificity
  JOURNAL   J Biol Chem 277 (19), 16750-16757 (2002)
   PUBMED   11875072
  REMARK    GeneRIF: Peroxisome proliferator-activated receptor (PPAR) gamma
            coactivator-1 recruitment regulates PPAR subtype specificity.
REFERENCE   9  (bases 1 to 2440)
  AUTHORS   Kakuma,T., Wang,Z.W., Pan,W., Unger,R.H. and Zhou,Y.T.
  TITLE     Role of leptin in peroxisome proliferator-activated receptor gamma
            coactivator-1 expression
  JOURNAL   Endocrinology 141 (12), 4576-4582 (2000)
   PUBMED   11108270
REFERENCE   10 (bases 1 to 2440)
  AUTHORS   Goto,M., Terada,S., Kato,M., Katoh,M., Yokozeki,T., Tabata,I. and
            Shimokawa,T.
  TITLE     cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in
            swimming-exercised rats
  JOURNAL   Biochem Biophys Res Commun 274 (2), 350-354 (2000)
   PUBMED   10913342
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB025784.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB025784.1, AY237127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2440
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Z"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..2440
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /note="PPARG coactivator 1 alpha"
                     /db_xref="GeneID:83516"
                     /db_xref="RGD:620925"
     exon            1..89
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2432
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /note="PGC-1-alpha; PPARGC-1-alpha; PPAR-gamma coactivator
                     1-alpha; peroxisome proliferative activated receptor,
                     gamma, coactivator 1 alpha; PGC-1alpha; PPAR gamma
                     coactivator 1alpha variant form-1; Ppargc1a-vf1;
                     peroxisome proliferative activated receptor gamma
                     coactivator 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator 1-alpha"
                     /protein_id="NP_112637.1"
                     /db_xref="GeneID:83516"
                     /db_xref="RGD:620925"
                     /translation="MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDL
                     DTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDED
                     GLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECS
                     GLSTQNHANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDP
                     PHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENK
                     TIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSEC
                     SGTQGSHSTKKGPEQSELYAQLSKSSVLSRGHEERKTKRPSLRLFGDHDYCQSVNSKT
                     DILINISQELQDSRQLDFKDASCDWQGHICSSTDSSQCYLRETLEASKQVSPCSTRKQ
                     LQDQEIRAELNKHFGHPSQAVFDDKVDKTSELRDGNFSNEQFSKLPVFINSGLAMDGL
                     FDDSEDENDKLSYPWDGTQSYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSR
                     SRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRS
                     PYSRRPRYDSYEANEHERLKRDEYRREYEKRESERAKQRERQKQKAIEERRVIYVGKI
                     RPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSN
                     ETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR"
     exon            90..269
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..464
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..587
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..792
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..838
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..912
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1828
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1933
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2054
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2176
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2328
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2440
                     /gene="Ppargc1a"
                     /gene_synonym="LRPGC1; PGC-1v; PGCvf; PGCvf-1; PGCvf1;
                     Ppargc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggagttga aaaagcttga ctggcgtcat tcaggagctg gatggcttgg gacatgtgca
       61 gccaagactc tgtatggagt gacatagagt gtgctgccct ggttggtgag gaccagcctc
      121 tttgcccaga tcttcctgaa cttgaccttt ctgaacttga tgtgaatgac ctggacacag
      181 acagctttct gggtggattg aagtggtgta gtgaccaatc agaaatcata tccaaccagt
      241 acaacaatga gcccgcgaac atattcgaga agatagatga agagaatgag gcaaacttgc
      301 tagcggtcct cacagagaca ctggacagtc tcccggtgga tgaagacgga ttgccctcat
      361 ttgatgcact gacagatgga gacgtgacca ctgacaacga ggccagtcct tcctccatgc
      421 ctgacggcac ccctccccct caggaggcag aagagccgtc tctacttaag aagctcttac
      481 tggcgccagc caacactcag ctcagctaca atgaatgcag cggtcttagc actcagaacc
      541 atgcaaacca cacccacagg atcagaacaa accctgccat tgttaagacc gagaattcat
      601 ggagcaataa agcaaagagc atttgtcaac agcaaaagcc acaaagacgt ccctgctcag
      661 agcttctcaa gtatctgacc acaaacgatg accctcctca caccaaaccc acagagaaca
      721 gaaacagcag cagagacaaa tgtgcttcca aaaagaagtc ccatacacaa ccgcagtcgc
      781 aacatgctca agccaaacca acaactttat ctcttcctct gaccccagag tcaccaaatg
      841 accccaaggg ttccccattt gagaacaaga ctattgagcg aaccttaagt gtggaactct
      901 ctggaactgc aggcctaact cctcccacga ctcctcctca taaagccaac caagataacc
      961 ctttcaaggc ttcgccaaag ctgaagccct cttgcaagac cgtggtgcca ccaccaacaa
     1021 agagggcccg gtacagtgag tgttctggta cccaaggcag ccactccacc aagaaagggc
     1081 cggagcaatc tgagttatac gcacaactca gcaagtcctc agtgctcagc cgaggacacg
     1141 aggaaaggaa gactaaacgg cccagtctac ggctgtttgg tgatcatgac tactgtcagt
     1201 cagtcaattc caaaacggat atactcatta acatatcaca ggagctccaa gactctagac
     1261 aactagactt caaagatgcc tcctgtgact ggcaggggca catctgttct tccacagatt
     1321 caagccagtg ctacctgaga gagactttgg aggccagcaa gcaggtctct ccttgcagca
     1381 ccagaaaaca gctccaagac caggaaatcc gagctgagct gaacaagcac ttcggtcatc
     1441 ccagtcaagc tgtttttgac gacaaagtag acaagaccag tgaactacgg gatggcaact
     1501 tcagtaatga acaattctcc aaactacctg tgtttataaa ttcaggacta gccatggatg
     1561 gcctatttga tgacagtgaa gatgaaaatg ataaactgag ctacccttgg gatggcacgc
     1621 agtcctattc attgttcgat gtgtcgcctt cttgctcttc ctttaactct ccgtgtcgag
     1681 attcagtgtc accaccgaaa tccttatttt ctcaaagacc ccaaaggatg cgctctcgtt
     1741 cgagatcctt ttctcgacac aggtcgtgtt cccgatcacc atattccagg tcaagatcaa
     1801 ggtccccagg cagtagatcc tcttcaagat cctgttacta ttatgaatca agccactaca
     1861 gacaccgcac acatcgcaat tctcccttgt atgtgagatc acgttcaagg tcaccctaca
     1921 gccgtaggcc caggtatgac agctatgaag ccaatgagca cgaaaggctc aagagggacg
     1981 aataccgcag agagtatgag aagcgggagt ctgaaagggc caagcagaga gagaggcaga
     2041 agcagaaagc aattgaagag cgccgtgtga tttacgttgg taaaatcaga cctgacacaa
     2101 cgcggacaga actgagagac cgctttgaag tttttggtga aattgaggaa tgcaccgtaa
     2161 atctgcggga tgatggagac agctatggtt tcattaccta ccgttacacc tgtgacgctt
     2221 tcgctgctct tgagaatgga tatactttac gcaggtcgaa tgaaactgac ttcgagctgt
     2281 acttttgtgg acggaagcaa tttttcaagt ctaactatgc agacctagat tcaaactcag
     2341 acgattttga ccctgcttcc accaagagca agtatgactc tctggatttt gatagtttac
     2401 tgaaggaagc tcagagaagc ttgcgcaggt aacgtgttcc
//
