LOCUS       NM_001145367            2008 bp    mRNA    linear   ROD 08-MAR-2025
DEFINITION  Rattus norvegicus peroxisome proliferator-activated receptor gamma
            (Pparg), transcript variant 3, mRNA.
ACCESSION   NM_001145367
VERSION     NM_001145367.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2008)
  AUTHORS   Li,Y., Wei,X., Xiao,R., Chen,Y., Xiong,T., Fang,Z.M., Huo,B.,
            Guo,X., Luo,H., Wu,X., Liu,L., Zhu,X.H., Hu,Q., Jiang,D.S. and
            Yi,X.
  TITLE     SMYD2-Methylated PPARgamma Facilitates Hypoxia-Induced Pulmonary
            Hypertension by Activating Mitophagy
  JOURNAL   Circ Res 135 (1), 93-109 (2024)
   PUBMED   38770649
  REMARK    GeneRIF: SMYD2-Methylated PPARgamma Facilitates Hypoxia-Induced
            Pulmonary Hypertension by Activating Mitophagy.
REFERENCE   2  (bases 1 to 2008)
  AUTHORS   Geng,Q., Xu,J., Cao,X., Wang,Z., Jiao,Y., Diao,W., Wang,X.,
            Wang,Z., Zhang,M., Zhao,L., Yang,L., Deng,T., Fan,B., Xu,Y., Jia,L.
            and Xiao,C.
  TITLE     PPARG-mediated autophagy activation alleviates inflammation in
            rheumatoid arthritis
  JOURNAL   J Autoimmun 146, 103214 (2024)
   PUBMED   38648706
  REMARK    GeneRIF: PPARG-mediated autophagy activation alleviates
            inflammation in rheumatoid arthritis.
REFERENCE   3  (bases 1 to 2008)
  AUTHORS   Lai,W., Yu,L. and Deng,Y.
  TITLE     PPARgamma alleviates preeclampsia development by regulating lipid
            metabolism and ferroptosis
  JOURNAL   Commun Biol 7 (1), 429 (2024)
   PUBMED   38594496
  REMARK    GeneRIF: PPARgamma alleviates preeclampsia development by
            regulating lipid metabolism and ferroptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2008)
  AUTHORS   Li,S., Lyu,Q., Shi,Q., Bai,Y., Ren,X. and Ma,J.
  TITLE     Intermittent short-duration reoxygenation relieves high-altitude
            pulmonary hypertension via NOX4/H2O2/PPAR-gamma axis
  JOURNAL   Clin Sci (Lond) 138 (3), 103-115 (2024)
   PUBMED   38237016
  REMARK    GeneRIF: Intermittent short-duration reoxygenation relieves
            high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-gamma axis.
REFERENCE   5  (bases 1 to 2008)
  AUTHORS   Cheng,P., Wei,H.Z., Chen,H.W., Wang,Z.Q., Mao,P. and Zhang,H.H.
  TITLE     DNMT3a-mediated methylation of PPARgamma promote intervertebral
            disc degeneration by regulating the NF-kappaB pathway
  JOURNAL   J Cell Mol Med 28 (2), e18048 (2024)
   PUBMED   37986543
  REMARK    GeneRIF: DNMT3a-mediated methylation of PPARgamma promote
            intervertebral disc degeneration by regulating the NF-kappaB
            pathway.
REFERENCE   6  (bases 1 to 2008)
  AUTHORS   Kliewer,S.A., Sundseth,S.S., Jones,S.A., Brown,P.J., Wisely,G.B.,
            Koble,C.S., Devchand,P., Wahli,W., Willson,T.M., Lenhard,J.M. and
            Lehmann,J.M.
  TITLE     Fatty acids and eicosanoids regulate gene expression through direct
            interactions with peroxisome proliferator-activated receptors alpha
            and gamma
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4318-4323 (1997)
   PUBMED   9113987
REFERENCE   7  (bases 1 to 2008)
  AUTHORS   Adams,M., Reginato,M.J., Shao,D., Lazar,M.A. and Chatterjee,V.K.
