LOCUS       NM_013196               2021 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Rattus norvegicus peroxisome proliferator activated receptor alpha
            (Ppara), mRNA.
ACCESSION   NM_013196
VERSION     NM_013196.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2021)
  AUTHORS   Hu,T., Yu,W.P., Wang,X.Q., Wang,Z.Y., Xu,Z.Q., Hu,F.J., Liu,J.C.,
            Yu,F. and Wang,L.J.
  TITLE     Activation of PPAR-alpha attenuates myocardial ischemia/reperfusion
            injury by inhibiting ferroptosis and mitochondrial injury via
            upregulating 14-3-3eta
  JOURNAL   Sci Rep 14 (1), 15246 (2024)
   PUBMED   38956068
  REMARK    GeneRIF: Activation of PPAR-alpha attenuates myocardial
            ischemia/reperfusion injury by inhibiting ferroptosis and
            mitochondrial injury via upregulating 14-3-3eta.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2021)
  AUTHORS   Zhu,L., Yao,X., Mo,Y., Chen,M.W., Li,S.C., Liu,J.Q. and Liu,H.Y.
  TITLE     miR-4433a-3p promotes granulosa cell apoptosis by targeting
            peroxisome proliferator-activated receptor alpha and inducing
            immune cell infiltration in polycystic ovarian syndrome
  JOURNAL   J Assist Reprod Genet 40 (6), 1447-1459 (2023)
   PUBMED   37204637
  REMARK    GeneRIF: miR-4433a-3p promotes granulosa cell apoptosis by
            targeting peroxisome proliferator-activated receptor alpha and
            inducing immune cell infiltration in polycystic ovarian syndrome.
REFERENCE   3  (bases 1 to 2021)
  AUTHORS   Shen,W., Yang,L., Yang,Y., Wang,P., Tao,X., Shen,Y., Wang,S. and
            Shen,Y.
  TITLE     PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARalpha
            Activation in Rats Fed High-Fat Diet
  JOURNAL   Antioxid Redox Signal 38 (16-18), 1184-1200 (2023)
   PUBMED   36401357
  REMARK    GeneRIF: PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent
            PPARalpha Activation in Rats Fed High-Fat Diet.
REFERENCE   4  (bases 1 to 2021)
  AUTHORS   Zhao,H.X., Zhang,Z., Hu,F., Wei,Q.F., Yu,Y.S. and Zhao,H.D.
  TITLE     Swimming exercise activates peroxisome proliferator-activated
            receptor-alpha and mitigates age-related renal fibrosis in rats
  JOURNAL   Mol Cell Biochem 478 (5), 1109-1116 (2023)
   PUBMED   36219352
  REMARK    GeneRIF: Swimming exercise activates peroxisome
            proliferator-activated receptor-alpha and mitigates age-related
            renal fibrosis in rats.
REFERENCE   5  (bases 1 to 2021)
  AUTHORS   DeFronzo,R.A.
  TITLE     Chiglitazar: a novel pan-PPAR agonist
  JOURNAL   Sci Bull (Beijing) 66 (15), 1497-1498 (2021)
   PUBMED   36654276
REFERENCE   6  (bases 1 to 2021)
  AUTHORS   Kliewer,S.A., Sundseth,S.S., Jones,S.A., Brown,P.J., Wisely,G.B.,
            Koble,C.S., Devchand,P., Wahli,W., Willson,T.M., Lenhard,J.M. and
            Lehmann,J.M.
  TITLE     Fatty acids and eicosanoids regulate gene expression through direct
            interactions with peroxisome proliferator-activated receptors alpha
            and gamma
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4318-4323 (1997)
   PUBMED   9113987
REFERENCE   7  (bases 1 to 2021)
  AUTHORS   Chu,R., Lin,Y., Rao,M.S. and Reddy,J.K.
  TITLE     Cloning and identification of rat deoxyuridine triphosphatase as an
            inhibitor of peroxisome proliferator-activated receptor alpha
  JOURNAL   J Biol Chem 271 (44), 27670-27676 (1996)
   PUBMED   8910358
REFERENCE   8  (bases 1 to 2021)
  AUTHORS   Shalev,A., Siegrist-Kaiser,C.A., Yen,P.M., Wahli,W., Burger,A.G.,
            Chin,W.W. and Meier,C.A.
  TITLE     The peroxisome proliferator-activated receptor alpha is a
            phosphoprotein: regulation by insulin
  JOURNAL   Endocrinology 137 (10), 4499-4502 (1996)
   PUBMED   8828512
REFERENCE   9  (bases 1 to 2021)
  AUTHORS   Kliewer,S.A., Forman,B.M., Blumberg,B., Ong,E.S., Borgmeyer,U.,
            Mangelsdorf,D.J., Umesono,K. and Evans,R.M.
  TITLE     Differential expression and activation of a family of murine
            peroxisome proliferator-activated receptors
  JOURNAL   Proc Natl Acad Sci U S A 91 (15), 7355-7359 (1994)
   PUBMED   8041794
REFERENCE   10 (bases 1 to 2021)
  AUTHORS   Gottlicher,M., Widmark,E., Li,Q. and Gustafsson,J.A.
