LOCUS       NM_001135871            1154 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus inorganic pyrophosphatase 2 (Ppa2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001135871 XM_227690
VERSION     NM_001135871.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1154)
  AUTHORS   Guimier,A., Gordon,C.T., Godard,F., Ravenscroft,G., Oufadem,M.,
            Vasnier,C., Rambaud,C., Nitschke,P., Bole-Feysot,C., Masson,C.,
            Dauger,S., Longman,C., Laing,N.G., Kugener,B., Bonnet,D.,
            Bouvagnet,P., Di Filippo,S., Probst,V., Redon,R., Charron,P.,
            Rotig,A., Lyonnet,S., Dautant,A., de Pontual,L., di Rago,J.P.,
            Delahodde,A. and Amiel,J.
  TITLE     Biallelic PPA2 Mutations Cause Sudden Unexpected Cardiac Arrest in
            Infancy
  JOURNAL   Am J Hum Genet 99 (3), 666-673 (2016)
   PUBMED   27523598
REFERENCE   2  (bases 1 to 1154)
  AUTHORS   Kennedy,H., Haack,T.B., Hartill,V., Matakovic,L., Baumgartner,E.R.,
            Potter,H., Mackay,R., Alston,C.L., O'Sullivan,S., McFarland,R.,
            Connolly,G., Gannon,C., King,R., Mead,S., Crozier,I., Chan,W.,
            Florkowski,C.M., Sage,M., Hofken,T., Alhaddad,B., Kremer,L.S.,
            Kopajtich,R., Feichtinger,R.G., Sperl,W., Rodenburg,R.J.,
            Minet,J.C., Dobbie,A., Strom,T.M., Meitinger,T., George,P.M.,
            Johnson,C.A., Taylor,R.W., Prokisch,H., Doudney,K. and Mayr,J.A.
  TITLE     Sudden Cardiac Death Due to Deficiency of the Mitochondrial
            Inorganic Pyrophosphatase PPA2
  JOURNAL   Am J Hum Genet 99 (3), 674-682 (2016)
   PUBMED   27523597
REFERENCE   3  (bases 1 to 1154)
  AUTHORS   Xing,Y., Igarashi,H., Wang,X. and Sakaguchi,N.
  TITLE     Protein phosphatase subunit G5PR is needed for inhibition of B cell
            receptor-induced apoptosis
  JOURNAL   J Exp Med 202 (5), 707-719 (2005)
   PUBMED   16129705
REFERENCE   4  (bases 1 to 1154)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 16, 2008 this sequence version replaced XM_227690.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.42374.1,
                                           SRR22399489.2998084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               JAXUCZ010000002.1  224474873-224475014
            143-207             JAXUCZ010000002.1  224488868-224488932
            208-252             JAXUCZ010000002.1  224490490-224490534
            253-306             JAXUCZ010000002.1  224494544-224494597
            307-426             JAXUCZ010000002.1  224503488-224503607
            427-513             JAXUCZ010000002.1  224512664-224512750
            514-640             JAXUCZ010000002.1  224522545-224522671
            641-768             JAXUCZ010000002.1  224541077-224541204
            769-854             JAXUCZ010000002.1  224543814-224543899
            855-924             JAXUCZ010000002.1  224547694-224547763
            925-964             JAXUCZ010000002.1  224550589-224550628
            965-1154            JAXUCZ010000002.1  224551912-224552101
FEATURES             Location/Qualifiers
     source          1..1154
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1154
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /note="inorganic pyrophosphatase 2"
                     /db_xref="GeneID:310856"
                     /db_xref="RGD:1307965"
     CDS             1..993
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /EC_number="3.6.1.1"
                     /note="pyrophosphatase (inorganic) 2"
                     /codon_start=1
                     /product="inorganic pyrophosphatase 2, mitochondrial"
                     /protein_id="NP_001129343.1"
                     /db_xref="GeneID:310856"
                     /db_xref="RGD:1307965"
                     /translation="MRALLPLLSVGRGWRVGAAALPPRRVMSLYRTEELGHPRSKDYR
                     LFFKHVAGHYISPFHDIPLKADCEEEHGIPRKKARNDEYKASFNMVVEIPRWTNAKME
                     IATEEPLNPIKQDTKNGRLRYTPNIFPHKGYIWNYGALPQTWEDPHLKDKSTNCCGDN
                     DPIDVCEIGSKVLSRGDVVHVKILGTLALIDQSETDWKIIAINVNDPEAEKFHDIDDV
                     KKFKPGYLEATVNWFRLYKVPDGKPENKFAFNGEFKNKAFALEVINSAHEHWKEMVMK
                     KCDKGAISCVNVHICDSPFHCTTEEARSLVESIPTPSMSKESSVEEEVWHFLRN"
     exon            1..142
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            143..207
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            208..252
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            253..306
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            307..426
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            427..513
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            514..640
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            641..768
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            769..854
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            855..924
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            925..964
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1154
                     /gene="Ppa2"
                     /gene_synonym="RGD1307965"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgcgcgc tgctgccact gctgagcgtc ggccgagggt ggcgcgtggg ggccgccgcc
       61 ctccctccgc gccgcgtaat gtccctgtac cgcacggagg agctgggcca tccccgctcg
      121 aaggattacc gcctgttctt caagcacgta gctggccact acatctcccc tttccatgac
      181 attcctctga aggcagactg tgaagaggaa catggcattc ccaggaaaaa ggcacggaat
      241 gatgaatata aggcttcgtt taatatggtt gtggaaatac ctcggtggac aaatgccaag
      301 atggagattg ccaccgagga gccactgaac cccattaagc aagacaccaa gaacgggagg
      361 ctgcgctaca ccccgaacat cttcccccac aagggctaca tatggaatta cggggccctc
      421 cctcagacct gggaagatcc tcatctaaaa gacaagagta caaactgctg tggagacaac
      481 gaccccattg acgtttgtga aataggctcc aaggttcttt cccgtggaga cgtggtccat
      541 gtgaagatcc tggggacttt ggcacttatc gatcagagtg aaacagattg gaaaataatt
      601 gctatcaatg tgaatgatcc tgaggctgaa aaatttcatg atattgatga tgttaagaag
      661 ttcaaaccag gttacctaga agccactgtc aattggttta gactctataa ggtaccagat
      721 ggaaaaccag aaaacaagtt tgcttttaat ggagaattca aaaacaaggc ttttgccctc
      781 gaagttatta actctgcaca tgaacattgg aaagagatgg tgatgaagaa gtgtgacaag
      841 ggagctatca gttgtgtgaa cgtgcacatc tgtgatagcc ctttccactg cactacagag
      901 gaagcaaggt cactagttga atcgatccca acaccttcaa tgagtaaaga aagcagtgta
      961 gaagaagaag tgtggcactt cctccgcaac tgatggggac tctggggctt ctgcactgag
     1021 actttaaacc tccgaggacc ccggggactc cttttccttt agtgctcttg tgaagcaagt
     1081 ggatgaccgt ctgataactt cctgtccgac atcattgtta aaacttttta aataaacttg
     1141 taaataaata ctaa
//