  TITLE     Transcriptional activation by peroxisome proliferator-activated
            receptor gamma is inhibited by phosphorylation at a consensus
            mitogen-activated protein kinase site
  JOURNAL   J Biol Chem 272 (8), 5128-5132 (1997)
   PUBMED   9030579
REFERENCE   8  (bases 1 to 2008)
  AUTHORS   Hu,E., Kim,J.B., Sarraf,P. and Spiegelman,B.M.
  TITLE     Inhibition of adipogenesis through MAP kinase-mediated
            phosphorylation of PPARgamma
  JOURNAL   Science 274 (5295), 2100-2103 (1996)
   PUBMED   8953045
REFERENCE   9  (bases 1 to 2008)
  AUTHORS   Zhang,B., Berger,J., Zhou,G., Elbrecht,A., Biswas,S.,
            White-Carrington,S., Szalkowski,D. and Moller,D.E.
  TITLE     Insulin- and mitogen-activated protein kinase-mediated
            phosphorylation and activation of peroxisome proliferator-activated
            receptor gamma
  JOURNAL   J Biol Chem 271 (50), 31771-31774 (1996)
   PUBMED   8943212
REFERENCE   10 (bases 1 to 2008)
  AUTHORS   Kliewer,S.A., Forman,B.M., Blumberg,B., Ong,E.S., Borgmeyer,U.,
            Mangelsdorf,D.J., Umesono,K. and Evans,R.M.
  TITLE     Differential expression and activation of a family of murine
            peroxisome proliferator-activated receptors
  JOURNAL   Proc Natl Acad Sci U S A 91 (15), 7355-7359 (1994)
   PUBMED   8041794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. Both variants 2 and 3
            encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF246458.1, SRR26643285.17440.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000004.1  150095831-150096134
            305-371             JAXUCZ010000004.1  150117390-150117456
            372-599             JAXUCZ010000004.1  150173269-150173496
            600-769             JAXUCZ010000004.1  150174816-150174985
            770-908             JAXUCZ010000004.1  150183532-150183670
            909-1108            JAXUCZ010000004.1  150193950-150194149
            1109-1559           JAXUCZ010000004.1  150203893-150204343
            1560-2008           JAXUCZ010000004.1  150220656-150221104
FEATURES             Location/Qualifiers
     source          1..2008
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2008
                     /gene="Pparg"
                     /gene_synonym="PPARgamma2"
                     /note="peroxisome proliferator-activated receptor gamma"
                     /db_xref="GeneID:25664"
                     /db_xref="RGD:3371"
     exon            1..304
                     /gene="Pparg"
                     /gene_synonym="PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..371
                     /gene="Pparg"
                     /gene_synonym="PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            372..599
                     /gene="Pparg"
                     /gene_synonym="PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..1807
                     /gene="Pparg"
                     /gene_synonym="PPARgamma2"
                     /note="isoform 2 is encoded by transcript variant 3;
                     PPAR-gamma; nuclear receptor subfamily 1 group C member 3;
                     peroxisome proliferator activator receptor, gamma"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     isoform 2"
                     /protein_id="NP_001138839.1"
                     /db_xref="GeneID:25664"
                     /db_xref="RGD:3371"
                     /translation="MVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVDFSSIS
                     APHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSN
                     SLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKC
                     QYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYD
                     SYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVA
                     IRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNK
                     DGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILS
                     GDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQL
                     LHVIKKTETDMSLHPLLQEIYKDLY"
     exon            600..769
                     /gene="Pparg"
                     /gene_synonym="PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..908
                     /gene="Pparg"
                     /gene_synonym="PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1108
                     /gene="Pparg"
                     /gene_synonym="PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1559
                     /gene="Pparg"
                     /gene_synonym="PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..2008
                     /gene="Pparg"
                     /gene_synonym="PPARgamma2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggtcggcc gcacggacgc acattgcccg ccaagccgcc gcctcaggtc agagtcgccc
       61 cgggccacaa ggcccgccgc agggacgctg aagaagagac ctggggcgcc gcactggggt
      121 accgggtcgt gtgaggcctg aggggactga gtgtgacgac aaggtgacca ggctgagggg
      181 acgggctgag gagaagtcat actcagacag gacccggtga gactgacagc ctgacgaggt
      241 ctctctcggc tgaggggacg cgggctgaga agtcactttc tgaccggact gtgtgacaga
      301 caagatttga aagaagctgt gaaccactaa tatccaagga catttttgaa aacaaggact
      361 accctttact gaaattacca tggttgacac agagatgcca ttctggccca ccaacttcgg
      421 aatcagctct gtggacctct ctgtgatgga tgaccactcc cattcctttg acatcaaacc
      481 ctttaccacg gttgatttct ccagcatttc tgctccacac tatgaagaca tcccgttcac
      541 aagagctgac ccaatggttg ctgattacaa atatgacctg aagctccaag aataccaaag
      601 tgcgatcaaa gtagagcctg cgtccccgcc ttattattct gaaaaaaccc aactctacaa
      661 caggccacat gaagagcctt caaactccct catggccatc gagtgccgag tctgtgggga
      721 taaagcatca ggcttccact atggagtcca tgcttgtgaa ggatgcaagg gttttttccg
      781 aagaaccatc cgattgaagc ttatttatga taggtgtgat cttaactgtc ggatccacaa
      841 aaagagtaga aataaatgtc agtactgtcg gtttcagaag tgccttgctg tggggatgtc
      901 tcacaatgcc atcaggtttg ggcgaatgcc acaggccgag aaggagaagc tgttggcgga
      961 gatctccagt gatatcgacc agctgaaccc agagtctgct gatctgcgag ccctggcaaa
     1021 gcatttgtat gactcataca taaagtcctt cccgctgacc aaagccaagg cgagggcgat
     1081 cttgacagga aagacaacag acaaatcacc atttgtcatc tacgacatga attccttaat
     1141 gatgggagaa gacaaaatca agttcaaaca tatcaccccc ctgcaggagc agagcaaaga
     1201 ggtggccatc cgcatttttc aagggtgcca gtttcgatcc gtggaagctg tgcaagagat
     1261 cacagagtat gccaaaaata tccctggttt cattaacctt gacttgaatg accaagtgac
     1321 tctgctcaag tatggtgtcc atgagatcat ctacaccatg ctggcctccc tgatgaataa
     1381 agatggagtc ctcatatcag agggacaagg attcatgacc agggagttcc tcaaaagcct
     1441 gcggaagccc tttggtgact ttatggagcc taagtttgag tttgctgtga agttcaatgc
     1501 actggaatta gatgacagtg acttggccat atttatagct gtcattattc tcagtggaga
     1561 ccgcccaggc ttgctgaacg tgaagcccat cgaggacatc caagacaacc tgctgcaggc
     1621 cctggaactc cagctgaagc tgaaccaccc ggagtcctcc cagctgttcg ccaaggtgct
     1681 ccagaagatg acagacctca ggcagattgt cacagagcac gtgcagctac tgcatgtgat
     1741 caagaagacg gagacagata tgagccttca ccctctgctc caggagatct acaaggactt
     1801 gtattagcag aaaagtccca gtcgctgaca aagtgttcct tctatcgatt gcactattat
     1861 tttgagggga aaaaaatctg acacctaaga aatttactgt gaaaaaagca tttaaaaaca
     1921 aaaagtttta gaacatgatc tattttatgc atattgttta taaagataca tttacaattt
     1981 acttttaata ttaaaaatta ccacacta
//