  TITLE     Fatty acids activate a chimera of the clofibric acid-activated
            receptor and the glucocorticoid receptor
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4653-4657 (1992)
   PUBMED   1316614
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013196.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M88592.1, SRR26643287.18982.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               JAXUCZ010000007.1  118712607-118712857
            252-338             JAXUCZ010000007.1  118713551-118713637
            339-585             JAXUCZ010000007.1  118754321-118754567
            586-746             JAXUCZ010000007.1  118760603-118760763
            747-885             JAXUCZ010000007.1  118762468-118762606
            886-1088            JAXUCZ010000007.1  118764448-118764650
            1089-1536           JAXUCZ010000007.1  118771833-118772280
            1537-2021           JAXUCZ010000007.1  118774709-118775193
FEATURES             Location/Qualifiers
     source          1..2021
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2021
                     /gene="Ppara"
                     /gene_synonym="PPAR"
                     /note="peroxisome proliferator activated receptor alpha"
                     /db_xref="GeneID:25747"
                     /db_xref="RGD:3369"
     exon            1..251
                     /gene="Ppara"
                     /gene_synonym="PPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            252..338
                     /gene="Ppara"
                     /gene_synonym="PPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            339..585
                     /gene="Ppara"
                     /gene_synonym="PPAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1784
                     /gene="Ppara"
                     /gene_synonym="PPAR"
                     /note="PPAR-alpha; nuclear receptor subfamily 1 group C
                     member 1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor
                     alpha"
                     /protein_id="NP_037328.1"
                     /db_xref="GeneID:25747"
                     /db_xref="RGD:3369"
                     /translation="MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSLGEE
                     SSGSFSFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPAVPTSTDESPGNALNIEC
                     RICGDKASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHK
                     CLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLAKRIHEAYLKNF
                     NMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVENKEAEVRFFHCC
                     QCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAY
                     GNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLL
                     NIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKT
                     ESDAALHPLLQEIYRDMY"
     exon            586..746
                     /gene="Ppara"
                     /gene_synonym="PPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            747..885
                     /gene="Ppara"
                     /gene_synonym="PPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1088
                     /gene="Ppara"
                     /gene_synonym="PPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1536
                     /gene="Ppara"
                     /gene_synonym="PPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..2021
                     /gene="Ppara"
                     /gene_synonym="PPAR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaactgtccg ctacttcgag tccccttgag cgccgtgtgc cggctctgaa cattggcgtt
       61 cgcagctgtt ttgtgggctg gagggttcgt ggagtcctgg aactgaagcg acgctgggtc
      121 ctctggttgt ccccttgagg ggagggcaca cgagcgggga catcggggcg ctcccttccc
      181 acagcgtggt gcatttgggc gtaactcacc gggaggcgtt tcctgagacc ctcggggatc
      241 ttagaggcga gccaagactg aagttcaagg ccctgccttc cctgtgaact gacatttgtg
      301 actggtcaag ctcaggacac aagacgttgt catcacagat tggtgctctg tggcccgcct
      361 ggccacaacc attcaacatg gtggacacag agagccccat ctgtcctctc tccccacttg
      421 aagcagatga cctggaaagt cccttatctg aagaattctt acaagagatg ggaaacattc
      481 aagagatttc tcagtccctc ggagaggaga gttccggaag ctttagtttt gcggactacc
      541 agtacttagg gagctgtcca ggctcggagg gctctgtcat cacagacacc ctctctccag
      601 cttccagccc ctcctcagtc agctgccctg ctgtccccac cagtacagat gagtcccctg
      661 gcaatgcact gaacatcgag tgtcgaatat gtggggacaa ggcctcagga taccactatg
      721 gagtccacgc atgtgaaggc tgcaagggct tctttcggcg aactattcgg ctaaagctgg
      781 cgtacgacaa gtgtgatcga agctgcaaga ttcagaaaaa gaaccggaac aaatgccagt
      841 actgccgttt ccacaagtgc ctgtccgtcg ggatgtcaca caatgcaatc cgttttggaa
      901 gaatgccaag atctgagaaa gcaaaactga aggcagaaat ccttacctgt gaacacgatc
      961 tgaaagattc ggaaactgca gacctcaaat ctctggccaa gagaatccac gaagcctacc
     1021 tgaagaactt caacatgaac aaggtcaagg cccgggtcat actcgcagga aagactagca
     1081 acaatccgcc ttttgtcata catgacatgg agaccttgtg catggctgag aagacgcttg
     1141 tggccaagat ggtagccaac ggcgttgaaa acaaggaggc agaggtccga ttcttccact
     1201 gctgccagtg catgtccgtg gagaccgtca ccgagctcac ggaatttgcc aaggctatcc
     1261 caggctttgc aaacttggac ttgaatgacc aggttacctt gctgaagtac ggtgtgtatg
     1321 aagccatctt cacgatgctg tcctccttga tgaacaaaga cgggatgctg atcgcgtacg
     1381 gcaatggctt catcacccga gagttcctaa agaacctgag gaagccattc tgcgacatca
     1441 tggaacccaa gtttgacttc gctatgaagt tcaatgccct cgaactggat gacagtgaca
     1501 tttccctttt tgtggctgct ataatttgct gtggagatcg gcctggcctt ctaaacatag
     1561 gatacattga gaagttgcag gaggggattg tgcacgtgct caagctccac ctgcagagca
     1621 accatccgga tgataccttt ctcttcccaa aactccttca aaaaatggtg gacctccggc
     1681 agctggtcac ggagcatgcg cagctcgtgc aggtcatcaa gaagaccgag tcagacgcgg
     1741 cgttgcaccc actgttgcaa gagatctaca gagacatgta ctgatttttc ctgagatggt
     1801 aggccgttgc cactgttcag ggacctctga ggtctgcggc cccatacagg agagcaggga
     1861 tttgcacaga tggcctccct ccttaccctt ggagatgaag agggctgagc ctaggcaatg
     1921 caggctcctc ccacatcctt actttctgaa tgagcacttc taagacttcc tgctactgaa
     1981 atggtggtga tcagaggcta gtaggattca gacaattaca g
//
